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    EPF1 epidermal patterning factor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816621, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EPF1
    Official Full Name
    epidermal patterning factor 1
    Primary source
    TAIR:AT2G20875
    Locus tag
    AT2G20875
    See related
    Araport:AT2G20875
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EPIDERMAL PATTERNING FACTOR 1
    Summary
    Encodes a secretory peptide EPF1 involved in stomatal development. EPF1 is related to EPF2 which controls asymmetric cell divisions during stomatal devlopment. Its transcript levels change after inducing MUTE expression in a mute background.
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    Genomic context

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    See EPF1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (8982863..8983814, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene lipoic acid synthase 1 Neighboring gene cell wall protein precursor Neighboring gene uncharacterized protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene photosystem II reaction center PSB29 protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The secretory peptide gene EPF1 enforces the stomatal one-cell-spacing rule. Hara K, et al. Genes Dev, 2007 Jul 15. PMID 17639078, Free PMC Article
    2. The signaling peptide EPF2 controls asymmetric cell divisions during stomatal development. Hunt L, et al. Curr Biol, 2009 May 26. PMID 19398336
    3. Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling. Qi X, et al. Elife, 2017 Mar 7. PMID 28266915, Free PMC Article
    4. Evolutionary relationship and structural characterization of the EPF/EPFL gene family. Takata N, et al. PLoS One, 2013. PMID 23755192, Free PMC Article
    5. Differential effects of the peptides Stomagen, EPF1 and EPF2 on activation of MAP kinase MPK6 and the SPCH protein level. Jewaria PK, et al. Plant Cell Physiol, 2013 Aug. PMID 23686240

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, the authors report that EPF1 and its primary receptor ERECTA-LIKE1 (ERL1) target MUTE, a transcription factor specifying the proliferation-to-differentiation switch within the stomatal cell lineages. In turn, MUTE directly induces ERL1.
      Title: Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling.
    2. EPF1/EPF2-like proteins form an additional disulfide bond in their loop regions and show greater flexibility in these regions than EPFL9/Stomagen-like peptides.
      Title: Evolutionary relationship and structural characterization of the EPF/EPFL gene family.
    3. EPF1 and EPF2 are able to activate the MAP kinase MPK6, and that both EPF1 and EPF2 are able to decrease the SPCH level, whereas stomagen is able to increase it.
      Title: Differential effects of the peptides Stomagen, EPF1 and EPF2 on activation of MAP kinase MPK6 and the SPCH protein level.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127657.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of stomatal complex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    epidermal patterning factor 1
    NP_179684.1
    • EPIDERMAL PATTERNING FACTOR 1 (EPF1); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT1G71866.1); Has 74 Blast hits to 74 proteins in 11 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 74; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8982863..8983814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127657.4 → NP_179684.1  epidermal patterning factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179684.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S8I4
      UniProtKB/TrEMBL
      A0A178VX97, A0A5S9X054
      Conserved Domains (1) summary
      pfam17181
      Location:53 → 103
      EPF; Epidermal patterning factor proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S8I4.1

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