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    ZDHHC13 zinc finger DHHC-type palmitoyltransferase 13 [ Homo sapiens (human) ]

    Gene ID: 54503, updated on 3-Dec-2024

    Summary

    Official Symbol
    ZDHHC13provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 13provided by HGNC
    Primary source
    HGNC:HGNC:18413
    See related
    Ensembl:ENSG00000177054 MIM:612815; AllianceGenome:HGNC:18413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIP14L; HIP3RP
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity and palmitoyltransferase activity. Involved in positive regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 18.5), urinary bladder (RPKM 11.0) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZDHHC13 in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (19117104..19176415)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (19237229..19296555)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (19138715..19197962)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member X9, pseudogene Neighboring gene MAS related GPR family member X2 Neighboring gene Sharpr-MPRA regulatory region 14303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3197 Neighboring gene VISTA enhancer hs2144 Neighboring gene VISTA enhancer hs2145 Neighboring gene CSRP3 and E2F8 antisense RNA 1 Neighboring gene cysteine and glycine rich protein 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:19253866-19255065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3198 Neighboring gene E2F transcription factor 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10852, FLJ10941, MGC64994

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi-associated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC13
    Names
    DHHC-13
    HIP14-related protein
    huntingtin interacting protein HIP3RP
    huntingtin-interacting protein 14-related protein
    probable palmitoyltransferase ZDHHC13
    putative MAPK-activating protein PM03
    putative NF-kappa-B-activating protein 209
    zinc finger DHHC domain-containing protein 13
    zinc finger DHHC-type containing 13
    zinc finger, DHHC domain containing 13
    NP_001001483.1
    NP_061901.2
    XP_005253053.1
    XP_011518496.1
    XP_011518497.1
    XP_047283094.1
    XP_047283095.1
    XP_047283096.1
    XP_047283097.1
    XP_047283098.1
    XP_047283099.1
    XP_047283100.1
    XP_054225133.1
    XP_054225134.1
    XP_054225135.1
    XP_054225136.1
    XP_054225137.1
    XP_054225138.1
    XP_054225139.1
    XP_054225140.1
    XP_054225141.1
    XP_054225142.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001483.3NP_001001483.1  palmitoyltransferase ZDHHC13 isoform 2

      See identical proteins and their annotated locations for NP_001001483.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' region which results in translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC050690, BC056152
      Consensus CDS
      CCDS44551.1
      UniProtKB/Swiss-Prot
      Q8IUH4
      Related
      ENSP00000382288.3, ENST00000399351.7
      Conserved Domains (5) summary
      cd00204
      Location:15139
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01529
      Location:293429
      zf-DHHC; DHHC palmitoyltransferase
      pfam12796
      Location:23117
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:439
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1849
      ANK; ANK repeat [structural motif]
    2. NM_019028.3NP_061901.2  palmitoyltransferase ZDHHC13 isoform 1

      See identical proteins and their annotated locations for NP_061901.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB097014, BC056152
      Consensus CDS
      CCDS44550.1
      UniProtKB/Swiss-Prot
      Q7Z2D3, Q86VK2, Q8IUH4, Q9NV30, Q9NV99
      UniProtKB/TrEMBL
      A8K5N3
      Related
      ENSP00000400113.2, ENST00000446113.7
      Conserved Domains (4) summary
      COG0666
      Location:145271
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:79192
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:81112
      ANK; ANK repeat [structural motif]
      pfam01529
      Location:423559
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      19117104..19176415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520195.2XP_011518497.1  palmitoyltransferase ZDHHC13 isoform X6

      See identical proteins and their annotated locations for XP_011518497.1

      UniProtKB/Swiss-Prot
      Q8IUH4
      Conserved Domains (5) summary
      cd00204
      Location:15139
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01529
      Location:293429
      zf-DHHC; DHHC palmitoyltransferase
      pfam12796
      Location:23117
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:439
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1849
      ANK; ANK repeat [structural motif]
    2. XM_047427141.1XP_047283097.1  palmitoyltransferase ZDHHC13 isoform X4

      UniProtKB/TrEMBL
      A8K5N3
    3. XM_005252996.3XP_005253053.1  palmitoyltransferase ZDHHC13 isoform X6

      See identical proteins and their annotated locations for XP_005253053.1

      UniProtKB/Swiss-Prot
      Q8IUH4
      Conserved Domains (5) summary
      cd00204
      Location:15139
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01529
      Location:293429
      zf-DHHC; DHHC palmitoyltransferase
      pfam12796
      Location:23117
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:439
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1849
      ANK; ANK repeat [structural motif]
    4. XM_047427142.1XP_047283098.1  palmitoyltransferase ZDHHC13 isoform X7

    5. XM_047427143.1XP_047283099.1  palmitoyltransferase ZDHHC13 isoform X7

    6. XM_047427139.1XP_047283095.1  palmitoyltransferase ZDHHC13 isoform X2

      UniProtKB/TrEMBL
      A8K5N3
    7. XM_011520194.3XP_011518496.1  palmitoyltransferase ZDHHC13 isoform X5

      Conserved Domains (7) summary
      cd00204
      Location:99212
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01529
      Location:443513
      zf-DHHC; DHHC palmitoyltransferase
      pfam12796
      Location:106199
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:222277
      Ank_5; Ankyrin repeats (many copies)
      pfam13900
      Location:220
      GVQW; Putative domain of unknown function
      sd00045
      Location:101132
      ANK; ANK repeat [structural motif]
      cl00337
      Location:347410
      PT_UbiA; UbiA family of prenyltransferases (PTases)
    8. XM_047427144.1XP_047283100.1  palmitoyltransferase ZDHHC13 isoform X8

    9. XM_047427140.1XP_047283096.1  palmitoyltransferase ZDHHC13 isoform X3

      UniProtKB/TrEMBL
      A8K5N3
    10. XM_047427138.1XP_047283094.1  palmitoyltransferase ZDHHC13 isoform X1

      UniProtKB/TrEMBL
      A8K5N3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      19237229..19296555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369163.1XP_054225138.1  palmitoyltransferase ZDHHC13 isoform X6

    2. XM_054369161.1XP_054225136.1  palmitoyltransferase ZDHHC13 isoform X4

      UniProtKB/TrEMBL
      A8K5N3
    3. XM_054369164.1XP_054225139.1  palmitoyltransferase ZDHHC13 isoform X6

    4. XM_054369165.1XP_054225140.1  palmitoyltransferase ZDHHC13 isoform X7

    5. XM_054369166.1XP_054225141.1  palmitoyltransferase ZDHHC13 isoform X7

    6. XM_054369159.1XP_054225134.1  palmitoyltransferase ZDHHC13 isoform X2

      UniProtKB/TrEMBL
      A8K5N3
    7. XM_054369162.1XP_054225137.1  palmitoyltransferase ZDHHC13 isoform X5

    8. XM_054369167.1XP_054225142.1  palmitoyltransferase ZDHHC13 isoform X8

    9. XM_054369160.1XP_054225135.1  palmitoyltransferase ZDHHC13 isoform X3

      UniProtKB/TrEMBL
      A8K5N3
    10. XM_054369158.1XP_054225133.1  palmitoyltransferase ZDHHC13 isoform X1

      UniProtKB/TrEMBL
      A8K5N3