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    Ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294711, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppwd1provided by RGD
    Official Full Name
    peptidylprolyl isomerase domain and WD repeat containing 1provided by RGD
    Primary source
    RGD:1310204
    See related
    EnsemblRapid:ENSRNOG00000012505 AllianceGenome:RGD:1310204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310204
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in nuclear body. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPWD1 (peptidylprolyl isomerase domain and WD repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 56.7), Thymus (RPKM 56.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ppwd1 in Genome Data Viewer
    Location:
    2q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (37069744..37094252, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (35337301..35360661, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (34288853..34313094, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene shieldin complex subunit 3 Neighboring gene tripartite motif-containing 23 Neighboring gene centromere protein K Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 6 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidylprolyl isomerase domain and WD repeat-containing protein 1
    NP_001099876.1
    XP_006231949.1
    XP_038957858.1
    XP_038957859.1
    XP_063137576.1
    XP_063137577.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106406.1NP_001099876.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1

      See identical proteins and their annotated locations for NP_001099876.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473955
      UniProtKB/TrEMBL
      A0A8I6G302, A6I5F6, D3ZVP6
      Related
      ENSRNOP00000016863.5, ENSRNOT00000016863.7
      Conserved Domains (4) summary
      COG2319
      Location:89311
      WD40; WD40 repeat [General function prediction only]
      cd01927
      Location:495643
      cyclophilin_WD40; cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. ...
      sd00039
      Location:136177
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:89318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      37069744..37094252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281506.1XP_063137576.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G302
    2. XM_006231887.5XP_006231949.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G302
      Conserved Domains (3) summary
      cd01927
      Location:414562
      cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
      sd00039
      Location:5596
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:8237
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_063281507.1XP_063137577.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X5

    4. XM_039101930.2XP_038957858.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:136177
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:89318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_039101931.2XP_038957859.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:136177
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:89318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...