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    SLCO1A2 solute carrier organic anion transporter family member 1A2 [ Homo sapiens (human) ]

    Gene ID: 6579, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SLCO1A2provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 1A2provided by HGNC
    Primary source
    HGNC:HGNC:10956
    See related
    Ensembl:ENSG00000084453 MIM:602883; AllianceGenome:HGNC:10956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OATP; OATP-A; OATP1A2; SLC21A3
    Summary
    This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
    Expression
    Biased expression in brain (RPKM 6.2), lung (RPKM 0.9) and 2 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SLCO1A2 in Genome Data Viewer
    Location:
    12p12.1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (21264600..21419634, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (21143252..21298332, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21417534..21572568, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family member 1B1 Neighboring gene uncharacterized LOC124903123 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:21386467-21387666 Neighboring gene uncharacterized LOC124902895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:21402494-21402994 Neighboring gene NANOG hESC enhancer GRCh37_chr12:21477387-21477904 Neighboring gene NANOG hESC enhancer GRCh37_chr12:21491840-21492346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21546997-21547930 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21547931-21548862 Neighboring gene islet amyloid polypeptide Neighboring gene NANOG hESC enhancer GRCh37_chr12:21569666-21570167 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21572391-21572952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6087 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene elongin C pseudogene 31 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6090 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21654373-21655080 Neighboring gene RecQ like helicase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. Lee W, et al. J Biol Chem, 2005 Mar 11. PMID 15632119
    2. Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier. Cheng Z, et al. Xenobiotica, 2012 Sep. PMID 22509823
    3. Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions. Arakawa H, et al. Biochem Pharmacol, 2012 Oct 15. PMID 22864060
    4. The SLCO1A2 gene, encoding human organic anion-transporting polypeptide 1A2, is transactivated by the vitamin D receptor. Eloranta JJ, et al. Mol Pharmacol, 2012 Jul. PMID 22474172
    5. Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2. Zhou F, et al. AAPS J, 2013 Oct. PMID 23918469, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1.
      Title: The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1.
    2. Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants.
      Title: Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants.
    3. Pharmacogenomics of celiprolol - evidence for a role of P-glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics.
      Title: Pharmacogenomics of celiprolol - evidence for a role of P-glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics.
    4. Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis.
      Title: Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis.
    5. SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma.
      Title: SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma.
    6. Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment.
      Title: Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment.
    7. Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone.
      Title: Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone.
    8. In the regulation of the function and expression of OATP1A2.
      Title: The 5'-AMP-Activated Protein Kinase Regulates the Function and Expression of Human Organic Anion Transporting Polypeptide 1A2.
    9. These results indicate that the SLCO1A2 rs4149009 G > A polymorphism might affect MTX pharmacokinetics by interfering with the function of miRNAs.
      Title: Association between a microRNA binding site polymorphism in SLCO1A2 and the risk of delayed methotrexate elimination in Chinese children with acute lymphoblastic leukemia.
    10. Our findings uncover novel associations of progressive supranuclear palsy with SLCO1A2 (rs11568563) and DUSP10 (rs6687758) variants
      Title: Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association meta-analysis for total serum bilirubin levels.
    EBI GWAS Catalog
    Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
    EBI GWAS Catalog
    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables organic cation transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bile acid and bile salt transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic anion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in organic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium-independent organic anion transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 1A2
    Names
    OATP-1
    organic anion transporting polypeptide A
    organic anion-transporting polypeptide 1
    sodium-independent organic anion transporter
    solute carrier family 21 (organic anion transporter), member 3
    solute carrier family 21 member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386878.1 → NP_001373807.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC006559, AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    2. NM_001386879.1 → NP_001373808.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Related
      ENSP00000508235.1, ENST00000683939.1
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    3. NM_001386880.1 → NP_001373809.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    4. NM_001386881.1 → NP_001373810.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC006559, AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    5. NM_001386882.2 → NP_001373811.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    6. NM_001386886.1 → NP_001373815.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:18 → 536
      MFS; Major Facilitator Superfamily

    7. NM_001386887.1 → NP_001373816.1  solute carrier organic anion transporter family member 1A2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:18 → 538
      MFS; Major Facilitator Superfamily

    8. NM_001386890.1 → NP_001373819.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 469
      oat; sodium-independent organic anion transporter

    9. NM_001386908.1 → NP_001373837.1  solute carrier organic anion transporter family member 1A2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 538
      oat; sodium-independent organic anion transporter

    10. NM_001386919.1 → NP_001373848.1  solute carrier organic anion transporter family member 1A2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 538
      oat; sodium-independent organic anion transporter

    11. NM_001386920.1 → NP_001373849.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 469
      oat; sodium-independent organic anion transporter

    12. NM_001386921.1 → NP_001373850.1  solute carrier organic anion transporter family member 1A2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 525
      oat; sodium-independent organic anion transporter

    13. NM_001386922.1 → NP_001373851.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 493
      oat; sodium-independent organic anion transporter

    14. NM_001386926.1 → NP_001373855.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:18 → 536
      MFS; Major Facilitator Superfamily

    15. NM_001386927.1 → NP_001373856.1  solute carrier organic anion transporter family member 1A2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 538
      oat; sodium-independent organic anion transporter

    16. NM_001386929.1 → NP_001373858.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 493
      oat; sodium-independent organic anion transporter

    17. NM_001386931.1 → NP_001373860.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 469
      oat; sodium-independent organic anion transporter

    18. NM_001386937.1 → NP_001373866.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC006559, AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 493
      oat; sodium-independent organic anion transporter

    19. NM_001386938.1 → NP_001373867.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Related
      ENSP00000394854.1, ENST00000458504.5
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 493
      oat; sodium-independent organic anion transporter

    20. NM_001386939.1 → NP_001373868.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 493
      oat; sodium-independent organic anion transporter

    21. NM_001386940.1 → NP_001373869.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 493
      oat; sodium-independent organic anion transporter

    22. NM_001386946.1 → NP_001373875.1  solute carrier organic anion transporter family member 1A2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1 → 518
      MFS; Major Facilitator Superfamily

    23. NM_001386947.1 → NP_001373876.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:18 → 536
      MFS; Major Facilitator Superfamily

    24. NM_001386948.1 → NP_001373877.1  solute carrier organic anion transporter family member 1A2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1 → 518
      MFS; Major Facilitator Superfamily

    25. NM_001386949.1 → NP_001373878.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:18 → 536
      MFS; Major Facilitator Superfamily

    26. NM_001386951.1 → NP_001373880.1  solute carrier organic anion transporter family member 1A2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1 → 517
      MFS; Major Facilitator Superfamily

    27. NM_001386952.1 → NP_001373881.1  solute carrier organic anion transporter family member 1A2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1 → 518
      MFS; Major Facilitator Superfamily

    28. NM_001386953.1 → NP_001373882.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 469
      oat; sodium-independent organic anion transporter

    29. NM_001386954.1 → NP_001373883.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 469
      oat; sodium-independent organic anion transporter

    30. NM_001386958.1 → NP_001373887.1  solute carrier organic anion transporter family member 1A2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:1 → 518
      MFS; Major Facilitator Superfamily

    31. NM_001386959.1 → NP_001373888.1  solute carrier organic anion transporter family member 1A2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1 → 518
      MFS; Major Facilitator Superfamily

    32. NM_001386960.1 → NP_001373889.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:18 → 536
      MFS; Major Facilitator Superfamily

    33. NM_001386961.1 → NP_001373890.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 469
      oat; sodium-independent organic anion transporter

    34. NM_001386962.1 → NP_001373891.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 493
      oat; sodium-independent organic anion transporter

    35. NM_001386963.1 → NP_001373892.1  solute carrier organic anion transporter family member 1A2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1 → 451
      MFS; Major Facilitator Superfamily

    36. NM_021094.4 → NP_066580.1  solute carrier organic anion transporter family member 1A2 isoform 1

      See identical proteins and their annotated locations for NP_066580.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. The translation of this protein may be modulated by multiple upstream ORFs that are present in the 5' UTR.
      Source sequence(s)
      AC022224, BX093727, DA216595, U21943
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    37. NM_134431.5 → NP_602307.1  solute carrier organic anion transporter family member 1A2 isoform 1

      See identical proteins and their annotated locations for NP_602307.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. The translation of this protein may be modulated by multiple upstream ORFs that are present in the 5' UTR.
      Source sequence(s)
      AC006559, AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Related
      ENSP00000305974.6, ENST00000307378.10
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    RNA

    1. NR_170340.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022224

    2. NR_170341.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022224

    3. NR_170343.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Related
      ENST00000480394.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      21264600..21419634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520819.2 → XP_011519121.1  solute carrier organic anion transporter family member 1A2 isoform X1

      See identical proteins and their annotated locations for XP_011519121.1

      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    2. XM_024449138.2 → XP_024304906.1  solute carrier organic anion transporter family member 1A2 isoform X1

      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      21143252..21298332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373011.1 → XP_054228986.1  solute carrier organic anion transporter family member 1A2 isoform X1

      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4

    2. XM_054373010.1 → XP_054228985.1  solute carrier organic anion transporter family member 1A2 isoform X1

      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005075.2: Suppressed sequence

      Description
      NM_005075.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46721.1 GenPept UniProtKB/Swiss-Prot:P46721

    Gene LinkOut

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