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HSP90AA4P heat shock protein 90 alpha family class A member 4, pseudogene [ Homo sapiens (human) ]

Gene ID: 3323, updated on 5-Jan-2025

Summary

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Official Symbol
HSP90AA4Pprovided by HGNC
Official Full Name
heat shock protein 90 alpha family class A member 4, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:5255
See related
AllianceGenome:HGNC:5255
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP90Ad; HSPCAL2
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Predicted to be involved in cellular response to heat; protein folding; and protein stabilization. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including myelin sheath; neuronal cell body; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See HSP90AA4P in Genome Data Viewer
Location:
4q35.2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (189472906..189475853)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (192829528..192832472)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (190394060..190397007)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900838 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:190229364-190230563 Neighboring gene uncharacterized LOC105377614 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:190400698-190401256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:190405217-190405972 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:190405973-190406728 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:190471799-190472998 Neighboring gene uncharacterized LOC105377615 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:190523074-190524273 Neighboring gene long intergenic non-protein coding RNA 1262

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14. Ozawa K, et al. Genomics, 1992 Feb. PMID 1740332
  2. Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders. Wu X, et al. Nat Cancer, 2021 Apr. PMID 34568836, Free PMC Article
  3. The HSP90 family of genes in the human genome: insights into their divergence and evolution. Chen B, et al. Genomics, 2005 Dec. PMID 16269234
  4. α-Dystrobrevin distribution and association with other proteins in human promyelocytic NB4 cells treated for granulocytic differentiation. Borutinskaite VV, et al. Mol Biol Rep, 2011 Jun. PMID 20111909
  5. CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement. Beyer T, et al. Mol Cell Proteomics, 2018 Jul. PMID 29615496, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Other Names

  • heat shock 90kD protein 1, alpha-like 2
  • heat shock 90kDa protein 1, alpha-like 2
  • heat shock protein 90Ad
  • heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene
  • heat shock protein 90kDa alpha family class A member 4, pseudogene

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_003014.3 

    Range
    101..3048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    189472906..189475853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_187679.1 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    111049..113996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    192829528..192832472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_036692.1: Suppressed sequence

    Description
    NR_036692.1: This RefSeq was permanently suppressed because there is insufficient evidence that this locus is transcribed.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58FG1.1 GenPept UniProtKB/Swiss-Prot:Q58FG1

Gene LinkOut

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