ALB3 63 kDa inner membrane family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ALB3
Official Full Name: 63 kDa inner membrane family protein
Primary source: TAIR:AT2G28800
Locus tag: AT2G28800
See related: Araport:AT2G28800
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ABL3; ALBINO 3; CHLOROPLAST MEMBRANE PROTEIN ALB3; F8N16.9; F8N16_9
Summary: member of Chloroplast membrane protein ALBINO3 family. Similar to pea PPF1 and may play a role in plant senescence.
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Genomic context

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See ALB3 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 10

Sequence:: Chromosome: 2; NC_003071.7 (12356321..12359568, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ALB3 contributes to the process of protein insertion into the thylakoids via the ALB3-chloroplast signal recognition particle pathway.
Title: Genetic and Physical Interaction Studies Reveal Functional Similarities between ALBINO3 and ALBINO4 in Arabidopsis.
Data indicate that the conserved positively charged residue was not required for the E. coli YidC or the A. thaliana Alb3 to functionally complement the E. coli YidC depletion strain or to promote insertion of YidC-dependent membrane proteins.
Title: The role of the strictly conserved positively charged residue differs among the Gram-positive, Gram-negative, and chloroplast YidC homologs.
TerC, together with ALB3, facilitates de novo synthesis of thylakoid membrane proteins.
Title: The Arabidopsis Tellurite resistance C protein together with ALB3 is involved in photosystem II protein synthesis.
cpSRP43 inserts into a dimeric Alb3 translocation pore during cpSRP-dependent delivery of light-harvesting chlorophyll a,b-binding proteins
Title: Interaction studies between the chloroplast signal recognition particle subunit cpSRP43 and the full-length translocase Alb3 reveal a membrane-embedded binding region in Alb3 protein.
Propose that cpSRP43 is crucial for the binding of LHCP-loaded cpSRP and cpFtsY to Alb3. In addition, data suggest that a direct interaction between Alb3 and LHCP contributes to the formation of this complex.
Title: Interplay between the cpSRP pathway components, the substrate LHCP and the translocase Alb3: an in vivo and in vitro study.
The activation of TFL1 expression by PPF1 defines an important pathway possibly essential for the negative regulation of plant senescence in transgenic Arabidopsis. [PPF1]
Title: PPF1 may suppress plant senescence via activating TFL1 in transgenic Arabidopsis plants.
Alb3 is adapted for the chloroplast-specific Alb3-cpSRP43 interaction in post-translational targeting by extending the spectrum of chromodomain interactions.
Title: The C terminus of the Alb3 membrane insertase recruits cpSRP43 to the thylakoid membrane.
alb3 mutants generally exhibit defects in the biogenesis of light-harvesting chlorophyll proteins and other thylakoidal membrane proteins that are more severe than in the cpftsY mutants.
Title: Non-identical contributions of two membrane-bound cpSRP components, cpFtsY and Alb3, to thylakoid biogenesis.
Alb3 has a role in insertion of a subset of the light-harvesting chlorophyll-binding proteins, while Alb4 is required for proper chloroplast biogenesis
Title: A second thylakoid membrane-localized Alb3/OxaI/YidC homologue is involved in proper chloroplast biogenesis in Arabidopsis thaliana.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001124933.1

Supported by ESTs:

NM_001202697.1

Supported by ESTs:

NM_128439.3

Supported by ESTs:

NM_179794.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables membrane insertase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-transporting ATPase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein import into chloroplast thylakoid membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization to chloroplast	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thylakoid membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast thylakoid	HDA more info	PubMed
located_in chloroplast thylakoid membrane	HDA more info	PubMed
located_in chloroplast thylakoid membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	HDA more info	PubMed

General protein information

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Preferred Names: 63 kDa inner membrane family protein

NP_001118405.1

ALBINO 3 (ALB3); CONTAINS InterPro DOMAIN/s: Membrane insertion protein, OxaA/YidC (InterPro:IPR001708), Membrane insertion protein, OxaA/YidC, core (InterPro:IPR020001); BEST Arabidopsis thaliana protein match is: OxaA/YidC-like membrane insertion protein (TAIR:AT1G24490.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_001189626.1

ALBINO 3 (ALB3); CONTAINS InterPro DOMAIN/s: Membrane insertion protein, OxaA/YidC (InterPro:IPR001708), Membrane insertion protein, OxaA/YidC, core (InterPro:IPR020001); BEST Arabidopsis thaliana protein match is: OxaA/YidC-like membrane insertion protein (TAIR:AT1G24490.1).

NP_180446.1

ALBINO 3 (ALB3); FUNCTIONS IN: P-P-bond-hydrolysis-driven protein transmembrane transporter activity; INVOLVED IN: protein import into chloroplast thylakoid membrane, thylakoid membrane organization, regulation of cell aging; LOCATED IN: chloroplast thylakoid membrane, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Membrane insertion protein, OxaA/YidC (InterPro:IPR001708), Membrane insertion protein, OxaA/YidC, core (InterPro:IPR020001); BEST Arabidopsis thaliana protein match is: OxaA/YidC-like membrane insertion protein (TAIR:AT1G24490.1); Has 8837 Blast hits to 8795 proteins in 2578 species: Archae - 0; Bacteria - 5819; Metazoa - 151; Fungi - 71; Plants - 148; Viruses - 0; Other Eukaryotes - 2648 (source: NCBI BLink).

NP_850125.1

ALBINO 3 (ALB3); FUNCTIONS IN: P-P-bond-hydrolysis-driven protein transmembrane transporter activity; INVOLVED IN: protein import into chloroplast thylakoid membrane, thylakoid membrane organization, regulation of cell aging; LOCATED IN: chloroplast thylakoid membrane, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Membrane insertion protein, OxaA/YidC (InterPro:IPR001708), Membrane insertion protein, OxaA/YidC, core (InterPro:IPR020001); BEST Arabidopsis thaliana protein match is: OxaA/YidC-like membrane insertion protein (TAIR:AT1G24490.1); Has 8356 Blast hits to 8354 proteins in 2523 species: Archae - 0; Bacteria - 5716; Metazoa - 103; Fungi - 31; Plants - 135; Viruses - 0; Other Eukaryotes - 2371 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

12356321..12359568 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128439.3 → NP_180446.1 63 kDa inner membrane family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180446.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04665, Q8LBP4

UniProtKB/TrEMBL

A0A178VUV3, A0A5S9X2C4, A0A7G2ED52

Conserved Domains (1) summary

pfam02096
Location:140 → 354

60KD_IMP; 60Kd inner membrane protein
NM_001124933.1 → NP_001118405.1 63 kDa inner membrane family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001118405.1

Status: REVIEWED

UniProtKB/TrEMBL

B3H4X4

Conserved Domains (1) summary

pfam02096
Location:140 → 339

60KD_IMP; 60Kd inner membrane protein
NM_001202697.1 → NP_001189626.1 63 kDa inner membrane family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189626.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2ED52, F4IJM1

Conserved Domains (1) summary

pfam02096
Location:140 → 324

60KD_IMP; 60Kd inner membrane protein
NM_179794.2 → NP_850125.1 63 kDa inner membrane family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850125.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LBP4

Conserved Domains (1) summary

pfam02096
Location:140 → 341

60KD_IMP; 60Kd inner membrane protein