NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622890921|ref|XP_014978386|]
View 

low-density lipoprotein receptor isoform X2 [Macaca mulatta]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11081348)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 529-569 3.30e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 64.49  E-value: 3.30e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622890921 529 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIEWPNGITLD 569
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
195-231 5.60e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.73  E-value: 5.60e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622890921 195 SPCSAFEFHCRSGECIHSGWRCDGGPDCKDKSDEENC 231
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 487-526 3.16e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.71  E-value: 3.16e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622890921 487 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVDP 526
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
107-143 6.64e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 6.64e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622890921 107 KTCSQDEFRCHDGKCIYRQFVCDSDRDCLDGSDEASC 143
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
235-270 1.20e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.20e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1622890921 235 TCRPDEFQCSDGTCIHGSRQCDREYDCKDMSDEVGC 270
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 553-595 1.37e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.37e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622890921  553 YSLVTENIEWPNGITLDFPSGRLYWVDSKLHSISSIDVNGGNR 595
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 2.48e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.10  E-value: 2.48e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622890921  25 DRCERNEFQCEDGKCISYKWVCDGTAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
147-179 3.08e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 3.08e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622890921 147 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 5.99e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.95  E-value: 5.99e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622890921  66 VTCKSGDFSCGGRvnRCIPQFWRCDGEVDCENGSDEQDC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 439-483 6.73e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.86  E-value: 6.73e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622890921 439 NRIYWSDLSQRmiYSTQLDRAHSvSSYDTVISRDLQAPDGLAVDW 483
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
278-308 2.32e-07

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 2.32e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1622890921 278 GPNKFKCHSGECISLDKVCNMARDCRDWSDE 308
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 616-656 5.62e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 5.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622890921 616 DKVFWTDIINEAIFSANRLTGSDI-NLLAENLLSPEDMVLFH 656
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 318-346 2.52e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.54  E-value: 2.52e-06
                          10        20
                  ....*....|....*....|....*....
gi 1622890921 318 CLDNNGGCSHICNDLKIGYECLCPDGFQL 346
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
354-388 2.76e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 2.76e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1622890921  354 DIDECQDPDTCSQ--LCVNLEGSYKCQCEEGFQLDPH 388
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 671-711 1.15e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622890921 671 TLSNGGCQYLCLPAPQinpqspKFTCTCPDGMLLAKDMRSC 711
Cdd:pfam14670   2 SVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 419-457 3.06e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 3.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622890921  419 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMIYSTQLD 457
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 529-569 3.30e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 64.49  E-value: 3.30e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622890921 529 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIEWPNGITLD 569
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
195-231 5.60e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.73  E-value: 5.60e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622890921 195 SPCSAFEFHCRSGECIHSGWRCDGGPDCKDKSDEENC 231
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 487-526 3.16e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.71  E-value: 3.16e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622890921 487 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVDP 526
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
107-143 6.64e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 6.64e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622890921 107 KTCSQDEFRCHDGKCIYRQFVCDSDRDCLDGSDEASC 143
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
235-270 1.20e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.20e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1622890921 235 TCRPDEFQCSDGTCIHGSRQCDREYDCKDMSDEVGC 270
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 553-595 1.37e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.37e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622890921  553 YSLVTENIEWPNGITLDFPSGRLYWVDSKLHSISSIDVNGGNR 595
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 2.48e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.10  E-value: 2.48e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622890921  25 DRCERNEFQCEDGKCISYKWVCDGTAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
147-179 3.08e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 3.08e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622890921 147 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 197-231 4.78e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 4.78e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622890921 197 CSAFEFHCRSGECIHSGWRCDGGPDCKDKSDEENC 231
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 5.99e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.95  E-value: 5.99e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622890921  66 VTCKSGDFSCGGRvnRCIPQFWRCDGEVDCENGSDEQDC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 439-483 6.73e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.86  E-value: 6.73e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622890921 439 NRIYWSDLSQRmiYSTQLDRAHSvSSYDTVISRDLQAPDGLAVDW 483
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 109-143 9.76e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 9.76e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622890921 109 CSQDEFRCHDGKCIYRQFVCDSDRDCLDGSDEASC 143
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 467-508 1.63e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.76  E-value: 1.63e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622890921  467 TVISRDLQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKR 508
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 236-270 1.88e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.88e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622890921 236 CRPDEFQCSDGTCIHGSRQCDREYDCKDMSDEVGC 270
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 147-179 3.49e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.49e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1622890921  147 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 108-140 3.53e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.53e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1622890921  108 TCSQDEFRCHDGKCIYRQFVCDSDRDCLDGSDE 140
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 573-615 5.41e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 5.41e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622890921 573 GRLYWVDSKLH-SISSIDVNGGNRKTILedKERLAHPFSLAIFE 615
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 68-104 1.15e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 1.15e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622890921  68 CKSGDFSCGGRvnRCIPQFWRCDGEVDCENGSDEQDC 104
Cdd:cd00112     1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-180 1.30e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 1.30e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622890921 148 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW 180
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 235-267 1.55e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 1.55e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1622890921  235 TCRPDEFQCSDGTCIHGSRQCDREYDCKDMSDE 267
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 197-228 2.20e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 2.20e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622890921  197 CSAFEFHCRSGECIHSGWRCDGGPDCKDKSDE 228
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-58 2.28e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 2.28e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622890921  27 CERNEFQCEDGKCISYKWVCDGTAECQDGSDE 58
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-58 3.07e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 3.07e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1622890921   26 RCERNEFQCEDGKCISYKWVCDGTAECQDGSDE 58
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-101 6.84e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.84e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622890921   67 TCKSGDFSCGGRvnRCIPQFWRCDGEVDCENGSDE 101
Cdd:smart00192   1 TCPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
278-308 2.32e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 2.32e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1622890921 278 GPNKFKCHSGECISLDKVCNMARDCRDWSDE 308
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 509-549 5.11e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 5.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622890921  509 KTLFRENGSKPRAIVVDPVHGFMYWTDWGTPaKIKKGGLNG 549
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDG 40
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 616-656 5.62e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 5.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622890921 616 DKVFWTDIINEAIFSANRLTGSDI-NLLAENLLSPEDMVLFH 656
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 466-628 9.82e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 51.14  E-value: 9.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 466 DTVISRDLQAPDGLAVDwiHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTp 539
Cdd:cd14963    94 EKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPGSEpgelsyPNGIAVDE-DGNIYVADSGN- 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 540 akikkgglNGVDIYSLVTENIEW-------------PNGITLDfPSGRLYWVDSKLHSISSIDVNGGNRKTIL---EDKE 603
Cdd:cd14963   169 --------GRIQVFDKNGKFIKElngspdgksgfvnPRGIAVD-PDGNLYVVDNLSHRVYVFDEQGKELFTFGgrgKDDG 239

                         170       180
                  ....*....|....*....|....*.
gi 1622890921 604 RLAHPFSLAIFEDKVFW-TDIINEAI 628
Cdd:cd14963   240 QFNLPNGLFIDDDGRLYvTDRENNRV 265
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
421-593 1.08e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.85  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 421 SLIPNLRNVVALDTEVASNRIYWSDLSQRMIYSTQLDrAHSVSSYDT----VISR--DLQAPDGLAVDWIHSNIYWTDSV 494
Cdd:COG3391    52 GGVALLAGLGLGAAAVADADGADAGADGRRLYVANSG-SGRVSVIDLatgkVVATipVGGGPRGLAVDPDGGRLYVADSG 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 495 LGTVSVADTK-GVKRKTLfrENGSKPRAIVVDPVHGFMYWTDWGTP--AKIkkgglngVDIYSLVTENI-------EWPN 564
Cdd:COG3391   131 NGRVSVIDTAtGKVVATI--PVGAGPHGIAVDPDGKRLYVANSGSNtvSVI-------VSVIDTATGKVvatipvgGGPV 201

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1622890921 565 GITLDfPSGRLYWV--------DSKLHSISSIDVNGG 593
Cdd:COG3391   202 GVAVS-PDGRRLYVanrgsntsNGGSNTVSVIDLATL 237
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 318-346 2.52e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.54  E-value: 2.52e-06
                          10        20
                  ....*....|....*....|....*....
gi 1622890921 318 CLDNNGGCSHICNDLKIGYECLCPDGFQL 346
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 278-308 2.72e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 2.72e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1622890921 278 GPNKFKCHSGECISLDKVCNMARDCRDWSDE 308
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
354-388 2.76e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 2.76e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1622890921  354 DIDECQDPDTCSQ--LCVNLEGSYKCQCEEGFQLDPH 388
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 354-386 1.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.62e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622890921 354 DIDECQDPDTCS--QLCVNLEGSYKCQCEEGFQLD 386
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 278-308 2.03e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.24  E-value: 2.03e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622890921  278 GPNKFKCHSGECISLDKVCNMARDCRDWSDE 308
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 671-711 1.15e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622890921 671 TLSNGGCQYLCLPAPQinpqspKFTCTCPDGMLLAKDMRSC 711
Cdd:pfam14670   2 SVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
354-382 1.31e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.31e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622890921 354 DIDECQDP-DTCSQ--LCVNLEGSYKCQCEEG 382
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 419-457 3.06e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 3.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622890921  419 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMIYSTQLD 457
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 529-569 3.30e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 64.49  E-value: 3.30e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622890921 529 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIEWPNGITLD 569
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
195-231 5.60e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.73  E-value: 5.60e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622890921 195 SPCSAFEFHCRSGECIHSGWRCDGGPDCKDKSDEENC 231
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 487-526 3.16e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.71  E-value: 3.16e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622890921 487 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVDP 526
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
107-143 6.64e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 6.64e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622890921 107 KTCSQDEFRCHDGKCIYRQFVCDSDRDCLDGSDEASC 143
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
235-270 1.20e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.20e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1622890921 235 TCRPDEFQCSDGTCIHGSRQCDREYDCKDMSDEVGC 270
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 553-595 1.37e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.37e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622890921  553 YSLVTENIEWPNGITLDFPSGRLYWVDSKLHSISSIDVNGGNR 595
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 2.48e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.10  E-value: 2.48e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622890921  25 DRCERNEFQCEDGKCISYKWVCDGTAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
147-179 3.08e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 3.08e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622890921 147 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 197-231 4.78e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 4.78e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622890921 197 CSAFEFHCRSGECIHSGWRCDGGPDCKDKSDEENC 231
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 5.99e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.95  E-value: 5.99e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622890921  66 VTCKSGDFSCGGRvnRCIPQFWRCDGEVDCENGSDEQDC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 439-483 6.73e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.86  E-value: 6.73e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622890921 439 NRIYWSDLSQRmiYSTQLDRAHSvSSYDTVISRDLQAPDGLAVDW 483
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 109-143 9.76e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 9.76e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622890921 109 CSQDEFRCHDGKCIYRQFVCDSDRDCLDGSDEASC 143
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 467-508 1.63e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.76  E-value: 1.63e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622890921  467 TVISRDLQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKR 508
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 236-270 1.88e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.88e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622890921 236 CRPDEFQCSDGTCIHGSRQCDREYDCKDMSDEVGC 270
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 147-179 3.49e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.49e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1622890921  147 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 108-140 3.53e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.53e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1622890921  108 TCSQDEFRCHDGKCIYRQFVCDSDRDCLDGSDE 140
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 573-615 5.41e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 5.41e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622890921 573 GRLYWVDSKLH-SISSIDVNGGNRKTILedKERLAHPFSLAIFE 615
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 68-104 1.15e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 1.15e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622890921  68 CKSGDFSCGGRvnRCIPQFWRCDGEVDCENGSDEQDC 104
Cdd:cd00112     1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-180 1.30e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 1.30e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622890921 148 CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW 180
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 235-267 1.55e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 1.55e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1622890921  235 TCRPDEFQCSDGTCIHGSRQCDREYDCKDMSDE 267
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 197-228 2.20e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 2.20e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622890921  197 CSAFEFHCRSGECIHSGWRCDGGPDCKDKSDE 228
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-58 2.28e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 2.28e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622890921  27 CERNEFQCEDGKCISYKWVCDGTAECQDGSDE 58
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-58 3.07e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 3.07e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1622890921   26 RCERNEFQCEDGKCISYKWVCDGTAECQDGSDE 58
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-101 6.84e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.84e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622890921   67 TCKSGDFSCGGRvnRCIPQFWRCDGEVDCENGSDE 101
Cdd:smart00192   1 TCPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
278-308 2.32e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 2.32e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1622890921 278 GPNKFKCHSGECISLDKVCNMARDCRDWSDE 308
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 509-549 5.11e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 5.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622890921  509 KTLFRENGSKPRAIVVDPVHGFMYWTDWGTPaKIKKGGLNG 549
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDG 40
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 616-656 5.62e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 5.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622890921 616 DKVFWTDIINEAIFSANRLTGSDI-NLLAENLLSPEDMVLFH 656
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 466-628 9.82e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 51.14  E-value: 9.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 466 DTVISRDLQAPDGLAVDwiHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTp 539
Cdd:cd14963    94 EKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPGSEpgelsyPNGIAVDE-DGNIYVADSGN- 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 540 akikkgglNGVDIYSLVTENIEW-------------PNGITLDfPSGRLYWVDSKLHSISSIDVNGGNRKTIL---EDKE 603
Cdd:cd14963   169 --------GRIQVFDKNGKFIKElngspdgksgfvnPRGIAVD-PDGNLYVVDNLSHRVYVFDEQGKELFTFGgrgKDDG 239

                         170       180
                  ....*....|....*....|....*.
gi 1622890921 604 RLAHPFSLAIFEDKVFW-TDIINEAI 628
Cdd:cd14963   240 QFNLPNGLFIDDDGRLYvTDRENNRV 265
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
421-593 1.08e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.85  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 421 SLIPNLRNVVALDTEVASNRIYWSDLSQRMIYSTQLDrAHSVSSYDT----VISR--DLQAPDGLAVDWIHSNIYWTDSV 494
Cdd:COG3391    52 GGVALLAGLGLGAAAVADADGADAGADGRRLYVANSG-SGRVSVIDLatgkVVATipVGGGPRGLAVDPDGGRLYVADSG 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 495 LGTVSVADTK-GVKRKTLfrENGSKPRAIVVDPVHGFMYWTDWGTP--AKIkkgglngVDIYSLVTENI-------EWPN 564
Cdd:COG3391   131 NGRVSVIDTAtGKVVATI--PVGAGPHGIAVDPDGKRLYVANSGSNtvSVI-------VSVIDTATGKVvatipvgGGPV 201

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1622890921 565 GITLDfPSGRLYWV--------DSKLHSISSIDVNGG 593
Cdd:COG3391   202 GVAVS-PDGRRLYVanrgsntsNGGSNTVSVIDLATL 237
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 318-346 2.52e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.54  E-value: 2.52e-06
                          10        20
                  ....*....|....*....|....*....
gi 1622890921 318 CLDNNGGCSHICNDLKIGYECLCPDGFQL 346
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 278-308 2.72e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 2.72e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1622890921 278 GPNKFKCHSGECISLDKVCNMARDCRDWSDE 308
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
354-388 2.76e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 2.76e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1622890921  354 DIDECQDPDTCSQ--LCVNLEGSYKCQCEEGFQLDPH 388
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 473-625 1.21e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 47.70  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 473 LQAPDGLAVDwIHSNIYWTDSVLGTVSVADTKGvKRKTLFRENGSK------PRAIVVDPvHGFMYWTDWGTpAKIKK-- 544
Cdd:cd05819     7 LNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDG-NFITSFGSFGSGdgqfnePAGVAVDS-DGNLYVADTGN-HRIQKfd 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 545 ---GGLNGVDIYSLVTENIEWPNGITLDfPSGRLYWVDSKLHSISSIDVNGGNRKTI---LEDKERLAHPFSLAIF-EDK 617
Cdd:cd05819    83 pdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDsDGN 161


                  ....*...
gi 1622890921 618 VFWTDIIN 625
Cdd:cd05819   162 IYVADTGN 169
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 354-386 1.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.62e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622890921 354 DIDECQDPDTCS--QLCVNLEGSYKCQCEEGFQLD 386
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 278-308 2.03e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.24  E-value: 2.03e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622890921  278 GPNKFKCHSGECISLDKVCNMARDCRDWSDE 308
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 473-613 9.92e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 44.89  E-value: 9.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 473 LQAPDGLAVDWiHSNIYWTDSVLGTVSVADTKGVKRKTLFRENG---SKPRAIVVDPvHGFMYWTDwGTPAKIKKGGLNG 549
Cdd:cd14962    11 LTRPYGVAADG-RGRIYVADTGRGAVFVFDLPNGKVFVIGNAGPnrfVSPIGVAIDA-NGNLYVSD-AELGKVFVFDRDG 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622890921 550 VDIYSlVTENIEW--PNGITLDFPSGRLYWVDSKLHSISSIDVNGGNRKTILEDKE---RLAHPFSLAI 613
Cdd:cd14962    88 KFLRA-IGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRGSgpgEFNLPTDLAV 155
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 671-711 1.15e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622890921 671 TLSNGGCQYLCLPAPQinpqspKFTCTCPDGMLLAKDMRSC 711
Cdd:pfam14670   2 SVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 473-617 1.57e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 44.59  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 473 LQAPDGLAVDWiHSNIYWTDSVLGTVSVADTKGVKRKTL----FRENGSKPRAIVVDpvHGFMYWTDWGtPAKIKKGGLN 548
Cdd:cd14963    55 FKYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKYFpekkDRVKLISPAGLAID--DGKLYVSDVK-KHKVIVFDLE 130

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622890921 549 GVDIYSLVTE-----NIEWPNGITLDfPSGRLYWVDSKLHSISSIDVNGGNRKTI---LEDKERLAHPFSLAIFEDK 617
Cdd:cd14963   131 GKLLLEFGKPgsepgELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELngsPDGKSGFVNPRGIAVDPDG 206
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 476-613 6.03e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 42.69  E-value: 6.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 476 PDGLAVDwIHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTpAKIKKGGLNG 549
Cdd:cd05819    57 PAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLAS-FGGSGDGdgefngPRGIAVDS-SGNIYVADTGN-HRIQKFDPDG 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622890921 550 VDIYSLVTENIEW-----PNGITLDfPSGRLYWVDSKLHSISSIDVNGGNRKTILE---DKERLAHPFSLAI 613
Cdd:cd05819   133 EFLTTFGSGGSGPgqfngPTGVAVD-SDGNIYVADTGNHRIQVFDPDGNFLTTFGStgtGPGQFNYPTGIAV 203
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 352-391 7.07e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 7.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622890921 352 CEDIDECQD-PDTCSQLCVNLEGSYKCQCEEGFQLDPHTKA 391
Cdd:cd01475   184 CVVPDLCATlSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA pfam07645
Calcium-binding EGF domain;
354-382 1.31e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.31e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622890921 354 DIDECQDP-DTCSQ--LCVNLEGSYKCQCEEG 382
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 419-457 3.06e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 3.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622890921  419 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMIYSTQLD 457
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 437-597 3.48e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 40.26  E-value: 3.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 437 ASNRIYWSDLSQRMIYstqldRAHSVSSYDTVISRDLQAPDGLAVDWiHSNIYWTDSVLGtVSVADTKGVKRKTLFRENG 516
Cdd:COG3386    17 PDGRLYWVDIPGGRIH-----RYDPDGGAVEVFAEPSGRPNGLAFDP-DGRLLVADHGRG-LVRFDPADGEVTVLADEYG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 517 SKPRA---IVVDPvHGFMYWTDwgTPAKIKKGGLngvdiY--------SLVTENIEWPNGITLDfPSGR-LYWVDSKLHS 584
Cdd:COG3386    90 KPLNRpndGVVDP-DGRLYFTD--MGEYLPTGAL-----YrvdpdgslRVLADGLTFPNGIAFS-PDGRtLYVADTGAGR 160

                         170
                  ....*....|....*..
gi 1622890921 585 ISSIDVNG----GNRKT 597
Cdd:COG3386   161 IYRFDLDAdgtlGNRRV 177
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
472-637 3.57e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.39  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 472 DLQAPDGLAVDwIHSNIYWTDSVLGTVSVADTKGVKRKTL-FRENGSKPRAIVVDPvHGFMYWTDwgtpakikkGGLNGV 550
Cdd:COG4257    57 GGSGPHGIAVD-PDGNLWFTDNGNNRIGRIDPKTGEITTFaLPGGGSNPHGIAFDP-DGNLWFTD---------QGGNRI 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 551 DIYSLVTENIEW---------PNGITLDfPSGRLYWVDSKLHSISSIDVNGGNRKTIlEDKERLAHPFSLAI-FEDKVFW 620
Cdd:COG4257   126 GRLDPATGEVTEfplptggagPYGIAVD-PDGNLWVTDFGANAIGRIDPDTGTLTEY-ALPTPGAGPRGLAVdPDGNLWV 203

                         170
                  ....*....|....*..
gi 1622890921 621 TDIINEAIFSANRLTGS 637
Cdd:COG4257   204 ADTGSGRIGRFDPKTGT 220
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 357-388 3.87e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 3.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622890921 357 ECQDPDTCS--QLCVNLEGSYKCQCEEGFQLDPH 388
Cdd:cd00053     1 ECAASNPCSngGTCVNTPGSYRCVCPPGYTGDRS 34
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 473-585 4.39e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 39.99  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890921 473 LQAPDGLAVDwIHSNIYWTDSVLGTVSVADTKGvKRKTLFRENG------SKPRAIVVDPvHGFMYWTDWGT------PA 540
Cdd:cd05819   148 FNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDG-NFLTTFGSTGtgpgqfNYPTGIAVDS-DGNIYVADSGNnrvqvfDP 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622890921 541 KIKKGGLNGVDIYSLvtENIEWPNGITLDfPSGRLYWVDSKLHSI 585
Cdd:cd05819   225 DGAGFGGNGNFLGSD--GQFNRPSGLAVD-SDGNLYVADTGNNRI 266
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 364-392 6.00e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 35.30  E-value: 6.00e-03
                          10        20
                  ....*....|....*....|....*....
gi 1622890921 364 CSQLCVNLEGSYKCQCEEGFQLDPHTKAC 392
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF smart00181
Epidermal growth factor-like domain;
357-388 6.72e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.19  E-value: 6.72e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1622890921  357 ECQDPDTCSQ-LCVNLEGSYKCQCEEGFQLDPH 388
Cdd:smart00181   1 ECASGGPCSNgTCINTPGSYTCSCPPGYTGDKR 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH