SWA1 transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: SWA1
Official Full Name: transducin family protein / WD-40 repeat family protein
Primary source: TAIR:AT2G47990
Locus tag: AT2G47990
See related: Araport:AT2G47990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: EDA13; EDA19; EMBRYO SAC DEVELOPMENT ARREST 13; EMBRYO SAC DEVELOPMENT ARREST 19; SLOW WALKER1; T9J23.30
Summary: Encodes a transducin family nucleolar protein with six WD40 repeats that is most likely involved in 18S rRNA biogenesis. The slow progression of the gametophytic division cycles in swa1 suggested that the SWA1 protein is required for the normal progression of mitotic division cycles through the regulation of cell metabolism. Ubiquitously expressed throughout the plant.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See SWA1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (19636867..19638678, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLOW WALKER1 most likely plays a role in rRNA biogenesis that is essential for the progression of the mitotic division cycles during gametogenesis in plants. [SLOW WALKER1] [SWA1]
Title: SLOW WALKER1, essential for gametogenesis in Arabidopsis, encodes a WD40 protein involved in 18S ribosomal RNA biogenesis.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

At-8.5BJ-393 (e-PCR)
- UniSTS:229391

At-8BJ-050 (e-PCR)
- UniSTS:229419

NM_130366.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo sac development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within megagametogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

Go to the top of the page Help

Preferred Names: transducin family protein / WD-40 repeat family protein

NP_182320.1

SLOW WALKER1 (SWA1); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), U3 small nucleolar RNA-associated protein 15, C-terminal (InterPro:IPR018983), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT3G49660.1); Has 33528 Blast hits to 20320 proteins in 654 species: Archae - 34; Bacteria - 4945; Metazoa - 12077; Fungi - 7782; Plants - 4404; Viruses - 6; Other Eukaryotes - 4280 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

19636867..19638678 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130366.3 → NP_182320.1 transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_182320.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O82266, Q8GXN5

UniProtKB/TrEMBL

A0A178VXZ3, A0A5S9X7Y1

Conserved Domains (4) summary

COG2319
Location:96 → 329

WD40; WD40 repeat [General function prediction only]

pfam09384
Location:381 → 520

UTP15_C; UTP15 C terminal

sd00039
Location:97 → 133

7WD40; WD40 repeat [structural motif]

cl02567
Location:94 → 328

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...