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    Ppp6r2 protein phosphatase 6, regulatory subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300146, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp6r2provided by RGD
    Official Full Name
    protein phosphatase 6, regulatory subunit 2provided by RGD
    Primary source
    RGD:1563990
    See related
    EnsemblRapid:ENSRNOG00000026425 AllianceGenome:RGD:1563990
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Saps2; RGD1563990
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R2 (protein phosphatase 6 regulatory subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 212.8), Brain (RPKM 191.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp6r2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122164968..122236625)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120285378..120356995)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130188609..130260209)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene plexin B2 Neighboring gene microRNA 349 Neighboring gene DENN domain containing 6B Neighboring gene SET binding factor 1 Neighboring gene adrenomedullin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. Schmid EM, et al. PLoS Biol, 2006 Sep. PMID 16903783, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory subunit 2
    Names
    SAPS domain family, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106789.1 → NP_001100259.1  serine/threonine-protein phosphatase 6 regulatory subunit 2

      See identical proteins and their annotated locations for NP_001100259.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474027
      UniProtKB/TrEMBL
      A6K7L0, F1M6T6
      Conserved Domains (2) summary
      PHA03247
      Location:624 → 897
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      122164968..122236625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078856.2 → XP_038934784.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV49
      Conserved Domains (2) summary
      PHA03247
      Location:651 → 924
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    2. XM_039078866.2 → XP_038934794.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/TrEMBL
      A6K7L0, F1M6T6
      Conserved Domains (2) summary
      PHA03247
      Location:624 → 897
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    3. XM_063263337.1 → XP_063119407.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/TrEMBL
      A6K7L0, F1M6T6

    4. XM_039078863.2 → XP_038934791.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV49
      Conserved Domains (2) summary
      PHA03247
      Location:651 → 924
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    5. XM_063263333.1 → XP_063119403.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV49

    6. XM_039078860.2 → XP_038934788.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV49
      Related
      ENSRNOP00000069349.2, ENSRNOT00000078423.3
      Conserved Domains (2) summary
      PHA03247
      Location:651 → 924
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    7. XM_039078858.2 → XP_038934786.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV49
      Conserved Domains (2) summary
      PHA03247
      Location:651 → 924
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    8. XM_039078857.2 → XP_038934785.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV49
      Conserved Domains (2) summary
      PHA03247
      Location:651 → 924
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    9. XM_039078867.2 → XP_038934795.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/TrEMBL
      A6K7L0, F1M6T6
      Conserved Domains (2) summary
      PHA03247
      Location:624 → 897
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    10. XM_063263339.1 → XP_063119409.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/TrEMBL
      A6K7L0, F1M6T6

    11. XM_063263338.1 → XP_063119408.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/TrEMBL
      A6K7L0, F1M6T6
      Related
      ENSRNOP00000011070.8, ENSRNOT00000011070.9

    12. XM_063263345.1 → XP_063119415.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X9

    13. XM_063263344.1 → XP_063119414.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

    14. XM_063263335.1 → XP_063119405.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X2

    15. XM_063263334.1 → XP_063119404.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV49

    16. XM_063263341.1 → XP_063119411.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/TrEMBL
      A6K7L0, F1M6T6

    17. XM_063263336.1 → XP_063119406.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

    18. XM_063263340.1 → XP_063119410.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/TrEMBL
      A6K7L0, F1M6T6

    19. XM_039078859.2 → XP_038934787.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV49
      Conserved Domains (2) summary
      PHA03247
      Location:651 → 924
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    20. XM_063263342.1 → XP_063119412.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/TrEMBL
      A6K7L0, F1M6T6

    21. XM_008765688.4 → XP_008763910.2  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV49
      Conserved Domains (2) summary
      PHA03247
      Location:651 → 924
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    22. XM_063263343.1 → XP_063119413.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/TrEMBL
      A6K7L0, F1M6T6

    23. XM_039078868.2 → XP_038934796.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:583 → 856
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:60 → 466
      SAPS; SIT4 phosphatase-associated protein

    24. XM_039078869.2 → XP_038934797.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:511 → 784
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 394
      SAPS; SIT4 phosphatase-associated protein

    25. XM_039078870.2 → XP_038934798.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:511 → 784
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 394
      SAPS; SIT4 phosphatase-associated protein

    26. XM_039078871.1 → XP_038934799.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

      Conserved Domains (2) summary
      PHA03247
      Location:393 → 666
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:26 → 276
      SAPS; SIT4 phosphatase-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version

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