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    Cntrob centrobin, centrosomal BRCA2 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 216846, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cntrobprovided by MGI
    Official Full Name
    centrobin, centrosomal BRCA2 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:2443290
    See related
    Ensembl:ENSMUSG00000032782 AllianceGenome:MGI:2443290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lip8; Nip2; 9830165K03Rik
    Summary
    Predicted to enable protein domain specific binding activity. Predicted to be involved in centriole replication; centrosome separation; and mitotic cytokinetic process. Predicted to be located in cytoplasm. Predicted to be active in centriole and centrosome. Is expressed in early conceptus and testis. Orthologous to human CNTROB (centrobin, centriole duplication and spindle assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.8), thymus adult (RPKM 11.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cntrob in Genome Data Viewer
    Location:
    11 B3; 11 42.51 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69188735..69214720, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69297909..69323898, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23194 Neighboring gene predicted gene, 40039 Neighboring gene STARR-positive B cell enhancer ABC_E3964 Neighboring gene STARR-positive B cell enhancer ABC_E1829 Neighboring gene trafficking protein particle complex 1 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, beta member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in centrosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in centrosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centrosome separation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic cytokinetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centrobin
    Names
    LYST-interacting protein 8
    centrosomal BRCA2-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172560.3NP_766148.2  centrobin

      See identical proteins and their annotated locations for NP_766148.2

      Status: VALIDATED

      Source sequence(s)
      AK036710, AK147774, AL645527
      Consensus CDS
      CCDS24888.2
      UniProtKB/Swiss-Prot
      B0QZN4, Q5NCF3, Q8CB62
      Related
      ENSMUSP00000090651.6, ENSMUST00000092973.6
      Conserved Domains (5) summary
      cd14686
      Location:366422
      bZIP; coiled coil [structural motif]
      pfam15619
      Location:199374
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cd16269
      Location:368379
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:297411
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21462
      Location:363425
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69188735..69214720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156561.1XP_036012454.1  centrobin isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:568813
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:176554
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. XM_036156562.1XP_036012455.1  centrobin isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:443637
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:179447
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    3. XM_011248918.3XP_011247220.1  centrobin isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:571816
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:179557
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    4. XM_011248916.3XP_011247218.1  centrobin isoform X1

      See identical proteins and their annotated locations for XP_011247218.1

      Conserved Domains (2) summary
      PHA03247
      Location:571765
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:179557
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    5. XM_036156563.1XP_036012456.1  centrobin isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:285479
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:3284
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    6. XM_017314454.3XP_017169943.1  centrobin isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:387581
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:71385
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    7. XM_036156565.1XP_036012458.1  centrobin isoform X7

      Conserved Domains (2) summary
      PHA03247
      Location:259453
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:10263
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    8. XM_036156564.1XP_036012457.1  centrobin isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:285479
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:3284
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    9. XM_006532878.5XP_006532941.1  centrobin isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:285479
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:3284
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type