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    TTR1 Disease resistance protein (TIR-NBS-LRR class) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834536, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TTR1
    Official Full Name
    Disease resistance protein (TIR-NBS-LRR class)
    Primary source
    TAIR:AT5G45050
    Locus tag
    AT5G45050
    See related
    Araport:AT5G45050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATWRKY16; K21C13.24; K21C13_24; TOLERANT TO TOBACCO RINGSPOT NEPOVIRUS 1; WRKY16
    Summary
    Encodes a member of the WRKY Transcription Factor (Group II-e) family.
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    Genomic context

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    See TTR1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (18176894..18181973, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DSS1 homolog on chromosome V Neighboring gene Glutathione S-transferase family protein Neighboring gene ncRNA Neighboring gene Trypsin family protein Neighboring gene Cytochrome c Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene phloem protein 2-A8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4. Saucet SB, et al. Nat Commun, 2015 Mar 6. PMID 25744164
    2. The WRKY superfamily of plant transcription factors. Eulgem T, et al. Trends Plant Sci, 2000 May. PMID 10785665
    3. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
    5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An R gene pair that resembles and is linked to RRS1/RPS4, designated as RRS1B/RPS4B, confers recognition of AvrRps4 from Pseudomonas syringae. [RRS1B]
      Title: Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344582.1
    NM_001344583.1
    NM_123873.3
    NM_180802.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response-activating signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plant-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS-LRR class)
    NP_199318.2
    • TOLERANT TO TOBACCO RINGSPOT NEPOVIRUS 1 (TTR1); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to virus, plant-type hypersensitive response; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657), NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) (TAIR:AT5G45260.1); Has 18972 Blast hits to 14972 proteins in 610 species: Archae - 6; Bacteria - 638; Metazoa - 199; Fungi - 9; Plants - 17764; Viruses - 2; Other Eukaryotes - 354 (source: NCBI BLink).
    NP_851133.1
    • TOLERANT TO TOBACCO RINGSPOT NEPOVIRUS 1 (TTR1); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to virus, plant-type hypersensitive response; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657), NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) (TAIR:AT5G45260.1); Has 19463 Blast hits to 15000 proteins in 640 species: Archae - 10; Bacteria - 753; Metazoa - 207; Fungi - 5; Plants - 18197; Viruses - 4; Other Eukaryotes - 287 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18176894..18181973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123873.3 → NP_199318.2  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199318.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UNI2, F4KBS5
      Conserved Domains (7) summary
      smart00774
      Location:1153 → 1209
      WRKY; DNA binding domain
      PLN03210
      Location:14 → 1022
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:571 → 593
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:594 → 616
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam01582
      Location:7 → 137
      TIR; TIR domain
      pfam07725
      Location:570 → 589
      LRR_3; Leucine Rich Repeat
      pfam13191
      Location:164 → 274
      AAA_16; AAA ATPase domain

    2. NM_001344582.1 → NP_001332492.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UNI2, A0A1P8BH45

    3. NM_180802.2 → NP_851133.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851133.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FL92
      UniProtKB/TrEMBL
      A0A178UNI2
      Conserved Domains (6) summary
      smart00774
      Location:1181 → 1237
      WRKY; DNA binding domain
      PLN03210
      Location:14 → 1050
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00034
      Location:594 → 616
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam01582
      Location:7 → 137
      TIR; TIR domain
      pfam07725
      Location:570 → 589
      LRR_3; Leucine Rich Repeat
      pfam13191
      Location:164 → 274
      AAA_16; AAA ATPase domain

    4. NM_001344583.1 → NP_001332491.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UNI2, A0A1P8BH86
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FL92.1

    Gene LinkOut

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