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    DCAF13 DDB1 and CUL4 associated factor 13 [ Homo sapiens (human) ]

    Gene ID: 25879, updated on 10-Dec-2024

    Summary

    Official Symbol
    DCAF13provided by HGNC
    Official Full Name
    DDB1 and CUL4 associated factor 13provided by HGNC
    Primary source
    HGNC:HGNC:24535
    See related
    Ensembl:ENSG00000164934 MIM:616196; AllianceGenome:HGNC:24535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GM83; Sof1; WDSOF1; HSPC064
    Summary
    Enables nuclear estrogen receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including decidualization; epigenetic programming in the zygotic pronuclei; and spindle assembly involved in female meiosis. Located in several cellular components, including centrosome; cytosol; and nuclear lumen. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 16.5), kidney (RPKM 11.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DCAF13 in Genome Data Viewer
    Location:
    8q22.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (103415386..103443453)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (104543035..104571087)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (104427614..104455681)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1011, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:104427001-104427622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:104430836-104431727 Neighboring gene solute carrier family 25 member 32 Neighboring gene uncharacterized LOC105375690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19459 Neighboring gene Sharpr-MPRA regulatory region 6081 Neighboring gene regulating synaptic membrane exocytosis 2 Neighboring gene prothymosin alpha pseudogene 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC126859, MGC138247, DKFZp564O0463

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex PubMed 
    located_in cell junction  
    located_in centrosome  
    located_in cytosol  
    is_active_in nucleolus  
    located_in nucleolus PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    part_of small-subunit processome  

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 13
    Names
    WD repeat and SOF domain-containing protein 1
    WD repeats and SOF1 domain containing

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416065.1 → NP_001402994.1  DDB1- and CUL4-associated factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC012213
    2. NM_015420.7 → NP_056235.5  DDB1- and CUL4-associated factor 13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC012213, AK027799, CA429438
      Consensus CDS
      CCDS34934.2
      UniProtKB/Swiss-Prot
      Q3MII9, Q8NCH8, Q8TC51, Q96JY7, Q9NV06, Q9NZX3
      Related
      ENSP00000484962.1, ENST00000612750.5
      Conserved Domains (3) summary
      cd00200
      Location:59 → 353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:70 → 107
      7WD40; WD40 repeat [structural motif]
      pfam04158
      Location:354 → 435
      Sof1; Sof1-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      103415386..103443453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      104543035..104571087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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