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    TAF7 TATA-box binding protein associated factor 7 [ Homo sapiens (human) ]

    Gene ID: 6879, updated on 10-Dec-2024

    Summary

    Official Symbol
    TAF7provided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 7provided by HGNC
    Primary source
    HGNC:HGNC:11541
    See related
    Ensembl:ENSG00000178913 MIM:600573; AllianceGenome:HGNC:11541
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAF2F; TAFII55
    Summary
    The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See TAF7 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (141318490..141320784, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (141843793..141846087, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (140698057..140700351, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 57 pseudogene Neighboring gene uncharacterized LOC105378199 Neighboring gene Sharpr-MPRA regulatory region 13681 Neighboring gene solute carrier family 25 member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23294 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:140713237-140713466 Neighboring gene protocadherin gamma subfamily A, 1 Neighboring gene protocadherin gamma cluster Neighboring gene protocadherin gamma subfamily A, 2 Neighboring gene protocadherin gamma subfamily A, 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:140745768-140745946 Neighboring gene protocadherin gamma subfamily B, 1 Neighboring gene protocadherin gamma subfamily A, 4 Neighboring gene protocadherin gamma subfamily B, 2 Neighboring gene protocadherin gamma subfamily A, 5 Neighboring gene protocadherin gamma subfamily B, 3 Neighboring gene protocadherin gamma subfamily A, 6 Neighboring gene protocadherin gamma subfamily A, 7 Neighboring gene protocadherin gamma subfamily B, 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23295 Neighboring gene protocadherin gamma subfamily A, 8 Neighboring gene protocadherin gamma subfamily B, 5 Neighboring gene protocadherin gamma subfamily A, 9 Neighboring gene protocadherin gamma subfamily B, 6 Neighboring gene protocadherin gamma subfamily A, 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23296 Neighboring gene protocadherin gamma subfamily B, 7 Neighboring gene protocadherin gamma subfamily A, 11 Neighboring gene protocadherin gamma subfamily B, 8 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:140821493-140821993 Neighboring gene protocadherin gamma subfamily A, 12 Neighboring gene protocadherin gamma subfamily B, 9 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (634 hits/1292 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study of lung function decline in adults with and without asthma.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
    tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
    tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
    tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
    tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation PubMed 
    involved_in RNA polymerase II preinitiation complex assembly  
    involved_in RNA polymerase II preinitiation complex assembly PubMed 
    involved_in RNA polymerase II preinitiation complex assembly  
    involved_in estrogen receptor signaling pathway  
    involved_in mRNA transcription by RNA polymerase II PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of MHC class I biosynthetic process PubMed 
    involved_in negative regulation of MHC class II biosynthetic process PubMed 
    involved_in negative regulation of protein kinase activity PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II PubMed 
    involved_in regulation of DNA repair PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_positive_effect spermine transport  
    involved_in transcription by RNA polymerase II PubMed 
    involved_in transcription initiation at RNA polymerase II promoter PubMed 
    Component Evidence Code Pubs
    part_of MLL1 complex PubMed 
    located_in cytoplasm  
    located_in male germ cell nucleus  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    is_active_in nucleus PubMed 
    located_in nucleus  
    part_of transcription factor TFIID complex  
    part_of transcription factor TFIID complex PubMed 
    part_of transcription factor TFIID complex PubMed 
    part_of transcription factor TFIID complex  
    part_of transcription factor TFTC complex PubMed 
    part_of transcription factor TFTC complex PubMed 
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 7
    Names
    RNA polymerase II TBP-associated factor subunit F
    TAF(II)55
    TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
    TAFII-55
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD
    TBP-associated factor F
    transcription factor IID subunit TAFII55
    transcription initiation factor TFIID, 55 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_000012.2 

      Range
      28687..30981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005642.3 → NP_005633.2  transcription initiation factor TFIID subunit 7

      See identical proteins and their annotated locations for NP_005633.2

      Status: REVIEWED

      Source sequence(s)
      AC005618
      Consensus CDS
      CCDS4259.1
      UniProtKB/Swiss-Prot
      B2RBV9, Q13036, Q15545
      Related
      ENSP00000312709.5, ENST00000313368.8
      Conserved Domains (2) summary
      COG5271
      Location:185 → 305
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam04658
      Location:12 → 177
      TAFII55_N; TAFII55 protein conserved region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      141318490..141320784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      141843793..141846087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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