U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    CALR calreticulin [ Homo sapiens (human) ]

    Gene ID: 811, updated on 10-Dec-2024

    Summary

    Official Symbol
    CALRprovided by HGNC
    Official Full Name
    calreticulinprovided by HGNC
    Primary source
    HGNC:HGNC:1455
    See related
    Ensembl:ENSG00000179218 MIM:109091; AllianceGenome:HGNC:1455
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RO; CRT; SSA; CALR1; cC1qR; HEL-S-99n
    Summary
    Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]
    Expression
    Ubiquitous expression in thyroid (RPKM 564.2), placenta (RPKM 291.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CALR in Genome Data Viewer
    Location:
    19p13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12938609..12944489)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (13063097..13068974)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13049423..13055303)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 5695 Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene FARSA antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14093 Neighboring gene Sharpr-MPRA regulatory region 7930 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:13045760-13045865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14096 Neighboring gene CRISPRi-FlowFISH-validated RAD23A regulatory element 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13049721-13050470 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:13050707-13051906 Neighboring gene microRNA 6515 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13056454-13057146 Neighboring gene Sharpr-MPRA regulatory region 11818 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:13058093-13059292 Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:13063321-13064520 Neighboring gene GADD45G interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13067513-13068385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13079936-13080539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13080540-13081142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13085246-13085752 Neighboring gene DAN domain BMP antagonist family member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (34 hits/1289 screens)

    Associated conditions

    Description Tests
    Primary myelofibrosis
    MedGen: C0001815 OMIM: 254450 GeneReviews: Not available
    Compare labs
    Thrombocythemia 1
    MedGen: C3277671 OMIM: 187950 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    EBI GWAS Catalog
    Seventy-five genetic loci influencing the human red blood cell.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with calreticulin (CALR) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with calreticulin (CALR) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    env The ubiquitous eukaryotic protein calreticulin binds to newly synthesized HIV-1 gp160, suggesting that calreticulin might act as a chaperone PubMed
    Rev rev HIV-1 Rev interacting protein, calreticulin (CALR), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CALR is increased by RRE PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of calreticulin (CALR) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ26680

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables RNA binding PubMed 
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    enables calcium ion binding PubMed 
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    enables carbohydrate binding PubMed 
    enables complement component C1q complex binding PubMed 
    enables complement component C1q complex binding PubMed 
    enables hormone binding  
    enables integrin binding PubMed 
    enables iron ion binding  
    enables mRNA binding PubMed 
    enables molecular sequestering activity PubMed 
    enables nuclear androgen receptor binding PubMed 
    enables nuclear export signal receptor activity PubMed 
    enables peptide binding  
    enables protein binding PubMed 
    enables protein folding chaperone PubMed 
    enables protein-folding chaperone binding PubMed 
    enables ubiquitin protein ligase binding PubMed 
    enables unfolded protein binding PubMed 
    enables zinc ion binding PubMed 
    Items 1 - 25 of 46
    Process Evidence Code Pubs
    involved_in ERAD pathway  
    involved_in cardiac muscle cell differentiation  
    involved_in cellular response to electrical stimulus  
    involved_in cellular response to lithium ion  
    involved_in cellular response to virus  
    involved_in cellular senescence PubMed 
    involved_in cortical actin cytoskeleton organization  
    involved_in intracellular calcium ion homeostasis PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of intracellular steroid hormone receptor signaling pathway PubMed 
    involved_in negative regulation of neuron differentiation PubMed 
    involved_in negative regulation of retinoic acid receptor signaling pathway PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of translation PubMed 
    involved_in negative regulation of translation PubMed 
    involved_in negative regulation of trophoblast cell migration PubMed 
    involved_in nuclear receptor-mediated glucocorticoid signaling pathway PubMed 
    involved_in peptide antigen assembly with MHC class I protein complex PubMed 
    involved_in peptide antigen assembly with MHC class I protein complex PubMed 
    acts_upstream_of positive regulation of cell cycle PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of dendritic cell chemotaxis PubMed 
    involved_in positive regulation of endothelial cell migration PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of substrate adhesion-dependent cell spreading PubMed 
    involved_in protein export from nucleus PubMed 
    involved_in protein folding  
    involved_in protein folding PubMed 
    involved_in protein folding in endoplasmic reticulum PubMed 
    involved_in protein localization to nucleus PubMed 
    involved_in protein maturation by protein folding PubMed 
    involved_in protein stabilization  
    involved_in protein stabilization PubMed 
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of apoptotic process PubMed 
    involved_in regulation of meiotic nuclear division  
    involved_in response to biphenyl  
    involved_in response to estradiol  
    involved_in response to glycoside  
    involved_in response to peptide  
    involved_in response to testosterone  
    involved_in response to xenobiotic stimulus  
    involved_in sequestering of calcium ion PubMed 
    involved_in spermatogenesis  
    Items 1 - 25 of 46
    Items 1 - 20 of 36
    Component Evidence Code Pubs
    part_of MHC class I peptide loading complex PubMed 
    part_of MHC class I peptide loading complex PubMed 
    located_in acrosomal vesicle  
    located_in cell surface PubMed 
    located_in collagen-containing extracellular matrix  
    located_in cortical granule  
    located_in cytolytic granule  
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    located_in endocytic vesicle lumen  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum lumen PubMed 
    located_in endoplasmic reticulum lumen  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum quality control compartment  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane  
    located_in external side of plasma membrane  
    located_in extracellular exosome PubMed 
    located_in extracellular region  
    located_in extracellular space PubMed 
    located_in extracellular space PubMed 
    located_in focal adhesion PubMed 
    located_in glutamatergic synapse  
    located_in lumenal side of endoplasmic reticulum membrane  
    located_in membrane PubMed 
    located_in membrane PubMed 
    located_in nuclear envelope PubMed 
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    located_in phagocytic vesicle membrane  
    located_in postsynapse  
    located_in ribosome PubMed 
    located_in sarcoplasmic reticulum lumen  
    located_in smooth endoplasmic reticulum  
    Items 1 - 20 of 36

    General protein information

    Preferred Names
    calreticulin
    Names
    CRP55
    ERp60
    HACBP
    Sicca syndrome antigen A (autoantigen Ro; calreticulin)
    calregulin
    endoplasmic reticulum resident protein 60
    epididymis secretory sperm binding protein Li 99n
    grp60

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029662.1 RefSeqGene

      Range
      5001..10891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_828

    mRNA and Protein(s)

    1. NM_004343.4 → NP_004334.1  calreticulin precursor

      See identical proteins and their annotated locations for NP_004334.1

      Status: REVIEWED

      Source sequence(s)
      AC092069
      Consensus CDS
      CCDS12288.1
      UniProtKB/Swiss-Prot
      P27797, Q6IAT4, Q9UDG2
      UniProtKB/TrEMBL
      Q53G71, V9HW88
      Related
      ENSP00000320866.4, ENST00000316448.10
      Conserved Domains (1) summary
      pfam00262
      Location:23 → 332
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12938609..12944489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      13063097..13068974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.