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    JAZ1 jasmonate-zim-domain protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838501, updated on 18-Sep-2024

    Summary

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    Official Symbol
    JAZ1
    Official Full Name
    jasmonate-zim-domain protein 1
    Primary source
    TAIR:AT1G19180
    Locus tag
    AT1G19180
    See related
    Araport:AT1G19180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtJAZ1; jasmonate-zim-domain protein 1; T29M8.5; T29M8_5; TIFY10A
    Summary
    JAZ1 is a nuclear-localized protein involved in jasmonate signaling. JAZ1 transcript levels rise in response to a jasmonate stimulus. JAZ1 can interact with the COI1 F-box subunit of an SCF E3 ubiquitin ligase in a yeast-two-hybrid assay only in the presence of jasmonate-isoleucine (JA-ILE) or coronatine. Application of jasmonate methyl ester to Arabidopsis roots reduces the levels of a JAZ1:GUS fusion protein, presumably by stimulating ubiquitin-proteasome-mediated degradation. The Jas domain appears to be important for JAZ1-COI1 interactions in the presence of coronatine. Two positive residues (R205 and R206) in the Jas domain shown to be important for coronatine -dependent COI1 binding are not required for binding AtMYC2.
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    Genomic context

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    See JAZ1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (6621777..6623668)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene cyclin-dependent kinase, putative (DUF581)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Arabidopsis JAZ gene expression during Pseudomonas syringae pathogenesis. Demianski AJ, et al. Mol Plant Pathol, 2012 Jan. PMID 21726394, Free PMC Article
    2. Inhibition of the JAZ1 gene causes activation of camalexin biosynthesis in Arabidopsis callus cultures. Makhazen DS, et al. J Biotechnol, 2021 Dec 10. PMID 34736953
    3. The positive regulatory roles of the TIFY10 proteins in plant responses to alkaline stress. Zhu D, et al. PLoS One, 2014. PMID 25375909, Free PMC Article
    4. The Arabidopsis CORONATINE INSENSITIVE1 protein is a jasmonate receptor. Yan J, et al. Plant Cell, 2009 Aug. PMID 19717617, Free PMC Article
    5. ABA signaling is negatively regulated by GbWRKY1 through JAZ1 and ABI1 to affect salt and drought tolerance. Luo X, et al. Plant Cell Rep, 2020 Feb. PMID 31713664

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of the JAZ1 gene causes activation of camalexin biosynthesis in Arabidopsis callus cultures.
      Title: Inhibition of the JAZ1 gene causes activation of camalexin biosynthesis in Arabidopsis callus cultures.
    2. ABA signaling is negatively regulated by GbWRKY1 through JAZ1 and ABI1 to affect salt and drought tolerance.
      Title: ABA signaling is negatively regulated by GbWRKY1 through JAZ1 and ABI1 to affect salt and drought tolerance.
    3. The study reports the development of a fluorescence anisotropy-based in vitro binding assay system to screen for the ligands of the COI1-JAZ1 co-receptors. The assay enabled the first quantitative analysis of the affinity values and JAZ1-subtype selectivity of various endogenous jasmonate derivatives, such as coronatine, jasmonic acid, and 12-hydroxyjasmonoyl-l-isoleucine.
      Title: A comprehensive in vitro fluorescence anisotropy assay system for screening ligands of the jasmonate COI1-JAZ co-receptor in plants.
    4. the C-terminal domain of the bHLH members (GLABRA3 [GL3], ENHANCER OF GLABRA3 [EGL3] and TRANSPARENT TESTA8 [TT8]) interacted with JAZs.
      Title: The C-terminal domains of Arabidopsis GL3/EGL3/TT8 interact with JAZ proteins and mediate dimeric interactions.
    5. JAZ1 and JAZ10 were the only JAZ proteins still showing interaction with the mutant MYC proteins, due to a second MYC interaction domain, besides the classical Jas domain.
      Title: Change of a conserved amino acid in the MYC2 and MYC3 transcription factors leads to release of JAZ repression and increased activity.
    6. JAZ gene expression was examined during infection of Arabidopsis by Pseudomonas syringae strain DC3000.
      Title: Analysis of Arabidopsis JAZ gene expression during Pseudomonas syringae pathogenesis.
    7. JAZ1 incorporates into high-molecular weight protein complexes of > 1 MDa.
      Title: Dissection of the one-MegaDalton JAZ1 protein complex.
    8. results suggest that MYC3 and MYC4 are JAZ-interacting transcription factors that regulate jasmonate responses
      Title: Characterization of JAZ-interacting bHLH transcription factors that regulate jasmonate responses in Arabidopsis.
    9. Findings indicate that JAZ splice variants have reduced capacity to form stable complexes with COI1 in the presence of the bioactive stereoisomer of the hormone (3R,7S)-JA-Ile.
      Title: Alternative splicing expands the repertoire of dominant JAZ repressors of jasmonate signaling.
    10. identification of a third critical component of the jasmonate co-receptor complex, inositol pentakisphosphate, which interacts with both COI1 and JAZ adjacent to the ligand
      Title: Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332386.1
    NM_101776.3
    NM_202133.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cellular response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cellular response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    jasmonate-zim-domain protein 1
    NP_001319041.1
    • jasmonate-zim-domain protein 1 (JAZ1); CONTAINS InterPro DOMAIN/s: Tify (InterPro:IPR010399), CCT domain-like (InterPro:IPR018467); BEST Arabidopsis thaliana protein match is: TIFY domain/Divergent CCT motif family protein (TAIR:AT1G74950.1); Has 439 Blast hits to 432 proteins in 29 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 439; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
    NP_973862.1
    • TIFY10A; CONTAINS InterPro DOMAIN/s: Tify (InterPro:IPR010399), CCT domain-like (InterPro:IPR018467); BEST Arabidopsis thaliana protein match is: TIFY domain/Divergent CCT motif family protein (TAIR:AT1G74950.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6621777..6623668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332386.1 → NP_001319041.1  jasmonate-zim-domain protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LAG5, Q93Z09, Q9LMA8
      UniProtKB/TrEMBL
      A0A178W7G1, A0A5S9V532
      Conserved Domains (2) summary
      pfam06200
      Location:121 → 154
      tify; tify domain
      pfam09425
      Location:202 → 226
      CCT_2; Divergent CCT motif

    2. NM_101776.3 → NP_564075.1  jasmonate-zim-domain protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564075.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LAG5, Q93Z09, Q9LMA8
      UniProtKB/TrEMBL
      A0A178W7G1, A0A5S9V532
      Conserved Domains (2) summary
      pfam06200
      Location:121 → 154
      tify; tify domain
      pfam09425
      Location:202 → 226
      CCT_2; Divergent CCT motif

    3. NM_202133.1 → NP_973862.1  jasmonate-zim-domain protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3ED96
      Conserved Domains (2) summary
      pfam06200
      Location:55 → 88
      tify; tify domain
      pfam09425
      Location:136 → 160
      CCT_2; Divergent CCT motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LMA8.1

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