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    TOP3A DNA topoisomerase III alpha [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 700830, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TOP3Aprovided by VGNC
    Official Full Name
    DNA topoisomerase III alphaprovided by VGNC
    Primary source
    VGNC:VGNC:78622
    See related
    Ensembl:ENSMMUG00000013533
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TOP3A in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (18123859..18162594, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (18447838..18490330, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene LLGL scribble cell polarity complex component 1 Neighboring gene FLII actin remodeling protein Neighboring gene mitochondrial elongation factor 2 Neighboring gene SMCR8-C9orf72 complex subunit Neighboring gene serine hydroxymethyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase 3-alpha
    Names
    topoisomerase (DNA) III alpha
    XP_014974251.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      18123859..18162594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015118765.2 → XP_014974251.2  DNA topoisomerase 3-alpha

      UniProtKB/TrEMBL
      F6Z6P9, G7NJ30, H9EWR7, H9Z0Q7
      Related
      ENSMMUP00000017797.4, ENSMMUT00000019001.4
      Conserved Domains (4) summary
      cd03362
      Location:35 → 193
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      cd00186
      Location:202 → 617
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
      pfam06839
      Location:895 → 939
      zf-GRF; GRF zinc finger
      pfam01396
      Location:655 → 694
      zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger
    Nucleotide Protein
    Heading Accession and Version

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