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TAF15 TATA-box binding protein associated factor 15 [ Homo sapiens (human) ]

Gene ID: 8148, updated on 27-Nov-2024

Summary

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Official Symbol
TAF15provided by HGNC
Official Full Name
TATA-box binding protein associated factor 15provided by HGNC
Primary source
HGNC:HGNC:11547
See related
Ensembl:ENSG00000270647 MIM:601574; AllianceGenome:HGNC:11547
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Npl3; RBP56; TAF2N; TAFII68
Summary
This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in testis (RPKM 46.3), lymph node (RPKM 45.2) and 25 other tissues See more
Orthologs
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Genomic context

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See TAF15 in Genome Data Viewer
Location:
17q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35809484..35847242)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36757395..36795152)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34136488..34174246)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12079 Neighboring gene growth arrest specific 2 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34092667-34093167 Neighboring gene chromosome 17 open reading frame 50 Neighboring gene matrix metallopeptidase 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34121971-34122509 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:34136503-34137204 Neighboring gene probable ribosome biogenesis protein RLP24 Neighboring gene HEAT repeat containing 9 Neighboring gene uncharacterized LOC105371745 Neighboring gene C-C motif chemokine ligand 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator. Kim S, et al. Int J Cancer, 2008 Jun 1. PMID 18330902
  2. TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs. Ballarino M, et al. Oncogene, 2013 Sep 26. PMID 23128393
  3. The SGYS motif of TAF15 prion-like domain is critical to amyloid fibril formation. Chen J, et al. Biophys J, 2022 Jul 5. PMID 35643629, Free PMC Article
  4. The TET family of proteins: functions and roles in disease. Tan AY, et al. J Mol Cell Biol, 2009 Dec. PMID 19783543, Free PMC Article
  5. Domains involved in TAF15 subcellular localisation: dependence on cell type and ongoing transcription. Marko M, et al. Gene, 2012 Sep 15. PMID 22771914

See all (210) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.
    Title: circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.
  2. circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3.
    Title: circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3.
  3. TAF15 amyloid filaments in frontotemporal lobar degeneration.
    Title: TAF15 amyloid filaments in frontotemporal lobar degeneration.
  4. m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma.
    Title: m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma.
  5. TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway.
    Title: TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway.
  6. CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway.
    Title: CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway.
  7. LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway.
    Title: LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway.
  8. The SGYS motif of TAF15 prion-like domain is critical to amyloid fibril formation.
    Title: The SGYS motif of TAF15 prion-like domain is critical to amyloid fibril formation.
  9. LncRNA GAS5 activates the HIF1A/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers.
    Title: LncRNA GAS5 activates the HIF1A/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers.
  10. SCF-Slimb is critical for Glycogen synthase kinase-3beta-mediated suppression of TAF15-induced neurotoxicity in Drosophila.
    Title: SCF-Slimb is critical for Glycogen synthase kinase-3β-mediated suppression of TAF15-induced neurotoxicity in Drosophila.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Extraskeletal myxoid chondrosarcoma
MedGen: C1275278 OMIM: 612237 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa (TAF15) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TATA-binding protein-associated factor 2N
Names
RBP56/CSMF fusion
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)
TATA box-binding protein-associated factor 2N (RNA-binding protein 56)
TBP-associated factor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023279.1 RefSeqGene

    Range
    5001..42759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003487.4 → NP_003478.1  TATA-binding protein-associated factor 2N isoform 2

    See identical proteins and their annotated locations for NP_003478.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1, that results in a shorter protein (isoform 2).
    Source sequence(s)
    AI351964, AK313223, BC039129, DB166653
    Consensus CDS
    CCDS59279.1
    UniProtKB/Swiss-Prot
    Q92804
    Related
    ENSP00000474609.1, ENST00000604841.5
    Conserved Domains (4) summary
    COG0724
    Location:219 → 316
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12535
    Location:229 → 314
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    sd00025
    Location:355 → 376
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:351 → 381
    zf-RanBP; Zn-finger in Ran binding protein and others

  2. NM_139215.3 → NP_631961.1  TATA-binding protein-associated factor 2N isoform 1

    See identical proteins and their annotated locations for NP_631961.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI351964, AK314194, BC046099, BG403710
    Consensus CDS
    CCDS32623.1
    UniProtKB/Swiss-Prot
    B2R837, Q86X94, Q92751, Q92804
    Related
    ENSP00000474096.1, ENST00000605844.6
    Conserved Domains (5) summary
    cd12535
    Location:232 → 317
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    sd00025
    Location:358 → 379
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:354 → 384
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam15991
    Location:1 → 124
    G_path_suppress; G-protein pathway suppressor
    cl25887
    Location:136 → 315
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    35809484..35847242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    44016..81774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    36757395..36795152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92804.1 GenPept UniProtKB/Swiss-Prot:Q92804

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