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BAZ2B bromodomain adjacent to zinc finger domain 2B [ Homo sapiens (human) ]

Gene ID: 29994, updated on 27-Nov-2024

Summary

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Official Symbol
BAZ2Bprovided by HGNC
Official Full Name
bromodomain adjacent to zinc finger domain 2Bprovided by HGNC
Primary source
HGNC:HGNC:963
See related
Ensembl:ENSG00000123636 MIM:605683; AllianceGenome:HGNC:963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WALp4
Summary
This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac mark in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD). [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 5.2) and 25 other tissues See more
Orthologs
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Genomic context

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See BAZ2B in Genome Data Viewer
Location:
2q24.2
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (159315312..159712442, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (159772618..160169805, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160175490..160568953, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16684 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:160067858-160068472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160081586-160082095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160082096-160082604 Neighboring gene uncharacterized LOC105373716 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53635 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53624 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53665 Neighboring gene microRNA 6888 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160113609-160113777 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:160128197-160128698 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:160128699-160129198 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53748 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160143174-160143343 Neighboring gene WD repeat, sterile alpha motif and U-box domain containing 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:160205700-160206899 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:160294250-160295449 Neighboring gene Sharpr-MPRA regulatory region 4770 Neighboring gene CAPZA1 pseudogene 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53833 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:160455742-160456242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:160471010-160471538 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160472595-160473121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160480245-160480746 Neighboring gene BAZ2B antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160568592-160569258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160594100-160595092 Neighboring gene RPS3A pseudogene 13 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53909 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53950 Neighboring gene LY75-CD302 readthrough Neighboring gene uncharacterized LOC124906083 Neighboring gene CD302 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex. Breindl M, et al. Nucleic Acids Res, 2024 Jan 11. PMID 38000389, Free PMC Article
  2. Circulating tumor DNA, and clinical features to guide rechallenge with BRAF inhibitors in BRAF-V600E mutated metastatic colorectal cancer. Ros J, et al. Ann Oncol, 2024 Feb. PMID 37866812
  3. Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. Arking DE, et al. PLoS Genet, 2011 Jun. PMID 21738491, Free PMC Article
  4. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. Ferguson FM, et al. J Med Chem, 2013 Dec 27. PMID 24304323, Free PMC Article
  5. Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking. Ferguson FM, et al. Biochemistry, 2014 Oct 28. PMID 25266743, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circulating tumor DNA, and clinical features to guide rechallenge with BRAF inhibitors in BRAF-V600E mutated metastatic colorectal cancer.
    Title: Circulating tumor DNA, and clinical features to guide rechallenge with BRAF inhibitors in BRAF-V600E mutated metastatic colorectal cancer.
  2. Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex.
    Title: Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex.
  3. The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State.
    Title: The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State.
  4. BAZ2B haploinsufficiency as a cause of developmental delay, intellectual disability, and autism spectrum disorder.
    Title: BAZ2B haploinsufficiency as a cause of developmental delay, intellectual disability, and autism spectrum disorder.
  5. Study identified BAZ2B as a major interactant of small hepatitis delta virus (HDV) antigen (S-HDAg) in human hepatocytes. BAZ2B bromodomain, which generally binds the K14acXXR motif in histone H3-tail, recognizes the same K72acXXR motif in S-HDAg. S-HDAg mimics histone H3 acetylation to recruit BAZ2B-associated remodeling factor complexes and RNA Pol II on the HDV ribonucleoproteins to sustain HDV replication.
    Title: Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication.
  6. Synergistic inhibition of BDs encoded in BAZ2A/B, BRD9, and BET proteins induces apoptosis of triple-negative breast cancer (TNBC) by a combinatorial suppression of ribosomal DNA transcription and ETS-regulated genes.
    Title: GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer.
  7. Phosphorylation, acetylation, or poly(ADP-ribosyl)ation of the linker residues may therefore act as a cellular mechanism to transiently tune BAZ2B histone-binding affinity.
    Title: A histone-mimicking interdomain linker in a multidomain protein modulates multivalent histone binding.
  8. Data suggest that binding of helical tail of histone 3 (H3) with PHD ('plant homeodomain') fingers of BAZ2A or BAZ2B (bromodomain adjacent to zinc finger domain 2A or 2B) requires molecular recognition of secondary structure motifs within H3 tail and could represent an additional layer of regulation in epigenetic processes.
    Title: Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.
  9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of bromodomain adjacent to zinc finger domain, 2B (BAZ2B) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13504, FLJ20669, FLJ45644, AC009961.3, DKFZp434H071, DKFZp686D1284, DKFZp762I0516

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bromodomain adjacent to zinc finger domain protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051314.1 RefSeqGene

    Range
    100892..398461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001289975.1 → NP_001276904.1  bromodomain adjacent to zinc finger domain protein 2B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC008277, AC009506
    Consensus CDS
    CCDS74594.1
    UniProtKB/Swiss-Prot
    Q9UIF8
    Related
    ENSP00000376533.1, ENST00000392782.5
    Conserved Domains (8) summary
    cd05503
    Location:2029 → 2125
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1053 → 1115
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:742 → 811
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1896 → 1944
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam15346
    Location:861 → 1014
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1682 → 1720
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:959 → 979
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:816 → 1000
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001329857.2 → NP_001316786.1  bromodomain adjacent to zinc finger domain protein 2B isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the CDS, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AC008277, AC009506

  3. NM_001329858.2 → NP_001316787.1  bromodomain adjacent to zinc finger domain protein 2B isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and contains an additional alternate exon in the CDS, compared to variant 1. It encodes isoform d, which is shorter than isoform a.
    Source sequence(s)
    AC008277, AC009506

  4. NM_013450.4 → NP_038478.2  bromodomain adjacent to zinc finger domain protein 2B isoform a

    See identical proteins and their annotated locations for NP_038478.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC008277, AC009506
    Consensus CDS
    CCDS2209.2
    UniProtKB/Swiss-Prot
    D3DPA8, Q96EA1, Q96SQ8, Q9P252, Q9UIF8, Q9Y4N8
    Related
    ENSP00000376534.2, ENST00000392783.7
    Conserved Domains (8) summary
    cd05503
    Location:2065 → 2161
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1089 → 1151
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:744 → 816
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1932 → 1980
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam15346
    Location:897 → 1050
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1718 → 1756
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:995 → 1015
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:852 → 1036
    GBP_C; Guanylate-binding protein, C-terminal domain

RNA

  1. NR_110586.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate exon structure, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC009961

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    159315312..159712442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444047.1 → XP_047300003.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  2. XM_047444046.1 → XP_047300002.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  3. XM_047444040.1 → XP_047299996.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  4. XM_047444044.1 → XP_047300000.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  5. XM_047444043.1 → XP_047299999.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  6. XM_047444055.1 → XP_047300011.1  bromodomain adjacent to zinc finger domain protein 2B isoform X17

  7. XM_047444052.1 → XP_047300008.1  bromodomain adjacent to zinc finger domain protein 2B isoform X12

  8. XM_047444038.1 → XP_047299994.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  9. XM_017003920.2 → XP_016859409.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    Conserved Domains (7) summary
    cd05503
    Location:2111 → 2207
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1100 → 1162
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:744 → 816
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1978 → 2026
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam13868
    Location:886 → 1072
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:1383 → 1415
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl25599
    Location:25 → 209
    Nucleoporin_FG2; Nucleoporin FG repeated region

  10. XM_047444048.1 → XP_047300004.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  11. XM_047444039.1 → XP_047299995.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  12. XM_047444045.1 → XP_047300001.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  13. XM_047444041.1 → XP_047299997.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  14. XM_047444042.1 → XP_047299998.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  15. XM_005246488.3 → XP_005246545.2  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    See identical proteins and their annotated locations for XP_005246545.2

    Conserved Domains (7) summary
    cd05503
    Location:2111 → 2207
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1100 → 1162
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:744 → 816
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1978 → 2026
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam13868
    Location:886 → 1072
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:1383 → 1415
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl25599
    Location:25 → 209
    Nucleoporin_FG2; Nucleoporin FG repeated region

  16. XM_047444051.1 → XP_047300007.1  bromodomain adjacent to zinc finger domain protein 2B isoform X11

  17. XM_047444037.1 → XP_047299993.1  bromodomain adjacent to zinc finger domain protein 2B isoform X2

  18. XM_005246492.5 → XP_005246549.2  bromodomain adjacent to zinc finger domain protein 2B isoform X4

    Conserved Domains (10) summary
    cd05503
    Location:2109 → 2205
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1098 → 1160
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:742 → 814
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1976 → 2024
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam14738
    Location:864 → 958
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
    pfam15346
    Location:904 → 1075
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1727 → 1765
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:1039 → 1049
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:978 → 1069
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23765
    Location:913 → 1021
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  19. XM_047444059.1 → XP_047300015.1  bromodomain adjacent to zinc finger domain protein 2B isoform X24

  20. XM_005246489.5 → XP_005246546.2  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    See identical proteins and their annotated locations for XP_005246546.2

    Conserved Domains (7) summary
    cd05503
    Location:2111 → 2207
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1100 → 1162
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:744 → 816
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1978 → 2026
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam13868
    Location:886 → 1072
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:1383 → 1415
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl25599
    Location:25 → 209
    Nucleoporin_FG2; Nucleoporin FG repeated region

  21. XM_047444064.1 → XP_047300020.1  bromodomain adjacent to zinc finger domain protein 2B isoform X30

  22. XM_047444057.1 → XP_047300013.1  bromodomain adjacent to zinc finger domain protein 2B isoform X19

  23. XM_011511045.1 → XP_011509347.1  bromodomain adjacent to zinc finger domain protein 2B isoform X15

    Conserved Domains (10) summary
    cd05503
    Location:2046 → 2142
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1035 → 1097
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:679 → 751
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1913 → 1961
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam14738
    Location:801 → 895
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
    pfam15346
    Location:841 → 1012
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1664 → 1702
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:976 → 986
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:915 → 1006
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23765
    Location:850 → 958
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  24. XM_047444062.1 → XP_047300018.1  bromodomain adjacent to zinc finger domain protein 2B isoform X28

  25. XM_047444056.1 → XP_047300012.1  bromodomain adjacent to zinc finger domain protein 2B isoform X18

  26. XM_011511050.1 → XP_011509352.1  bromodomain adjacent to zinc finger domain protein 2B isoform X21

    Conserved Domains (10) summary
    cd05503
    Location:2011 → 2107
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1000 → 1062
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:644 → 716
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1878 → 1926
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam14738
    Location:766 → 860
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
    pfam15346
    Location:806 → 977
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1629 → 1667
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:941 → 951
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:880 → 971
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23765
    Location:815 → 923
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  27. XM_047444050.1 → XP_047300006.1  bromodomain adjacent to zinc finger domain protein 2B isoform X9

  28. XM_017003924.1 → XP_016859413.1  bromodomain adjacent to zinc finger domain protein 2B isoform X8

  29. XM_047444061.1 → XP_047300017.1  bromodomain adjacent to zinc finger domain protein 2B isoform X27

  30. XM_047444060.1 → XP_047300016.1  bromodomain adjacent to zinc finger domain protein 2B isoform X26

  31. XM_011511052.1 → XP_011509354.1  bromodomain adjacent to zinc finger domain protein 2B isoform X25

    Conserved Domains (10) summary
    cd05503
    Location:1979 → 2075
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:968 → 1030
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:646 → 715
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1846 → 1894
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam14738
    Location:734 → 828
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
    pfam15346
    Location:774 → 945
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1597 → 1635
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:909 → 919
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:848 → 939
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23765
    Location:783 → 891
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  32. XM_047444058.1 → XP_047300014.1  bromodomain adjacent to zinc finger domain protein 2B isoform X23

  33. XM_017003930.2 → XP_016859419.1  bromodomain adjacent to zinc finger domain protein 2B isoform X20

  34. XM_011511043.1 → XP_011509345.1  bromodomain adjacent to zinc finger domain protein 2B isoform X10

    Related
    ENSP00000520831.1, ENST00000718451.1
    Conserved Domains (8) summary
    cd05503
    Location:2066 → 2162
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1055 → 1117
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:744 → 813
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1933 → 1981
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam15346
    Location:863 → 1016
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1684 → 1722
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:961 → 981
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:818 → 1002
    GBP_C; Guanylate-binding protein, C-terminal domain

  35. XM_047444049.1 → XP_047300005.1  bromodomain adjacent to zinc finger domain protein 2B isoform X7

  36. XM_011511038.3 → XP_011509340.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

    Conserved Domains (9) summary
    cd05503
    Location:2109 → 2205
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1098 → 1160
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:744 → 816
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1976 → 2024
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam14738
    Location:866 → 960
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
    pfam15346
    Location:906 → 1075
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1727 → 1765
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:1039 → 1049
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:956 → 1069
    GBP_C; Guanylate-binding protein, C-terminal domain

  37. XM_011511042.1 → XP_011509344.1  bromodomain adjacent to zinc finger domain protein 2B isoform X6

    Conserved Domains (10) summary
    cd05503
    Location:2076 → 2172
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1100 → 1162
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:744 → 816
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1943 → 1991
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam14738
    Location:866 → 960
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
    pfam15346
    Location:906 → 1077
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1729 → 1767
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:1041 → 1051
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:980 → 1071
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23765
    Location:915 → 1023
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  38. XM_011511056.2 → XP_011509358.1  bromodomain adjacent to zinc finger domain protein 2B isoform X32

    Conserved Domains (7) summary
    cd05503
    Location:1295 → 1391
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:284 → 346
    DDT; domain in different transcription and chromosome remodeling factors
    cd15630
    Location:1162 → 1210
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam15614
    Location:913 → 951
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:231 → 242
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:164 → 261
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23765
    Location:99 → 207
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  39. XM_011511051.1 → XP_011509353.1  bromodomain adjacent to zinc finger domain protein 2B isoform X22

    Conserved Domains (9) summary
    cd05503
    Location:2038 → 2134
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1062 → 1124
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:742 → 811
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1905 → 1953
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam14738
    Location:830 → 924
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
    pfam15346
    Location:861 → 1023
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1691 → 1729
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:1012 → 1023
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:944 → 1039
    GBP_C; Guanylate-binding protein, C-terminal domain

  40. XM_047444063.1 → XP_047300019.1  bromodomain adjacent to zinc finger domain protein 2B isoform X29

  41. XM_047444054.1 → XP_047300010.1  bromodomain adjacent to zinc finger domain protein 2B isoform X16

  42. XM_011511044.1 → XP_011509346.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

    Conserved Domains (9) summary
    cd05503
    Location:2075 → 2171
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:1064 → 1126
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:744 → 813
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15630
    Location:1942 → 1990
    PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
    pfam14738
    Location:832 → 926
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
    pfam15346
    Location:872 → 1041
    ARGLU; Arginine and glutamate-rich 1
    pfam15614
    Location:1693 → 1731
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:1014 → 1025
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:946 → 1041
    GBP_C; Guanylate-binding protein, C-terminal domain

  43. XM_047444053.1 → XP_047300009.1  bromodomain adjacent to zinc finger domain protein 2B isoform X14

  44. XM_017003923.1 → XP_016859412.1  bromodomain adjacent to zinc finger domain protein 2B isoform X5

  45. XM_047444065.1 → XP_047300021.1  bromodomain adjacent to zinc finger domain protein 2B isoform X31

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    159772618..160169805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341579.1 → XP_054197554.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  2. XM_054341573.1 → XP_054197548.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  3. XM_054341576.1 → XP_054197551.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  4. XM_054341594.1 → XP_054197569.1  bromodomain adjacent to zinc finger domain protein 2B isoform X17

  5. XM_054341589.1 → XP_054197564.1  bromodomain adjacent to zinc finger domain protein 2B isoform X12

  6. XM_054341570.1 → XP_054197545.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  7. XM_054341571.1 → XP_054197546.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  8. XM_054341577.1 → XP_054197552.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  9. XM_054341574.1 → XP_054197549.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  10. XM_054341575.1 → XP_054197550.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  11. XM_054341578.1 → XP_054197553.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  12. XM_054341572.1 → XP_054197547.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  13. XM_054341580.1 → XP_054197555.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  14. XM_054341588.1 → XP_054197563.1  bromodomain adjacent to zinc finger domain protein 2B isoform X11

  15. XM_054341569.1 → XP_054197544.1  bromodomain adjacent to zinc finger domain protein 2B isoform X2

  16. XM_054341581.1 → XP_054197556.1  bromodomain adjacent to zinc finger domain protein 2B isoform X4

  17. XM_054341601.1 → XP_054197576.1  bromodomain adjacent to zinc finger domain protein 2B isoform X24

  18. XM_054341606.1 → XP_054197581.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

  19. XM_054341608.1 → XP_054197583.1  bromodomain adjacent to zinc finger domain protein 2B isoform X30

  20. XM_054341596.1 → XP_054197571.1  bromodomain adjacent to zinc finger domain protein 2B isoform X19

  21. XM_054341592.1 → XP_054197567.1  bromodomain adjacent to zinc finger domain protein 2B isoform X15

  22. XM_054341605.1 → XP_054197580.1  bromodomain adjacent to zinc finger domain protein 2B isoform X28

  23. XM_054341595.1 → XP_054197570.1  bromodomain adjacent to zinc finger domain protein 2B isoform X18

  24. XM_054341598.1 → XP_054197573.1  bromodomain adjacent to zinc finger domain protein 2B isoform X21

  25. XM_054341586.1 → XP_054197561.1  bromodomain adjacent to zinc finger domain protein 2B isoform X9

  26. XM_054341585.1 → XP_054197560.1  bromodomain adjacent to zinc finger domain protein 2B isoform X8

  27. XM_054341604.1 → XP_054197579.1  bromodomain adjacent to zinc finger domain protein 2B isoform X27

  28. XM_054341603.1 → XP_054197578.1  bromodomain adjacent to zinc finger domain protein 2B isoform X26

  29. XM_054341602.1 → XP_054197577.1  bromodomain adjacent to zinc finger domain protein 2B isoform X25

  30. XM_054341600.1 → XP_054197575.1  bromodomain adjacent to zinc finger domain protein 2B isoform X23

  31. XM_054341597.1 → XP_054197572.1  bromodomain adjacent to zinc finger domain protein 2B isoform X20

  32. XM_054341587.1 → XP_054197562.1  bromodomain adjacent to zinc finger domain protein 2B isoform X10

  33. XM_054341584.1 → XP_054197559.1  bromodomain adjacent to zinc finger domain protein 2B isoform X7

  34. XM_054341568.1 → XP_054197543.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

  35. XM_054341583.1 → XP_054197558.1  bromodomain adjacent to zinc finger domain protein 2B isoform X6

  36. XM_054341610.1 → XP_054197585.1  bromodomain adjacent to zinc finger domain protein 2B isoform X32

  37. XM_054341599.1 → XP_054197574.1  bromodomain adjacent to zinc finger domain protein 2B isoform X22

  38. XM_054341607.1 → XP_054197582.1  bromodomain adjacent to zinc finger domain protein 2B isoform X29

  39. XM_054341593.1 → XP_054197568.1  bromodomain adjacent to zinc finger domain protein 2B isoform X16

  40. XM_054341590.1 → XP_054197565.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

  41. XM_054341591.1 → XP_054197566.1  bromodomain adjacent to zinc finger domain protein 2B isoform X14

  42. XM_054341582.1 → XP_054197557.1  bromodomain adjacent to zinc finger domain protein 2B isoform X5

  43. XM_054341609.1 → XP_054197584.1  bromodomain adjacent to zinc finger domain protein 2B isoform X31

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UIF8.3 GenPept UniProtKB/Swiss-Prot:Q9UIF8

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