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    IL17D interleukin 17D [ Homo sapiens (human) ]

    Gene ID: 53342, updated on 10-Dec-2024

    Summary

    Official Symbol
    IL17Dprovided by HGNC
    Official Full Name
    interleukin 17Dprovided by HGNC
    Primary source
    HGNC:HGNC:5984
    See related
    Ensembl:ENSG00000172458 MIM:607587; AllianceGenome:HGNC:5984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL-17D
    Summary
    The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 13.7), ovary (RPKM 2.3) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See IL17D in Genome Data Viewer
    Location:
    13q12.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (20701513..20723098)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (19894661..19916241)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21275652..21297237)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 88 Neighboring gene solute carrier family 35 member E1 pseudogene 1 Neighboring gene RNA, U2 small nuclear 7, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5157 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:21290864-21291578 Neighboring gene Sharpr-MPRA regulatory region 1468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21303728-21304255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21304256-21304782 Neighboring gene EEF1A lysine methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7426 Neighboring gene RAN pseudogene 8 Neighboring gene exportin 4 Neighboring gene uncharacterized LOC124903129

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (21 hits/1253 screens)

    EBI GWAS Catalog

    Description
    Genetic determinants of P wave duration and PR segment.
    EBI GWAS Catalog
    GWAS of dental caries patterns in the permanent dentition.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ30846

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular space PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385221.1 → NP_001372150.1  interleukin-17D isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Isoforms a and b are the same length but differ in their N-termini.
      Source sequence(s)
      AL161772, AL512652
      Conserved Domains (1) summary
      pfam06083
      Location:96 → 177
      IL17; Interleukin-17
    2. NM_001385222.1 → NP_001372151.1  interleukin-17D isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (b). Isoforms a and b are the same length but differ in their N-termini.
      Source sequence(s)
      AL161772, AL512652
      Conserved Domains (1) summary
      pfam06083
      Location:96 → 177
      IL17; Interleukin-17
    3. NM_001385223.1 → NP_001372152.1  interleukin-17D isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
      Source sequence(s)
      AL161772, AL512652
      Consensus CDS
      CCDS9292.1
      UniProtKB/Swiss-Prot
      B1AM69, Q8TAD2
      Conserved Domains (1) summary
      pfam06083
      Location:89 → 170
      IL17; Interleukin-17
    4. NM_001385224.1 → NP_001372153.1  interleukin-17D isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
      Source sequence(s)
      AL161772, AL512652
      Consensus CDS
      CCDS9292.1
      UniProtKB/Swiss-Prot
      B1AM69, Q8TAD2
      Related
      ENSP00000508385.1, ENST00000682841.1
      Conserved Domains (1) summary
      pfam06083
      Location:89 → 170
      IL17; Interleukin-17
    5. NM_001385225.1 → NP_001372154.1  interleukin-17D isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL512652
      Conserved Domains (1) summary
      pfam06083
      Location:11 → 86
      IL17; Interleukin-17
    6. NM_001386973.1 → NP_001373902.1  interleukin-17D isoform e

      Status: REVIEWED

      Source sequence(s)
      AL512652
      Conserved Domains (1) summary
      pfam06083
      Location:9 → 82
      IL17; Interleukin-17
    7. NM_138284.2 → NP_612141.1  interleukin-17D isoform c precursor

      See identical proteins and their annotated locations for NP_612141.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
      Source sequence(s)
      AL161772, AL512652
      Consensus CDS
      CCDS9292.1
      UniProtKB/Swiss-Prot
      B1AM69, Q8TAD2
      Related
      ENSP00000302924.3, ENST00000304920.3
      Conserved Domains (1) summary
      pfam06083
      Location:89 → 170
      IL17; Interleukin-17

    RNA

    1. NR_169590.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL512652
    2. NR_169591.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161772, AL512652

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      20701513..20723098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      19894661..19916241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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