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Dut deoxyuridine triphosphatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 497778, updated on 27-Nov-2024

Summary

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Official Symbol
Dutprovided by RGD
Official Full Name
deoxyuridine triphosphataseprovided by RGD
Primary source
RGD:620849
See related
EnsemblRapid:ENSRNOG00000007221 AllianceGenome:RGD:620849
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dutp; PIP4
Summary
Enables several functions, including dUTP diphosphatase activity; peroxisome proliferator activated receptor binding activity; and pyrimidine deoxyribonucleotide binding activity. Involved in several processes, including liver development; pyrimidine deoxyribonucleotide metabolic process; and regulation of protein-containing complex assembly. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 344.2), Thymus (RPKM 330.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dut in Genome Data Viewer
Location:
3q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (132952258..132963433)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (112498864..112509994)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (117514399..117525450)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 1 Neighboring gene ribosomal protein L32, pseudogene 1 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene fibrillin 1 Neighboring gene uncharacterized LOC120101649

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of candidate growth-regulating genes that are overexpressed in late gestation fetal liver in the rat. Gruppuso PA, et al. Biochim Biophys Acta, 2000 Dec 1. PMID 11121581
  2. Purification and characterization of deoxyuridine triphosphate nucleotidohydrolase from anemic rat spleen: a trimer composition of the enzyme protein. Hokari S, et al. Arch Biochem Biophys, 1987 Mar. PMID 3032103
  3. Deoxyuridine triphosphate nucleotidohydrolase activity and its correlation with multiplication of erythroid cells in rat spleen. Hokari S, et al. Biochem Int, 1987 May. PMID 2841940
  4. dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure. Dos Santos RS, et al. Diabetes, 2017 Apr. PMID 28073829
  5. Immunohistochemical detection of dUTPase in intracranial tumors. Romeike BF, et al. Pathol Res Pract, 2005. PMID 16325515

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DUT inhibition by two independent siRNAs increased apoptosis in beta-cells.
    Title: dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dUTP diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dUTP diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dUTP diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxisome proliferator activated receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyrimidine deoxyribonucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dTMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dUMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dUMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dUMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dUTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dUTP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
deoxyuridine 5'-triphosphate nucleotidohydrolase
Names
PPAR-interacting protein 4
dUTP pyrophosphatase
dUTPase
NP_001035361.1
NP_446044.1
XP_008760410.1
XP_038961577.1
XP_038961579.1
XP_063140395.1
XP_063140396.1
XP_063140397.1
XP_063140398.1
XP_063140399.1
XP_063140400.1
XP_063140401.1
XP_063140402.1
XP_063140403.1
XP_063140404.1
XP_063140405.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040271.2 → NP_001035361.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2

    See identical proteins and their annotated locations for NP_001035361.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' CDS compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HPW6
    Conserved Domains (1) summary
    cl00493
    Location:2 → 159
    trimeric_dUTPase; Trimeric dUTP diphosphatases

  2. NM_053592.3 → NP_446044.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 1

    See identical proteins and their annotated locations for NP_446044.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P70583
    UniProtKB/TrEMBL
    A6HPW5
    Related
    ENSRNOP00000009549.1, ENSRNOT00000009549.4
    Conserved Domains (1) summary
    cl00493
    Location:51 → 203
    trimeric_dUTPase; Trimeric dUTP diphosphatases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    132952258..132963433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762188.3 → XP_008760410.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X7

    Conserved Domains (1) summary
    cl00493
    Location:66 → 163
    trimeric_dUTPase; Trimeric dUTP diphosphatases

  2. XM_063284332.1 → XP_063140402.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X9

  3. XM_063284327.1 → XP_063140397.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X3

  4. XM_063284331.1 → XP_063140401.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X8

  5. XM_063284326.1 → XP_063140396.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X2

  6. XM_063284329.1 → XP_063140399.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X5

    Related
    ENSRNOP00000112289.1, ENSRNOT00000137124.1

  7. XM_063284330.1 → XP_063140400.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X6

  8. XM_063284333.1 → XP_063140403.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X10

  9. XM_063284334.1 → XP_063140404.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X11

  10. XM_063284325.1 → XP_063140395.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X1

  11. XM_063284328.1 → XP_063140398.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X4

  12. XM_063284335.1 → XP_063140405.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X12

  13. XM_039105649.2 → XP_038961577.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X12

    Conserved Domains (1) summary
    cl00493
    Location:18 → 110
    trimeric_dUTPase; Trimeric dUTP diphosphatases

  14. XM_039105651.2 → XP_038961579.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X13

    Conserved Domains (1) summary
    cl00493
    Location:42 → 109
    trimeric_dUTPase; Trimeric dUTP diphosphatases

RNA

  1. XR_010064679.1 RNA Sequence

  2. XR_010064680.1 RNA Sequence

  3. XR_010064681.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70583.3 GenPept UniProtKB/Swiss-Prot:P70583

Gene LinkOut

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