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    gei-1 START domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175436, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gei-1
    Official Full Name
    START domain-containing protein
    Primary source
    WormBase:WBGene00001559
    Locus tag
    CELE_F45H7.2
    See related
    AllianceGenome:WB:WBGene00001559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Is expressed in pharynx. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein); STARD13 (StAR related lipid transfer domain containing 13); and STARD8 (StAR related lipid transfer domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gei-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    26
    Sequence:
    Chromosome: III; NC_003281.10 (3344873..3363427)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serine/threonine-protein kinase prk-2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of the interacting molecules with GEX-3 by a novel functional screening. Tsuboi D, et al. Biochem Biophys Res Commun, 2002 Apr 5. PMID 11922622
    2. Systematic analysis of genes required for synapse structure and function. Sieburth D, et al. Nature, 2005 Jul 28. PMID 16049479
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    START domain-containing protein
    NP_001254868.1
    • Confirmed by transcript evidence
    NP_001254869.1
    • Confirmed by transcript evidence
    NP_497694.3
    • Confirmed by transcript evidence
    NP_497695.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3344873..3363427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065294.6 → NP_497695.3  START domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497695.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20442
      Conserved Domains (3) summary
      cd04375
      Location:876 → 1103
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
      cl14643
      Location:1126 → 1325
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
      cl15755
      Location:444 → 499
      SAM_superfamily; SAM (Sterile alpha motif )

    2. NM_065293.6 → NP_497694.3  START domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497694.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20440
      Conserved Domains (3) summary
      cd04375
      Location:1052 → 1279
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
      cl14643
      Location:1302 → 1501
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
      cl15755
      Location:444 → 499
      SAM_superfamily; SAM (Sterile alpha motif )

    3. NM_001267939.3 → NP_001254868.1  START domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7FZT8
      Conserved Domains (3) summary
      cd04375
      Location:883 → 1110
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
      cl14643
      Location:1133 → 1332
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
      cl15755
      Location:275 → 330
      SAM_superfamily; SAM (Sterile alpha motif )

    4. NM_001267940.3 → NP_001254869.1  START domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0P276
      Conserved Domains (1) summary
      cl14643
      Location:20 → 219
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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