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    Chmp4b charged multivesicular body protein 4B [ Mus musculus (house mouse) ]

    Gene ID: 75608, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chmp4bprovided by MGI
    Official Full Name
    charged multivesicular body protein 4Bprovided by MGI
    Primary source
    MGI:MGI:1922858
    See related
    Ensembl:ENSMUSG00000038467 AllianceGenome:MGI:1922858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snf7-2; 2010012F05Rik
    Summary
    Predicted to enable protein homodimerization activity. Involved in regulation of autophagy. Located in cytosol; endosome membrane; and nucleus. Is expressed in several structures, including branchial arch; central nervous system; limb bud; mandibular process; and sensory organ. Human ortholog(s) of this gene implicated in cataract 31 multiple types. Orthologous to human CHMP4B (charged multivesicular body protein 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 92.6), bladder adult (RPKM 83.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Chmp4b in Genome Data Viewer
    Location:
    2 H1; 2 76.79 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (154498949..154536703)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (154657026..154694783)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06130 Neighboring gene peroxisomal membrane protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E228 Neighboring gene zinc finger protein 341 Neighboring gene predicted gene 14198 Neighboring gene STARR-positive B cell enhancer ABC_E7873 Neighboring gene STARR-positive B cell enhancer ABC_E6003 Neighboring gene RIKEN cDNA 9030607L20 gene Neighboring gene ribisomal protein L5, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:154538008-154538309 Neighboring gene predicted gene 14215

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Items 1 - 25 of 41
    Process Evidence Code Pubs
    involved_in autophagosome maturation  
    involved_in autophagy  
    involved_in exit from mitosis  
    involved_in exit from mitosis  
    involved_in late endosome to lysosome transport  
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway  
    involved_in maintenance of lens transparency  
    involved_in maintenance of lens transparency  
    involved_in membrane fission  
    involved_in membrane fission  
    involved_in membrane fission PubMed 
    involved_in midbody abscission  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in mitotic metaphase chromosome alignment  
    involved_in multivesicular body assembly PubMed 
    involved_in multivesicular body sorting pathway  
    involved_in multivesicular body-lysosome fusion PubMed 
    involved_in nervous system process  
    involved_in nervous system process  
    involved_in nuclear membrane reassembly  
    involved_in nuclear membrane reassembly  
    involved_in nucleus organization  
    involved_in plasma membrane repair  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane  
    involved_in protein polymerization  
    involved_in protein polymerization  
    involved_in protein transport  
    involved_in regulation of autophagy PubMed 
    involved_in regulation of centrosome duplication  
    involved_in regulation of centrosome duplication  
    involved_in regulation of mitotic spindle assembly  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
    involved_in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway  
    involved_in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway  
    involved_in vesicle budding from membrane  
    involved_in vesicle fusion with vacuole PubMed 
    involved_in viral budding  
    involved_in viral budding from plasma membrane  
    involved_in viral budding via host ESCRT complex  
    Items 1 - 25 of 41
    Items 1 - 20 of 30
    Component Evidence Code Pubs
    part_of ESCRT III complex  
    part_of ESCRT III complex  
    part_of ESCRT III complex  
    located_in amphisome membrane  
    located_in autophagosome membrane  
    located_in cytoplasm  
    is_active_in cytoplasmic side of plasma membrane  
    located_in cytoplasmic side of plasma membrane  
    located_in cytoplasmic side of plasma membrane  
    located_in cytosol PubMed 
    located_in endosome  
    located_in endosome membrane PubMed 
    is_active_in glutamatergic synapse  
    located_in kinetochore  
    located_in kinetochore microtubule  
    located_in lysosomal membrane  
    located_in membrane PubMed 
    part_of membrane coat  
    part_of membrane coat  
    located_in midbody  
    is_active_in multivesicular body  
    located_in multivesicular body membrane  
    located_in nuclear envelope  
    located_in nuclear envelope  
    part_of nuclear pore  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in plasma membrane  
    is_active_in postsynaptic density  
    located_in vesicle  
    Items 1 - 20 of 30

    General protein information

    Preferred Names
    charged multivesicular body protein 4b
    Names
    chromatin modifying protein 4B
    chromatin-modifying protein 4b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029362.4NP_083638.1  charged multivesicular body protein 4b

      See identical proteins and their annotated locations for NP_083638.1

      Status: VALIDATED

      Source sequence(s)
      AL929557
      Consensus CDS
      CCDS16938.1
      UniProtKB/Swiss-Prot
      A2AVM1, Q3TXM7, Q91VM7, Q922P1, Q9D8B3
      Related
      ENSMUSP00000036206.10, ENSMUST00000044277.10
      Conserved Domains (1) summary
      pfam03357
      Location:24198
      Snf7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      154498949..154536703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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