NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15227184|ref|NP_182320|]
View 

transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

U3 small nucleolar RNA-associated protein 15( domain architecture ID 11456900)

U3 small nucleolar RNA-associated protein 15 is involved in nucleolar processing of pre-18S ribosomal RNA

Gene Ontology:  GO:0042274|GO:0006364|GO:0003723

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 381-523 1.94e-43

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


:

Pssm-ID: 462782  Cd Length: 146  Bit Score: 151.10  E-value: 1.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184   381 EKPSKDDYLVKEKKGLKLTRHDKLLKKFRHKEALVSVLEE--KKPANVVAVMEELVARRKLMKCVSNMEEGELGMLLGFL 458
Cdd:pfam09384   2 YKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPgvKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLLKFL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15227184   459 QRYCTVQRYSGLLMGLTKKVLETRAEDIKGKNEFKGLLRNLKREVNQEIRIQQSLLEIQGVIAPL 523
Cdd:pfam09384  82 IKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
53-346 6.45e-41

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 6.45e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  53 SSVAALAFSPVHPHSLAVAHSATVSL-FSSQSLSSSRRFSFRDVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTL 131
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLwDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 132 RSHSAPARFVKY-PvqDKLHLVSGGDDGVVKYWDVAGATVISDLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDARv 210
Cdd:COG2319 159 TGHSGAVTSVAFsP--DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA- 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 211 hTSNWIAEIN-HGLPVEDVVYLPSGGLIATAGG-NSVKVWDLiGGGKMVCSMESHNKTVTSLRVarmeSAESR-LVSVAL 287
Cdd:COG2319 235 -TGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWDL-ATGELLRTLTGHSGGVNSVAF----SPDGKlLASGSD 308

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 288 DGYMKVFDYGRAKVTYSMR-FPAPLMSLGLSPDGSTRVIGGSNGMVfagkkKVRDVVGGQ 346
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTV-----RLWDLATGE 363
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 381-523 1.94e-43

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 151.10  E-value: 1.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184   381 EKPSKDDYLVKEKKGLKLTRHDKLLKKFRHKEALVSVLEE--KKPANVVAVMEELVARRKLMKCVSNMEEGELGMLLGFL 458
Cdd:pfam09384   2 YKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPgvKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLLKFL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15227184   459 QRYCTVQRYSGLLMGLTKKVLETRAEDIKGKNEFKGLLRNLKREVNQEIRIQQSLLEIQGVIAPL 523
Cdd:pfam09384  82 IKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
53-346 6.45e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 6.45e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  53 SSVAALAFSPVHPHSLAVAHSATVSL-FSSQSLSSSRRFSFRDVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTL 131
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLwDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 132 RSHSAPARFVKY-PvqDKLHLVSGGDDGVVKYWDVAGATVISDLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDARv 210
Cdd:COG2319 159 TGHSGAVTSVAFsP--DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA- 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 211 hTSNWIAEIN-HGLPVEDVVYLPSGGLIATAGG-NSVKVWDLiGGGKMVCSMESHNKTVTSLRVarmeSAESR-LVSVAL 287
Cdd:COG2319 235 -TGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWDL-ATGELLRTLTGHSGGVNSVAF----SPDGKlLASGSD 308

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 288 DGYMKVFDYGRAKVTYSMR-FPAPLMSLGLSPDGSTRVIGGSNGMVfagkkKVRDVVGGQ 346
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTV-----RLWDLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-328 7.14e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 7.14e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  94 DVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKYPVQDKLhLVSGGDDGVVKYWDVAGATVISD 173
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 174 LLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDarVHTSNWIAEIN-HGLPVEDVVYLPSGGLIATAGGN-SVKVWDLi 251
Cdd:cd00200  89 LTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWD--VETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDgTIKLWDL- 164

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15227184 252 GGGKMVCSMESHNKTVTSLRVArmeSAESRLVSVALDGYMKVFDYGRAKVTYSMR-FPAPLMSLGLSPDGSTrVIGGS 328
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFS---PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYL-LASGS 238
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 96-313 2.30e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.81  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184   96 VSSVCFRSD-GALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKYPVQDKLHLVSGGDDGVVKYWDVAGATVISDL 174
Cdd:PLN00181 535 LSGICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTI 614

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  175 lGHKDYVRCGDCSPVNDSMLVTGSYDHTVKVWDARVHTSNWIAEINHGLPVEDVVYLPSGGLIATAGGNSVKVWDLiggg 254
Cdd:PLN00181 615 -KTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL---- 689

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  255 kmvcSMESHNKTVTSLRVARMESAESRLVSVAL-DGYMKVFDYGRAKVTYSMRFPAPLMS 313
Cdd:PLN00181 690 ----SMSISGINETPLHSFMGHTNVKNFVGLSVsDGYIATGSETNEVFVYHKAFPMPVLS 745
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 169-207 6.81e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.81e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 15227184    169 TVISDLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWD 207
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
169-207 6.22e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 6.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15227184   169 TVISDLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWD 207
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 381-523 1.94e-43

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 151.10  E-value: 1.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184   381 EKPSKDDYLVKEKKGLKLTRHDKLLKKFRHKEALVSVLEE--KKPANVVAVMEELVARRKLMKCVSNMEEGELGMLLGFL 458
Cdd:pfam09384   2 YKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPgvKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLLKFL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15227184   459 QRYCTVQRYSGLLMGLTKKVLETRAEDIKGKNEFKGLLRNLKREVNQEIRIQQSLLEIQGVIAPL 523
Cdd:pfam09384  82 IKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
53-346 6.45e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 6.45e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  53 SSVAALAFSPVHPHSLAVAHSATVSL-FSSQSLSSSRRFSFRDVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTL 131
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLwDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 132 RSHSAPARFVKY-PvqDKLHLVSGGDDGVVKYWDVAGATVISDLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDARv 210
Cdd:COG2319 159 TGHSGAVTSVAFsP--DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA- 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 211 hTSNWIAEIN-HGLPVEDVVYLPSGGLIATAGG-NSVKVWDLiGGGKMVCSMESHNKTVTSLRVarmeSAESR-LVSVAL 287
Cdd:COG2319 235 -TGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWDL-ATGELLRTLTGHSGGVNSVAF----SPDGKlLASGSD 308

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 288 DGYMKVFDYGRAKVTYSMR-FPAPLMSLGLSPDGSTRVIGGSNGMVfagkkKVRDVVGGQ 346
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTV-----RLWDLATGE 363
WD40 COG2319
WD40 repeat [General function prediction only];
55-346 1.46e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.35  E-value: 1.46e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  55 VAALAFSPVHPHSLAVAHSATVSLFSSQSLSSSRRFSFRDVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTLRSH 134
Cdd:COG2319  40 ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGH 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 135 SAPARFVKY-PvqDKLHLVSGGDDGVVKYWDVAGATVISDLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDarVHTS 213
Cdd:COG2319 120 TGAVRSVAFsP--DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWD--LATG 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 214 NWIAEIN-HGLPVEDVVYLPSGGLIATAGG-NSVKVWDLiGGGKMVCSMESHNKTVTSLRVarmeSAESR-LVSVALDGY 290
Cdd:COG2319 195 KLLRTLTgHTGAVRSVAFSPDGKLLASGSAdGTVRLWDL-ATGKLLRTLTGHSGSVRSVAF----SPDGRlLASGSADGT 269

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15227184 291 MKVFDYGRAKVTYSMR-FPAPLMSLGLSPDGSTRVIGGSNGMVfagkkKVRDVVGGQ 346
Cdd:COG2319 270 VRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTV-----RLWDLATGK 321
WD40 COG2319
WD40 repeat [General function prediction only];
94-332 2.15e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 2.15e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  94 DVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKY-PvqDKLHLVSGGDDGVVKYWDVAGATVIS 172
Cdd:COG2319 163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsP--DGKLLASGSADGTVRLWDLATGKLLR 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 173 DLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDarVHTSNWIAEINHGL-PVEDVVYLPSGGLIATAGG-NSVKVWDL 250
Cdd:COG2319 241 TLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWD--LATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDdGTVRLWDL 317

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 251 iGGGKMVCSMESHNKTVTSLRVARmesAESRLVSVALDGYMKVFDYGRAKVTYSMR-FPAPLMSLGLSPDGSTRVIGGSN 329
Cdd:COG2319 318 -ATGKLLRTLTGHTGAVRSVAFSP---DGKTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSPDGRTLASGSAD 393


                ...
gi 15227184 330 GMV 332
Cdd:COG2319 394 GTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-328 7.14e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 7.14e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  94 DVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKYPVQDKLhLVSGGDDGVVKYWDVAGATVISD 173
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 174 LLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDarVHTSNWIAEIN-HGLPVEDVVYLPSGGLIATAGGN-SVKVWDLi 251
Cdd:cd00200  89 LTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWD--VETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDgTIKLWDL- 164

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15227184 252 GGGKMVCSMESHNKTVTSLRVArmeSAESRLVSVALDGYMKVFDYGRAKVTYSMR-FPAPLMSLGLSPDGSTrVIGGS 328
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFS---PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYL-LASGS 238
WD40 COG2319
WD40 repeat [General function prediction only];
94-346 8.05e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 8.05e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  94 DVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKYPvQDKLHLVSGGDDGVVKYWDVAGATVISD 173
Cdd:COG2319  37 AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-PDGRLLASASADGTVRLWDLATGLLLRT 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 174 LLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDarVHTSNWIAEIN-HGLPVEDVVYLPSGGLIATAGG-NSVKVWDLi 251
Cdd:COG2319 116 LTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWD--LATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWDL- 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 252 GGGKMVCSMESHNKTVTSLRVarmeSAESR-LVSVALDGYMKVFDYGRAKVTYSMRFP-APLMSLGLSPDGSTRVIGGSN 329
Cdd:COG2319 192 ATGKLLRTLTGHTGAVRSVAF----SPDGKlLASGSADGTVRLWDLATGKLLRTLTGHsGSVRSVAFSPDGRLLASGSAD 267

                       250
                ....*....|....*..
gi 15227184 330 GMVfagkkKVRDVVGGQ 346
Cdd:COG2319 268 GTV-----RLWDLATGE 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-295 3.67e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 3.67e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  96 VSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKYPvQDKLHLVSGGDDGVVKYWDVAGATVISDLL 175
Cdd:cd00200  96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS-PDGTFVASSSQDGTIKLWDLRTGKCVATLT 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 176 GHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDARvhTSNWIAEIN-HGLPVEDVVYLPSGGLIATAGG-NSVKVWDLiGG 253
Cdd:cd00200 175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLS--TGKCLGTLRgHENGVNSVAFSPDGYLLASGSEdGTIRVWDL-RT 250

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 15227184 254 GKMVCSMESHNKTVTSLRVArmeSAESRLVSVALDGYMKVFD 295
Cdd:cd00200 251 GECVQTLSGHTNSVTSLAWS---PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
94-250 2.58e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 2.58e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  94 DVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKY-PvqDKLHLVSGGDDGVVKYWDVAGATVIS 172
Cdd:COG2319 247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFsP--DGKLLASGSDDGTVRLWDLATGKLLR 324

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 173 DLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDarVHTSNWIAEIN-HGLPVEDVVYLPSGGLIATAGG-NSVKVWDL 250
Cdd:COG2319 325 TLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWD--LATGELLRTLTgHTGAVTSVAFSPDGRTLASGSAdGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-333 6.47e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.12  E-value: 6.47e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 128 LRTLRSHSAPARFVKYpVQDKLHLVSGGDDGVVKYWDVAGATVISDLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWD 207
Cdd:cd00200   2 RRTLKGHTGGVTCVAF-SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 208 arVHTSNWIAEIN-HGLPVEDVVYLPSGGLIATAGG-NSVKVWDLIgGGKMVCSMESHNKTVTSLRVarmeSAESRLVSV 285
Cdd:cd00200  80 --LETGECVRTLTgHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVE-TGKCLTTLRGHTDWVNSVAF----SPDGTFVAS 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 15227184 286 A-LDGYMKVFDYGRAKVTYSMRFP-APLMSLGLSPDGSTRVIGGSNGMVF 333
Cdd:cd00200 153 SsQDGTIKLWDLRTGKCVATLTGHtGEVNSVAFSPDGEKLLSSSSDGTIK 202
WD40 COG2319
WD40 repeat [General function prediction only];
94-209 2.69e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 2.69e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  94 DVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKY-PvqDKLHLVSGGDDGVVKYWDVAGATVIS 172
Cdd:COG2319 289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsP--DGKTLASGSDDGTVRLWDLATGELLR 366

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15227184 173 DLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDAR 209
Cdd:COG2319 367 TLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 96-313 2.30e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.81  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184   96 VSSVCFRSD-GALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKYPVQDKLHLVSGGDDGVVKYWDVAGATVISDL 174
Cdd:PLN00181 535 LSGICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTI 614

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  175 lGHKDYVRCGDCSPVNDSMLVTGSYDHTVKVWDARVHTSNWIAEINHGLPVEDVVYLPSGGLIATAGGNSVKVWDLiggg 254
Cdd:PLN00181 615 -KTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL---- 689

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  255 kmvcSMESHNKTVTSLRVARMESAESRLVSVAL-DGYMKVFDYGRAKVTYSMRFPAPLMS 313
Cdd:PLN00181 690 ----SMSISGINETPLHSFMGHTNVKNFVGLSVsDGYIATGSETNEVFVYHKAFPMPVLS 745
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 94-295 2.53e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 66.26  E-value: 2.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184   94 DVVSSVCFRSDGALFAACDLSGVVQVFDIKermalrtlrSHSAPARFVKYPVQD----------------KLHLVSGGDD 157
Cdd:PLN00181 484 NLVCAIGFDRDGEFFATAGVNKKIKIFECE---------SIIKDGRDIHYPVVElasrsklsgicwnsyiKSQVASSNFE 554

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  158 GVVKYWDVAGATVISDLLGHKDYVRCGDCSPVNDSMLVTGSYDHTVKVWdarvhtsnwiaEINHGLPVEDV--------V 229
Cdd:PLN00181 555 GVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW-----------SINQGVSIGTIktkaniccV 623

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15227184  230 YLPSGGLIATAGGNS---VKVWDLIGGGKMVCSMESHNKTVTSLRVARmesaESRLVSVALDGYMKVFD 295
Cdd:PLN00181 624 QFPSESGRSLAFGSAdhkVYYYDLRNPKLPLCTMIGHSKTVSYVRFVD----SSTLVSSSTDNTLKLWD 688
WD40 COG2319
WD40 repeat [General function prediction only];
94-167 2.41e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 2.41e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15227184  94 DVVSSVCFRSDGALFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKYPvQDKLHLVSGGDDGVVKYWDVAG 167
Cdd:COG2319 331 GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS-PDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 169-207 6.81e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.81e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 15227184    169 TVISDLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWD 207
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
169-207 6.22e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 6.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15227184   169 TVISDLLGHKDYVRCGDCSPvNDSMLVTGSYDHTVKVWD 207
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
107-253 7.51e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 7.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 107 LFAACDLSGVVQVFDIKERMALRTLRSHSAPARFVKYPVQDKLHLVSGGDDGVVKYwDVAGATVISDL-LGhkDYVRCGD 185
Cdd:COG3391  82 LYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVI-DTATGKVVATIpVG--AGPHGIA 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184 186 CSPVNDSMLVTGSYDHT----VKVWDARvhTSNWIAEINHGLPVEDVVYLPSGGLI---------ATAGGNSVKVWDLIG 252
Cdd:COG3391 159 VDPDGKRLYVANSGSNTvsviVSVIDTA--TGKVVATIPVGGGPVGVAVSPDGRRLyvanrgsntSNGGSNTVSVIDLAT 236


                .
gi 15227184 253 G 253
Cdd:COG3391 237 L 237
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 177-208 1.95e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.44  E-value: 1.95e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15227184   177 HKDYVRCGDCSPvNDSMLVTGSYDHTVKVWDA 208
Cdd:pfam20426 123 HKDVVSCVAVTS-DGSILATGSYDTTVMVWEV 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 128-164 2.78e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.78e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 15227184    128 LRTLRSHSAPARFVKYpVQDKLHLVSGGDDGVVKYWD 164
Cdd:smart00320   5 LKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 151-249 6.52e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.11  E-value: 6.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227184  151 LVSGGDDGVVKYWDVAGATVISDLLGHKDYVRCGDCSpVNDSMLVTGSYDHTVKVWDARVHTSNWIAEINHGLPVEDVVY 230
Cdd:PTZ00421 141 LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLW 219

                         90       100
                 ....*....|....*....|....
gi 15227184  231 LPSGGLIATAGGNS-----VKVWD 249
Cdd:PTZ00421 220 AKRKDLIITLGCSKsqqrqIMLWD 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH