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Conserved domains on  [gi|392894424|ref|NP_497695|]
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START domain-containing protein [Caenorhabditis elegans]

Protein Classification

RhoGAP/SRPBCC family protein( domain architecture ID 10337210)

RhoGAP (Rho GTPase-activating protein)/SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) family protein may have a deep hydrophobic ligand-binding pocket and may function as a GTPase-activating protein for Rho family proteins

CATH:  3.30.530.20|1.10.555.10
Gene Ontology:  GO:0005488|GO:0007165|GO:0005096|GO:0051056
PubMed:  18922149|15246431|17222083|12480336|28163190|15928333|18831011
SCOP:  3000738|4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 876-1103 7.02e-122

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239840  Cd Length: 220  Bit Score: 377.14  E-value: 7.02e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  876 DGAVFGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNTdvfvgenLLDSTQVH 955
Cdd:cd04375     1 DKNVFGVPLLVNLQRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNV-------NYDGQQAY 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  956 DVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQN 1035
Cdd:cd04375    74 DVADMLKQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATN 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392894424 1036 LSVCFTPSLFQLGASRLDKVTPgNRRHKTVGATGLPSEKEMKEARACQLCLTMLIEYVQTVFMVPDGL 1103
Cdd:cd04375   154 LAVCLAPSLFHLNTSRRENSSP-ARRMQRKKSLGKPDQKELSENKAAHQCLAYMIEECNTLFMVPKEM 220
SRPBCC super family cl14643
START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; SRPBCC ...
 1126-1325 8.46e-96

START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; SRPBCC domains have a deep hydrophobic ligand-binding pocket; they bind diverse ligands. Included in this superfamily are the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), as well as the SRPBCC domains of phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of this superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


The actual alignment was detected with superfamily member cd08869:

Pssm-ID: 472699  Cd Length: 197  Bit Score: 305.39  E-value: 8.46e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1126 SFLVDRVIDLIRDHSDQWKNWTIEGSFRGIEISSKRPSDSHPLKTFRVWLNVPAGPKSVMMRLLKERYTWDSSVINWRHL 1205
Cdd:cd08869     1 SYLERCVQDLLREARDKSKGWVSVSSSDHVELAFKKVDDGHPLRLWRASTEVEAPPEEVLQRILRERHLWDDDLLQWKVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1206 EYVSApDTDIHQYVVNETIGHPTKDCHVARFHSSGLTEirGACAIAERSVKCTEDQLLGGVSATIFDQRFLIEPVSGGQS 1285
Cdd:cd08869    81 ETLDE-DTEVYQYVTNSMAPHPTRDYVVLRTWRTDLPK--GACVLVETSVEHTEPVPLGGVRAVVLASRYLIEPCGSGKS 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 392894424 1286 RVNYIARVDLKGRSLQWYNKSFGSIMCRHLDRLRESFHLG 1325
Cdd:cd08869   158 RVTHICRVDLRGRSPEWYNKVYGHLCARELLRIRDSFRQL 197
SAM_superfamily super family cl15755
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 444-499 7.34e-14

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


The actual alignment was detected with superfamily member cd09538:

Pssm-ID: 472832  Cd Length: 60  Bit Score: 67.44  E-value: 7.34e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  444 VDACSWLRKAGFSKYADQFEEGKLPI-VAS--KDPTLLEAD-LRALNRRIDVLNRCHTMK 499
Cdd:cd09538     1 KEACKWLRAAGFPQYAQLYEDSQFPIdISAvkRDHDFLDRDsLQALIRRLNTLNKCASMK 60
 
Name Accession Description Interval E-value
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 876-1103 7.02e-122

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 377.14  E-value: 7.02e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  876 DGAVFGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNTdvfvgenLLDSTQVH 955
Cdd:cd04375     1 DKNVFGVPLLVNLQRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNV-------NYDGQQAY 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  956 DVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQN 1035
Cdd:cd04375    74 DVADMLKQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATN 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392894424 1036 LSVCFTPSLFQLGASRLDKVTPgNRRHKTVGATGLPSEKEMKEARACQLCLTMLIEYVQTVFMVPDGL 1103
Cdd:cd04375   154 LAVCLAPSLFHLNTSRRENSSP-ARRMQRKKSLGKPDQKELSENKAAHQCLAYMIEECNTLFMVPKEM 220
START_RhoGAP cd08869
C-terminal lipid-binding START domain of mammalian STARD8, -12, -13 and related proteins, ...
 1126-1325 8.46e-96

C-terminal lipid-binding START domain of mammalian STARD8, -12, -13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD8 (also known as deleted in liver cancer 3/DLC3, and Arhgap38), STARD12 (also known as DLC-1, Arhgap7, and p122-RhoGAP), and STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. Some, including STARD12, -and -13, also have an N-terminal SAM (sterile alpha motif) domain; these have a SAM-RhoGAP-START domain organization. This subfamily is involved in cancer development. A large spectrum of cancers have dysregulated genes encoding these proteins. The precise function of the START domain in this subfamily is unclear.


Pssm-ID: 176878  Cd Length: 197  Bit Score: 305.39  E-value: 8.46e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1126 SFLVDRVIDLIRDHSDQWKNWTIEGSFRGIEISSKRPSDSHPLKTFRVWLNVPAGPKSVMMRLLKERYTWDSSVINWRHL 1205
Cdd:cd08869     1 SYLERCVQDLLREARDKSKGWVSVSSSDHVELAFKKVDDGHPLRLWRASTEVEAPPEEVLQRILRERHLWDDDLLQWKVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1206 EYVSApDTDIHQYVVNETIGHPTKDCHVARFHSSGLTEirGACAIAERSVKCTEDQLLGGVSATIFDQRFLIEPVSGGQS 1285
Cdd:cd08869    81 ETLDE-DTEVYQYVTNSMAPHPTRDYVVLRTWRTDLPK--GACVLVETSVEHTEPVPLGGVRAVVLASRYLIEPCGSGKS 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 392894424 1286 RVNYIARVDLKGRSLQWYNKSFGSIMCRHLDRLRESFHLG 1325
Cdd:cd08869   158 RVTHICRVDLRGRSPEWYNKVYGHLCARELLRIRDSFRQL 197
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 895-1093 9.62e-50

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 173.99  E-value: 9.62e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424    895 LPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNTDvfvgenLLDSTQVHDVADLLKQYFRDLPEPLMT 974
Cdd:smart00324    3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDL------DLSEYDVHDVAGLLKLFLRELPEPLIT 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424    975 VKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQLGAsrldk 1054
Cdd:smart00324   77 YELYEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPD----- 151

                           170       180       190
                    ....*....|....*....|....*....|....*....
gi 392894424   1055 vtpgnrrhktvgatglPSEKEMKEARACQLCLTMLIEYV 1093
Cdd:smart00324  152 ----------------GEVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 896-1046 1.51e-48

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 169.65  E-value: 1.51e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424   896 PRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESysgNTDVFVgenLLDSTQVHDVADLLKQYFRDLPEPLMTV 975
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDR---GPDVDL---DLEEEDVHVVASLLKLFLRELPEPLLTF 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392894424   976 KMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQ 1046
Cdd:pfam00620   75 ELYEEFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLR 145
START pfam01852
START domain;
1144-1321 3.57e-15

START domain;


Pssm-ID: 426476  Cd Length: 205  Bit Score: 75.90  E-value: 3.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  1144 KNWTIEGSFRGIEISSKRPSDSHpLKTFRVWLNVPAGPKSVMMRLLK---ERYTWDSSVINWRHLEYVSaPDTDIHQYVV 1220
Cdd:pfam01852   19 PGWVLLSSNENGDVVLQIVEPDH-GEASRASGVVPMVAALLVAELLKdmeYRAQWDKDVRSAETLEVIS-SGGDLQYYVA 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  1221 NETIGHPtkdcHVAR---FHSSGLTEIRGACAIAERSV-KCTEDQLLGGVSATIFDQRFLIEPVSGGQSRVNYIARVDLK 1296
Cdd:pfam01852   97 ALVAPSP----LSPRdfvFLRYWRRLGGGVYVIVDRSVtHPQFPPSSGYVRAERLPSGYLIQPCGNGPSKVTWVSHADLK 172

                          170       180       190
                   ....*....|....*....|....*....|...
gi 392894424  1297 GRSLQWYNKSFGS--------IMCRHLDRLRES 1321
Cdd:pfam01852  173 GWLPSWLLRSLYKsgmpegakTWVATLQRLCEK 205
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 1144-1309 1.69e-14

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


Pssm-ID: 214575  Cd Length: 205  Bit Score: 73.62  E-value: 1.69e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424   1144 KNWTIEGSFRGIEISSKRPSDSH-PLKTFRVWLNVPAGP----KSVMMRLlKERYTWDSSVINWRHLEYVSaPDTDIHQY 1218
Cdd:smart00234   18 EGWVLSSENENGDEVRSIFSPGRkPGEAFRLVGVVPMVCadlvEELMDDL-EYRPEWDKNVAKAETLEVID-NGTVIYHY 95

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424   1219 VVNETIGH--PTKDCHVARFHSSGlteiRGACAIAERSVKCTED-QLLGGVSATIFDQRFLIEPVSGGQSRVNYIARVDL 1295
Cdd:smart00234   96 VSKFAAGPvsPRDFVFVRYWREDE----DGSYAVVDVSVTHPTSpPESGYVRAENLPSGLLIEPLGNGPSKVTWVSHADL 171

                           170
                    ....*....|....
gi 392894424   1296 KGRSLQWYNKSFGS 1309
Cdd:smart00234  172 KGWLPHWLVRSLIK 185
SAM_DLC1,2-like cd09538
SAM domain of DLC1,2-like subfamily; SAM (sterile alpha motif) domain of DLC-1,2-like (Deleted ...
 444-499 7.34e-14

SAM domain of DLC1,2-like subfamily; SAM (sterile alpha motif) domain of DLC-1,2-like (Deleted in liver cancer) subfamily is a protein-protein interaction domain located at the N-terminus of the protein. Members of this subfamily do not form dimers/oligomers through their SAM domains. They participate in regulation of cell migration and lipid transfer. SAM domain of human DLC1 protein contains the EF1A1 (eukaryotic elongation factor) binding motif, thus SAM facilitates recruitment of EF1A1 to the membrane periphery and suppresses cell migration. Human Dlc2 gene is known as a tumor suppressor gene. It was found underexpressed in hepatocellular carcinoma.


Pssm-ID: 188937  Cd Length: 60  Bit Score: 67.44  E-value: 7.34e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  444 VDACSWLRKAGFSKYADQFEEGKLPI-VAS--KDPTLLEAD-LRALNRRIDVLNRCHTMK 499
Cdd:cd09538     1 KEACKWLRAAGFPQYAQLYEDSQFPIdISAvkRDHDFLDRDsLQALIRRLNTLNKCASMK 60
 
Name Accession Description Interval E-value
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 876-1103 7.02e-122

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 377.14  E-value: 7.02e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  876 DGAVFGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNTdvfvgenLLDSTQVH 955
Cdd:cd04375     1 DKNVFGVPLLVNLQRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNV-------NYDGQQAY 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  956 DVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQN 1035
Cdd:cd04375    74 DVADMLKQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATN 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392894424 1036 LSVCFTPSLFQLGASRLDKVTPgNRRHKTVGATGLPSEKEMKEARACQLCLTMLIEYVQTVFMVPDGL 1103
Cdd:cd04375   154 LAVCLAPSLFHLNTSRRENSSP-ARRMQRKKSLGKPDQKELSENKAAHQCLAYMIEECNTLFMVPKEM 220
START_RhoGAP cd08869
C-terminal lipid-binding START domain of mammalian STARD8, -12, -13 and related proteins, ...
 1126-1325 8.46e-96

C-terminal lipid-binding START domain of mammalian STARD8, -12, -13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD8 (also known as deleted in liver cancer 3/DLC3, and Arhgap38), STARD12 (also known as DLC-1, Arhgap7, and p122-RhoGAP), and STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. Some, including STARD12, -and -13, also have an N-terminal SAM (sterile alpha motif) domain; these have a SAM-RhoGAP-START domain organization. This subfamily is involved in cancer development. A large spectrum of cancers have dysregulated genes encoding these proteins. The precise function of the START domain in this subfamily is unclear.


Pssm-ID: 176878  Cd Length: 197  Bit Score: 305.39  E-value: 8.46e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1126 SFLVDRVIDLIRDHSDQWKNWTIEGSFRGIEISSKRPSDSHPLKTFRVWLNVPAGPKSVMMRLLKERYTWDSSVINWRHL 1205
Cdd:cd08869     1 SYLERCVQDLLREARDKSKGWVSVSSSDHVELAFKKVDDGHPLRLWRASTEVEAPPEEVLQRILRERHLWDDDLLQWKVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1206 EYVSApDTDIHQYVVNETIGHPTKDCHVARFHSSGLTEirGACAIAERSVKCTEDQLLGGVSATIFDQRFLIEPVSGGQS 1285
Cdd:cd08869    81 ETLDE-DTEVYQYVTNSMAPHPTRDYVVLRTWRTDLPK--GACVLVETSVEHTEPVPLGGVRAVVLASRYLIEPCGSGKS 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 392894424 1286 RVNYIARVDLKGRSLQWYNKSFGSIMCRHLDRLRESFHLG 1325
Cdd:cd08869   158 RVTHICRVDLRGRSPEWYNKVYGHLCARELLRIRDSFRQL 197
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 895-1093 9.62e-50

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 173.99  E-value: 9.62e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424    895 LPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNTDvfvgenLLDSTQVHDVADLLKQYFRDLPEPLMT 974
Cdd:smart00324    3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDL------DLSEYDVHDVAGLLKLFLRELPEPLIT 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424    975 VKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQLGAsrldk 1054
Cdd:smart00324   77 YELYEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPD----- 151

                           170       180       190
                    ....*....|....*....|....*....|....*....
gi 392894424   1055 vtpgnrrhktvgatglPSEKEMKEARACQLCLTMLIEYV 1093
Cdd:smart00324  152 ----------------GEVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 896-1046 1.51e-48

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 169.65  E-value: 1.51e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424   896 PRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESysgNTDVFVgenLLDSTQVHDVADLLKQYFRDLPEPLMTV 975
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDR---GPDVDL---DLEEEDVHVVASLLKLFLRELPEPLLTF 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392894424   976 KMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQ 1046
Cdd:pfam00620   75 ELYEEFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLR 145
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 896-1092 1.60e-41

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 150.14  E-value: 1.60e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  896 PRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESysGNTDVFvgenlLDSTQVHDVADLLKQYFRDLPEPLMTV 975
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDR--GEDIDD-----LEDYDVHDVASLLKLYLRELPEPLIPF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  976 KMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFqlgasrldkv 1055
Cdd:cd00159    74 ELYDEFIELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLL---------- 143

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 392894424 1056 tpgnrRHKTvgatglPSEKEMKEARACQLCLTMLIEY 1092
Cdd:cd00159   144 -----RPPD------SDDELLEDIKKLNEIVEFLIEN 169
START_STARD13-like cd08909
C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also ...
 1125-1323 4.68e-40

C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. The precise function of the START domain in this subgroup is unclear.


Pssm-ID: 176918  Cd Length: 205  Bit Score: 147.37  E-value: 4.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1125 RSFLVDRVIDLIRDHSDQWKNWTIEGSFRGIEISSKRPSDSHPLKTFRVWLNVPAGPKSVMMRLLKERYTWDSSVINWRH 1204
Cdd:cd08909     8 QTYLESLIQNLQKEAKEKFKGWISCSSSDNTELAYKKVGDGNPLRLWKVSVEVEAPPSVVLNRVLRERHLWDEDFLQWKV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1205 LEYVSApDTDIHQYVVNETIGHPTKDCHVARFHSSGLTeiRGACAIAERSVKCTEDQLLGGVSATIFDQRFLIEPVSGGQ 1284
Cdd:cd08909    88 VETLDK-QTEVYQYVLNCMAPHPSRDFVVLRSWRTDLP--KGACSLVSVSVEHEEAPLLGGVRAVVLDSQYLIEPCGSGK 164

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 392894424 1285 SRVNYIARVDLKGRSLQWYNKSFGSIMCRHLDRLRESFH 1323
Cdd:cd08909   165 SRLTHICRVDLKGHSPEWYNKGFGHLCAAEAARIRNSFQ 203
START_STARD8-like cd08907
C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also ...
 1125-1322 1.89e-39

C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD8 (also known as deleted in liver cancer 3/DLC3, and Arhgap38) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. The precise function of the START domain in this subgroup is unclear.


Pssm-ID: 176916  Cd Length: 205  Bit Score: 145.83  E-value: 1.89e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1125 RSFLVDRVIDLIRDHSDQWKNWTIEGSFRGIEISSKRPSDSHPLKTFRVWLNVPAGPKSVMMRLLKERYTWDSSVINWRH 1204
Cdd:cd08907     8 RAYLEDNVQCLLREASERFKGWHSAPGPDNTELACKKVGDGHPLRLWKVSTEVEAPPSVVLQRVLRERHLWDEDLLHSQV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1205 LEYVSaPDTDIHQYVVNETIGHPTKDCHVARFHSSGLTeiRGACAIAERSVKCTEDQLLGGVSATIFDQRFLIEPVSGGQ 1284
Cdd:cd08907    88 IEALE-NNTEVYHYVTDSMAPHPRRDFVVLRMWRSDLP--RGGCLLVSQSVDHDNPQLEAGVRAVLLTSQYLIEPCGMGR 164

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 392894424 1285 SRVNYIARVDLKGRSLQWYNKSFGSIMCRHLDRLRESF 1322
Cdd:cd08907   165 SRLTHICRADLRGRSPDWYNKVFGHLCAMEVARIRDSF 202
START_STARD12-like cd08908
C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also ...
 1127-1322 2.89e-34

C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD12 (also known as DLC-1, Arhgap7, and p122-RhoGAP) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subgroup also have an N-terminal SAM (sterile alpha motif) domain and a RhoGAP domain, and have a SAM-RhoGAP-START domain organization. The precise function of the START domain in this subgroup is unclear.


Pssm-ID: 176917  Cd Length: 204  Bit Score: 130.90  E-value: 2.89e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1127 FLVDRVIDLIRDHSDQWKNWTIEGSFRGIEISSKRPSDSHPLKTFRVWLNVPAGPKSVMMRLLKERYTWDSSVINWRHLE 1206
Cdd:cd08908    10 FLQDCVDGLFKEVKEKFKGWVSYSTSEQAELSYKKVSEGPPLRLWRTTIEVPAAPEEILKRLLKEQHLWDVDLLDSKVIE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1207 YVSApDTDIHQYVVNETIGHPTKDCHVARFHSSGLTeiRGACAIAERSVKcTEDQLLGGVSATIFDQRFLIEPVSGGQSR 1286
Cdd:cd08908    90 ILDS-QTEIYQYVQNSMAPHPARDYVVLRTWRTNLP--KGACALLATSVD-HDRAPVAGVRVNVLLSRYLIEPCGSGKSK 165

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 392894424 1287 VNYIARVDLKGRSLQWYNKSFGSIMCRHLDRLRESF 1322
Cdd:cd08908   166 LTYMCRIDLRGHMPEWYTKSFGHLCAAEVVKIRDSF 201
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 913-1101 1.61e-30

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 119.88  E-value: 1.61e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  913 TVGIFRKNGVKSRIAELRSIIESysgntdvfvGENLLDSTQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVE 992
Cdd:cd04394    37 TEGLFRKSGSVVRQKELKAKLEG---------GEACLSSALPCDVAGLLKQFFRELPEPLLPYDLHEALLKAQELPTDEE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  993 RITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQLGAsrldkvtpgnrrhktvGATGLPS 1072
Cdd:cd04394   108 RKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLFQSEE----------------GGEKMSS 171

                         170       180
                  ....*....|....*....|....*....
gi 392894424 1073 EKEMKEARACQLcLTMLIEYVQTVFMVPD 1101
Cdd:cd04394   172 STEKRLRLQAAV-VQTLIDNASNIGIVPD 199
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 895-1100 3.97e-28

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 113.30  E-value: 3.97e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  895 LPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSiiesysgNTDVFVGENLLDSTQVHDVADLLKQYFRDLPEPLMT 974
Cdd:cd04376     9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLRE-------EFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  975 VKMSEVFANICSVVPDvERITALQYAILLLPDENREALKTLLLFLKEVSRNSQV-----------NNMTAQNLSVCFTPS 1043
Cdd:cd04376    82 RELYTAFIGTALLEPD-EQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLATIFGPN 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 392894424 1044 LFQLGASRLDKVTPGNRRhktvgatglpsekeMKEARACQLCLTMLIEYVQTVFMVP 1100
Cdd:cd04376   161 LLHKQKSGEREFVQASLR--------------IEESTAIINVVQTMIDNYEELFMVS 203
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 880-1045 3.15e-27

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 110.19  E-value: 3.15e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNTDVFVGENLldSTQVHDVAD 959
Cdd:cd04398     1 FGVPLEDLILREGDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLLISPEDY--ESDIHSVAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  960 LLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVC 1039
Cdd:cd04398    79 LLKLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLAII 158


                  ....*.
gi 392894424 1040 FTPSLF 1045
Cdd:cd04398   159 WGPTLM 164
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 912-1100 4.17e-26

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 107.82  E-value: 4.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  912 ETVGIFRKNGVKSRIAELRSIIESysgntDVFVGENLLDSTQVHDVADLLKQYFRDLPEPLMTVKMSEVFANiCSVVPDV 991
Cdd:cd04391    39 ETEGILRIPGSAQRVKFLCQELEA-----KFYEGTFLWDQVKQHDAASLLKLFIRELPQPLLTVEYLPAFYS-VQGLPSK 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  992 E-RITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFqlgasrldkvTPGNRRHKTVgaTGL 1070
Cdd:cd04391   113 KdQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVAMIMAPNLF----------PPRGKHSKDN--ESL 180

                         170       180       190
                  ....*....|....*....|....*....|
gi 392894424 1071 PSEKEMKeARACQLCLTMlIEYVQTVFMVP 1100
Cdd:cd04391   181 QEEVNMA-AGCANIMRLL-IRYQDLLWTVP 208
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 880-1044 1.43e-25

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 105.50  E-value: 1.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRTGYFLPRPIL--EVMKFLRNIAPETVGIFRKNGVKSRIAELRsiiESYSGNTDVfvgeNLLDSTQVHDV 957
Cdd:cd04404     6 FGVSLQFLKEKNPEQEPIPPVvrETVEYLQAHALTTEGIFRRSANTQVVKEVQ---QKYNMGEPV----DFDQYEDVHLP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  958 ADLLKQYFRDLPEPLMTVKMSEVFANICSVvPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLS 1037
Cdd:cd04404    79 AVILKTFLRELPEPLLTFDLYDDIVGFLNV-DKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLA 157


                  ....*..
gi 392894424 1038 VCFTPSL 1044
Cdd:cd04404   158 VVFGPNL 164
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 915-1046 3.84e-25

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 103.93  E-value: 3.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  915 GIFRKNGVKSRIAELRSIIESYSGNTDVFVGENlldstQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERI 994
Cdd:cd04385    35 GIYRKNGKNSSVKKLLEAFRKDARSVQLREGEY-----TVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAELENKDERI 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 392894424  995 TALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQ 1046
Cdd:cd04385   110 ARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQ 161
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 880-1057 2.98e-24

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 101.61  E-value: 2.98e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRTGyfLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESysGntdvfvGENLLDSTQVHDVAD 959
Cdd:cd04402     2 FGQPLSNICEDDN--LPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNS--G------VEVDLKAEPVLLLAS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  960 LLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVC 1039
Cdd:cd04402    72 VLKDFLRNIPGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVC 151

                         170       180
                  ....*....|....*....|....
gi 392894424 1040 FTPSLFQLGASR------LDKVTP 1057
Cdd:cd04402   152 IAPSLLWPPASSelqnedLKKVTS 175
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 879-1044 5.06e-22

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 95.60  E-value: 5.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  879 VFGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNTDVfvgenLLDSTQVHDVA 958
Cdd:cd04386     4 VFGTPLEEHLKRTGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGTFSLPL-----DEFYSDPHAVA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  959 DLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSV 1038
Cdd:cd04386    79 SALKSYLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAI 158


                  ....*.
gi 392894424 1039 CFTPSL 1044
Cdd:cd04386   159 VLAPNL 164
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 880-1091 5.81e-22

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 94.81  E-value: 5.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRTGyflPRPILeVMKFLRNI---APETVGIFRKNGVKSRIAELRSIIESYSGNTDvfvgenlLDSTQVHD 956
Cdd:cd04377     1 FGVSLSSLTSEDR---SVPLV-LEKLLEHIemhGLYTEGIYRKSGSANKIKELRQGLDTDPDSVN-------LEDYPIHV 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  957 VADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNL 1036
Cdd:cd04377    70 ITSVLKQWLRELPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANAL 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 392894424 1037 SVCFTPSLFqlgasrldkvtpgnRRHKTVgatglPSEKEMKEARACQLCLTMLIE 1091
Cdd:cd04377   150 AIVFAPCIL--------------RCPDTA-----DPLQSLQDVSKTTTCVETLIK 185
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 896-1065 1.26e-20

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 90.98  E-value: 1.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  896 PRPI---LE-VMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYsGNTDVfvgeNLLDSTqVHDVADLLKQYFRDLPEP 971
Cdd:cd04373    12 EKPIpifLEkCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQD-HNLDL----VSKDFT-VNAVAGALKSFFSELPDP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  972 LMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQLGASR 1051
Cdd:cd04373    86 LIPYSMHLELVEAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPTLMRPDFTS 165

                         170
                  ....*....|....
gi 392894424 1052 LDKVTpGNRRHKTV 1065
Cdd:cd04373   166 MEALS-ATRIYQTI 178
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 912-1044 1.22e-19

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 88.23  E-value: 1.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  912 ETVGIFRKNGVKSRIAELRSIIESysGNTDVfvgeNLLDS--TQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVP 989
Cdd:cd04395    35 ETVGIYRVPGNNAAISALQEELNR--GGFDI----DLQDPrwRDVNVVSSLLKSFFRKLPEPLFTNELYPDFIEANRIED 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 392894424  990 DVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSL 1044
Cdd:cd04395   109 PVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTL 163
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 912-1044 1.97e-19

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 87.83  E-value: 1.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  912 ETVGIFRKNGVKSRIAELRSIIESYSGNTDVFVgeNLLDST-QVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPD 990
Cdd:cd04374    45 NEQGLYRVVGVNSKVQKLLSLGLDPKTSTPGDV--DLDNSEwEIKTITSALKTYLRNLPEPLMTYELHNDFINAAKSENL 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 392894424  991 VERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSL 1044
Cdd:cd04374   123 ESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTL 176
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 879-1046 1.42e-18

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 85.25  E-value: 1.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  879 VFGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETvGIFRKNGVKSRIAELRSIIESysgntdvfvgENLLDSTQ----- 953
Cdd:cd04384     2 VFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVD-GIYRLSGIASNIQRLRHEFDS----------EQIPDLTKdvyiq 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  954 -VHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMT 1032
Cdd:cd04384    71 dIHSVSSLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMH 150

                         170
                  ....*....|....
gi 392894424 1033 AQNLSVCFTPSLFQ 1046
Cdd:cd04384   151 AKNLAIVWAPNLLR 164
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 880-1044 1.46e-18

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 84.79  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRT----GYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESySGNTDvfvgenlLDSTQVH 955
Cdd:cd04381     1 FGASLSLAVERSrchdGIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNR-RESPN-------LEEYEPP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  956 DVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQN 1035
Cdd:cd04381    73 TVASLLKQYLRELPEPLLTKELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQN 152


                  ....*....
gi 392894424 1036 LSVCFTPSL 1044
Cdd:cd04381   153 ISIVLSPTV 161
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 878-1092 1.47e-18

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 85.92  E-value: 1.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  878 AVFGVGLDVIFNRTGYfLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIesysgNTDVFVGENLLDST-QVHD 956
Cdd:cd04396    16 AISIVDEDGEQYVYGY-IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIF-----STPPDYGKSFDWDGyTVHD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  957 VADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDV-----------------ERITALQYAILLLPDENREALKTLLLFL 1019
Cdd:cd04396    90 AASVLRRYLNNLPEPLVPLDLYEEFRNPLRKRPRIlqymkgrineplntdidQAIKEYRDLITRLPNLNRQLLLYLLDLL 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392894424 1020 KEVSRNSQVNNMTAQNLSVCFTPSLFqlgasrldkvtpGNRRHktvgatglpsEKEMKEARACQLCLTMLIEY 1092
Cdd:cd04396   170 AVFARNSDKNLMTASNLAAIFQPGIL------------SHPDH----------EMDPKEYKLSRLVVEFLIEH 220
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 899-1044 1.70e-18

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 85.59  E-value: 1.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  899 ILEVMKFL-RNIAPEtvGIFRKNGVKSRIAELRSIIESysGNT-DVFVGEnlldsTQVHDVADLLKQYFRDLPEPLMTVK 976
Cdd:cd04392    13 IYQLIEYLeKNLRVE--GLFRKPGNSARQQELRDLLNS--GTDlDLESGG-----FHAHDCATVLKGFLGELPEPLLTHA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  977 MSEVF---ANIC--------SVVPDVER-ITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSL 1044
Cdd:cd04392    84 HYPAHlqiADLCqfdekgnkTSAPDKERlLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHL 163
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 880-1050 2.18e-18

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 85.21  E-value: 2.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRTGYFLPRPILeVMKFLRNI---APETVGIFRKNGVKSRIAELRSIIESYSGNTDVfvGENLLDSTQVhd 956
Cdd:cd04379     1 FGVPLSRLVEREGESRDVPIV-LQKCVQEIerrGLDVIGLYRLCGSAAKKKELRDAFERNSAAVEL--SEELYPDINV-- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  957 VADLLKQYFRDLPEPLMTVKMSEVFANICSVVP--DVERITALQYAIL-LLPDENREALKTLLLFLKEVSRNSQVNNMTA 1033
Cdd:cd04379    76 ITGVLKDYLRELPEPLITPQLYEMVLEALAVALpnDVQTNTHLTLSIIdCLPLSAKATLLLLLDHLSLVLSNSERNKMTP 155

                         170
                  ....*....|....*..
gi 392894424 1034 QNLSVCFTPSLFQLGAS 1050
Cdd:cd04379   156 QNLAVCFGPVLMFCSQE 172
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 879-1044 1.35e-17

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 82.41  E-value: 1.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  879 VFGVGLDVIFNRT-----GYFLPRPILEVMKFL---RNIAPEtvGIFRKNGVKSRIAELRsiiESYSGNTDVfvgeNLLD 950
Cdd:cd04400     1 IFGSPLEEAVELSshkynGRDLPSVVYRCIEYLdknRAIYEE--GIFRLSGSASVIKQLK---ERFNTEYDV----DLFS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  951 STQVHD---VADLLKQYFRDLPEPLMTVKMSEVFANICSVVPD-VERITALQYAILLLPDENREALKTLLLFLKEVSRNS 1026
Cdd:cd04400    72 SSLYPDvhtVAGLLKLYLRELPTLILGGELHNDFKRLVEENHDrSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHS 151

                         170
                  ....*....|....*...
gi 392894424 1027 QVNNMTAQNLSVCFTPSL 1044
Cdd:cd04400   152 DVNKMNLRNVCIVFSPTL 169
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 880-1056 1.60e-17

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 82.28  E-value: 1.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESysGNTDVFVgenLLDSTQVHDVAD 959
Cdd:cd04387     1 FGVKISTVTKRERSKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDT--NNKDVSV---MLSEMDVNAIAG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  960 LLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVC 1039
Cdd:cd04387    76 TLKLYFRELPEPLFTDELYPNFAEGIALSDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATV 155

                         170
                  ....*....|....*..
gi 392894424 1040 FTPSLFQLGASRLDKVT 1056
Cdd:cd04387   156 FGPTLLRPSEKESKIPT 172
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 878-1046 7.14e-17

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 80.56  E-value: 7.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  878 AVFGVGLDVIFNRTGYFLPR--PIL--EVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIE-----SYSGNTDVfvgenl 948
Cdd:cd04390     1 GVFGQRLEDTVAYERKFGPRlvPILveQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDagerpSFDSDTDV------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  949 ldstqvHDVADLLKQYFRDLPEPLMTVKMSEVFAnICSVVPDVERITALQ---YAILLLPDENREALKTLLLFLKEVSRN 1025
Cdd:cd04390    75 ------HTVASLLKLYLRELPEPVIPWAQYEDFL-SCAQLLSKDEEKGLGelmKQVSILPKVNYNLLSYICRFLDEVQSN 147

                         170       180
                  ....*....|....*....|.
gi 392894424 1026 SQVNNMTAQNLSVCFTPSLFQ 1046
Cdd:cd04390   148 SSVNKMSVQNLATVFGPNILR 168
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 880-1046 2.87e-16

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 78.50  E-value: 2.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRTGyflPRPILeVMKFLRNIAPE---TVGIFRKNGVKSRIAELRSIIESYSGNTDvfvgenlLDSTQVHD 956
Cdd:cd04407     1 FGVRVGSLTSNKT---SVPIV-LEKLLEHVEMHglyTEGIYRKSGSANRMKELHQLLQADPENVK-------LENYPIHA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  957 VADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALqYAIL-LLPDENREALKTLLLFLKEVSRNSQVNNMTAQN 1035
Cdd:cd04407    70 ITGLLKQWLRELPEPLMTFAQYNDFLRAVELPEKQEQLQAI-YRVLeQLPTANHNTLERLIFHLVKVALEEDVNRMSPNA 148

                         170
                  ....*....|.
gi 392894424 1036 LSVCFTPSLFQ 1046
Cdd:cd04407   149 LAIVFAPCLLR 159
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 880-1103 3.29e-16

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 78.95  E-value: 3.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRTG-----------YFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNTDVFVGENL 948
Cdd:cd04397     1 FGVPLEILVEKFGadstlgvgpgkLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDLSKENP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  949 LDstqvhdVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQV 1028
Cdd:cd04397    81 VQ------LAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSHI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1029 NN-----MTAQNLSVCFTPSLFQlgaSRLDKVTPGNRRHKTVGATGLpsekemkearacqlcltmLIEYVQTVFMVPDGL 1103
Cdd:cd04397   155 DEetgskMDIHNLATVITPNILY---SKTDNPNTGDEYFLAIEAVNY------------------LIENNEEFCEVPDEL 213
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 879-1047 5.37e-16

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 77.50  E-value: 5.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  879 VFGVGLDVIFNR--TGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESysgNTDVFVGENlldsTQVHD 956
Cdd:cd04393     2 VFGVPLQELQQAgqPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDS---GEEVDLSKE----ADVCS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  957 VADLLKQYFRDLPEPLMTvkmSEVFANICSVVPDVER----ITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMT 1032
Cdd:cd04393    75 AASLLRLFLQELPEGLIP---ASLQIRLMQLYQDYNGedefGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMT 151

                         170
                  ....*....|....*
gi 392894424 1033 AQNLSVCFTPSLFQL 1047
Cdd:cd04393   152 AENLAAVFGPDVFHV 166
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 880-1046 1.12e-15

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 76.66  E-value: 1.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRsiiesYSGNTDVFVGENLLDSTQVHDVAD 959
Cdd:cd04403     1 FGCHLEALCQRENSTVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLR-----FAVDHDEKLDLDDSKWEDIHVITG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  960 LLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVC 1039
Cdd:cd04403    76 ALKLFFRELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIV 155


                  ....*..
gi 392894424 1040 FTPSLFQ 1046
Cdd:cd04403   156 FGPTLLR 162
START pfam01852
START domain;
1144-1321 3.57e-15

START domain;


Pssm-ID: 426476  Cd Length: 205  Bit Score: 75.90  E-value: 3.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  1144 KNWTIEGSFRGIEISSKRPSDSHpLKTFRVWLNVPAGPKSVMMRLLK---ERYTWDSSVINWRHLEYVSaPDTDIHQYVV 1220
Cdd:pfam01852   19 PGWVLLSSNENGDVVLQIVEPDH-GEASRASGVVPMVAALLVAELLKdmeYRAQWDKDVRSAETLEVIS-SGGDLQYYVA 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  1221 NETIGHPtkdcHVAR---FHSSGLTEIRGACAIAERSV-KCTEDQLLGGVSATIFDQRFLIEPVSGGQSRVNYIARVDLK 1296
Cdd:pfam01852   97 ALVAPSP----LSPRdfvFLRYWRRLGGGVYVIVDRSVtHPQFPPSSGYVRAERLPSGYLIQPCGNGPSKVTWVSHADLK 172

                          170       180       190
                   ....*....|....*....|....*....|...
gi 392894424  1297 GRSLQWYNKSFGS--------IMCRHLDRLRES 1321
Cdd:pfam01852  173 GWLPSWLLRSLYKsgmpegakTWVATLQRLCEK 205
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 915-1044 4.45e-15

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 75.54  E-value: 4.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  915 GIFRKNGVKSRIAELRSIIESysgntdvfvGENLLDSTQV--HDVADLLKQYFRDLPEPLMTVKMSEVF----------- 981
Cdd:cd04378    36 GIYRVSGSKARVEKLCQAFEN---------GKDLVELSELspHDISSVLKLFLRQLPEPLILFRLYNDFialakeiqrdt 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392894424  982 -----ANICSVVPDVerITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSL 1044
Cdd:cd04378   107 eedkaPNTPIEVNRI--IRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPTL 172
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 1144-1309 1.69e-14

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


Pssm-ID: 214575  Cd Length: 205  Bit Score: 73.62  E-value: 1.69e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424   1144 KNWTIEGSFRGIEISSKRPSDSH-PLKTFRVWLNVPAGP----KSVMMRLlKERYTWDSSVINWRHLEYVSaPDTDIHQY 1218
Cdd:smart00234   18 EGWVLSSENENGDEVRSIFSPGRkPGEAFRLVGVVPMVCadlvEELMDDL-EYRPEWDKNVAKAETLEVID-NGTVIYHY 95

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424   1219 VVNETIGH--PTKDCHVARFHSSGlteiRGACAIAERSVKCTED-QLLGGVSATIFDQRFLIEPVSGGQSRVNYIARVDL 1295
Cdd:smart00234   96 VSKFAAGPvsPRDFVFVRYWREDE----DGSYAVVDVSVTHPTSpPESGYVRAENLPSGLLIEPLGNGPSKVTWVSHADL 171

                           170
                    ....*....|....
gi 392894424   1296 KGRSLQWYNKSFGS 1309
Cdd:smart00234  172 KGWLPHWLVRSLIK 185
SAM_DLC1,2-like cd09538
SAM domain of DLC1,2-like subfamily; SAM (sterile alpha motif) domain of DLC-1,2-like (Deleted ...
 444-499 7.34e-14

SAM domain of DLC1,2-like subfamily; SAM (sterile alpha motif) domain of DLC-1,2-like (Deleted in liver cancer) subfamily is a protein-protein interaction domain located at the N-terminus of the protein. Members of this subfamily do not form dimers/oligomers through their SAM domains. They participate in regulation of cell migration and lipid transfer. SAM domain of human DLC1 protein contains the EF1A1 (eukaryotic elongation factor) binding motif, thus SAM facilitates recruitment of EF1A1 to the membrane periphery and suppresses cell migration. Human Dlc2 gene is known as a tumor suppressor gene. It was found underexpressed in hepatocellular carcinoma.


Pssm-ID: 188937  Cd Length: 60  Bit Score: 67.44  E-value: 7.34e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  444 VDACSWLRKAGFSKYADQFEEGKLPI-VAS--KDPTLLEAD-LRALNRRIDVLNRCHTMK 499
Cdd:cd09538     1 KEACKWLRAAGFPQYAQLYEDSQFPIdISAvkRDHDFLDRDsLQALIRRLNTLNKCASMK 60
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 915-1044 5.61e-13

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 69.45  E-value: 5.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  915 GIFRKNGVKSRIAELRSIIESysgntdvfvGENLLDSTQV--HDVADLLKQYFRDLPEPLMTVKMSEVF----------- 981
Cdd:cd04409    36 GIYRVNGAKSRVEKLCQAFEN---------GKDLVELSELspHDISNVLKLYLRQLPEPLILFRLYNEFiglakesqhvn 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392894424  982 -------------ANICSvvpDVERITaLQYAILL--LPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSL 1044
Cdd:cd04409   107 etqeakknsdkkwPNMCT---ELNRIL-LKSKDLLrqLPAPNYNTLQFLIVHLHRVSEQAEENKMSASNLGIIFGPTL 180
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 915-1044 6.60e-13

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 68.70  E-value: 6.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  915 GIFRKNGVKSRIAELRSIIESYSGNTDVfvGENLLDSTQVhdVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERI 994
Cdd:cd04372    36 GLYRVSGFAEEIEDVKMAFDRDGEKADI--SATVYPDINV--ITGALKLYFRDLPIPVITYDTYPKFIDAAKISNPDERL 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 392894424  995 TALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSL 1044
Cdd:cd04372   112 EAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTL 161
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 913-1046 3.63e-12

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 66.56  E-value: 3.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  913 TVGIFRKNGVKSRIAELRSIIESYSGNTDvfvgenlLDSTQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVE 992
Cdd:cd04406    33 TEGIYRKSGSTNKIKELRQGLDTDANSVN-------LDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERRE 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 392894424  993 RITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQ 1046
Cdd:cd04406   106 TVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILR 159
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 880-1044 1.87e-11

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 64.36  E-value: 1.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  880 FGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESysgntdvfvGENLL-DSTQVHD-- 956
Cdd:cd04383     3 FNGSLEEYIQDSGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFER---------GEDPLaDDQNDHDin 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  957 -VADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQN 1035
Cdd:cd04383    74 sVAGVLKLYFRGLENPLFPKERFEDLMSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYN 153


                  ....*....
gi 392894424 1036 LSVCFTPSL 1044
Cdd:cd04383   154 LAICFGPTL 162
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 912-1045 5.90e-11

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 63.08  E-value: 5.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  912 ETVGIFRKNGVKsriAELRSIIESY-SGNTDVfvgenLLDSTQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPD 990
Cdd:cd04382    34 TEEGLYRVSGSE---REVKALKEKFlRGKTVP-----NLSKVDIHVICGCLKDFLRSLKEPLITFALWKEFMEAAEILDE 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 392894424  991 VERITALQYAILLLPDENREALKTLLLFLKEVSRnSQVNNMTAQNLSVCFTPSLF 1045
Cdd:cd04382   106 DNSRAALYQAISELPQPNRDTLAFLILHLQRVAQ-SPECKMDINNLARVFGPTIV 159
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 915-1046 7.87e-08

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 54.05  E-value: 7.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  915 GIFRKNGVKSRIAELRSIIESysgntdvfvGENLLDSTQV--HDVADLLKQYFRDLPEPLMTVKMSEVF----------- 981
Cdd:cd04408    36 GIYRISGSKARVEKLCQAFEN---------GRDLVDLSGHspHDITSVLKHFLKELPEPVLPFQLYDDFialakelqrds 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392894424  982 ---ANICSVVPDVerITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQ 1046
Cdd:cd04408   107 ekaAESPSIVENI--IRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTLLR 172
START cd00177
Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family ...
 1145-1306 1.88e-07

Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and related domains, such as the START domain of the Arabidopsis homeobox protein GLABRA 2. The mammalian STARDs are grouped into 8 subfamilies. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some members of this family, specific lipids that bind in this pocket are known; these include cholesterol (STARD1/STARD3/ STARD4/STARD5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2/ STARD7/STARD10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). The START domain is found either alone or in association with other domains. Mammalian STARDs participate in the control of various cellular processes including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease. The Arabidopsis homeobox protein GLABRA 2 suppresses root hair formation in hairless epidermal root cells.


Pssm-ID: 176851 [Multi-domain]  Cd Length: 193  Bit Score: 52.73  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1145 NWTIEGSFRGIEISSKrPSDSHPLKTFRVWLNVPAGPKSVM--MRLLKERYTWDSSVINWRHLEYVSApDTDIHQYVVNE 1222
Cdd:cd00177    16 GWKLVKEKDGVKIYTK-PYEDSGLKLLKAEGVIPASPEQVFelLMDIDLRKKWDKNFEEFEVIEEIDE-HTDIIYYKTKP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424 1223 TIGHPTKD--CHVARFHSSGlteirGACAIAERSVKCTEDQLLGG-VSATIFDQRFLIEPVSGGQSRVNYIARVDLKGRS 1299
Cdd:cd00177    94 PWPVSPRDfvYLRRRRKLDD-----GTYVIVSKSVDHDSHPKEKGyVRAEIKLSGWIIEPLDPGKTKVTYVLQVDPKGSI 168


                  ....*...
gi 392894424 1300 LQW-YNKS 1306
Cdd:cd00177   169 PKSlVNSA 176
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 956-1028 2.46e-07

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 53.10  E-value: 2.46e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392894424  956 DVADLLKQYFRDLPEPLMTVKMSEVFANICSV-VPDVER--ITALQYAILLLPDENREALKTLLLFLKEVSRNSQV 1028
Cdd:cd04405   107 LLFKTIAKYYGQLKEPLLTFHLFDIFVGILELlGNGKEEvaLEALQLCLLLLPPASRRELRRLLRFMARAAKNDMP 182
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 913-1042 1.14e-06

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 50.47  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  913 TVGIFRKNGVKSRIAELRSIIESYSgntdvFVGENLLDstqVHDVADLLKQYFRDLPEPLMTvkmSEVFANICSVVPDVE 992
Cdd:cd04389    40 TEGIFRVPGDIDEVNELKLRVDQWD-----YPLSGLED---PHVPASLLKLWLRELEEPLIP---DALYQQCISASEDPD 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 392894424  993 RITALqyaILLLPDENREALKTLLLFLKEVSRNSQV--NNMTAQNLSVCFTP 1042
Cdd:cd04389   109 KAVEI---VQKLPIINRLVLCYLINFLQVFAQPENVahTKMDVSNLAMVFAP 157
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 924-1046 4.88e-06

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 48.72  E-value: 4.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  924 SRIAELRSIIESYSGNTDvfvgenlLDSTQVHDVADLLKQYFRDLPEPLMTvkmSEVFANICSVVPDVerITALQYAILL 1003
Cdd:cd04388    43 SSLTELRQILDCDAASVD-------LEQFDVAALADALKRYLLDLPNPVIP---APVYSEMISRAQEV--QSSDEYAQLL 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 392894424 1004 --------LPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQ 1046
Cdd:cd04388   111 rklirspnLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLLFR 161
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 893-1046 5.88e-04

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 42.71  E-value: 5.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894424  893 YFLPRPILEVMKFLRNIAPETVGIFRKNGVKS-RIAELRSIIESYSGNTDVFVGENlldstqVHDVADLLKQYFRDLPEP 971
Cdd:cd04380    48 LSIPKEIWRLVDYLYTRGLAQEGLFEEPGLPSePGELLAEIRDALDTGSPFNSPGS------AESVAEALLLFLESLPDP 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392894424  972 LMTvkmSEVFANI--CSVVPDVERITALQYAillLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQ 1046
Cdd:cd04380   122 IIP---YSLYERLleAVANNEEDKRQVIRIS---LPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLLR 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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