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    RRM2 ribonucleotide reductase regulatory subunit M2 [ Bos taurus (domestic cattle) ]

    Gene ID: 508167, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RRM2provided by VGNC
    Official Full Name
    ribonucleotide reductase regulatory subunit M2provided by VGNC
    Primary source
    VGNC:VGNC:34165
    See related
    BGD:BT19334; Ensembl:ENSBTAG00000008216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See RRM2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (87488673..87495961, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene hippocalcin like 1 Neighboring gene craniofacial development protein 2-like Neighboring gene cystin 1 Neighboring gene KLF transcription factor 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deoxyribonucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonucleoside-diphosphate reductase subunit M2
    NP_001231110.1
    NP_001231111.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244181.1 → NP_001231110.1  ribonucleoside-diphosphate reductase subunit M2 isoform 1

      See identical proteins and their annotated locations for NP_001231110.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC105511, DV801628, DV889429
      UniProtKB/TrEMBL
      E1BI58
      Related
      ENSBTAP00000102264.1, ENSBTAT00000100717.1
      Conserved Domains (1) summary
      PLN02492
      Location:70 → 389
      PLN02492; ribonucleoside-diphosphate reductase

    2. NM_001244182.1 → NP_001231111.1  ribonucleoside-diphosphate reductase subunit M2 isoform 2

      See identical proteins and their annotated locations for NP_001231111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to variant 1.
      Source sequence(s)
      BC105511, DV801628
      UniProtKB/TrEMBL
      A0A3Q1MLJ5, Q2HJE7
      Related
      ENSBTAP00000071896.1, ENSBTAT00000072262.1
      Conserved Domains (1) summary
      cl00264
      Location:57 → 341
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      87488673..87495961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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