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    Ppard peroxisome proliferator activator receptor delta [ Mus musculus (house mouse) ]

    Gene ID: 19015, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ppardprovided by MGI
    Official Full Name
    peroxisome proliferator activator receptor deltaprovided by MGI
    Primary source
    MGI:MGI:101884
    See related
    Ensembl:ENSMUSG00000002250 AllianceGenome:MGI:101884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NUC1; NUC-1; Nr1c2; Pparb; PPAR[b]; Pparb/d; PPAR-beta; PPARdelta; PPAR-delta
    Summary
    Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of myoblast differentiation; positive regulation of skeletal muscle tissue regeneration; and regulation of gene expression. Acts upstream of or within several processes, including keratinocyte migration; keratinocyte proliferation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Used to study Huntington's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in duodenum adult (RPKM 102.2), colon adult (RPKM 88.9) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Ppard in Genome Data Viewer
    Location:
    17 A3.3; 17 14.64 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28451715..28520446)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28232754..28301469)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 523 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28344631-28344740 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28348857-28349040 Neighboring gene STARR-seq mESC enhancer starr_42195 Neighboring gene STARR-positive B cell enhancer ABC_E7505 Neighboring gene differentially expressed in FDCP 6 Neighboring gene STARR-positive B cell enhancer ABC_E10940 Neighboring gene STARR-seq mESC enhancer starr_42199 Neighboring gene STARR-positive B cell enhancer ABC_E4200 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28393851-28394218 Neighboring gene RIKEN cDNA 1810013A23 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28407203-28407312 Neighboring gene STARR-positive B cell enhancer ABC_E10941 Neighboring gene STARR-positive B cell enhancer ABC_E2476 Neighboring gene Fanconi anemia, complementation group E Neighboring gene ribosomal protein L10A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (11)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific PubMed 
    enables NF-kappaB binding  
    enables NF-kappaB binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables enzyme activator activity PubMed 
    enables fatty acid binding  
    enables linoleic acid binding  
    enables linoleic acid binding  
    enables lipid binding  
    enables lipid binding  
    enables nuclear receptor activity  
    enables nuclear receptor activity  
    enables nuclear receptor activity  
    enables nuclear receptor activity PubMed 
    enables prostacyclin receptor activity PubMed 
    enables protein binding PubMed 
    enables sequence-specific double-stranded DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription coactivator binding  
    enables transcription coactivator binding  
    enables zinc ion binding  
    Items 1 - 25 of 86
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within adipose tissue development PubMed 
    acts_upstream_of_or_within anagen PubMed 
    involved_in apoptotic process  
    involved_in apoptotic signaling pathway  
    involved_in apoptotic signaling pathway  
    acts_upstream_of_or_within axon ensheathment PubMed 
    involved_in cell differentiation  
    acts_upstream_of_or_within cell differentiation PubMed 
    acts_upstream_of_or_within cell differentiation PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within cell-substrate adhesion PubMed 
    acts_upstream_of_or_within cellular response to hypoxia PubMed 
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to nutrient levels  
    involved_in cellular response to nutrient levels  
    involved_in decidualization  
    acts_upstream_of_or_within embryo implantation PubMed 
    involved_in embryo implantation PubMed 
    involved_in energy homeostasis PubMed 
    involved_in energy homeostasis  
    acts_upstream_of_or_within epidermis development PubMed 
    acts_upstream_of epithelial cell proliferation PubMed 
    acts_upstream_of fat cell proliferation PubMed 
    involved_in fatty acid beta-oxidation PubMed 
    involved_in fatty acid metabolic process  
    involved_in fatty acid oxidation  
    involved_in fatty acid transport PubMed 
    involved_in heart development  
    involved_in hormone-mediated signaling pathway  
    involved_in intracellular receptor signaling pathway  
    acts_upstream_of_or_within keratinocyte migration PubMed 
    acts_upstream_of_or_within keratinocyte proliferation PubMed 
    acts_upstream_of_or_within lipid metabolic process PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cholesterol storage  
    involved_in negative regulation of collagen biosynthetic process  
    involved_in negative regulation of collagen biosynthetic process  
    NOT acts_upstream_of_or_within negative regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation PubMed 
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of miRNA transcription PubMed 
    involved_in negative regulation of myoblast differentiation PubMed 
    involved_in negative regulation of smooth muscle cell migration  
    involved_in negative regulation of smooth muscle cell migration  
    involved_in negative regulation of smooth muscle cell proliferation  
    involved_in negative regulation of smooth muscle cell proliferation  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in phospholipid biosynthetic process  
    involved_in phospholipid biosynthetic process  
    acts_upstream_of_or_within placenta development PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of epidermis development  
    involved_in positive regulation of epidermis development  
    acts_upstream_of_or_within positive regulation of fat cell proliferation PubMed 
    involved_in positive regulation of fatty acid metabolic process  
    involved_in positive regulation of fatty acid oxidation  
    involved_in positive regulation of fatty acid oxidation  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus  
    involved_in positive regulation of myoblast proliferation PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of skeletal muscle tissue regeneration PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in proteoglycan metabolic process  
    involved_in proteoglycan metabolic process  
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within regulation of fat cell differentiation PubMed 
    involved_in regulation of insulin secretion PubMed 
    involved_in regulation of skeletal muscle satellite cell proliferation PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to activity  
    involved_in response to glucose  
    involved_in response to vitamin A  
    involved_in vasodilation  
    involved_in vasodilation  
    acts_upstream_of_or_within wound healing PubMed 
    Items 1 - 25 of 86
    Component Evidence Code Pubs
    located_in chromatin PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    is_active_in nucleus  

    General protein information

    Preferred Names
    peroxisome proliferator-activated receptor delta
    Names
    PPARdelta/beta
    Peroxisome proliferator-activated receptor beta
    nuclear hormone receptor 1
    nuclear receptor subfamily 1 group C member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411509.1NP_001398438.1  peroxisome proliferator-activated receptor delta isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126937, CT025652
      UniProtKB/TrEMBL
      A0A3B2W7W2
    2. NM_001411510.1NP_001398439.1  peroxisome proliferator-activated receptor delta isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT025652
      UniProtKB/Swiss-Prot
      P35396, P37239
      UniProtKB/TrEMBL
      A0A3B2W7W2, Q546I3
    3. NM_001411520.1NP_001398449.1  peroxisome proliferator-activated receptor delta isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC126937, CT025652
    4. NM_001411521.1NP_001398450.1  peroxisome proliferator-activated receptor delta isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC126937, CT025652
      UniProtKB/TrEMBL
      A0A3B2W7W2
      Related
      ENSMUSP00000156879.2, ENSMUST00000232879.2
    5. NM_001411522.1NP_001398451.1  peroxisome proliferator-activated receptor delta isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC126937, CT025652
    6. NM_001411526.1NP_001398455.1  peroxisome proliferator-activated receptor delta isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC126937, CT025652
      UniProtKB/Swiss-Prot
      P35396, P37239
      UniProtKB/TrEMBL
      A0A3B2W7W2, Q546I3
    7. NM_011145.4NP_035275.1  peroxisome proliferator-activated receptor delta isoform 1

      See identical proteins and their annotated locations for NP_035275.1

      Status: VALIDATED

      Source sequence(s)
      AC126937, CT025652
      Consensus CDS
      CCDS28575.1
      UniProtKB/Swiss-Prot
      P35396, P37239
      UniProtKB/TrEMBL
      A0A3B2W7W2, Q546I3
      Related
      ENSMUSP00000002320.9, ENSMUST00000002320.16
      Conserved Domains (2) summary
      cd06932
      Location:172439
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:72155
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28451715..28520446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160409.1XP_036016302.1  peroxisome proliferator-activated receptor delta isoform X2

      UniProtKB/TrEMBL
      A0A3B2W7W2
      Conserved Domains (2) summary
      cd06932
      Location:134401
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cl02596
      Location:56117
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
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