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    HB-2 homeobox protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827384, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HB-2
    Official Full Name
    homeobox protein 2
    Primary source
    TAIR:AT4G16780
    Locus tag
    AT4G16780
    See related
    Araport:AT4G16780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA HOMEOBOX PROTEIN 2; ATHB-2; ATHB2; DL4415W; FCAALL.101; HAT4; homeobox protein 2
    Summary
    Encodes a homeodomain-leucine zipper protein that is rapidly and strongly induced by changes in the ratio of red to far-red light. It is also involved in cell expansion and cell proliferation and in the response to auxin.
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    Genomic context

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    See HB-2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (9449114..9450905)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ATP-dependent caseinolytic (Clp) protease/crotonase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The HAT4 gene of Arabidopsis encodes a developmental regulator. Schena M, et al. Genes Dev, 1993 Mar. PMID 8449400
    2. Shade avoidance responses are mediated by the ATHB-2 HD-zip protein, a negative regulator of gene expression. Steindler C, et al. Development, 1999 Oct. PMID 10477292
    3. The Arabidopsis Athb-2 and -4 genes are strongly induced by far-red-rich light. Carabelli M, et al. Plant J, 1993 Sep. PMID 8106086
    4. The Athb-1 and -2 HD-Zip domains homodimerize forming complexes of different DNA binding specificities. Sessa G, et al. EMBO J, 1993 Sep. PMID 8253077, Free PMC Article
    5. Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function. Turchi L, et al. Development, 2013 May. PMID 23578926

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis thaliana homeobox protein2 (ATHB2)together with auxin-inducible IAA29, is diurnally expressed with a peak at dawn under the control of PHYTOCHROME-INTERACTING FACTOR4 (PIF4) and PIF5. [AtHB2]
      Title: Phytochrome-interacting factor 4 and 5 (PIF4 and PIF5) activate the homeobox ATHB2 and auxin-inducible IAA29 genes in the coincidence mechanism underlying photoperiodic control of plant growth of Arabidopsis thaliana.
    2. a genetic system consisting of HD-Zip II and HD-Zip III genes (ATHB2, ATHB4) cooperates in establishing bilateral symmetry and patterning along the adaxial-abaxial axis in the embryo as well as in controlling SAM activity
      Title: Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_117780.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within red or far-red light signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to far red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within secondary thickening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within shade avoidance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein 2
    NP_193411.1
    • homeobox protein 2 (HB-2); CONTAINS InterPro DOMAIN/s: HD-ZIP protein, N-terminal (InterPro:IPR006712), Helix-turn-helix motif, lambda-like repressor (InterPro:IPR000047), Homeobox (InterPro:IPR001356), Homeobox, conserved site (InterPro:IPR017970), Homeodomain-like (InterPro:IPR009057), Leucine zipper, homeobox-associated (InterPro:IPR003106), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeobox-leucine zipper protein 4 (HB-4) / HD-ZIP protein (TAIR:AT5G47370.1); Has 7230 Blast hits to 7123 proteins in 465 species: Archae - 0; Bacteria - 0; Metazoa - 4716; Fungi - 327; Plants - 2046; Viruses - 18; Other Eukaryotes - 123 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9449114..9450905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117780.4 → NP_193411.1  homeobox protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193411.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5Y7H1, A5Y7H2, A5Y7H3, A5Y7H4, A5Y7H5, A5Y7H6, A5Y7H7, A5Y7H8, A5Y7H9, A5Y7I0, A5Y7I1, A5Y7I2, A5Y7I3, A5Y7I4, A5Y7I5, Q05466
      UniProtKB/TrEMBL
      A0A654FQ84
      Conserved Domains (3) summary
      smart00340
      Location:184 → 227
      HALZ; homeobox associated leucin zipper
      smart00389
      Location:128 → 182
      HOX; Homeodomain
      pfam04618
      Location:8 → 107
      HD-ZIP_N; HD-ZIP protein N terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05466.1

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