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    CR88 Chaperone protein htpG family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814930, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CR88
    Official Full Name
    Chaperone protein htpG family protein
    Primary source
    TAIR:AT2G04030
    Locus tag
    AT2G04030
    See related
    Araport:AT2G04030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtHsp90.5; AtHsp90C; EMB1956; EMBRYO DEFECTIVE 1956; F3C11.14; F3C11_14; HEAT SHOCK PROTEIN 88.1; HEAT SHOCK PROTEIN 90.5; Hsp88.1; HSP90.5
    Summary
    Encodes a chloroplast-targeted 90-kDa heat shock protein located in the stroma involved in red-light mediated deetiolation response and crucial for protein import into the chloroplast stroma. Mutants are resistant to chlorate, have elongated hypocotyls in light, and affect the expression of NR2, CAB, and RBCS but NOT NR1 and NiR.
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    Genomic context

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    See CR88 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Sequence:
    Chromosome: 2; NC_003071.7 (1281754..1286144)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene root meristem growth factor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene zinc transporter 7 precursor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A chlorate-resistant mutant defective in the regulation of nitrate reductase gene expression in Arabidopsis defines a new HY locus. Lin Y, et al. Plant Cell, 1997 Jan. PMID 9014362, Free PMC Article
    2. The chlorate-resistant and photomorphogenesis-defective mutant cr88 encodes a chloroplast-targeted HSP90. Cao D, et al. Plant J, 2003 Jan. PMID 12943545
    3. Cosuppression of the chloroplast localized molecular chaperone HSP90.5 impairs plant development and chloroplast biogenesis in Arabidopsis. Oh SE, et al. BMC Res Notes, 2014 Sep 13. PMID 25216779, Free PMC Article
    4. Identification of HSP90C as a substrate of E3 ligase TaSAP5 through ubiquitylome profiling. Zhang N, et al. Plant Sci, 2019 Oct. PMID 31481192
    5. Chloroplast-targeted Hsp90 plays essential roles in plastid development and embryogenesis in Arabidopsis possibly linking with VIPP1. Feng J, et al. Physiol Plant, 2014 Feb. PMID 23875936

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtHsp90.5 may help in the disassembly of VIPP1 for thylakoid membrane formation and/or maintenance.
      Title: Chloroplast-targeted Hsp90 plays essential roles in plastid development and embryogenesis in Arabidopsis possibly linking with VIPP1.
    2. Results show that the induction expression of ABA-responsive genes under salt and drought stress was delayed by constitutive overexpression of cytosolic AtHsp90.2, but was hardly affected by that of organellar AtHsp90.5 and AtHsp90.7.
      Title: Overexpression of AtHsp90.2, AtHsp90.5 and AtHsp90.7 in Arabidopsis thaliana enhances plant sensitivity to salt and drought stresses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_126439.4
    NM_179601.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within de-etiolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein import into chloroplast stroma IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to chlorate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Chaperone protein htpG family protein
    NP_178487.1
    • CR88; FUNCTIONS IN: ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: mitochondrion, plasma membrane, chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Chaperone protein htpG (InterPro:IPR001404), Heat shock protein Hsp90, conserved site (InterPro:IPR019805), Heat shock protein Hsp90, C-terminal (InterPro:IPR020576), Heat shock protein Hsp90, N-terminal (InterPro:IPR020575), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), ATPase-like, ATP-binding domain (InterPro:IPR003594); BEST Arabidopsis thaliana protein match is: HEAT SHOCK PROTEIN 89.1 (TAIR:AT3G07770.1); Has 8928 Blast hits to 8878 proteins in 2458 species: Archae - 4; Bacteria - 3413; Metazoa - 2083; Fungi - 313; Plants - 465; Viruses - 0; Other Eukaryotes - 2650 (source: NCBI BLink).
    NP_849932.1
    • CR88; FUNCTIONS IN: ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: mitochondrion, chloroplast stroma, plasma membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Chaperone protein htpG (InterPro:IPR001404), Heat shock protein Hsp90, conserved site (InterPro:IPR019805), Heat shock protein Hsp90, C-terminal (InterPro:IPR020576), Heat shock protein Hsp90, N-terminal (InterPro:IPR020575), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), ATPase-like, ATP-binding domain (InterPro:IPR003594); BEST Arabidopsis thaliana protein match is: HEAT SHOCK PROTEIN 89.1 (TAIR:AT3G07770.1); Has 8908 Blast hits to 8859 proteins in 2447 species: Archae - 4; Bacteria - 3393; Metazoa - 2086; Fungi - 314; Plants - 461; Viruses - 0; Other Eukaryotes - 2650 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      1281754..1286144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126439.4 → NP_178487.1  Chaperone protein htpG family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178487.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IU89, Q0WMQ3, Q0WMV4, Q8LPS0, Q9SIF2
      UniProtKB/TrEMBL
      A0A178VPV7, A0A5S9WWZ5, O23638
      Conserved Domains (1) summary
      PRK05218
      Location:77 → 738
      PRK05218; heat shock protein 90; Provisional

    2. NM_179601.1 → NP_849932.1  Chaperone protein htpG family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849932.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O23638
      Conserved Domains (3) summary
      PRK05218
      Location:77 → 735
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:264 → 765
      HSP90; Hsp90 protein
      pfam02518
      Location:104 → 210
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SIF2.1

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