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    Mta2 metastasis-associated gene family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 23942, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mta2provided by MGI
    Official Full Name
    metastasis-associated gene family, member 2provided by MGI
    Primary source
    MGI:MGI:1346340
    See related
    Ensembl:ENSMUSG00000071646 AllianceGenome:MGI:1346340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mmta2; Mta1l1; Mata1l1
    Summary
    Enables histone deacetylase activity and transcription coregulator activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within genomic imprinting; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Used to study systemic lupus erythematosus. Orthologous to human MTA2 (metastasis associated 1 family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 21.3), CNS E11.5 (RPKM 18.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mta2 in Genome Data Viewer
    Location:
    19 A; 19 6.04 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8919239..8929659)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8941920..8952300)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36629 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene echinoderm microtubule associated protein like 3 Neighboring gene rod outer segment membrane protein 1 Neighboring gene predicted gene 10353 Neighboring gene STARR-positive B cell enhancer ABC_E5684 Neighboring gene STARR-positive B cell enhancer ABC_E11018 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene STARR-positive B cell enhancer ABC_E3241 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:9041491-9041707 Neighboring gene eukaryotic translation elongation factor 1 gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables chromatin binding  
    enables histone deacetylase activity PubMed 
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding  
    enables transcription coactivator activity  
    enables transcription coregulator activity PubMed 
    enables transcription corepressor activity  
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    acts_upstream_of_or_within chromatin remodeling PubMed 
    acts_upstream_of_or_within chromosome organization PubMed 
    acts_upstream_of_or_within genomic imprinting PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of cell fate specification PubMed 
    involved_in regulation of fibroblast migration  
    involved_in regulation of fibroblast migration  
    involved_in regulation of stem cell differentiation PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex  
    part_of NuRD complex PubMed 
    part_of NuRD complex PubMed 
    part_of NuRD complex  
    part_of NuRD complex PubMed 
    located_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    part_of histone deacetylase complex PubMed 
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    metastasis-associated protein MTA2
    Names
    metastais-associated gene family, member 2
    metastasis-associated 1-like 1
    metastasis-associated protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412946.1NP_001399875.1  metastasis-associated protein MTA2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129217, AC130819
    2. NM_001412948.1NP_001399877.1  metastasis-associated protein MTA2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129217, AC130819
    3. NM_011842.4NP_035972.3  metastasis-associated protein MTA2 isoform 1

      See identical proteins and their annotated locations for NP_035972.3

      Status: VALIDATED

      Source sequence(s)
      AC129217, AC130819
      Consensus CDS
      CCDS29561.1
      UniProtKB/Swiss-Prot
      Q3TVT8, Q9R190
      UniProtKB/TrEMBL
      Q3TZP3
      Related
      ENSMUSP00000093959.3, ENSMUST00000096240.3
      Conserved Domains (6) summary
      smart00717
      Location:266313
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:267312
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:363413
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:366421
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3168
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:147198
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8919239..8929659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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