Isca1 iron-sulfur cluster assembly 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Isca1provided by MGI
Official Full Name: iron-sulfur cluster assembly 1provided by MGI
Primary source: MGI:MGI:1916296
See related: Ensembl:ENSMUSG00000044792 AllianceGenome:MGI:1916296
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hbld2; 1810010A06Rik
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 131.8), liver E14.5 (RPKM 87.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B2; 13 31.88 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (59903229..59917603, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (59755415..59769789, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest that cellular processes with different requirements for ISCA1, ISCA2 and ISCA1-ISCA2 complex seem to exist.
Title: ISCA1 is essential for mitochondrial Fe(4)S(4) biogenesis in vivo.
Data suggest that miR-210 induced repression of ISCU1/2 may contribute to HIF-1alpha-triggered alterations in neuronal energy metabolism after nickel exposure.
Title: MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.
Required for functional heme biosynthesis in erythroid cells.
Title: Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: iron-sulfur cluster assembly 1 homolog, mitochondrial

Names: HESB like domain containing 2; HESB-like domain-containing protein 2; iron-sulfur assembly protein IscA

NP_081197.1

EC 2.7.7.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026921.4 → NP_081197.1 iron-sulfur cluster assembly 1 homolog, mitochondrial precursor

See identical proteins and their annotated locations for NP_081197.1

Status: PROVISIONAL

Source sequence(s)

AC134869

Consensus CDS

CCDS26578.1

UniProtKB/Swiss-Prot

Q5SZT5, Q9D924

UniProtKB/TrEMBL

I3ITR1

Related

ENSMUSP00000054858.7, ENSMUST00000057115.7

Conserved Domains (1) summary

TIGR00049
Location:26 → 129

TIGR00049; Iron-sulfur cluster assembly accessory protein