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    NSP1 nitrile specifier protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820887, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NSP1
    Official Full Name
    nitrile specifier protein 1
    Primary source
    TAIR:AT3G16400
    Locus tag
    AT3G16400
    See related
    Araport:AT3G16400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMLP-470; ATNSP1; MYROSINASE-BINDING PROTEIN-LIKE PROTEIN-470; nitrile specifier protein 1; NITRILE SPECIFIER PROTEIN 1; T2O4.9
    Summary
    Encodes a nitrile-specifier protein NSP1 responsible for constitutive and herbivore-induced simple nitrile formation in rosette leaves. NSP1 is one out of five (At3g16400/NSP1, At2g33070/NSP2, At3g16390/NSP3, At3g16410/NSP4 and At5g48180/NSP5) A. thaliana epithiospecifier protein (ESP) homologues that promote simple nitrile, but not epithionitrile or thiocyanate formation.
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    Genomic context

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    See NSP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (5566083..5568545)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene poly(A) binding protein 6 Neighboring gene nitrile specifier protein 3 Neighboring gene miscRNA Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the nitrile-specifier protein NSP1 from Arabidopsis thaliana. Zhang W, et al. Biochem Biophys Res Commun, 2017 Jun 17. PMID 28479247
    2. Glucosinolate Content in Dormant and Germinating Arabidopsis thaliana Seeds Is Affected by Non-Functional Alleles of Classical Myrosinase and Nitrile-Specifier Protein Genes. Meier K, et al. Front Plant Sci, 2019. PMID 31850033, Free PMC Article
    3. The genetic basis of constitutive and herbivore-induced ESP-independent nitrile formation in Arabidopsis. Burow M, et al. Plant Physiol, 2009 Jan. PMID 18987211, Free PMC Article
    4. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of the nitrile-specifier protein NSP1
      Title: Crystal structure of the nitrile-specifier protein NSP1 from Arabidopsis thaliana.
    2. At3g16400 encodes a nitrile-specifier protein that controls constitutive and herbivore-induced simple nitrile formation in rosette leaves.
      Title: The genetic basis of constitutive and herbivore-induced ESP-independent nitrile formation in Arabidopsis.
    3. AtNSP1 is responsible for constitutive and herbivore-induced simple nitrile formation in Col-0 rosette leaves but do not support epithionitrile formation. [AtNSP1]
      Title: The genetic basis of constitutive and herbivore-induced ESP-independent nitrile formation in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035632.1
    NM_112511.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucosinolate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glucosinolate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nitrile biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to herbivore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed dormancy process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in seed germination IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    nitrile specifier protein 1
    NP_001030709.1
    • MYROSINASE-BINDING PROTEIN-LIKE PROTEIN-470 (ATMLP-470); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: glucosinolate catabolic process, response to herbivore, nitrile biosynthetic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: rosette leaf, cotyledon, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Kelch repeat type 1 (InterPro:IPR006652), Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Myrosinase-binding related, jacalin-like lectin (InterPro:IPR017388), Mannose-binding lectin (InterPro:IPR001229), Kelch-type beta propeller (InterPro:IPR015915); BEST Arabidopsis thaliana protein match is: nitrile specifier protein 4 (TAIR:AT3G16410.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_566546.1
    • nitrile specifier protein 1 (NSP1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: glucosinolate catabolic process, response to herbivore, nitrile biosynthetic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: rosette leaf, cotyledon, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Kelch repeat type 1 (InterPro:IPR006652), Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Myrosinase-binding related, jacalin-like lectin (InterPro:IPR017388), Mannose-binding lectin (InterPro:IPR001229), Kelch-type beta propeller (InterPro:IPR015915); BEST Arabidopsis thaliana protein match is: nitrile specifier protein 4 (TAIR:AT3G16410.1); Has 12798 Blast hits to 6850 proteins in 422 species: Archae - 13; Bacteria - 486; Metazoa - 7547; Fungi - 708; Plants - 2515; Viruses - 41; Other Eukaryotes - 1488 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5566083..5568545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112511.4 → NP_566546.1  nitrile specifier protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566546.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHB6, O04317, Q0WNW3, Q8LB83, Q9SDM9
      UniProtKB/TrEMBL
      A0A5S9XCN6
      Conserved Domains (6) summary
      PLN02193
      Location:1 → 470
      PLN02193; nitrile-specifier protein
      sd00038
      Location:221 → 265
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:318 → 358
      Kelch_1; Kelch motif
      pfam01419
      Location:13 → 142
      Jacalin; Jacalin-like lectin domain
      pfam13415
      Location:228 → 277
      Kelch_3; Galactose oxidase, central domain
      pfam13964
      Location:166 → 206
      Kelch_6; Kelch motif

    2. NM_001035632.1 → NP_001030709.1  nitrile specifier protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030709.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHB6, O04317, Q0WNW3, Q8LB83, Q9SDM9
      UniProtKB/TrEMBL
      A0A5S9XCN6
      Conserved Domains (6) summary
      PLN02193
      Location:1 → 470
      PLN02193; nitrile-specifier protein
      sd00038
      Location:221 → 265
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:318 → 358
      Kelch_1; Kelch motif
      pfam01419
      Location:13 → 142
      Jacalin; Jacalin-like lectin domain
      pfam13415
      Location:228 → 277
      Kelch_3; Galactose oxidase, central domain
      pfam13964
      Location:166 → 206
      Kelch_6; Kelch motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SDM9.2

    Gene LinkOut

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