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    Malsu1 mitochondrial assembly of ribosomal large subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 75593, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Malsu1provided by MGI
    Official Full Name
    mitochondrial assembly of ribosomal large subunit 1provided by MGI
    Primary source
    MGI:MGI:1922843
    See related
    Ensembl:ENSMUSG00000029815 AllianceGenome:MGI:1922843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Matsu1; 2410003K15Rik
    Summary
    Predicted to enable mitochondrial large ribosomal subunit binding activity. Predicted to be involved in negative regulation of mitochondrial translation; negative regulation of ribosome biogenesis; and ribosomal large subunit biogenesis. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human MALSU1 (mitochondrial assembly of ribosomal large subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 7.4), adrenal adult (RPKM 6.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Malsu1 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.82 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49050729..49116078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49073795..49139144)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6428 Neighboring gene glycoprotein (transmembrane) nmb Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:49023701-49023810 Neighboring gene STARR-seq mESC enhancer starr_15807 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene predicted gene 7890 Neighboring gene STARR-seq mESC enhancer starr_15808 Neighboring gene insulin-like growth factor 2 mRNA binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_15813 Neighboring gene predicted gene, 18010 Neighboring gene RIKEN cDNA D030074P21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:49158708-49158891

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
    2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mitochondrial large ribosomal subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitochondrial large ribosomal subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial assembly of ribosomal large subunit protein 1
    Names
    protein C7orf30 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029353.1 → NP_083629.1  mitochondrial assembly of ribosomal large subunit protein 1

      See identical proteins and their annotated locations for NP_083629.1

      Status: VALIDATED

      Source sequence(s)
      AK010366, AV085631, BY036157
      Consensus CDS
      CCDS51768.1
      UniProtKB/Swiss-Prot
      Q9CWV0
      Related
      ENSMUSP00000122941.3, ENSMUST00000128616.6
      Conserved Domains (1) summary
      pfam02410
      Location:89 → 188
      RsfS; Ribosomal silencing factor during starvation

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      49050729..49116078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506721.1 → XP_006506784.1  mitochondrial assembly of ribosomal large subunit protein 1 isoform X1

      Conserved Domains (1) summary
      pfam02410
      Location:89 → 188
      RsfS; Ribosomal silencing factor during starvation

    2. XM_006506722.3 → XP_006506785.1  mitochondrial assembly of ribosomal large subunit protein 1 isoform X2

      Conserved Domains (1) summary
      pfam02410
      Location:89 → 188
      RsfS; Ribosomal silencing factor during starvation

    3. XM_036152386.1 → XP_036008279.1  mitochondrial assembly of ribosomal large subunit protein 1 isoform X3

    4. XM_011241499.3 → XP_011239801.1  mitochondrial assembly of ribosomal large subunit protein 1 isoform X4

      Conserved Domains (1) summary
      pfam02410
      Location:22 → 69
      RsfS; Ribosomal silencing factor during starvation
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWV0.1 GenPept UniProtKB/Swiss-Prot:Q9CWV0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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