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Conserved domains on  [gi|569000435|ref|XP_006524406|]
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rho GTPase-activating protein 28 isoform X2 [Mus musculus]

Protein Classification

rho GTPase-activating protein( domain architecture ID 10138216)

rho GTPase-activating protein (GAP) acts by converting Rho-type GTPases to an inactive GDP-bound state, similar to human Rho GAP 18 that suppresses F-actin polymerization by inhibiting Rho

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 331-542 3.58e-116

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239856  Cd Length: 216  Bit Score: 347.03  E-value: 3.58e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 331 IFGVPLTVLLDNDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKWDKMCHREAA 410
Cdd:cd04391    1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 411 VMLKAFFRELPTSLFPVEYIPAFISlMERGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIS 490
Cdd:cd04391   81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569000435 491 TVMAPNLFFSRSKHS-----DCEELLLANTATHIIRLMLKYQKILWKVPSFLITQVR 542
Cdd:cd04391  160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 331-542 3.58e-116

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 347.03  E-value: 3.58e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 331 IFGVPLTVLLDNDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKWDKMCHREAA 410
Cdd:cd04391    1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 411 VMLKAFFRELPTSLFPVEYIPAFISlMERGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIS 490
Cdd:cd04391   81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569000435 491 TVMAPNLFFSRSKHS-----DCEELLLANTATHIIRLMLKYQKILWKVPSFLITQVR 542
Cdd:cd04391  160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 353-502 2.37e-44

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 155.78  E-value: 2.37e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435  353 PLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDaRFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPA 432
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFD-RGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435  433 FISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNLFFSRS 502
Cdd:pfam00620  80 FIEAAKL-PDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 352-527 5.48e-35

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 130.46  E-value: 5.48e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435   352 VPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELD--ARFNADKFKWDKMChreAAVMLKAFFRELPTSLFPVEY 429
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDsgPDPDLDLSEYDVHD---VAGLLKLFLRELPEPLITYEL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435   430 IPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNLFfsRSKHSDCEE 509
Cdd:smart00324  80 YEEFIEAAKL-EDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLL--RPPDGEVAS 156

                          170
                   ....*....|....*...
gi 569000435   510 LLLANTATHIIRLMLKYQ 527
Cdd:smart00324 157 LKDIRHQNTVIEFLIENA 174
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 331-542 3.58e-116

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 347.03  E-value: 3.58e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 331 IFGVPLTVLLDNDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKWDKMCHREAA 410
Cdd:cd04391    1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVKQHDAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 411 VMLKAFFRELPTSLFPVEYIPAFISlMERGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIS 490
Cdd:cd04391   81 SLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569000435 491 TVMAPNLFFSRSKHS-----DCEELLLANTATHIIRLMLKYQKILWKVPSFLITQVR 542
Cdd:cd04391  160 MIMAPNLFPPRGKHSkdnesLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 353-502 2.37e-44

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 155.78  E-value: 2.37e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435  353 PLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDaRFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPA 432
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFD-RGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435  433 FISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNLFFSRS 502
Cdd:pfam00620  80 FIEAAKL-PDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 353-526 2.13e-40

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 145.52  E-value: 2.13e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 353 PLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDA-RFNADKFKWDkmCHrEAAVMLKAFFRELPTSLFPVEYIP 431
Cdd:cd00159    1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRgEDIDDLEDYD--VH-DVASLLKLYLRELPEPLIPFELYD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 432 AFISLMeRGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNLFfsRSKHSDCEELL 511
Cdd:cd00159   78 EFIELA-KIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLL--RPPDSDDELLE 154

                        170
                 ....*....|....*
gi 569000435 512 LANTATHIIRLMLKY 526
Cdd:cd00159  155 DIKKLNEIVEFLIEN 169
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 352-527 5.48e-35

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 130.46  E-value: 5.48e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435   352 VPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELD--ARFNADKFKWDKMChreAAVMLKAFFRELPTSLFPVEY 429
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDsgPDPDLDLSEYDVHD---VAGLLKLFLRELPEPLITYEL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435   430 IPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNLFfsRSKHSDCEE 509
Cdd:smart00324  80 YEEFIEAAKL-EDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLL--RPPDGEVAS 156

                          170
                   ....*....|....*...
gi 569000435   510 LLLANTATHIIRLMLKYQ 527
Cdd:smart00324 157 LKDIRHQNTVIEFLIENA 174
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 332-498 7.56e-27

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 107.87  E-value: 7.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDNDrkkdpAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARF------NADKFKWDKMC 405
Cdd:cd04398    1 FGVPLEDLILRE-----GDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPlnvlliSPEDYESDIHS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 406 hreAAVMLKAFFRELPTSLFPVEYIPAFISLMeRGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMN 485
Cdd:cd04398   76 ---VASLLKLFFRELPEPLLTKALSREFIEAA-KIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMS 151

                        170
                 ....*....|...
gi 569000435 486 LWNISTVMAPNLF 498
Cdd:cd04398  152 VNNLAIIWGPTLM 164
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 328-535 1.56e-24

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 102.11  E-value: 1.56e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 328 DNGIFGVPLTVLLDndRKKDPavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDArfNADKFKWDKMCHR 407
Cdd:cd04375    1 DKNVFGVPLLVNLQ--RTGQP---LPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIES--STDNVNYDGQQAY 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 408 EAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPDiKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLW 487
Cdd:cd04375   74 DVADMLKQYFRDLPEPLLTNKLSETFIAIFQYVPK-EQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTAT 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569000435 488 NISTVMAPNLFF---------SRSKHS---------DCEELLLANTATHIIRLMLKYQKILWKVPS 535
Cdd:cd04375  153 NLAVCLAPSLFHlntsrrensSPARRMqrkkslgkpDQKELSENKAAHQCLAYMIEECNTLFMVPK 218
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 332-495 2.71e-24

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 100.59  E-value: 2.71e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDNDRKkdpavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDArfNADKFKWDKMCHREAAV 411
Cdd:cd04377    1 FGVSLSSLTSEDRS------VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDT--DPDSVNLEDYPIHVITS 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 412 MLKAFFRELPTSLFPVEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIST 491
Cdd:cd04377   73 VLKQWLRELPEPLMTFELYENFLRAMEL-EEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAI 151


                 ....
gi 569000435 492 VMAP 495
Cdd:cd04377  152 VFAP 155
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 349-534 3.74e-24

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 100.59  E-value: 3.74e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 349 AVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDArfNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVE 428
Cdd:cd04376    6 ARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR--GIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 429 YIPAFISLMERGPDIkvQFQALHLMVMALPDANRDTAQALMAFFNKVIANE-----------SKNRMNLWNISTVMAPNL 497
Cdd:cd04376   84 LYTAFIGTALLEPDE--QLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAadsidedgqevSGNKMTSLNLATIFGPNL 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 569000435 498 F----FSRSKHSDCEELLLANTAT-HIIRLMLKYQKILWKVP 534
Cdd:cd04376  162 LhkqkSGEREFVQASLRIEESTAIiNVVQTMIDNYEELFMVS 203
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 332-524 6.60e-24

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 99.39  E-value: 6.60e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDndRKKDpavKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREEL--DARFNADKFKWDKMCHREA 409
Cdd:cd04403    1 FGCHLEALCQ--RENS---TVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVdhDEKLDLDDSKWEDIHVITG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 410 AvmLKAFFRELPTSLFPVEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNI 489
Cdd:cd04403   76 A--LKLFFRELPEPLFPYSLFNDFVAAIKL-SDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNL 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 569000435 490 STVMAPNLFfsrskHSDCEElllANTATH------IIRLML 524
Cdd:cd04403  153 AIVFGPTLL-----RPEQET---GNIAVHmvyqnqIVELIL 185
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 331-497 1.73e-23

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 98.20  E-value: 1.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 331 IFGVPLTVLLDNDRKKDPAVKVPLVLQKFFQKVEESGLE-SEGIFRLSGCTAKVKQYREELDARFNADKFKWDKMCHREA 409
Cdd:cd04400    1 IFGSPLEEAVELSSHKYNGRDLPSVVYRCIEYLDKNRAIyEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 410 -AVMLKAFFRELPTSLFPVEYIPAFISLMERGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWN 488
Cdd:cd04400   81 vAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRN 160


                 ....*....
gi 569000435 489 ISTVMAPNL 497
Cdd:cd04400  161 VCIVFSPTL 169
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 332-537 6.55e-23

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 97.44  E-value: 6.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLL-----DNDRKKDP-AVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKWDKMC 405
Cdd:cd04397    1 FGVPLEILVekfgaDSTLGVGPgKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDLSKENP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 406 HREAAvMLKAFFRELPTSLFPVEYIPAFISlMERGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKV-----IANES 480
Cdd:cd04397   81 VQLAA-LLKKFLRELPDPLLTFKLYRLWIS-SQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVssfshIDEET 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569000435 481 KNRMNLWNISTVMAPNLFFSRSKHSDC-EELLLANTATHiirLMLKYQKILWKVPSFL 537
Cdd:cd04397  159 GSKMDIHNLATVITPNILYSKTDNPNTgDEYFLAIEAVN---YLIENNEEFCEVPDEL 213
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 332-517 1.04e-21

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 93.17  E-value: 1.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDNDRKKDPavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKqyreELDARFNADK---FKWDKMCHRe 408
Cdd:cd04404    6 FGVSLQFLKEKNPEQEP---IPPVVRETVEYLQAHALTTEGIFRRSANTQVVK----EVQQKYNMGEpvdFDQYEDVHL- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 409 AAVMLKAFFRELPTSLFPVEYIPAFISLMERGPDIKVQfqALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWN 488
Cdd:cd04404   78 PAVILKTFLRELPEPLLTFDLYDDIVGFLNVDKEERVE--RVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSN 155

                        170       180
                 ....*....|....*....|....*....
gi 569000435 489 ISTVMAPNLFFSRSKHSDCEELLLANTAT 517
Cdd:cd04404  156 LAVVFGPNLLWAKDASMSLSAINPINTFT 184
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 331-514 2.82e-21

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 91.75  E-value: 2.82e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 331 IFGVPLTVLldnDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKWDKMChrEAA 410
Cdd:cd04393    2 VFGVPLQEL---QQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVC--SAA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 411 VMLKAFFRELPTSLFPVEYIPAFISLMERGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIS 490
Cdd:cd04393   77 SLLRLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLA 156

                        170       180
                 ....*....|....*....|....
gi 569000435 491 TVMAPNLFFSRSKHSDCEELLLAN 514
Cdd:cd04393  157 AVFGPDVFHVYTDVEDMKEQEICS 180
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 332-518 5.04e-20

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 88.45  E-value: 5.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDNDRkkdpaVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKWDKMCHREAAV 411
Cdd:cd04387    1 FGVKISTVTKRER-----SKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSVMLSEMDVNAIAG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 412 MLKAFFRELPTSLFPVEYIPAFISLMERGPDIKVQFQALHLMvMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIST 491
Cdd:cd04387   76 TLKLYFRELPEPLFTDELYPNFAEGIALSDPVAKESCMLNLL-LSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLAT 154

                        170       180
                 ....*....|....*....|....*..
gi 569000435 492 VMAPNLFFSRSKHSDCEELLLANTATH 518
Cdd:cd04387  155 VFGPTLLRPSEKESKIPTNTMTDSWSL 181
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 331-525 1.05e-19

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 87.90  E-value: 1.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 331 IFGVPLtvlldNDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDA-RFNADKFKWDKMCHREA 409
Cdd:cd04386    4 VFGTPL-----EEHLKRTGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAgTFSLPLDEFYSDPHAVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 410 AVmLKAFFRELPTSLFPVEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNI 489
Cdd:cd04386   79 SA-LKSYLRELPDPLLTYNLYEDWVQAANK-PDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNI 156

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 569000435 490 STVMAPNLFFSRSKHSDCEelLLANTATH---IIRLMLK 525
Cdd:cd04386  157 AIVLAPNLLWAKNEGSLAE--MAAGTSVHvvaIVELIIS 193
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 332-497 1.93e-19

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 86.69  E-value: 1.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDNDRKKdpavKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARF---NADKFKWDKMchRE 408
Cdd:cd04395    2 FGVPLDDCPPSSENP----YVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGfdiDLQDPRWRDV--NV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 409 AAVMLKAFFRELPTSLFPVEYIPAFISlMERGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWN 488
Cdd:cd04395   76 VSSLLKSFFRKLPEPLFTNELYPDFIE-ANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRN 154


                 ....*....
gi 569000435 489 ISTVMAPNL 497
Cdd:cd04395  155 LAIVFGPTL 163
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 352-526 2.60e-19

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 86.21  E-value: 2.60e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 352 VPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELdaRFNADKFKWDKMCHREAAV--MLKAFFRELPTSLFPVEY 429
Cdd:cd04385   15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAF--RKDARSVQLREGEYTVHDVadVLKRFLRDLPDPLLTSEL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 430 IPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNLFfsrskHSDCEE 509
Cdd:cd04385   93 HAEWIEAAEL-ENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLF-----QTDEHS 166

                        170
                 ....*....|....*..
gi 569000435 510 LLLANTATHIIRLMLKY 526
Cdd:cd04385  167 VGQTSHEVKVIEDLIDN 183
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 332-497 7.82e-19

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 84.88  E-value: 7.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLdndrKKDPAvKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVkqyrEELDARFNADKFKWDKMCHREAAV 411
Cdd:cd04372    1 YGCDLTTLV----KAHNT-QRPMVVDMCIREIEARGLQSEGLYRVSGFAEEI----EDVKMAFDRDGEKADISATVYPDI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 412 -----MLKAFFRELPTSLFPVEYIPAFISLMeRGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNL 486
Cdd:cd04372   72 nvitgALKLYFRDLPIPVITYDTYPKFIDAA-KISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNA 150

                        170
                 ....*....|.
gi 569000435 487 WNISTVMAPNL 497
Cdd:cd04372  151 ENLGIVFGPTL 161
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 332-524 2.01e-18

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 83.66  E-value: 2.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDNDRKkdpavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKWDKMCHrEAAV 411
Cdd:cd04373    1 FGVPLANVVTSEKP------IPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDFTVN-AVAG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 412 MLKAFFRELPTSLFPVEYIPAFISLMERGPDIKvQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIST 491
Cdd:cd04373   74 ALKSFFSELPDPLIPYSMHLELVEAAKINDREQ-RLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSI 152

                        170       180       190
                 ....*....|....*....|....*....|...
gi 569000435 492 VMAPNLFfsRSKHSDCEELllanTATHIIRLML 524
Cdd:cd04373  153 CFWPTLM--RPDFTSMEAL----SATRIYQTII 179
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 331-538 2.47e-18

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 83.68  E-value: 2.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 331 IFGVPLTVLLDNDRKKDPAVKVPLVLQKFFQkveESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKwdKMChrEAA 410
Cdd:cd04394    1 VFGVPLHSLPHSTVPEYGNVPKFLVDACTFL---LDHLSTEGLFRKSGSVVRQKELKAKLEGGEACLSSA--LPC--DVA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 411 VMLKAFFRELPTSLFPVEYIPAFISLMERGPDiKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIS 490
Cdd:cd04394   74 GLLKQFFRELPEPLLPYDLHEALLKAQELPTD-EERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLA 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569000435 491 TVMAPNLFFSRSKH----SDCEELLLANTAthIIRLMLKYQKILWKVPSFLI 538
Cdd:cd04394  153 VIFAPNLFQSEEGGekmsSSTEKRLRLQAA--VVQTLIDNASNIGIVPDFIL 202
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 332-501 5.02e-18

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 82.90  E-value: 5.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLdndRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKWDKMCHREA-A 410
Cdd:cd04379    1 FGVPLSRLV---EREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINViT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 411 VMLKAFFRELPTSLFPVEYIPAFISLMERGPDIKVQFQALHLMVM--ALPDANRDTAQALMAFFNKVIANESKNRMNLWN 488
Cdd:cd04379   78 GVLKDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIidCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQN 157

                        170
                 ....*....|...
gi 569000435 489 ISTVMAPNLFFSR 501
Cdd:cd04379  158 LAVCFGPVLMFCS 170
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 332-500 1.04e-17

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 81.33  E-value: 1.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDNDRKKDpAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKWDKmchREAAV 411
Cdd:cd04381    1 FGASLSLAVERSRCHD-GIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEYEP---PTVAS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 412 MLKAFFRELPTSLFPVEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIST 491
Cdd:cd04381   77 LLKQYLRELPEPLLTKELMPRFEEACGR-PTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISI 155


                 ....*....
gi 569000435 492 VMAPNLFFS 500
Cdd:cd04381  156 VLSPTVQIS 164
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 332-498 2.99e-17

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 80.42  E-value: 2.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDNdrkKDPavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKwDKMCHREAAV 411
Cdd:cd04407    1 FGVRVGSLTSN---KTS---VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLE-NYPIHAITGL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 412 mLKAFFRELPTSLFPVEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIST 491
Cdd:cd04407   74 -LKQWLRELPEPLMTFAQYNDFLRAVEL-PEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAI 151


                 ....*..
gi 569000435 492 VMAPNLF 498
Cdd:cd04407  152 VFAPCLL 158
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 331-519 2.03e-16

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 77.93  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 331 IFGVPLTVLLDNDRKKdpavkVPLVLQKFFQKVEESGLeSEGIFRLSGCTAKVKQYREELDARFNADKFKwDKMCHREAA 410
Cdd:cd04384    2 VFGCDLTEHLLNSGQD-----VPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEFDSEQIPDLTK-DVYIQDIHS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 411 V--MLKAFFRELPTSLFPVEYIPAFISLMERGPDiKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWN 488
Cdd:cd04384   75 VssLCKLYFRELPNPLLTYQLYEKFSEAVSAASD-EERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKN 153

                        170       180       190
                 ....*....|....*....|....*....|.
gi 569000435 489 ISTVMAPNLFFSRSKHSDCeellLANTATHI 519
Cdd:cd04384  154 LAIVWAPNLLRSKQIESAC----FSGTAAFM 180
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 330-523 4.47e-15

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 74.40  E-value: 4.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 330 GIFGVPLTVLLDNDRKKDPAVkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDArfnADK--FKWDKMCHR 407
Cdd:cd04390    1 GVFGQRLEDTVAYERKFGPRL-VPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDA---GERpsFDSDTDVHT 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 408 EAAvMLKAFFRELPTSLFPVEYIPAFISLMER-GPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNL 486
Cdd:cd04390   77 VAS-LLKLYLRELPEPVIPWAQYEDFLSCAQLlSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSV 155

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 569000435 487 WNISTVMAPNLFfsRSKHSDCEELLlaNTATHIIRLM 523
Cdd:cd04390  156 QNLATVFGPNIL--RPKVEDPATIM--EGTPQIQQLM 188
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 331-530 1.45e-14

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 73.60  E-value: 1.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 331 IFGVPLT----------VLLDNDRKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKqyreELDARFNA---- 396
Cdd:cd04396    1 VFGVSLEeslkyasvaiSIVDEDGEQYVYGYIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIR----ELQLIFSTppdy 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 397 -DKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPDIKVQFQALH----------------LMVMALPD 459
Cdd:cd04396   77 gKSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEEFRNPLRKRPRILQYMKGRIneplntdidqaikeyrDLITRLPN 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569000435 460 ANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNLFFSRSKHSDCEELLLANTathIIRLMLKYQKIL 530
Cdd:cd04396  157 LNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPDHEMDPKEYKLSRL---VVEFLIEHQDKF 224
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 332-506 9.47e-13

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 67.03  E-value: 9.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDNDRKKDPAVKVPLVLQKFFQKVEES-GLESEGIFRLSGCTAKVKqyreELDARFNADKFKWDKMCH-REA 409
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALgGFQTEGIFRVPGDIDEVN----ELKLRVDQWDYPLSGLEDpHVP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 410 AVMLKAFFRELPTSLFPVEYIPAFISLMERgPDIKVQfqalhlMVMALPDANRDTAQALMAFFNKVI--ANESKNRMNLW 487
Cdd:cd04389   77 ASLLKLWLRELEEPLIPDALYQQCISASED-PDKAVE------IVQKLPIINRLVLCYLINFLQVFAqpENVAHTKMDVS 149

                        170
                 ....*....|....*....
gi 569000435 488 NISTVMAPNlfFSRSKHSD 506
Cdd:cd04389  150 NLAMVFAPN--ILRCTSDD 166
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 331-497 9.95e-13

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 67.32  E-value: 9.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 331 IFGVPLTVLLDNDRKKDPAVKVPLVLqkfFQKveesGLESEGIFRLSGCTAKVKQYREELDARFNADkfkwdkmCHREA- 409
Cdd:cd04402    1 LFGQPLSNICEDDNLPKPILDMLSLL---YQK----GPSTEGIFRRSANAKACKELKEKLNSGVEVD-------LKAEPv 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 410 ---AVMLKAFFRELPTSLFPVEYIPAFISLMERGPDIKVQfQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNL 486
Cdd:cd04402   67 lllASVLKDFLRNIPGSLLSSDLYEEWMSALDQENEEEKI-AELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDA 145

                        170
                 ....*....|.
gi 569000435 487 WNISTVMAPNL 497
Cdd:cd04402  146 FNLAVCIAPSL 156
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 365-542 1.66e-12

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 67.10  E-value: 1.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 365 ESGLESEGIFRLSGCTAKVKQYREELDARFNADKFKWDKMCHrEAAVMLKAFFRELPTSLFPVEYIPAFISLME------ 438
Cdd:cd04392   21 EKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAH-DCATVLKGFLGELPEPLLTHAHYPAHLQIADlcqfde 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 439 -----RGPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNLFFSRSKHSDceelLLA 513
Cdd:cd04392  100 kgnktSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTPE----DLH 175

                        170       180       190
                 ....*....|....*....|....*....|..
gi 569000435 514 NTATH---IIRLMLKYQKILWKVPSFLITQVR 542
Cdd:cd04392  176 ENAQKlnsIVTFMIKHSQKLFKAPAYLREDAR 207
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 332-495 7.02e-12

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 64.64  E-value: 7.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 332 FGVPLTVLLDNDRKkdpavkVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDArfNADKFKWDKMCHREAAV 411
Cdd:cd04406    1 FGVELSRLTSEDRS------VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDT--DANSVNLDDYNIHVIAS 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 412 MLKAFFRELPTSLFPVEYIPAFISLMERgPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNIST 491
Cdd:cd04406   73 VFKQWLRDLPNPLMTFELYEEFLRAMGL-QERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAI 151


                 ....
gi 569000435 492 VMAP 495
Cdd:cd04406  152 VFAP 155
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 363-519 9.27e-12

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 64.62  E-value: 9.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 363 VEESGLESEGIFRLSGCTAKVKQYREE-LDARFNADKFKWD--KMCHreaavMLKAFFRELPTSLFPVEYIPAFISLMEr 439
Cdd:cd04382   28 IEARGLTEEGLYRVSGSEREVKALKEKfLRGKTVPNLSKVDihVICG-----CLKDFLRSLKEPLITFALWKEFMEAAE- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 440 GPDIKVQFQALHLMVMALPDANRDTAQALMAFFNKViANESKNRMNLWNISTVMAPNLFFSRSKHSDCEElLLANTATHI 519
Cdd:cd04382  102 ILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRV-AQSPECKMDINNLARVFGPTIVGYSVPNPDPMT-ILQDTVRQP 179
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 351-497 1.67e-10

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 60.99  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 351 KVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVkqyrEELDARFNADKFKWDKMCH--REAAVMLKAFFRELPTSLFPVE 428
Cdd:cd04408   15 EVPFVVVRCTAEIENRALGVQGIYRISGSKARV----EKLCQAFENGRDLVDLSGHspHDITSVLKHFLKELPEPVLPFQ 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 429 YIPAFISL---MERGPDIKVQ--------FQALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNL 497
Cdd:cd04408   91 LYDDFIALakeLQRDSEKAAEspsiveniIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTL 170
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 356-497 8.00e-10

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 58.94  E-value: 8.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 356 LQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDARFNADK----FKWDKMCHREAAVMLKAFFRELPTSLFPVEYIP 431
Cdd:cd04374   32 VRKCIEAVETRGINEQGLYRVVGVNSKVQKLLSLGLDPKTSTPgdvdLDNSEWEIKTITSALKTYLRNLPEPLMTYELHN 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000435 432 AFISLMERG-PDIKVQfqALHLMVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNL 497
Cdd:cd04374  112 DFINAAKSEnLESRVN--AIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTL 176
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 352-506 1.22e-09

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 58.59  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 352 VPLVLQKFFQKVEESGLESEGIFRLSGCTAKVkqyrEELDARFNADKFKWDKMCHREAAV--MLKAFFRELPTSLFPVEY 429
Cdd:cd04378   16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARV----EKLCQAFENGKDLVELSELSPHDIssVLKLFLRQLPEPLILFRL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 430 IPAFISLM----------------ERGPDIKVQFQALhlmVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVM 493
Cdd:cd04378   92 YNDFIALAkeiqrdteedkapntpIEVNRIIRKLKDL---LRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVF 168

                        170
                 ....*....|...
gi 569000435 494 APNLFFSRSKHSD 506
Cdd:cd04378  169 GPTLIRPRPGDAD 181
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 344-497 3.62e-09

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 56.66  E-value: 3.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000435 344 RKKDPAVKVPLVLQKFFQKVEESGLESEGIFRLSGCTAKVKQYREELDArfNADKFKWDKMCH--REAAVMLKAFFRELP 421
Cdd:cd04383   10 YIQDSGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFER--GEDPLADDQNDHdiNSVAGVLKLYFRGLE 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569000435 422 TSLFPVEYipaFISLMERGPDIKVQFQALHL--MVMALPDANRDTAQALMAFFNKVIANESKNRMNLWNISTVMAPNL 497
Cdd:cd04383   88 NPLFPKER---FEDLMSCVKLENPTERVHQIreILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTL 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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