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    LDLR low density lipoprotein receptor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574283, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LDLRprovided by VGNC
    Official Full Name
    low density lipoprotein receptorprovided by VGNC
    Primary source
    VGNC:VGNC:74248
    See related
    Ensembl:ENSMMUG00000003611
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See LDLR in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (10851254..10893727)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (11109832..11154562)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Neighboring gene uncharacterized LOC114674158 Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene KN motif and ankyrin repeat domains 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-mediated process. Tserentsoodol N, et al. Mol Vis, 2006 Oct 27. PMID 17110914
    2. Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia. Nomura S, et al. Gene Ther, 2004 Oct. PMID 15269711
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    low-density lipoprotein receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032906.1 → NP_001028078.1  low-density lipoprotein receptor precursor

      See identical proteins and their annotated locations for NP_001028078.1

      Status: PROVISIONAL

      Source sequence(s)
      AY466854
      UniProtKB/TrEMBL
      A0A1D5RIY9, Q6S4M2
      Related
      ENSMMUP00000004821.4, ENSMMUT00000005117.4
      Conserved Domains (5) summary
      smart00135
      Location:546 → 588
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:347 → 381
      EGF_CA; Calcium-binding EGF-like domain
      pfam00057
      Location:195 → 231
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:522 → 562
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:311 → 339
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      10851254..10893727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028838328.1 → XP_028694161.1  low-density lipoprotein receptor isoform X1

      UniProtKB/TrEMBL
      A0A1D5RIY9
      Conserved Domains (5) summary
      smart00135
      Location:553 → 595
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:354 → 388
      EGF_CA; Calcium-binding EGF-like domain
      pfam00058
      Location:529 → 569
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam00057
      Location:195 → 231
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam14670
      Location:318 → 346
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_015122900.2 → XP_014978386.2  low-density lipoprotein receptor isoform X2

      UniProtKB/TrEMBL
      A0A1D5RIY9, F6QFM0
      Related
      ENSMMUP00000004819.4, ENSMMUT00000005115.4
      Conserved Domains (5) summary
      smart00135
      Location:553 → 595
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:354 → 388
      EGF_CA; Calcium-binding EGF-like domain
      pfam00058
      Location:529 → 569
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam00057
      Location:195 → 231
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam14670
      Location:318 → 346
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version

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