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    Arhgap28 Rho GTPase activating protein 28 [ Mus musculus (house mouse) ]

    Gene ID: 268970, updated on 3-Dec-2024

    Summary

    Official Symbol
    Arhgap28provided by MGI
    Official Full Name
    Rho GTPase activating protein 28provided by MGI
    Primary source
    MGI:MGI:2147003
    See related
    Ensembl:ENSMUSG00000024043 AllianceGenome:MGI:2147003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E130310N06
    Summary
    Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of stress fiber assembly. Predicted to be located in cell junction and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in lower leg bone. Human ortholog(s) of this gene implicated in allergic disease. Orthologous to human ARHGAP28 (Rho GTPase activating protein 28). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 7.1), ovary adult (RPKM 4.6) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Arhgap28 in Genome Data Viewer
    Location:
    17 E1.1- E1.2; 17 38.9 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (68149701..68311185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (67842706..68004197, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52321 Neighboring gene leucine rich repeat containing 30 Neighboring gene laminin, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_43107 Neighboring gene STARR-seq mESC enhancer starr_43108 Neighboring gene STARR-seq mESC enhancer starr_43110 Neighboring gene STARR-seq mESC enhancer starr_43111 Neighboring gene predicted gene, 36252 Neighboring gene predicted gene, 36312 Neighboring gene L3MBTL4 histone methyl-lysine binding protein Neighboring gene peroxiredoxin 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 28
    Names
    rho-type GTPase-activating protein 28

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347410.1NP_001334339.1  rho GTPase-activating protein 28 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154823, AC164159, CO043770
      Consensus CDS
      CCDS84329.1
      UniProtKB/TrEMBL
      A0A2X0SYT7
      Related
      ENSMUSP00000130960.2, ENSMUST00000163865.8
    2. NM_001426794.1NP_001413723.1  rho GTPase-activating protein 28 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154823, AC164159
      UniProtKB/TrEMBL
      A0A2X0SYT7, E9Q642
      Related
      ENSMUSP00000128194.2, ENSMUST00000164647.8
    3. NM_001426795.1NP_001413724.1  rho GTPase-activating protein 28 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154823, AC164159
      UniProtKB/TrEMBL
      A0A2X0SYT7, E9Q642
    4. NM_172964.4NP_766552.3  rho GTPase-activating protein 28 isoform 1

      See identical proteins and their annotated locations for NP_766552.3

      Status: VALIDATED

      Source sequence(s)
      AK087523, AK133720, AK141901, BB372888
      Consensus CDS
      CCDS28950.1
      UniProtKB/Swiss-Prot
      Q3TSH7, Q3UR11, Q3UZQ7, Q69ZM1, Q6NY11, Q8BN58
      UniProtKB/TrEMBL
      A0A2X0SYT7
      Related
      ENSMUSP00000024840.6, ENSMUST00000024840.12
      Conserved Domains (1) summary
      cd04391
      Location:381592
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      68149701..68311185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160630.1XP_036016523.1  rho GTPase-activating protein 28 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SYT7
      Conserved Domains (1) summary
      cd04391
      Location:408619
      RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
    2. XM_006524343.5XP_006524406.1  rho GTPase-activating protein 28 isoform X2

      See identical proteins and their annotated locations for XP_006524406.1

      UniProtKB/TrEMBL
      A0A2X0SYT7, E9Q642
      Conserved Domains (1) summary
      cd04391
      Location:331542
      RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...