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CDCA8 cell division cycle associated 8 [ Homo sapiens (human) ]

Gene ID: 55143, updated on 27-Nov-2024

Summary

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Official Symbol
CDCA8provided by HGNC
Official Full Name
cell division cycle associated 8provided by HGNC
Primary source
HGNC:HGNC:14629
See related
Ensembl:ENSG00000134690 MIM:609977; AllianceGenome:HGNC:14629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BOR; DasraB; MESRGP; BOREALIN
Summary
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
Expression
Biased expression in testis (RPKM 14.3), bone marrow (RPKM 12.4) and 13 other tissues See more
Orthologs
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Genomic context

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See CDCA8 in Genome Data Viewer
Location:
1p34.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (37692516..37709719)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (37557243..37574423)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38158188..38175391)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1490 Neighboring gene R-spondin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38096333-38096846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38098855-38099382 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38099911-38100438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38100439-38100965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38126219-38126852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38128815-38129348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38129349-38129881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38132271-38132990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38156929-38157439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38157440-38157949 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38157950-38158460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38158461-38158969 Neighboring gene AFG2 interacting ribosome maturation factor Neighboring gene MPRA-validated peak183 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38191191-38191692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38191693-38192192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38192280-38192780 Neighboring gene EPH receptor A10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38192781-38193281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38201025-38201524 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 677 Neighboring gene uncharacterized LOC105378650

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MiR-133a-3p inhibits the malignant progression of oesophageal cancer by targeting CDCA8. Wang X, et al. J Biochem, 2022 Jan 7. PMID 34117764
  2. Borealin-nucleosome interaction secures chromosome association of the chromosomal passenger complex. Abad MA, et al. J Cell Biol, 2019 Dec 2. PMID 31570499, Free PMC Article
  3. CDCA8 is a key mediator of estrogen-stimulated cell proliferation in breast cancer cells. Bu Y, et al. Gene, 2019 Jun 30. PMID 30953709
  4. Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis. Ci C, et al. Int J Mol Med, 2019 Jan. PMID 30431060, Free PMC Article
  5. Regulators CDCA8 as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma. Guo R, et al. J Cosmet Dermatol, 2022 Nov. PMID 35575979

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma.
    Title: CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma.
  2. CDCA8 promotes bladder cancer survival by stabilizing HIF1alpha expression under hypoxia.
    Title: CDCA8 promotes bladder cancer survival by stabilizing HIF1α expression under hypoxia.
  3. Cell division cycle-associated 8 is a prognostic biomarker related to immune invasion in hepatocellular carcinoma.
    Title: Cell division cycle-associated 8 is a prognostic biomarker related to immune invasion in hepatocellular carcinoma.
  4. A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis.
    Title: A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis.
  5. Regulators CDCA8 as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma.
    Title: Regulators CDCA8 as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma.
  6. Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer.
    Title: Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer.
  7. MiR-133a-3p inhibits the malignant progression of oesophageal cancer by targeting CDCA8.
    Title: MiR-133a-3p inhibits the malignant progression of oesophageal cancer by targeting CDCA8.
  8. Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology.
    Title: Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology.
  9. Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma.
    Title: Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma.
  10. Development and validation of hub genes for lymph node metastasis in patients with prostate cancer.
    Title: Development and validation of hub genes for lymph node metastasis in patients with prostate cancer.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10468, FLJ12042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle midzone assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic sister chromatid separation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromocenter IEA
Inferred from Electronic Annotation
more info
  
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromosome passenger complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
borealin
Names
Dasra B
cell division cycle-associated protein 8
dasra-B
hDasra-B
pluripotent embryonic stem cell-related gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256875.2 → NP_001243804.1  borealin

    See identical proteins and their annotated locations for NP_001243804.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC001651, BC008079
    Consensus CDS
    CCDS424.1
    UniProtKB/Swiss-Prot
    D3DPT4, Q53HL2, Q53HN1, Q96AM3, Q9NVW5
    UniProtKB/TrEMBL
    A8K7A2
    Related
    ENSP00000362146.1, ENST00000373055.6
    Conserved Domains (2) summary
    pfam10444
    Location:22 → 76
    Nbl1_Borealin_N; Nbl1 / Borealin N terminal
    pfam10512
    Location:163 → 275
    Borealin; Cell division cycle-associated protein 8

  2. NM_018101.4 → NP_060571.1  borealin

    See identical proteins and their annotated locations for NP_060571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY508815, BC008079
    Consensus CDS
    CCDS424.1
    UniProtKB/Swiss-Prot
    D3DPT4, Q53HL2, Q53HN1, Q96AM3, Q9NVW5
    UniProtKB/TrEMBL
    A8K7A2
    Related
    ENSP00000316121.2, ENST00000327331.2
    Conserved Domains (2) summary
    pfam10444
    Location:22 → 76
    Nbl1_Borealin_N; Nbl1 / Borealin N terminal
    pfam10512
    Location:163 → 275
    Borealin; Cell division cycle-associated protein 8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    37692516..37709719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    37557243..37574423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q53HL2.2 GenPept UniProtKB/Swiss-Prot:Q53HL2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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