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    golg-4 GRIP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    golg-4
    Official Full Name
    GRIP domain-containing protein
    Primary source
    WormBase:WBGene00010306
    Locus tag
    CELE_F59A2.6
    See related
    AllianceGenome:WB:WBGene00010306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi vesicle transport. Predicted to be active in Golgi apparatus. Orthologous to human GOLGA4 (golgin A4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See golg-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    18
    Sequence:
    Chromosome: III; NC_003281.10 (3405568..3425468)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Pre-mRNA cleavage complex subunit Clp1 C-terminal domain-containing protein;Protein clpf-1 Neighboring gene Nuclear Pore complex Protein Neighboring gene ACT domain-containing protein Neighboring gene ncRNA Neighboring gene protein-histidine N-methyltransferase Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene Spaetzle domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic impairment of autophagy intensifies expanded polyglutamine toxicity in Caenorhabditis elegans. Khan LA, et al. Biochem Biophys Res Commun, 2008 Apr 11. PMID 18261464
    2. The golgin coiled-coil proteins of the Golgi apparatus. Munro S. Cold Spring Harb Perspect Biol, 2011 Jun 1. PMID 21436057, Free PMC Article
    3. AP-1 Recruits SMAP-1/SMAPs to the trans-Golgi Network to Promote Sorting in Polarized Epithelia. Wang S, et al. Front Cell Dev Biol, 2021. PMID 34901019, Free PMC Article
    4. SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion. Wang X, et al. J Cell Biol, 2022 Jul 4. PMID 35604368, Free PMC Article
    5. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Shen X, et al. Cell Calcium, 2008 May. PMID 17854888

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GRIP domain-containing protein
    NP_001355507.1
    • Confirmed by transcript evidence
    NP_001355508.1
    • Confirmed by transcript evidence
    NP_001355509.1
    • Confirmed by transcript evidence
    NP_001355510.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3405568..3425468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001368620.3 → NP_001355510.1  GRIP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6PAV3
      Conserved Domains (4) summary
      PTZ00121
      Location:261 → 959
      PTZ00121; MAEBL; Provisional
      smart00755
      Location:1502 → 1550
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:535 → 1412
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04211
      Location:1374 → 1479
      SH3_and_anchor; SH3 domain protein

    2. NM_001368617.3 → NP_001355507.1  GRIP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6PCP8
      Conserved Domains (4) summary
      smart00755
      Location:1572 → 1620
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:577 → 1442
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04211
      Location:1444 → 1549
      SH3_and_anchor; SH3 domain protein
      pfam12128
      Location:207 → 884
      DUF3584; Protein of unknown function (DUF3584)

    3. NM_001368619.3 → NP_001355509.1  GRIP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6NI91
      Conserved Domains (4) summary
      smart00755
      Location:1530 → 1578
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:160 → 458
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:535 → 1400
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04211
      Location:1402 → 1507
      SH3_and_anchor; SH3 domain protein

    4. NM_001368618.3 → NP_001355508.1  GRIP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6N624
      Conserved Domains (4) summary
      smart00755
      Location:1544 → 1592
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:577 → 1454
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04211
      Location:1416 → 1521
      SH3_and_anchor; SH3 domain protein
      pfam12128
      Location:207 → 884
      DUF3584; Protein of unknown function (DUF3584)
    Nucleotide Protein
    Heading Accession and Version

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