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    LRRK1 leucine rich repeat kinase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694358, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LRRK1provided by VGNC
    Official Full Name
    leucine rich repeat kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:81446
    See related
    Ensembl:ENSMMUG00000013325
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See LRRK1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (80209241..80363268)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (79685163..79838679)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene gastric cancer associated WDR5 and KAT2A binding lncRNA Neighboring gene aldehyde dehydrogenase 1 family member A3 Neighboring gene uncharacterized LOC114679519 Neighboring gene chondroitin sulfate synthase 1 Neighboring gene selenoprotein S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat serine/threonine-protein kinase 1
    XP_014998668.2
    XP_014998669.2
    XP_014998670.2
    XP_014998671.2
    XP_028707176.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      80209241..80363268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015143183.2 → XP_014998669.2  leucine-rich repeat serine/threonine-protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      F6XKP7, G7MWB5
      Conserved Domains (7) summary
      COG4886
      Location:302 → 614
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14067
      Location:1248 → 1523
      STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
      sd00033
      Location:304 → 330
      LRR_RI; leucine-rich repeat [structural motif]
      sd00045
      Location:156 → 186
      ANK; ANK repeat [structural motif]
      pfam16095
      Location:844 → 1036
      COR; C-terminal of Roc, COR, domain
      pfam12796
      Location:126 → 218
      Ank_2; Ankyrin repeats (3 copies)
      cl21455
      Location:639 → 821
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_015143185.2 → XP_014998671.2  leucine-rich repeat serine/threonine-protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      G7MWB5
      Conserved Domains (7) summary
      COG4886
      Location:302 → 614
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14067
      Location:1248 → 1523
      STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
      sd00033
      Location:304 → 330
      LRR_RI; leucine-rich repeat [structural motif]
      sd00045
      Location:156 → 186
      ANK; ANK repeat [structural motif]
      pfam16095
      Location:844 → 1036
      COR; C-terminal of Roc, COR, domain
      pfam12796
      Location:126 → 218
      Ank_2; Ankyrin repeats (3 copies)
      cl21455
      Location:639 → 821
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_015143182.2 → XP_014998668.2  leucine-rich repeat serine/threonine-protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      F6XKP7, G7MWB5
      Related
      ENSMMUP00000017517.4, ENSMMUT00000018702.4
      Conserved Domains (7) summary
      COG4886
      Location:302 → 614
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14067
      Location:1248 → 1523
      STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
      sd00033
      Location:304 → 330
      LRR_RI; leucine-rich repeat [structural motif]
      sd00045
      Location:156 → 186
      ANK; ANK repeat [structural motif]
      pfam16095
      Location:844 → 1036
      COR; C-terminal of Roc, COR, domain
      pfam12796
      Location:126 → 218
      Ank_2; Ankyrin repeats (3 copies)
      cl21455
      Location:639 → 821
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_015143184.2 → XP_014998670.2  leucine-rich repeat serine/threonine-protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      F6XKP7, G7MWB5
      Conserved Domains (7) summary
      COG4886
      Location:302 → 614
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14067
      Location:1248 → 1523
      STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
      sd00033
      Location:304 → 330
      LRR_RI; leucine-rich repeat [structural motif]
      sd00045
      Location:156 → 186
      ANK; ANK repeat [structural motif]
      pfam16095
      Location:844 → 1036
      COR; C-terminal of Roc, COR, domain
      pfam12796
      Location:126 → 218
      Ank_2; Ankyrin repeats (3 copies)
      cl21455
      Location:639 → 821
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_028851343.1 → XP_028707176.1  leucine-rich repeat serine/threonine-protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      F6XKP7, G7MWB5
      Conserved Domains (7) summary
      COG4886
      Location:302 → 614
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14067
      Location:1248 → 1523
      STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
      sd00033
      Location:304 → 330
      LRR_RI; leucine-rich repeat [structural motif]
      sd00045
      Location:156 → 186
      ANK; ANK repeat [structural motif]
      pfam16095
      Location:844 → 1036
      COR; C-terminal of Roc, COR, domain
      pfam12796
      Location:126 → 218
      Ank_2; Ankyrin repeats (3 copies)
      cl21455
      Location:639 → 821
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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