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Conserved domains on  [gi|4757900|ref|NP_004334|]
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calreticulin precursor [Homo sapiens]

Protein Classification

calreticulin family protein( domain architecture ID 3910)

calreticulin family protein similar to calreticulin which is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Calreticulin super family cl02828
Calreticulin family;
23-332 3.04e-112

Calreticulin family;


The actual alignment was detected with superfamily member pfam00262:

Pssm-ID: 459737  Cd Length: 369  Bit Score: 333.76  E-value: 3.04e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900     23 FKEQFlDGDGWTSRWIESKHKSDF---------GKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFE-PFSNKGQTLV 92
Cdd:pfam00262   1 FFEQF-DDYDWESRWIPSKAKKDDsddeiakydGKWSVEEPTVYPGFEGDKGLVLKSKAKHHAISAKLDkPIDFKDKTLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900     93 VQFTVKHEQNIDCGGGYVKLFPNS--LDQTDMHGDSEYNIMFGPDICGPgTKKVHVIFNYKGKN------VLINKDIRCK 164
Cdd:pfam00262  80 VQYEVKLQNGLECGGAYIKLLSETndLDLEEFSDKTPYTIMFGPDKCGS-TNKVHFIFRHKNPKtgeyeeKHLKKPPKIR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900    165 DDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWD--FLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDK---- 238
Cdd:pfam00262 159 TDKLTHLYTLILRPDNTFEIRIDGEVVKSGNLLEDFKppVNPPKEIDDPNDKKPEDWDDREKIPDPNAVKPDDWDEdape 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900    239 -----------------PEHIPDPDAKKPEDWDEEMDGEWEPPVI-------------------QNPEYKGEWKPRQIDN 282
Cdd:pfam00262 239 fipdpdatkpegwledePEYIPDPEATKPEDWDEEEDGEWEAPLIpnpkceeapgcgpwkppmiKNPKYKGKWKPPMIDN 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4757900    283 PDYKGTWIHPEIDNPEYSPDPSIYA-YDNFGVLGLDLWQVKSGTIFDNFLI 332
Cdd:pfam00262 319 PNYKGEWKPRKIPNPDYFEDKHPFSnLEPIGAIGFELWSMSKDILFDNIYI 369
 
Name Accession Description Interval E-value
Calreticulin pfam00262
Calreticulin family;
23-332 3.04e-112

Calreticulin family;


Pssm-ID: 459737  Cd Length: 369  Bit Score: 333.76  E-value: 3.04e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900     23 FKEQFlDGDGWTSRWIESKHKSDF---------GKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFE-PFSNKGQTLV 92
Cdd:pfam00262   1 FFEQF-DDYDWESRWIPSKAKKDDsddeiakydGKWSVEEPTVYPGFEGDKGLVLKSKAKHHAISAKLDkPIDFKDKTLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900     93 VQFTVKHEQNIDCGGGYVKLFPNS--LDQTDMHGDSEYNIMFGPDICGPgTKKVHVIFNYKGKN------VLINKDIRCK 164
Cdd:pfam00262  80 VQYEVKLQNGLECGGAYIKLLSETndLDLEEFSDKTPYTIMFGPDKCGS-TNKVHFIFRHKNPKtgeyeeKHLKKPPKIR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900    165 DDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWD--FLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDK---- 238
Cdd:pfam00262 159 TDKLTHLYTLILRPDNTFEIRIDGEVVKSGNLLEDFKppVNPPKEIDDPNDKKPEDWDDREKIPDPNAVKPDDWDEdape 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900    239 -----------------PEHIPDPDAKKPEDWDEEMDGEWEPPVI-------------------QNPEYKGEWKPRQIDN 282
Cdd:pfam00262 239 fipdpdatkpegwledePEYIPDPEATKPEDWDEEEDGEWEAPLIpnpkceeapgcgpwkppmiKNPKYKGKWKPPMIDN 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4757900    283 PDYKGTWIHPEIDNPEYSPDPSIYA-YDNFGVLGLDLWQVKSGTIFDNFLI 332
Cdd:pfam00262 319 PNYKGEWKPRKIPNPDYFEDKHPFSnLEPIGAIGFELWSMSKDILFDNIYI 369
PLN02744 PLN02744
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
175-252 2.68e-03

dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex


Pssm-ID: 215397 [Multi-domain]  Cd Length: 539  Bit Score: 39.84  E-value: 2.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4757900   175 IVRPDNTYEVKIdnSQVESGSLEDDWDFlppKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPED 252
Cdd:PLN02744 169 IVKGDGAKEIKV--GEVIAITVEEEEDI---GKFKDYKPSSSAAPAAPKAKPSPPPPKEEEVEKPASSPEPKASKPSA 241
 
Name Accession Description Interval E-value
Calreticulin pfam00262
Calreticulin family;
23-332 3.04e-112

Calreticulin family;


Pssm-ID: 459737  Cd Length: 369  Bit Score: 333.76  E-value: 3.04e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900     23 FKEQFlDGDGWTSRWIESKHKSDF---------GKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFE-PFSNKGQTLV 92
Cdd:pfam00262   1 FFEQF-DDYDWESRWIPSKAKKDDsddeiakydGKWSVEEPTVYPGFEGDKGLVLKSKAKHHAISAKLDkPIDFKDKTLV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900     93 VQFTVKHEQNIDCGGGYVKLFPNS--LDQTDMHGDSEYNIMFGPDICGPgTKKVHVIFNYKGKN------VLINKDIRCK 164
Cdd:pfam00262  80 VQYEVKLQNGLECGGAYIKLLSETndLDLEEFSDKTPYTIMFGPDKCGS-TNKVHFIFRHKNPKtgeyeeKHLKKPPKIR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900    165 DDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWD--FLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDK---- 238
Cdd:pfam00262 159 TDKLTHLYTLILRPDNTFEIRIDGEVVKSGNLLEDFKppVNPPKEIDDPNDKKPEDWDDREKIPDPNAVKPDDWDEdape 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757900    239 -----------------PEHIPDPDAKKPEDWDEEMDGEWEPPVI-------------------QNPEYKGEWKPRQIDN 282
Cdd:pfam00262 239 fipdpdatkpegwledePEYIPDPEATKPEDWDEEEDGEWEAPLIpnpkceeapgcgpwkppmiKNPKYKGKWKPPMIDN 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4757900    283 PDYKGTWIHPEIDNPEYSPDPSIYA-YDNFGVLGLDLWQVKSGTIFDNFLI 332
Cdd:pfam00262 319 PNYKGEWKPRKIPNPDYFEDKHPFSnLEPIGAIGFELWSMSKDILFDNIYI 369
PLN02744 PLN02744
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
175-252 2.68e-03

dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex


Pssm-ID: 215397 [Multi-domain]  Cd Length: 539  Bit Score: 39.84  E-value: 2.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4757900   175 IVRPDNTYEVKIdnSQVESGSLEDDWDFlppKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPED 252
Cdd:PLN02744 169 IVKGDGAKEIKV--GEVIAITVEEEEDI---GKFKDYKPSSSAAPAAPKAKPSPPPPKEEEVEKPASSPEPKASKPSA 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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