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    SLCO1A2 solute carrier organic anion transporter family member 1A2 [ Homo sapiens (human) ]

    Gene ID: 6579, updated on 10-Dec-2024

    Summary

    Official Symbol
    SLCO1A2provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 1A2provided by HGNC
    Primary source
    HGNC:HGNC:10956
    See related
    Ensembl:ENSG00000084453 MIM:602883; AllianceGenome:HGNC:10956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OATP; OATP-A; OATP1A2; SLC21A3
    Summary
    This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
    Expression
    Biased expression in brain (RPKM 6.2), lung (RPKM 0.9) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLCO1A2 in Genome Data Viewer
    Location:
    12p12.1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (21264600..21419634, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (21143252..21298332, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21417534..21572568, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family member 1B1 Neighboring gene uncharacterized LOC124903123 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:21386467-21387666 Neighboring gene uncharacterized LOC124902895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:21402494-21402994 Neighboring gene NANOG hESC enhancer GRCh37_chr12:21477387-21477904 Neighboring gene NANOG hESC enhancer GRCh37_chr12:21491840-21492346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21546997-21547930 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21547931-21548862 Neighboring gene islet amyloid polypeptide Neighboring gene NANOG hESC enhancer GRCh37_chr12:21569666-21570167 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21572391-21572952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6087 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene elongin C pseudogene 31 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6090 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:21654373-21655080 Neighboring gene RecQ like helicase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association meta-analysis for total serum bilirubin levels.
    EBI GWAS Catalog
    Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
    EBI GWAS Catalog
    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in basal plasma membrane PubMed 
    is_active_in basolateral plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 1A2
    Names
    OATP-1
    organic anion transporting polypeptide A
    organic anion-transporting polypeptide 1
    sodium-independent organic anion transporter
    solute carrier family 21 (organic anion transporter), member 3
    solute carrier family 21 member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386878.1NP_001373807.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC006559, AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    2. NM_001386879.1NP_001373808.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Related
      ENSP00000508235.1, ENST00000683939.1
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    3. NM_001386880.1NP_001373809.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    4. NM_001386881.1NP_001373810.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC006559, AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    5. NM_001386882.2NP_001373811.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    6. NM_001386886.1NP_001373815.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:18536
      MFS; Major Facilitator Superfamily
    7. NM_001386887.1NP_001373816.1  solute carrier organic anion transporter family member 1A2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:18538
      MFS; Major Facilitator Superfamily
    8. NM_001386890.1NP_001373819.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    9. NM_001386908.1NP_001373837.1  solute carrier organic anion transporter family member 1A2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1538
      oat; sodium-independent organic anion transporter
    10. NM_001386919.1NP_001373848.1  solute carrier organic anion transporter family member 1A2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1538
      oat; sodium-independent organic anion transporter
    11. NM_001386920.1NP_001373849.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    12. NM_001386921.1NP_001373850.1  solute carrier organic anion transporter family member 1A2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1525
      oat; sodium-independent organic anion transporter
    13. NM_001386922.1NP_001373851.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    14. NM_001386926.1NP_001373855.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:18536
      MFS; Major Facilitator Superfamily
    15. NM_001386927.1NP_001373856.1  solute carrier organic anion transporter family member 1A2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1538
      oat; sodium-independent organic anion transporter
    16. NM_001386929.1NP_001373858.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    17. NM_001386931.1NP_001373860.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    18. NM_001386937.1NP_001373866.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC006559, AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    19. NM_001386938.1NP_001373867.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Related
      ENSP00000394854.1, ENST00000458504.5
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    20. NM_001386939.1NP_001373868.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    21. NM_001386940.1NP_001373869.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    22. NM_001386946.1NP_001373875.1  solute carrier organic anion transporter family member 1A2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1518
      MFS; Major Facilitator Superfamily
    23. NM_001386947.1NP_001373876.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:18536
      MFS; Major Facilitator Superfamily
    24. NM_001386948.1NP_001373877.1  solute carrier organic anion transporter family member 1A2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1518
      MFS; Major Facilitator Superfamily
    25. NM_001386949.1NP_001373878.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:18536
      MFS; Major Facilitator Superfamily
    26. NM_001386951.1NP_001373880.1  solute carrier organic anion transporter family member 1A2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1517
      MFS; Major Facilitator Superfamily
    27. NM_001386952.1NP_001373881.1  solute carrier organic anion transporter family member 1A2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1518
      MFS; Major Facilitator Superfamily
    28. NM_001386953.1NP_001373882.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    29. NM_001386954.1NP_001373883.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    30. NM_001386958.1NP_001373887.1  solute carrier organic anion transporter family member 1A2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:1518
      MFS; Major Facilitator Superfamily
    31. NM_001386959.1NP_001373888.1  solute carrier organic anion transporter family member 1A2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1518
      MFS; Major Facilitator Superfamily
    32. NM_001386960.1NP_001373889.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:18536
      MFS; Major Facilitator Superfamily
    33. NM_001386961.1NP_001373890.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    34. NM_001386962.1NP_001373891.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Consensus CDS
      CCDS91662.1
      UniProtKB/TrEMBL
      B4DJE6, B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    35. NM_001386963.1NP_001373892.1  solute carrier organic anion transporter family member 1A2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC022224
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      cl28910
      Location:1451
      MFS; Major Facilitator Superfamily
    36. NM_021094.4NP_066580.1  solute carrier organic anion transporter family member 1A2 isoform 1

      See identical proteins and their annotated locations for NP_066580.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. The translation of this protein may be modulated by multiple upstream ORFs that are present in the 5' UTR.
      Source sequence(s)
      AC022224, BX093727, DA216595, U21943
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    37. NM_134431.5NP_602307.1  solute carrier organic anion transporter family member 1A2 isoform 1

      See identical proteins and their annotated locations for NP_602307.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. The translation of this protein may be modulated by multiple upstream ORFs that are present in the 5' UTR.
      Source sequence(s)
      AC006559, AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Related
      ENSP00000305974.6, ENST00000307378.10
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter

    RNA

    1. NR_170340.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022224
    2. NR_170341.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022224
    3. NR_170343.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Related
      ENST00000480394.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      21264600..21419634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520819.2XP_011519121.1  solute carrier organic anion transporter family member 1A2 isoform X1

      See identical proteins and their annotated locations for XP_011519121.1

      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    2. XM_024449138.2XP_024304906.1  solute carrier organic anion transporter family member 1A2 isoform X1

      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      21143252..21298332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373011.1XP_054228986.1  solute carrier organic anion transporter family member 1A2 isoform X1

      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4
    2. XM_054373010.1XP_054228985.1  solute carrier organic anion transporter family member 1A2 isoform X1

      UniProtKB/Swiss-Prot
      P46721, Q9UGP7
      UniProtKB/TrEMBL
      B7ZAD4

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