|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
202-617 |
1.40e-159 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 474.79 E-value: 1.40e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 202 DAVDVRQELDLRIGAAFTRFQTLRLQKifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKvthdhkdgiv 281
Cdd:cd00186 5 NAQLARRILDRLVGFNLSRLLTKKLRR-------KGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK---------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 282 efnwkrhrlfnhtaclvlyqlcmedpMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYIS 361
Cdd:cd00186 68 --------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLIT 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 362 YPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERggPTPRNGNKSDQAHPPIHPTKYT------NSLQGDEQRLYE 435
Cdd:cd00186 122 YPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGR--RNPKRGKKEQGAHEAIRPTKVAptpeleANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 436 FIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSDK-ILPVYERGSRFQPSTVEMVDGETSP 514
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEeEPPPLKEGDELKLEEVELEEKETQP 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 515 PKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKL 594
Cdd:cd00186 280 PPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEK-KKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410 420
....*....|....*....|...
gi 1622877943 595 ICDGKKDKFVVLRQQVQKYKQVF 617
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
36-711 |
5.49e-157 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 484.12 E-value: 5.49e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 36 VLCVAEKNDAAKGIADLLSNGRM--RRREGLSkfnkIYEFDYhlyGQSVTMVMtSVSGHLLAHDFRMQFRKWQSCNPLVL 113
Cdd:PRK07219 2 ELIIAEKNNAARRIADILSGGKAkkKRVNGVP----YYEFER---KGEKWIVI-GLSGHIVTVDFPEEYGDWRDVDPAEL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 114 FEAEIEKYCP-ENFVDIKKTLERETRQcqaLVIWTDCDREGENIGFEIIHVCKTVKpNLQVLRARFSEITPHAVRTACEN 192
Cdd:PRK07219 74 IDADPVKKITkQNYINALKKLAKDADE---IIIATDYDREGELIGKEAYHILREVC-QVPVKRARFSSLTKKEIRKAFEN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 193 LTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQkifpEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKV 272
Cdd:PRK07219 150 PDEIDFNLADAGEARQIIDLYWGAALTRFLSLSVR----QLGRWDFLSVGRVQTPTLAFIVDREREIRAFDPEDYWKIEA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 273 THD----HKDGIVEFNWKRHRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETM 348
Cdd:PRK07219 226 LLDkeaqYFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAM 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 349 RIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNS--L 426
Cdd:PRK07219 306 EIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKEYGPYAESILEQENIKPTEGKKETTDHPPIHPVDVPKReeL 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 427 QGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVE 506
Cdd:PRK07219 386 SDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKELPDLEEGEKLKVNKIE 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 507 MVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVglTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRA 586
Cdd:PRK07219 466 IEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV--IEGDPPRPTDLGIAVIEALEKYAPEIVSEEMTA 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 587 ELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQeeiypampepIRKCPQCNKDMV 666
Cdd:PRK07219 544 QLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEIGDHLAGSLKAENRSLKT----------IGKCPECGGDLI 613
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 1622877943 667 LKTKKNGGFYLSCMGFPECRSAMWLPD----SVLeasrdSSVCPVCQPH 711
Cdd:PRK07219 614 IIRTDKGSRFVGCSGYPDCRNTFPLPStgriKVL-----DEVCEKCGLP 657
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
195-602 |
1.73e-136 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 416.26 E-value: 1.73e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 195 EPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQKifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVT- 273
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKG-------NKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATl 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 274 HDHKDGIVEFNWKRHRLFNHTACLVLYQLCmEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEK 353
Cdd:pfam01131 74 KDGGGVFANAKWKRGRIFDKEEAEAILEKL-KKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 354 LYTQ-GYISYPRTETNIFPRDLNLTVLVEQQTPDP-RWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY---TNSLQG 428
Cdd:pfam01131 153 LYEKhGLITYPRTDSTYLSDDATLKAILEYLTKNYgKYLPYAPRLLKKTKGKLTVGNAKVTAHEAIRPTGDipvLPELSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 429 DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSD-KILPVYERGSRFQPSTVEM 507
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDeEELPELKEGEELKVTQVEV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 508 VDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMgYEMSKPDLRAE 587
Cdd:pfam01131 313 EEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKK-KSLVPTELGKALVEALEKF-PDLVDPELTAE 390
|
410
....*....|....*
gi 1622877943 588 LEADLKLICDGKKDK 602
Cdd:pfam01131 391 LEEKLDEIAEGKLDW 405
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
315-568 |
1.99e-106 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 331.52 E-value: 1.99e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 315 RSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR-WGAFA 393
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKeYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 394 QSILERGGptPRNGNKSDQAHPPIHPTKYTNS------LQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVA 467
Cdd:smart00437 81 VVLLKPRK--PRKGKKAQGAHEAIRPTKPIFTpelekeLSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 468 HGLVILARNYLDVYPYDHW-SDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 546
Cdd:smart00437 159 KGKTLLFDGWLKVYPEEKKeEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLL 238
|
250 260
....*....|....*....|..
gi 1622877943 547 ARMYVGLTPdKRFLPGHLGMGL 568
Cdd:smart00437 239 DRGYVTKKK-KKLIPTELGIAV 259
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
131-608 |
2.95e-92 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 303.94 E-value: 2.95e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 131 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCKTVKPnlqVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQEL 210
Cdd:COG0550 63 KELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKP---VKRVVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRIL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 211 DLRIGAAFTRFQTLRLQKifpevlaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKR--- 287
Cdd:COG0550 140 DRLVGYNLSPLLWKKVKR---------GLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKidg 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 288 HRLFNHTACLVLYQLCmEDPMATVVEVRSKPKSKwRPQAL-DTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE 366
Cdd:COG0550 211 KKILDEEEAEAILAAL-KGKTFTVTSVEKKPKKR-NPPPPfTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTD 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 367 -TNIfPRDLNltvlveqqtpdprwGAFAQSILERGGP-----TPR--NGNKSDQ-AHPPIHPT---KYTNSLQGDEQRLY 434
Cdd:COG0550 289 sVRL-SEDAV--------------AAAREYIEALYGKeylpeKPRvyKTSKNAQeAHEAIRPTgvtRTPESLSGDEFKLY 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 435 EFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDH-----WSDKILPVYERGSRFQPSTVEMVD 509
Cdd:COG0550 354 DLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeeeEEEKRLPPLKEGEKLKLKKIEPEQ 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 510 GETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGM---GLVEGYDSmgyEMSKPDLRA 586
Cdd:COG0550 434 HFTKPPPRYTEASLVKAMEELGIGRPSTYASIIETLQDRGYVERE-GKRLVPTELGFiviDLLEEHFP---DLVDYEFTA 509
|
490 500
....*....|....*....|..
gi 1622877943 587 ELEADLKLICDGKKDKFVVLRQ 608
Cdd:COG0550 510 KMEEKLDEIAEGKLDWKDVLEE 531
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
39-685 |
2.71e-86 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 290.19 E-value: 2.71e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 39 VAEKNDAAKGIADLLSNGRMRRReglSKFNKIYefdYHLYGQSVTMVMTSVSGHL--LAHDFRMQFR----KWQScnplv 112
Cdd:TIGR01057 1 IAEKPKVAAKIAGALSDGRVLKK---SEYGVPY---WEVRRDGKKIIVASAVGHLfgLHPKSRGGYPvfdiEWVP----- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 113 LFEAEIEK-YCPENFVDIKKTLERETRqcqaLVIWTDCDREGENIGFEIIHVCKTVKPnlqVLRARFSEITPHAVRTACE 191
Cdd:TIGR01057 70 IFEFDKGKgYVSKYIKALSKLAKGADE----YINACDYDIEGEVIGFKALKYFCGVER---AKRMKFSTLTKQDIRRAYA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 192 NLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQKIFPEVLaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIK 271
Cdd:TIGR01057 143 NPEEIDYGMVDAGMARHILDWYWGINLSRALMEAIRAAAGRWV---ILSAGRVQGPTLAFLVEREREINLFVPKPYWVIK 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 272 VTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIA 351
Cdd:TIGR01057 220 ATLEKGGGVFDARPEKWKIWSEEEAKSIKEELKKSPWAAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQSIA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 352 EKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPT--KYTNSLQGD 429
Cdd:TIGR01057 300 QELYEEALISYPRTSSQKLPPSINYRAILDNLAKGPLYREAAERLLETGVLKPVEGKKEDPAHPAIHPTgeIPSQELSKD 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 430 EQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVEMVD 509
Cdd:TIGR01057 380 EKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKFEEKELPPLDRGDKIKVVRVDVRV 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 510 GETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPghLGMGLVEGYDSMGYEMSKPDLRAELE 589
Cdd:TIGR01057 460 KETQPPARYDKASLIREMESRGLGTKATRARIIETLYKRGYIEGKKSIKVTP--LGEAVIETLQRYCPEIISEELTRRFE 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 590 ADLKLICDGKKDKFVVLRQQVQKYKQVFIEAvakAKKLDEAlaqyfgnGTELA---QQEEIypampepIRKCPQCNKDMV 666
Cdd:TIGR01057 538 SKLEDIMSGRITKDEVIDEAKKRLRKILEEF---KKRLDDI-------GIELGkslGSVEV-------VGKCPKCGGKLV 600
|
650
....*....|....*....
gi 1622877943 667 LKTKKNGGFYLsCMGFPEC 685
Cdd:TIGR01057 601 SKYAKKGRFVG-CSNYPEC 618
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
35-193 |
9.55e-48 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 167.03 E-value: 9.55e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 35 KVLCVAEKNDAAKGIADLLSNGRMRRREGlskfnkiyeFDYHLYGQSVTMVMTSVSGHLLAHDFRMQFRKWQSCNPL--V 112
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKKKGKG---------RYYEFYGEGGGYVVTWASGHLLELDFPEEYDPWDKVWPLedP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 113 LFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKTVKpNLQVLRARFSEITPHAVRTACEN 192
Cdd:cd03362 72 LFPAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVK-RKPVKRAWFSSLTPKAIRRAFKN 150
|
.
gi 1622877943 193 L 193
Cdd:cd03362 151 L 151
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
895-939 |
5.84e-19 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 80.91 E-value: 5.84e-19
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1622877943 895 TSCLCSQPAVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDEN 939
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
811-852 |
3.02e-17 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 76.29 E-value: 3.02e-17
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1622877943 811 VTCNCGQEAVLLTVRKEGPNQGRQFFKCNGG---SCNFFLWADSP 852
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGrekQCGFFQWADEV 45
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
655-694 |
1.37e-11 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 59.96 E-value: 1.37e-11
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1622877943 655 IRKCPQCNKDMVLKTKKNGGFYlSCMGFPECRSAMWLPDS 694
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFV-GCSNYPECRFTRPLKKN 39
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
36-181 |
2.83e-09 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 55.06 E-value: 2.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 36 VLCVAEKNDAAKGIADLLSNGrmrrreglskfnkiyefdyhlygqsvTMVMTSVSGHLLAHDFRMQFrkwqscnplvlfe 115
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGGG--------------------------FQAVVAVLGHLLSLEKGPKK------------- 41
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622877943 116 aeiekycpenfvDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKTVKPnlQVLRARFSEI 181
Cdd:pfam01751 42 ------------KALKALKELALKAKEVILATDPDREGEAIALKLLELKELLEN--AGGRVEFSEL 93
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
128-165 |
1.37e-06 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 46.87 E-value: 1.37e-06
10 20 30
....*....|....*....|....*....|....*...
gi 1622877943 128 DIKKTLERETRQCQaLVIWTDCDREGENIGFEIIHVCK 165
Cdd:smart00493 36 EQIKLLKKLAKKAE-VILATDPDREGEAIAWELAELLK 72
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
202-617 |
1.40e-159 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 474.79 E-value: 1.40e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 202 DAVDVRQELDLRIGAAFTRFQTLRLQKifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKvthdhkdgiv 281
Cdd:cd00186 5 NAQLARRILDRLVGFNLSRLLTKKLRR-------KGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK---------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 282 efnwkrhrlfnhtaclvlyqlcmedpMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYIS 361
Cdd:cd00186 68 --------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLIT 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 362 YPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERggPTPRNGNKSDQAHPPIHPTKYT------NSLQGDEQRLYE 435
Cdd:cd00186 122 YPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGR--RNPKRGKKEQGAHEAIRPTKVAptpeleANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 436 FIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSDK-ILPVYERGSRFQPSTVEMVDGETSP 514
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEeEPPPLKEGDELKLEEVELEEKETQP 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 515 PKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKL 594
Cdd:cd00186 280 PPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEK-KKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410 420
....*....|....*....|...
gi 1622877943 595 ICDGKKDKFVVLRQQVQKYKQVF 617
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
36-711 |
5.49e-157 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 484.12 E-value: 5.49e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 36 VLCVAEKNDAAKGIADLLSNGRM--RRREGLSkfnkIYEFDYhlyGQSVTMVMtSVSGHLLAHDFRMQFRKWQSCNPLVL 113
Cdd:PRK07219 2 ELIIAEKNNAARRIADILSGGKAkkKRVNGVP----YYEFER---KGEKWIVI-GLSGHIVTVDFPEEYGDWRDVDPAEL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 114 FEAEIEKYCP-ENFVDIKKTLERETRQcqaLVIWTDCDREGENIGFEIIHVCKTVKpNLQVLRARFSEITPHAVRTACEN 192
Cdd:PRK07219 74 IDADPVKKITkQNYINALKKLAKDADE---IIIATDYDREGELIGKEAYHILREVC-QVPVKRARFSSLTKKEIRKAFEN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 193 LTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQkifpEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKV 272
Cdd:PRK07219 150 PDEIDFNLADAGEARQIIDLYWGAALTRFLSLSVR----QLGRWDFLSVGRVQTPTLAFIVDREREIRAFDPEDYWKIEA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 273 THD----HKDGIVEFNWKRHRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETM 348
Cdd:PRK07219 226 LLDkeaqYFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAM 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 349 RIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNS--L 426
Cdd:PRK07219 306 EIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKEYGPYAESILEQENIKPTEGKKETTDHPPIHPVDVPKReeL 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 427 QGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVE 506
Cdd:PRK07219 386 SDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKELPDLEEGEKLKVNKIE 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 507 MVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVglTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRA 586
Cdd:PRK07219 466 IEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV--IEGDPPRPTDLGIAVIEALEKYAPEIVSEEMTA 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 587 ELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQeeiypampepIRKCPQCNKDMV 666
Cdd:PRK07219 544 QLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEIGDHLAGSLKAENRSLKT----------IGKCPECGGDLI 613
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 1622877943 667 LKTKKNGGFYLSCMGFPECRSAMWLPD----SVLeasrdSSVCPVCQPH 711
Cdd:PRK07219 614 IIRTDKGSRFVGCSGYPDCRNTFPLPStgriKVL-----DEVCEKCGLP 657
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
195-602 |
1.73e-136 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 416.26 E-value: 1.73e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 195 EPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQKifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVT- 273
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKG-------NKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATl 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 274 HDHKDGIVEFNWKRHRLFNHTACLVLYQLCmEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEK 353
Cdd:pfam01131 74 KDGGGVFANAKWKRGRIFDKEEAEAILEKL-KKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 354 LYTQ-GYISYPRTETNIFPRDLNLTVLVEQQTPDP-RWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY---TNSLQG 428
Cdd:pfam01131 153 LYEKhGLITYPRTDSTYLSDDATLKAILEYLTKNYgKYLPYAPRLLKKTKGKLTVGNAKVTAHEAIRPTGDipvLPELSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 429 DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSD-KILPVYERGSRFQPSTVEM 507
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDeEELPELKEGEELKVTQVEV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 508 VDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMgYEMSKPDLRAE 587
Cdd:pfam01131 313 EEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKK-KSLVPTELGKALVEALEKF-PDLVDPELTAE 390
|
410
....*....|....*
gi 1622877943 588 LEADLKLICDGKKDK 602
Cdd:pfam01131 391 LEEKLDEIAEGKLDW 405
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
37-726 |
6.72e-117 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 376.02 E-value: 6.72e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 37 LCVAEKNDAAKGIADLLSNGRMRRReglskfnKIYEFDYHLYGQSV--TMVMtSVSGHLLAHDFRMQFRKWQSCNPLVLF 114
Cdd:PRK07220 3 LIITEKNIAARRIAQILAPKKPKKT-------RVSGVDVYRYEDNGddTVVV-GLSGHIVNIDFPKEYNNWQKVDARDLI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 115 EAEIEK-YCPENFVDIKKTLERE-TRqcqaLVIWTDCDREGENIGFEIIHVCKTVKPNLQVLRARFSEITPHAVRTACEN 192
Cdd:PRK07220 75 DAEIITtPTQKKIVTALKKLGKEaDR----VTIATDYDREGELIGVEALNIIKKVNPDIKFDRVRYSAITKKEIERAFSN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 193 LTEPDQRVSDAVDVRQELDLRIGAAFTRFQTL---RLQKIFpevlaeqlISYGSCQFPTLGFVVERFKAIQAFVPEIFHR 269
Cdd:PRK07220 151 PVEVDFNLADAGHSRQVIDLVWGAALTRYISLaagRLGKMF--------LSVGRVQSPTLALIVDREKEREAFVPTPYWE 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 270 IKVTHDHKDGIVEFNWKRHRLFNHT-ACLVLYQLCMEdpmATVVEVRSKPKSKWRPQALDTVELEKLASrKLRINAKETM 348
Cdd:PRK07220 223 IYATLENNGETFVAQHSTRRFWEKEeADRVFEKLGKT---AEVTEVEKGTKTDKPPTPFNTTEFISAAN-SIGFSAANAM 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 349 RIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPrWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYT--NSL 426
Cdd:PRK07220 299 RIAESLYTNGYISYPRTDNTVYPESLDLREQIEIFAEGP-FGEYAQKLLEKGELVPTRGKKETTDHPPIYPASLAkkSEL 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 427 QGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVE 506
Cdd:PRK07220 378 KEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAPEDRLLPELSEGEELKVKKKE 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 507 MVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdkrFLPGHLGMGLVEGYDSMGYEMSKPDLRA 586
Cdd:PRK07220 458 MLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYIHGNP---IQPTNTAFAVVDALEKYAPTITKPDMTS 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 587 ELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAqyfgNGTelaQQEEIypampepIRKCPQCNKDMV 666
Cdd:PRK07220 535 RLEEDMDKIAEGKIKEDAVLEESREMLEQVFDELDKNREKIRESLR----EGL---REDKI-------IGKCPLCGSDLM 600
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622877943 667 LKTKKNGGFYLSCMGFPECRSAMWLPDS----VLEAsrdssvcpVCQPHPVYRLKLKfKRGSLP 726
Cdd:PRK07220 601 VRRSKRGSRFIGCEGYPECTFSLPLPKSgqiiVTDK--------VCEAHGLNHIRII-NGGKRP 655
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
315-568 |
1.99e-106 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 331.52 E-value: 1.99e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 315 RSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR-WGAFA 393
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKeYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 394 QSILERGGptPRNGNKSDQAHPPIHPTKYTNS------LQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVA 467
Cdd:smart00437 81 VVLLKPRK--PRKGKKAQGAHEAIRPTKPIFTpelekeLSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 468 HGLVILARNYLDVYPYDHW-SDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 546
Cdd:smart00437 159 KGKTLLFDGWLKVYPEEKKeEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLL 238
|
250 260
....*....|....*....|..
gi 1622877943 547 ARMYVGLTPdKRFLPGHLGMGL 568
Cdd:smart00437 239 DRGYVTKKK-KKLIPTELGIAV 259
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
37-726 |
1.43e-92 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 315.63 E-value: 1.43e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 37 LCVAEKNDAAKGIADLLSNG---RMRRREGLSkfnkIYEFDyhlygqsvTMVMTSVSGHLLAHDFRMQFRKWQSCN--PL 111
Cdd:PRK14973 3 LIIAEKNIAANRIAQILAGKtkvQVKKDGGVS----TYSFD--------DTVVVGLRGHVVEVDFEPGYTNWRSEEhtPR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 112 VLFEAEIEKYCPENfvDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKTVKPNLQVLRARFSEITPHAVRTACE 191
Cdd:PRK14973 71 SLIDADTIKKPTEK--KIVGLIQKLAKKADRVTIATDFDTEGELIGKEAYELVRAVNPKVPIDRARFSAITKEEIVTAFA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 192 NLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQKifpevLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIK 271
Cdd:PRK14973 149 EPTDLDFALAAAGEARQIIDLIWGASLTRFISLAAHR-----GGDNILSVGRVQSPTLAMIVDREKEIEAFVPEKYWMLS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 272 VTHDhKDGI-VEfnwKRH---RLFNHTACLVLYQlCMEDPMaTVVEVRSKPKSKWRPQALDTVELEKLASRkLRINAKET 347
Cdd:PRK14973 224 LATE-KDGEgIE---ARHthgRFTDSAAAEAAYD-ATKEPL-VVTEVKEGHKVDRAPTPFDTTTFIVAASR-LGFSAANA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 348 MRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVE--QQTPDPRWGAFAQSILErggPTPRNGNKSDQAHPPIHPTKYTNS 425
Cdd:PRK14973 297 MRIAEDLYMNGYISYPRTDNTIYPKSLDLNGVLAtlAKGAFSKDVAWVKDNRR---PVPTRGKKSSTDHPPIHPTGVATR 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 426 LQ-GDEQ-RLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPS 503
Cdd:PRK14973 374 EElGDDRwKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYSEAKENILPAFALGEKLPIL 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 504 TVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKrflPGHLGMGLVEGYDSMGYEMSKPD 583
Cdd:PRK14973 454 AVNLEEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVIGKLVSRKYIEGNPLR---PTLVGRAVTESLEEHAGTITEPD 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 584 LRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFieavakaKKLDEALAQYfgnGTELAQQ--EEIypampePIRKCPQC 661
Cdd:PRK14973 531 MTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAF-------DELEANEAVI---GRDIMERtaEEL------TIGPCPVC 594
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622877943 662 NKDMVLKtKKNGGFYLSCMGFPECRSAMWLPDSVL-EASRDSSVCPVcqpHPVYRLKLkFKRGSLP 726
Cdd:PRK14973 595 GKDLRIK-HIGSSQFIGCSGYPDCTFNIGLPGTTWgWAIRTDEVCPI---HHLNHVRL-IRKGARP 655
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
131-608 |
2.95e-92 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 303.94 E-value: 2.95e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 131 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCKTVKPnlqVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQEL 210
Cdd:COG0550 63 KELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKP---VKRVVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRIL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 211 DLRIGAAFTRFQTLRLQKifpevlaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKR--- 287
Cdd:COG0550 140 DRLVGYNLSPLLWKKVKR---------GLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKidg 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 288 HRLFNHTACLVLYQLCmEDPMATVVEVRSKPKSKwRPQAL-DTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE 366
Cdd:COG0550 211 KKILDEEEAEAILAAL-KGKTFTVTSVEKKPKKR-NPPPPfTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTD 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 367 -TNIfPRDLNltvlveqqtpdprwGAFAQSILERGGP-----TPR--NGNKSDQ-AHPPIHPT---KYTNSLQGDEQRLY 434
Cdd:COG0550 289 sVRL-SEDAV--------------AAAREYIEALYGKeylpeKPRvyKTSKNAQeAHEAIRPTgvtRTPESLSGDEFKLY 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 435 EFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDH-----WSDKILPVYERGSRFQPSTVEMVD 509
Cdd:COG0550 354 DLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeeeEEEKRLPPLKEGEKLKLKKIEPEQ 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 510 GETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGM---GLVEGYDSmgyEMSKPDLRA 586
Cdd:COG0550 434 HFTKPPPRYTEASLVKAMEELGIGRPSTYASIIETLQDRGYVERE-GKRLVPTELGFiviDLLEEHFP---DLVDYEFTA 509
|
490 500
....*....|....*....|..
gi 1622877943 587 ELEADLKLICDGKKDKFVVLRQ 608
Cdd:COG0550 510 KMEEKLDEIAEGKLDWKDVLEE 531
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
39-685 |
2.71e-86 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 290.19 E-value: 2.71e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 39 VAEKNDAAKGIADLLSNGRMRRReglSKFNKIYefdYHLYGQSVTMVMTSVSGHL--LAHDFRMQFR----KWQScnplv 112
Cdd:TIGR01057 1 IAEKPKVAAKIAGALSDGRVLKK---SEYGVPY---WEVRRDGKKIIVASAVGHLfgLHPKSRGGYPvfdiEWVP----- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 113 LFEAEIEK-YCPENFVDIKKTLERETRqcqaLVIWTDCDREGENIGFEIIHVCKTVKPnlqVLRARFSEITPHAVRTACE 191
Cdd:TIGR01057 70 IFEFDKGKgYVSKYIKALSKLAKGADE----YINACDYDIEGEVIGFKALKYFCGVER---AKRMKFSTLTKQDIRRAYA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 192 NLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQKIFPEVLaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIK 271
Cdd:TIGR01057 143 NPEEIDYGMVDAGMARHILDWYWGINLSRALMEAIRAAAGRWV---ILSAGRVQGPTLAFLVEREREINLFVPKPYWVIK 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 272 VTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIA 351
Cdd:TIGR01057 220 ATLEKGGGVFDARPEKWKIWSEEEAKSIKEELKKSPWAAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQSIA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 352 EKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPT--KYTNSLQGD 429
Cdd:TIGR01057 300 QELYEEALISYPRTSSQKLPPSINYRAILDNLAKGPLYREAAERLLETGVLKPVEGKKEDPAHPAIHPTgeIPSQELSKD 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 430 EQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVEMVD 509
Cdd:TIGR01057 380 EKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKFEEKELPPLDRGDKIKVVRVDVRV 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 510 GETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPghLGMGLVEGYDSMGYEMSKPDLRAELE 589
Cdd:TIGR01057 460 KETQPPARYDKASLIREMESRGLGTKATRARIIETLYKRGYIEGKKSIKVTP--LGEAVIETLQRYCPEIISEELTRRFE 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 590 ADLKLICDGKKDKFVVLRQQVQKYKQVFIEAvakAKKLDEAlaqyfgnGTELA---QQEEIypampepIRKCPQCNKDMV 666
Cdd:TIGR01057 538 SKLEDIMSGRITKDEVIDEAKKRLRKILEEF---KKRLDDI-------GIELGkslGSVEV-------VGKCPKCGGKLV 600
|
650
....*....|....*....
gi 1622877943 667 LKTKKNGGFYLsCMGFPEC 685
Cdd:TIGR01057 601 SKYAKKGRFVG-CSNYPEC 618
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
35-686 |
1.12e-78 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 270.71 E-value: 1.12e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 35 KVLCVAEKNDAAKGIADLLSNGRMRRReglsKFN-KIYEFDYhlYGQSVtmVMTSVSGHL--LAHD------FRMQFRkw 105
Cdd:PRK05776 2 YILVIAEKPKAARKIAEALSEKPIRCR----IYGvPYWIVKR--DGKKI--VVAPAAGHLfgLHTKskgfpvFDYEWK-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 106 qscnPLvlFEAEIEKYCPENFVDIKKTLERETRQcqaLVIWTDCDREGENIGFEII-HVCKTVKpnlqVLRARFSEITPH 184
Cdd:PRK05776 72 ----PL--YEIDKGSKYTKKYYELLSSLSKYADE---FINACDYDIEGSVIGYLIIkYLGDPKK----AKRMKFSALTKS 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 185 AVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRfqtlRLQKIFPEVLAEQLI-SYGSCQFPTLGFVVERFKAIQAFV 263
Cdd:PRK05776 139 DIRRAFRNLETLDYEMINAGIARHELDWLWGINVSR----ALMSSVRDASGKRVIlSAGRVQSPTLKYVVEREIERNLFV 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 264 PEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRIN 343
Cdd:PRK05776 215 PLPYFSVSIIIEKNGYEFTLKYENKKFETKEEAKEILEEIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 344 AKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP--TPRNGNKSDQAHPPIHPT- 420
Cdd:PRK05776 295 PYKTQSIAEDLYLDGLISYPRTNSQKLPPTLNIRNILKGLSRSPQYRPLVNLLLKETKGvlKPVQGPKDDPAHPAIYPTg 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 421 KYTNSLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDI--AQERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGS 498
Cdd:PRK05776 375 EPPKNLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVpgFPLVFSASGQRIEERGWLKYYPFHKFDEEELPLLKKGE 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 499 RFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYvgLTPDKRFL-PGHLGMGLVEGYDSMGY 577
Cdd:PRK05776 455 RVKIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKRGY--LTSNGKYIeVTPLGFGVAEVLEKYFP 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 578 EMSKPDLRAELEADLKLICDGKkdkfvVLRQQVqkykqvfieaVAKAKK-LDEALAQYFGN----GTELAQQEEIYPamp 652
Cdd:PRK05776 533 DIVSVELTRDFEEKLEMIRTGK-----ATREEV----------IEEAKEtLNKLLEEFKKNkdeiGEELAKALGLIK--- 594
|
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 1622877943 653 ePIRKCPQCNKDMV--------LKTKKNggfYLSCMGFPECR 686
Cdd:PRK05776 595 -PVGKCKICGREAYkdglckyhYEAKKR---LVKAYEEWKER 632
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
35-685 |
2.56e-63 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 227.35 E-value: 2.56e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 35 KVLCVAEKNDAAKGIADLLsnGRMRRREGlskfnkiyefdyHLYGQSVtmVMTSVSGHLLAH----DFRMQFRKWQ-SCN 109
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVL--KPHKKGDG------------YIEGNGY--IVTWAIGHLLELaepeAYDERYKRWRlEDL 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 110 PLVlfeaeiekycPENF--VDIKKT------LERETRQCQALVIWTDCDREGENIGFEIIHVCKTVKPnlqVLRARFSEI 181
Cdd:PRK07726 65 PII----------PEKWklVVKKKTakqfnvVKKLLKQATEIVIATDADREGELIAREILDYCGVRKP---IKRLWISSL 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 182 TPHAVRTACENL-----TEPdqrVSDAVDVRQELDLRIGAAFTRFQTLRLQKI-FPEVLaeqliSYGSCQFPTLGFVVER 255
Cdd:PRK07726 132 TDKAIKRAFANLkpgkeTIP---LYYSALARSRADWLVGINMTRAYTLLGRKAgYNGVL-----SVGRVQTPTLALVVRR 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 256 FKAIQAFVPEIFHRIKVTHDHKDGIvEFNW--------KRHRLFNHTACLVLYQLCMEDPmATVVEVRSKPKSKWRPQAL 327
Cdd:PRK07726 204 DEEIENFVPKPYWEVEAHLTPGERF-TAKWqpsepyqdEEGRLLDRPLAEQVVARIQGQP-AKVTEVETKRKKEYAPLLY 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 328 DTVELEKLASRKLRINAKETMRIAEKLY-TQGYISYPRTETNIFPRDLNLTVlveqqtPD-----PRWGAFAQSILERGG 401
Cdd:PRK07726 282 DLSELQIDANKRFGLSAKETLDIAQSLYeTHKLITYPRTDSRYLPEDMVATL------PEvlnaiSKVDPYLLLAPPVLD 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 402 PTPRNG---NKSDQAHPPIHPTKYT---NSLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILAR 475
Cdd:PRK07726 356 PSIRSRawnDKKVTAHHAIIPTEQPpnlSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEA 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 476 NYLDVYPYDHWSDK---ILPVYERGSRFQPSTVEMVDGETSPPKLLTEADLIALM-----------------EKHGIGTD 535
Cdd:PRK07726 436 GWKALLGKKEEDEEkeqPLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAMeniarfvqdkelkktlkETDGLGTE 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 536 ATHAEHIETIKARMYvgLTPDKRFL-PGHLGMGLVegyDSMGYEMSKPDLRAELEADLKLICDGKKDkfvvlrqqvqkyK 614
Cdd:PRK07726 516 ATRAGIIEKLFKRGY--LEKKGKYIhATDKGKQLI---DALPEELTSPDMTAKWEQALDQISEGQLS------------Y 578
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622877943 615 QVFI-EAVAKAKKLdeaLAQYfgngtelAQQEEIYPAMPEPIRKCPQCNKDMVLKTKKNGGFyLSCMGFPEC 685
Cdd:PRK07726 579 QDFMqPLKQWLKQL---VEQA-------KQSSEKYKFDNLTGPKCPDCGKPMLKVKGKNGKM-LVCQDRECG 639
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
131-708 |
8.82e-50 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 188.14 E-value: 8.82e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 131 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCKT-VKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQE 209
Cdd:PRK06599 65 DALKKAAKKADAVYLATDPDREGEAIAWHIAEVLKEaKLKDKNVKRVVFNEITKKAVQEAIENPRDIDMDLVDAQQARRA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 210 LDLRIGaaftrFqtlrlqKIFPeVLAEQL---ISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDG------I 280
Cdd:PRK06599 145 LDYLVG-----F------KLSP-LLWKKVrrgLSAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSNGepftakL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 281 VEFNWKR---HRLFNHTACLVLYQLcMEDPMATVVEVRSKPKSKwRPQA-LDTVELEKLASRKLRINAKETMRIAEKLY- 355
Cdd:PRK06599 213 VEVNGKKlekFSITNEEQAKALVKA-LEGQAYTVDKIEKKERKR-NPPPpFITSTLQQEASRKLGFSAKKTMRIAQKLYe 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 356 -------TQGYISYPRTETnifprdlnlTVLVEQQTPDPRwgafaQSILERGGP-----TPR---NGNKSDQ-AHPPIHP 419
Cdd:PRK06599 291 gidlgegTVGLITYMRTDS---------VRLSNEALDEAR-----KYITKKYGKeylpaKPRvykKKSKNAQeAHEAIRP 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 420 T--KYT-----NSLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFV--AHGLVILARNYLDVYPYD-----H 485
Cdd:PRK06599 357 TsiNRTpeslkPYLTPDQFKLYELIWKRTVASQMAPAILDQTSVDIASENGKYVfrATGSVILFPGFLKVYGESkddeeE 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 486 WSDKILPVYERGsrfQPSTVEMVDGE---TSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPG 562
Cdd:PRK06599 437 DDEKLLPPLKEG---EKLKLDELLPEqhfTEPPPRYSEASLVKKLEEYGIGRPSTYASIISTLQDREYVELE-KKRFIPT 512
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 563 HLGMG----LVEGY-DSMGYemskpDLRAELEADLKLICDGKKDKFVVLRQQVQKykqvFIEAVAKAKKLDEalaqyfgn 637
Cdd:PRK06599 513 DLGRIvndfLVEHFpKYVDY-----DFTAGLEDELDEIAEGKKDWKPVLREFWEP----FISNLEKVEEDVR-------- 575
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622877943 638 gTELAQQEEIYpampepiRKCPQCN-KDMVLKTKKNGGFyLSCMGFPECRSAMWLPDS-----VLEASRDSSVCPVC 708
Cdd:PRK06599 576 -TEKVTQEETD-------ETCPKCGgGPLVLKLGKNGKF-LGCSGYPECKYTKNITRDedepiEEEEIVEEEKCPKC 643
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
35-193 |
9.55e-48 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 167.03 E-value: 9.55e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 35 KVLCVAEKNDAAKGIADLLSNGRMRRREGlskfnkiyeFDYHLYGQSVTMVMTSVSGHLLAHDFRMQFRKWQSCNPL--V 112
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKKKGKG---------RYYEFYGEGGGYVVTWASGHLLELDFPEEYDPWDKVWPLedP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 113 LFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKTVKpNLQVLRARFSEITPHAVRTACEN 192
Cdd:cd03362 72 LFPAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVK-RKPVKRAWFSSLTPKAIRRAFKN 150
|
.
gi 1622877943 193 L 193
Cdd:cd03362 151 L 151
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
147-738 |
1.91e-47 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 183.07 E-value: 1.91e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 147 TDCDREGENIGFEIIHVCKtvKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGaaFTrfqtlrl 226
Cdd:PRK07561 94 TDPDREGEAIAWHLLEVLG--GDDVPVKRVVFNEITKNAIQEAFENPRELDINLVNAQQARRFLDRLVG--YM------- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 227 qkIFPeVLAEQL---ISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGI------VEFNWKRHRLF---NHT 294
Cdd:PRK07561 163 --VSP-LLWKKIargLSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTPRGDafearlTHLDGKKFAPVdllNEA 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 295 ACLVLYQLcMEDPMATVVEVRSKPKSKwRPQA-LDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE-TNIFP- 371
Cdd:PRK07561 240 QAEAAVAA-LEGARYSVASVEDKPTTR-KPSApFTTSTLQQEASRKLGFSVKKTMRIAQRLYEAGYITYMRTDsTNLSQe 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 372 -----RDLnltvlveqqtpdprwgafaqsILERGG-----PTPRN-GNKSD---QAHPPIHPT--KYTNS----LQGDEQ 431
Cdd:PRK07561 318 ainaaRGY---------------------IGDNYGkkylpEKPRQySSKAKnaqEAHEAIRPSdvFRTPDqlkgLEGDAQ 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 432 RLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYP-----YDHWSDKILPVYERGSRFQPSTVE 506
Cdd:PRK07561 377 RLYELIWKRFVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVegrddALDDEDRRLPALKVGDALTLEKLD 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 507 MVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVglTPDK-RFLPGHLGM---GLVEGY--DSMGYems 580
Cdd:PRK07561 457 PTQHFTKPPARYSEASLVKELEKLGIGRPSTYASIISTIQDRGYV--RLENrRFYPEKMGRivtDRLEEFfpRLVDY--- 531
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 581 kpDLRAELEADLKLICDGKKDKFVVLRqqvQKYKQvFIEAVAKAKKLDEAlaqyfgNGTELAQqeeiypaMPEPIRKCPQ 660
Cdd:PRK07561 532 --DFTARMEEELDDIANGEADWKPVLD---DFYKD-FSQQLEKAEELREE------GGMRPNQ-------MVITDRDCPT 592
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 661 CNKDMVLKTKKNGGFyLSCMGF---PECRSAMWL-PDSVLEASRDSS--------VCPVCQpHPVYRLKLKF-------- 720
Cdd:PRK07561 593 CGRGMGIRTGKTGVF-LGCSGYalkERCKTTRNLtPEEETLNVLEGEdaetralgADPECG-TAMVLRSGRFgpyvqege 670
|
650 660
....*....|....*....|..
gi 1622877943 721 ----KRGSLPPTMPLEfvcCIG 738
Cdd:PRK07561 671 gdkpRRLSLPKGNNPE---CVG 689
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
35-193 |
5.42e-41 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 147.37 E-value: 5.42e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 35 KVLCVAEKNDAAKGIADLLSNGRMRRREglskfnkiyefdyhlYGQSVTMVMTSVSGHLLAHDFRMQFRKWQSCNPLVLF 114
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGKGSKKKGF---------------YGEGGGYVVTASVGHLLELPFPEEYVDWDKDWPLELF 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622877943 115 EAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKtvKPNLQVLRARFSEITPHAVRTACENL 193
Cdd:cd01028 66 PFEPKYVVIPDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLK--CDNKPVKRAWFSEITPKAIREAFKNL 142
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
35-629 |
6.64e-40 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 159.83 E-value: 6.64e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 35 KVLCVAEKNDAAKGIAdllsngrmrrrEGLSKFNKiyEFDYHlygQSVTMVMTSVSGHLLA----HDFRMQFRKWQSCNP 110
Cdd:PRK08173 3 KALIIAEKPSVANDIA-----------RALGGFTK--HDEYF---ESDEYVLSSAVGHLLEiaapEEYEVKRGKWSFAHL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 111 LVLfeaeiekycPENF--VDIKKTLER--------ETRQCQALVIWTDCDREGENIGFEIIHVCKTVKPnlqVLRARFSE 180
Cdd:PRK08173 67 PVI---------PPHFdlNPIAKTESRlkvltkliKRKDVTRLINACDAGREGELIFRLIAQHAKAKKP---VKRLWLQS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 181 ITPHAVRTACENLTEPDQRVS--DAVDVRQELDLRIGAAFTRFQTLRLQKI--FpevlaeQLISYGSCQFPTLGFVVERF 256
Cdd:PRK08173 135 MTPQAIRDGFANLRSDEDMQPlaDAARCRSEADWLVGINGTRAMTAFNSKGggF------FLTTVGRVQTPTLSIVVERE 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 257 KAIQAFVPEIFHRIKVTHDHKDGIVEFNW-------------KR-HRLFNHTACLVLYQLCMEDPmATVVEvRSKPKSKW 322
Cdd:PRK08173 209 EKIRRFVPRDYWEVRAEFVAAAGFYEGRWfdpkfkkdefdpeKRaSRLWSEAAAEAIVAACRGKP-GTVTE-ESKPSTQL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 323 RPQALDTVELEKLASRKLRINAKETMRIAEKLYTQ-GYISYPRTETNIFPRDLNLTVL--VEQQTPDPRWGAFAQSILER 399
Cdd:PRK08173 287 SPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYLGTVKqtLEMLKESNNYLPHAKQILDK 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 400 G--GPTPR---NGNKSDqaHPPIHPTKYT-NSLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLVIL 473
Cdd:PRK08173 367 GwvKPNKRifdNSKISD--HFAIIPTLQApKSLSEPEQKLYDLVVKRFLAVFFPAAEFLVTTRITEVAGHHFKTEGKVLV 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 474 ARNYLDVYPYD-HWSDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEADLIALME----------------KHGIGTDA 536
Cdd:PRK08173 445 NPGWLAVYGKEaQGADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklveddelreamaEKGLGTPA 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 537 THAEHIETIKARMYV-----GLTPD-KRFlpgHLgMGLVEGYDSMgyEMSKPDLRAELEADLKLICDGKKDKFVVLRQQV 610
Cdd:PRK08173 525 TRAAIIEGLLGEKYLvregrELIPTaKAF---QL-MTLLRGLGVE--ELTSPELTGEWEYKLSQIERGKLSRDAFMQEIA 598
|
650
....*....|....*....
gi 1622877943 611 QKYKQVfieaVAKAKKLDE 629
Cdd:PRK08173 599 QMTQQI----VKRAKEYDS 613
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
133-715 |
1.03e-36 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 149.59 E-value: 1.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 133 LERETRQCQALVIWTDCDREGENIGFeiiHVCKTVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDL 212
Cdd:PRK06319 67 ICKLAKKCDVVYLSPDPDREGEAIAW---HIANQLPKNTKIQRISFNAITKGAVTEALKHPREIDMALVNAQQARRLLDR 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 213 RIGAAFTRFQTLRLQKifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKV-THDHKDG------IVEFNW 285
Cdd:PRK06319 144 IVGYKISPILSRKLQR-------RSGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVhLKDPKTQktfwahLYSVDG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 286 KRHR-------------LFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 352
Cdd:PRK06319 217 KKWEkeipegktedevlLINSKEKADHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQ 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 353 KLY---------TQGYISYPRTET-NIFPRDLNLTVLVEQQTpdprwgaFAQSILERGgPTPRNGNKSDQ-AHPPIHPTK 421
Cdd:PRK06319 297 TLYegvdldsegATGLITYMRTDSvRTDPEALKQVRKYIEGT-------FGKEFLPSS-PNVYTTKKMAQdAHEAIRPTD 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 422 YTNS-------LQGDEQRLYEFIVRHFLAccSQDAQGQETTVEIDIAQERFV---AHGLVILARNYLDVYP------YDH 485
Cdd:PRK06319 369 ITLTpeklrskLTEDQYKLYSLIWKRFVA--SQMIPAIYDTLAIRITTNKGIdlrATGSLLKFKGFLAVYEekrddeGDE 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 486 WSDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVgLTPDKRFLPGHLG 565
Cdd:PRK06319 447 EENIHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYT-LKENQRLRPTELG 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 566 MGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKA----------------KKLDE 629
Cdd:PRK06319 526 KIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWELFLPVVVTAEKEAfiprivteidcpkchkGKLVK 605
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 630 ALAQ---YFG-----------NGTELAQQEEIYPAMPEPIRKCPQCNKDMVLKTKKNGGFyLSCMGFPECRSAMWLPDSV 695
Cdd:PRK06319 606 IWAKnryFYGcseypecdyktSEEELTFNKEDYAEDTPWDSPCPLCGGEMKVRHGRFGTF-LGCENYPECRGIINIHKKG 684
|
650 660
....*....|....*....|....
gi 1622877943 696 LEAS--RDSSVCPV--CQPHPVYR 715
Cdd:PRK06319 685 EEGIepEETVPCPAigCTGHIVKR 708
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
35-628 |
3.51e-34 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 142.02 E-value: 3.51e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 35 KVLCVAEKNDAAKGIADLLSngrmrrrEGLSKFNKIYEfdyhlYGQSVTMVMTSVSGHLL----AHDFRMQFRKWQSCNP 110
Cdd:PRK14724 2 KTLVIAEKPSVAQDIVRALT-------PVAGKFEKHDE-----HFESDSYVVTSAVGHLVeiqaPEEFDVKRGKWSFANL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 111 LVLfeaeiekycPENFvDIKKTLERETR-----------QCQALVIWTDCDREGENIGFEIIHVCKTVKPNLQ--VLRAR 177
Cdd:PRK14724 70 PVI---------PPYF-DLKPVDKTKTRlnavvklakrkDVTELVNACDAGREGELIFRLIEQYAGGAKGGLGkpVKRLW 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 178 FSEITPHAVRTACENLTEPDQR--VSDAVDVRQELDLRIGAAFTRFQTL---RLQKIFpevlaeqLISYGSCQFPTLGFV 252
Cdd:PRK14724 140 LQSMTPQAIRDGFDNLRSDAQMqgLASAARSRSEADWLVGINGTRAMTAfnsRDGGFF-------LTTVGRVQTPTLSLV 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 253 VERFKAIQAFVPEIFHRIKVTHDHKDG-----IVEFNWKRH---------RLFNHTACLVLYQLCMEDPmATVVEvRSKP 318
Cdd:PRK14724 213 VEREEKIRKFVSRDYWEIHAGFHAEAGeylgkWFDPQWKKAsddpearadRVWSEREARAIADAVRGKA-ATVTE-ESKP 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 319 KSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQ-GYISYPRTETNIFPRDLnltVLVEQQTPDPRWGA------ 391
Cdd:PRK14724 291 TTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDY---LPVAKQTFEMLATSgmrhla 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 392 -FAQSILERG--GPTPR---NGNKSDqaHPPIHPTKYTNS-LQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQER 464
Cdd:PRK14724 368 pFAQQALDGNyvRPSKRifdNSKVSD--HFAIIPTTQAPSgLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHS 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 465 FVAHGLVILARNYLDVYPYDHWSD-----------KILPVyERGSRFQPSTVEMVDGETSPPKLLTEADLIALME----- 528
Cdd:PRK14724 446 FKTEGKVLVKPGWLAIYGKEAANEvedakdgdkgqPLVPV-KPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMEsagkq 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 529 -----------KHGIGTDATHAEHIETIKARMYVgLTPDKRFLPGHLG---MGLVEGYDSMgyEMSKPDLRAELEADLKL 594
Cdd:PRK14724 525 idddelreamqEKGLGTPATRAAIIEGLLTEKYM-LREGRELIPTAKAfqlMTLLRGLGVE--ELSRAELTGEWEYKLAQ 601
|
650 660 670
....*....|....*....|....*....|....*.
gi 1622877943 595 ICDGK--KDKFVvlrQQVQKYKQvfiEAVAKAKKLD 628
Cdd:PRK14724 602 MEKGQlsREAFM---QQIAAMTE---KLVKKAKEYD 631
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
95-608 |
2.04e-32 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 135.66 E-value: 2.04e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 95 AHDFRMQFrkwqscnplvlfeAEIEKycPENFVD-IKKTLeretRQCQALVIWTDCDREGENIGFEIIHVCKT--VKPNL 171
Cdd:PRK08780 47 ENGFAMRY-------------DLIDK--NEKHVEaIAKAA----KSADDLYLATDPDREGEAISWHLAEILKErgLLKDK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 172 QVLRARFSEITPHAVRTACENltePDQRVSDAVDVRQE---LDLRIGaaFTrFQTLRLQKIFPEvlaeqlISYGSCQFPT 248
Cdd:PRK08780 108 PMQRVVFTEITPRAIKEAMAK---PRDIASDLVDAQQArraLDYLVG--FN-LSPLLWRKIQRG------LSAGRVQSPA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 249 LGFVVERFKAIQAFVPEIFHRIKVTHDHKDGivEFNWKRHRLFNH-----------TACLVLYQLC-MEDPMATVVEVRS 316
Cdd:PRK08780 176 LRMIVEREEEIEAFIAREYWSIEADCAHPSQ--PFNAKLIKLDGQkfeqftitdgdTAEAARLRIQqAAQGTLHVTDVES 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 317 KPKsKWRPQA-LDTVELEKLASRKLRINAKETMRIAEKLY---------TQGYISYPRTETnifprdLNLTVLVEQQTPD 386
Cdd:PRK08780 254 KER-KRNPAPpFTTSTLQQEASRKLGFTTRRTMQVAQKLYegvdlgdegSVGLITYMRTDS------VNLSQDALAEIRD 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 387 PRWGAFAQSILERGGPTPRNGNKSDQ-AHPPIHPTKYTNS-------LQGDEQRLYEFIVRHFLACCSQDAQGQETTVEI 458
Cdd:PRK08780 327 VIARDYGTASLPDQPNTYKTKSKNAQeAHEAVRPTSALRTpaqvarfLSDDQRRLYELIWKRAVACQMIPATLNTVSVDL 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 459 DIAQER-FVAHGLVILARNYLDVY--------PYDHWSDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEADLIALMEK 529
Cdd:PRK08780 407 AAGSEHvFRATGSTVVVPGFLAVYeegkddksAEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKALEE 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 530 HGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGMG----LVEGYDS-MGYemskpDLRAELEADLKLICDGKKDKFV 604
Cdd:PRK08780 487 YGIGRPSTYASIISTLQFRKYVEME-GRRFRPTDVGRAvnkfLTGHFTRyVDY-----DFTARLEDDLDAVSRGEKEWIP 560
|
....
gi 1622877943 605 VLRQ 608
Cdd:PRK08780 561 LMEK 564
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
173-268 |
7.25e-32 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 119.22 E-value: 7.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 173 VLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQKifpevlaeQLISYGSCQFPTLGFV 252
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRN--------GVLSAGRVQTPTLGLI 72
|
90
....*....|....*.
gi 1622877943 253 VERFKAIQAFVPEIFH 268
Cdd:smart00436 73 VEREREIKNFVPKPYW 88
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
128-723 |
2.27e-23 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 106.49 E-value: 2.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 128 DIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKTVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVR 207
Cdd:COG0551 72 KKLKKDKKKKAKALAAALAAADDDAIEAAAAADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALA 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 208 QELDLRIGAAFTRFQTLRLQKIFPEVLAEQLISYGSCQFptLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKR 287
Cdd:COG0551 152 RLLLLAAASRALRLLLLLAAGRLRLLSAVAAGLLELEEL--LKEFEEEEEEEAAEEEEEEEEAKKKKEEDKKKKKKKKKK 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 288 HRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKET------MRIAEKLYTQGYIS 361
Cdd:COG0551 230 DKEEETKAIKKKKKAAEAVLAAKKAAKEAKAKKELPTTTTDALPEALATTSLTAAAAASAlaaallEEEGELLYTGGYIR 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 362 YPRTETNIFPRDLNLTVLVEQQTPDPrWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNS---LQGDEQRLYEFIV 438
Cdd:COG0551 310 YTRTPKSSEADALAALEALKKIAEEP-PDERAKKKKKKAKKKKASEAKETTDHPPIPPTTAAALlelLEDRKLLLELLVR 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 439 RHFLACCSQDAQGQETTVEIDIAQERFVAHGLVILARNYLDVYPYDHWSDKILPVYERGSRFQPSTVEMVDGETSPPKLL 518
Cdd:COG0551 389 RRFAAAADLAKVEELTKVEEADEEELVEAEGGLLEVLGEEEEDDEDEEEELLLPPLEEGEPLLLEELLLEKQTTTPPPRY 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 519 TEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDG 598
Cdd:COG0551 469 TTELLLKKLEEEGGGGRGTTATIIILILKRRYVVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGK 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 599 KKDKFVVLRqqvqKYKQVFIEAVAKAKKldealaqyfgngtelaQQEEIYPAMPEPI-RKCPQCNKDMVLKTKKNGGFyL 677
Cdd:COG0551 549 EDKVVEIRE----EEYPFFKKLLEIAEE----------------EGEEELSEEDEVLgEKCPKCGKPLVIKKGRYGKF-L 607
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 1622877943 678 SCMGFPECRSAMWLPDSVLEASRdssvCPVCQphpVYRLKLKFKRG 723
Cdd:COG0551 608 GCSNYPECKYTKPLPKPEVTGVK----CPKCG---KKLVLRKSKKG 646
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
895-939 |
5.84e-19 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 80.91 E-value: 5.84e-19
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1622877943 895 TSCLCSQPAVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDEN 939
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
811-852 |
3.02e-17 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 76.29 E-value: 3.02e-17
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1622877943 811 VTCNCGQEAVLLTVRKEGPNQGRQFFKCNGG---SCNFFLWADSP 852
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGrekQCGFFQWADEV 45
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
655-694 |
1.37e-11 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 59.96 E-value: 1.37e-11
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1622877943 655 IRKCPQCNKDMVLKTKKNGGFYlSCMGFPECRSAMWLPDS 694
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFV-GCSNYPECRFTRPLKKN 39
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
36-181 |
2.83e-09 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 55.06 E-value: 2.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 36 VLCVAEKNDAAKGIADLLSNGrmrrreglskfnkiyefdyhlygqsvTMVMTSVSGHLLAHDFRMQFrkwqscnplvlfe 115
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGGG--------------------------FQAVVAVLGHLLSLEKGPKK------------- 41
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622877943 116 aeiekycpenfvDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKTVKPnlQVLRARFSEI 181
Cdd:pfam01751 42 ------------KALKALKELALKAKEVILATDPDREGEAIALKLLELKELLEN--AGGRVEFSEL 93
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
131-192 |
8.99e-09 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 54.49 E-value: 8.99e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622877943 131 KTLERETRQCQALVIWTDCDREGENIGFeiiHVCKTVKPNLQVLRARFSEITPHAVRTACEN 192
Cdd:cd03363 64 KELKKLAKKADEIYLATDPDREGEAIAW---HLAEVLKLKKNVKRVVFNEITKEAIKEALKN 122
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
129-570 |
9.38e-07 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 53.02 E-value: 9.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 129 IKKTLER----ETRQCQALVIWTDCDREGENIGFEIIHVCKTVKPNLQV--LRARFSEITPHAVRTACE--NLTEPDQRV 200
Cdd:PTZ00407 110 IQETLERyieeKADNVTEIILATDPDREGELIAVHALQTIKRLYPKLKVpfSRAYMHSITEDGIRKAMRerHVEACDYDL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 201 SDAVDVRQELDlRI----GAAFTRFQTlrlqkifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFV------------- 263
Cdd:PTZ00407 190 ANAAETRHAMD-RIfgflGSSVVRAAN------------SQMRSIGRVQTPALILINEREDKIKAFLesnkstfevqamc 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 264 --PEIFHR-----IKVTHDHKDGIVEFNWK---RHRLfNHTACLVLYQLCMEdPMATVVEVRSKPkskwrPQALDTVELE 333
Cdd:PTZ00407 257 qfPSPHGTtfsqvVTITPDRKGGASHWATEaeaRRCL-EQWKLNNCTGFSVP-LEPKPQPSVVPP-----PQPFTMATAI 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 334 KLASRKLRINAKETMRIAEKLYTQGYISYPRTET-----NIFP----------------RDLNLTVLVEQQTPDPRWGAF 392
Cdd:PTZ00407 330 AKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDStrideSALPdiyaavkkefgkeflyRLEDRTVSAQEGKGSKKTGKK 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 393 AQSILERGGPTPRnGNKSDqAHPPIHPTK-YTN----SLQGDEQRLYEFIVRHFLA----------------CCSqdAQG 451
Cdd:PTZ00407 410 RSTKQKKGADTPV-GNVED-AHEAIRPTNiDTTgeslSLSPPTRAVYDLVRRNTLAvfmipmktekivatvkFTS--GSG 485
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 452 QETTVEI-------------------------------------------DIAQERFVAHGLVILARNYldvypydhwsd 488
Cdd:PTZ00407 486 EKLEFELqgkrvvepgwtrafhkgdkgttgpaeetdeditaveegapvvpSLSQEEFKAIMNLRSQLGS----------- 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 489 kilPVYERGSRFQPSTVEmvDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGL 568
Cdd:PTZ00407 555 ---GVQKGFFELRSPQVR--ENRPVPPLPHSEGTLIEELKNNGVGRPSTYPMIVKTLLARGYIAVNPKGRCETTPVGRML 629
|
..
gi 1622877943 569 VE 570
Cdd:PTZ00407 630 VE 631
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
128-165 |
1.37e-06 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 46.87 E-value: 1.37e-06
10 20 30
....*....|....*....|....*....|....*...
gi 1622877943 128 DIKKTLERETRQCQaLVIWTDCDREGENIGFEIIHVCK 165
Cdd:smart00493 36 EQIKLLKKLAKKAE-VILATDPDREGEAIAWELAELLK 72
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
309-732 |
4.02e-05 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 47.50 E-value: 4.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 309 ATVVEVRSKPKSKWRPQAldtvelEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR 388
Cdd:COG1754 256 AAAAAVREPPTPTTTTTA------QAATTTTTRAAAARTTRSAQQAARRTRLGGEGTYTTTTTTTTTTSAAAAAAAAAAA 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 389 WGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYT----------NSLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEI 458
Cdd:COG1754 330 ALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAaarrppaaraALLSDDRLLLELLLLRRTAAAAAAAAAATATTTAA 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 459 DIAQE----------RFVAHGLVILARNYLDVYPYDHwSDKILPVYERGSRFQPSTVEMVDGETSPPKLLTEADLIALME 528
Cdd:COG1754 410 AAAAGagavgtaaagAVFFFGGFLLFAEEEDDDEEDD-DDDDLPALEEGLPLLKEGVLADQHFTQPPPRYTEAPLVKRME 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 529 KHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGhlGMGLV------------EGYdsmgyemskpDLRAELEADLKLIC 596
Cdd:COG1754 489 ELGIGRPSTYASILSTLADRIYVRLD-KRRLIPE--DKGRLvtaflfsffrryVEY----------DFTADLEEFLDDVS 555
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 597 DGKKDKFVVLRQQVQKYKQvFIEAVAKAKKLDEALAqyfgngteLAQQEEIypaMPEPIRKCPQCNKDMVLKTKKNGGfY 676
Cdd:COG1754 556 DGELDWKAVLRRFWRDFSA-AYDETGDLRISEVLDA--------LEDLGEI---DPREINSCPLGTGGLSLRVGRYGP-F 622
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622877943 677 LSCMG-------FPECRSamwlPDS-VLEASRDSSVCPVCQP----------HPVYRLKLKF-----------------K 721
Cdd:COG1754 623 IECSNyeprrasIPECLA----PDElTPEKAEELLEAPADGPrvlgtdpetgKPIVLKDGRFgpyvqlgepekedkpkpK 698
|
490
....*....|.
gi 1622877943 722 RGSLPPTMPLE 732
Cdd:COG1754 699 RASLPKGMSPE 709
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
125-175 |
5.83e-05 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 42.41 E-value: 5.83e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1622877943 125 NFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKTVKPNLQVLR 175
Cdd:cd00188 32 ALNKTRELLKRLLGEAKEVIIATDADREGEAIALRLLELLKSLGKKVRRLL 82
|
|
| |
