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Conserved domains on  [gi|30684018|ref|NP_850125|]
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63 kDa inner membrane family protein [Arabidopsis thaliana]

Protein Classification

YidC/Oxa1 family membrane protein insertase( domain architecture ID 10489205)

YidC/Oxa1 family membrane protein insertase functions as a membrane protein chaperone and as an independent insertase for membrane proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
60KD_IMP pfam02096
60Kd inner membrane protein;
140-341 8.67e-65

60Kd inner membrane protein;


:

Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 203.09  E-value: 8.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018   140 YGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERIQLETSRLYKQAGVNPLAGCLPTLATIPVW 219
Cdd:pfam02096   1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018   220 IGLYQALSNvANEGLFTEGFFWIPSLGGPTSIAarqsgsgiswlfpfvdghpplgwydTVAYLVLPVLLIASQYVSMEIM 299
Cdd:pfam02096  81 IALYRVLRN-SIELRHAPFFLWIADLSAPDPIS-------------------------ILHYYILPILMGVTMFLQQKLT 134
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 30684018   300 KPPQTDDPAQKNTLLVfkFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:pfam02096 135 PAPQDQPPQMKMMMLY--FMPLMFLFFFLNFPAGLVLYWVVS 174
 
Name Accession Description Interval E-value
60KD_IMP pfam02096
60Kd inner membrane protein;
140-341 8.67e-65

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 203.09  E-value: 8.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018   140 YGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERIQLETSRLYKQAGVNPLAGCLPTLATIPVW 219
Cdd:pfam02096   1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018   220 IGLYQALSNvANEGLFTEGFFWIPSLGGPTSIAarqsgsgiswlfpfvdghpplgwydTVAYLVLPVLLIASQYVSMEIM 299
Cdd:pfam02096  81 IALYRVLRN-SIELRHAPFFLWIADLSAPDPIS-------------------------ILHYYILPILMGVTMFLQQKLT 134
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 30684018   300 KPPQTDDPAQKNTLLVfkFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:pfam02096 135 PAPQDQPPQMKMMMLY--FMPLMFLFFFLNFPAGLVLYWVVS 174
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
111-341 1.40e-64

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 203.81  E-value: 1.40e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 111 GWFGFISDAMELVLKILKDGLSAvhvpyaYGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERI 190
Cdd:COG0706   4 GWFGFIAKPLFWLLNFLHSLVGN------WGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 191 QLETSRLYKQAGVNPLAGCLPTLATIPVWIGLYQALSNVANegLFTEGFFWIPSLGGPTSIaarqsgsgiswlfpfvdgh 270
Cdd:COG0706  78 QQEMMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIE--LRHAPFLGIPDLSAPDPY------------------- 136
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30684018 271 pplgwydtvaYLVLPVLLIASQYVSMEIMkPPQTDDPAQKntlLVFKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:COG0706 137 ----------YIFLPILMGVTMFLQQKLN-PAPAQDPQQK---KMMYIMPLMFLFFFLSFPAGLVLYWVVS 193
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
141-341 9.49e-59

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 187.59  E-value: 9.49e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 141 GFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERIQLETSRLYKQAGVNPLAGCLPTLATIPVWI 220
Cdd:cd20070   1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 221 GLYQALSNVanEGLFTEGFFW-IPSLGGPTSiaarqsgsgiswlfpfvdghpplgwydtvaYLVLPVLLIASQYVSMEIM 299
Cdd:cd20070  81 ALYQVLRNS--IELRGAPFLWwILDLSAPDP------------------------------YYILPILMGVTMFLQQKLT 128
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 30684018 300 KPPQTDDPAQKNTLLvfKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:cd20070 129 PTPTDDQAPQQKMMM--YFMPVMFTFIFLSFPSGLVLYWLVS 168
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
140-341 3.31e-56

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 181.14  E-value: 3.31e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018   140 YGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERIQLETSRLYKQAGVNPLAGCLPTLATIPVW 219
Cdd:TIGR03592   2 WGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPIF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018   220 IGLYQALSNvaNEGLFTEGFFWIPSLGGPTsiaarqsgsgiswlfpfvdghpplgwydtvAYLVLPVLLIASQYVSMEIM 299
Cdd:TIGR03592  82 IALYQVLLR--SIELRHAPFLWIIDLSSPD------------------------------PYYILPILMGVTMFLQQKLS 129
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 30684018   300 KPPQTDDPAQKNTLlvfKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:TIGR03592 130 PKGPPDPAQQKMMM---YFMPLMFLFFFLSFPAGLVLYWVVS 168
PRK01318 PRK01318
membrane protein insertase; Provisional
111-341 2.53e-46

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 164.66  E-value: 2.53e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  111 GWFGFISDAMELVLKILKDGLSAvhvpyaYGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERI 190
Cdd:PRK01318 300 GWLWFITKPLFWLLDFLHSFVGN------WGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKM 373
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  191 QLETSRLYKQAGVNPLAGCLPTLATIPVWIGLYQALsnvaneglftegffwipslggPTSIAARQSgsgiswlfPFvdgh 270
Cdd:PRK01318 374 QQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVL---------------------LVSIELRHA--------PF---- 420
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  271 ppLGW------YDTV---AYLVLPVLLIASQYVSMeIMKPPQTdDPAQKNtllVFKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:PRK01318 421 --IGWihdlsaPDPYfilHIGLLPILMGITMFLQQ-KLNPTPT-DPMQAK---IMKFMPLIFTFFFLSFPAGLVLYWIVN 493
 
Name Accession Description Interval E-value
60KD_IMP pfam02096
60Kd inner membrane protein;
140-341 8.67e-65

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 203.09  E-value: 8.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018   140 YGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERIQLETSRLYKQAGVNPLAGCLPTLATIPVW 219
Cdd:pfam02096   1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018   220 IGLYQALSNvANEGLFTEGFFWIPSLGGPTSIAarqsgsgiswlfpfvdghpplgwydTVAYLVLPVLLIASQYVSMEIM 299
Cdd:pfam02096  81 IALYRVLRN-SIELRHAPFFLWIADLSAPDPIS-------------------------ILHYYILPILMGVTMFLQQKLT 134
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 30684018   300 KPPQTDDPAQKNTLLVfkFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:pfam02096 135 PAPQDQPPQMKMMMLY--FMPLMFLFFFLNFPAGLVLYWVVS 174
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
111-341 1.40e-64

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 203.81  E-value: 1.40e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 111 GWFGFISDAMELVLKILKDGLSAvhvpyaYGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERI 190
Cdd:COG0706   4 GWFGFIAKPLFWLLNFLHSLVGN------WGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 191 QLETSRLYKQAGVNPLAGCLPTLATIPVWIGLYQALSNVANegLFTEGFFWIPSLGGPTSIaarqsgsgiswlfpfvdgh 270
Cdd:COG0706  78 QQEMMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIE--LRHAPFLGIPDLSAPDPY------------------- 136
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30684018 271 pplgwydtvaYLVLPVLLIASQYVSMEIMkPPQTDDPAQKntlLVFKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:COG0706 137 ----------YIFLPILMGVTMFLQQKLN-PAPAQDPQQK---KMMYIMPLMFLFFFLSFPAGLVLYWVVS 193
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
141-341 9.49e-59

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 187.59  E-value: 9.49e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 141 GFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERIQLETSRLYKQAGVNPLAGCLPTLATIPVWI 220
Cdd:cd20070   1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 221 GLYQALSNVanEGLFTEGFFW-IPSLGGPTSiaarqsgsgiswlfpfvdghpplgwydtvaYLVLPVLLIASQYVSMEIM 299
Cdd:cd20070  81 ALYQVLRNS--IELRGAPFLWwILDLSAPDP------------------------------YYILPILMGVTMFLQQKLT 128
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 30684018 300 KPPQTDDPAQKNTLLvfKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:cd20070 129 PTPTDDQAPQQKMMM--YFMPVMFTFIFLSFPSGLVLYWLVS 168
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
140-341 3.31e-56

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 181.14  E-value: 3.31e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018   140 YGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERIQLETSRLYKQAGVNPLAGCLPTLATIPVW 219
Cdd:TIGR03592   2 WGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPIF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018   220 IGLYQALSNvaNEGLFTEGFFWIPSLGGPTsiaarqsgsgiswlfpfvdghpplgwydtvAYLVLPVLLIASQYVSMEIM 299
Cdd:TIGR03592  82 IALYQVLLR--SIELRHAPFLWIIDLSSPD------------------------------PYYILPILMGVTMFLQQKLS 129
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 30684018   300 KPPQTDDPAQKNTLlvfKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:TIGR03592 130 PKGPPDPAQQKMMM---YFMPLMFLFFFLSFPAGLVLYWVVS 168
PRK01318 PRK01318
membrane protein insertase; Provisional
111-341 2.53e-46

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 164.66  E-value: 2.53e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  111 GWFGFISDAMELVLKILKDGLSAvhvpyaYGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERI 190
Cdd:PRK01318 300 GWLWFITKPLFWLLDFLHSFVGN------WGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKM 373
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  191 QLETSRLYKQAGVNPLAGCLPTLATIPVWIGLYQALsnvaneglftegffwipslggPTSIAARQSgsgiswlfPFvdgh 270
Cdd:PRK01318 374 QQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVL---------------------LVSIELRHA--------PF---- 420
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  271 ppLGW------YDTV---AYLVLPVLLIASQYVSMeIMKPPQTdDPAQKNtllVFKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:PRK01318 421 --IGWihdlsaPDPYfilHIGLLPILMGITMFLQQ-KLNPTPT-DPMQAK---IMKFMPLIFTFFFLSFPAGLVLYWIVN 493
PRK00145 PRK00145
putative inner membrane protein translocase component YidC; Provisional
113-341 1.27e-35

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234665 [Multi-domain]  Cd Length: 223  Bit Score: 129.09  E-value: 1.27e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  113 FGFISDAMELVLKILKDGLSAV--HVPYAYGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERI 190
Cdd:PRK00145   2 MRYLNNAFVQFFKFIHGFVSSVisNPNFSYGIAIILVTLIIRLLILPLNIKQTKSSLRMNEIQPEIKKLQAKYKNDPQKL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  191 QLETSRLYKQAGVNPLAGCLPTLATIPVWIGLYQALSNVanEGLFTEGFFWIPSLGGPTsiaarqsgsgISWlfpfvdgh 270
Cdd:PRK00145  82 QQEMMKLYKEKGVNPLGGCLPLLIQWPILIALYYVFNNL--TGINGVSFLWIKDLAKPD----------ITW-------- 141
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30684018  271 pplgwydtvaylVLPVLLIASQYVSMEIMKPPQTDDPAQKNTLLVfkFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:PRK00145 142 ------------ILPILSGATTYLSGYLMTKADSSQAGQMKTMNI--GMSIFMGVMSWKFKSALVLYWVIG 198
PRK01315 PRK01315
putative inner membrane protein translocase component YidC; Provisional
139-341 6.44e-31

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234941  Cd Length: 329  Bit Score: 119.46  E-value: 6.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  139 AYGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERIQLETSRLYKQAGVNPLAGCLPTLATIPV 218
Cdd:PRK01315  41 TWVLSIVGLVIVIRALLIPLFVKQIKSQRNMQEIQPKMKKIQEKYKGDRERMSQEMMKLYKETGTNPLSSCLPLLLQMPI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  219 WIGLYQALSNVANEGlftEGffwIPSLGGPTSIAARQS---GSGISWLFpFVDGHPPLGWYDTVAyLVLPVLLIASQYVS 295
Cdd:PRK01315 121 FFALYRVLDSAASRG---DG---IGPINPPLLESFRHAhifGAPLAATF-LQALNAGNTAVQVVA-AVLIILMSASQFIT 192
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 30684018  296 -MEIMK---PPQT-DDPAQKNTLLVFKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:PRK01315 193 qLQLMTknmPPEAkTGPMAQQQKMLLYLFPLMFLVSGIAFPVGVLFYWLTS 243
PRK01001 PRK01001
putative inner membrane protein translocase component YidC; Provisional
111-347 2.71e-30

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234887 [Multi-domain]  Cd Length: 795  Bit Score: 121.83  E-value: 2.71e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  111 GWFGFISDAMELVLKILKDGLSavHVPYAYGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERI 190
Cdd:PRK01001 549 GFFSFITEPFAALLFIIMKFFK--FLTGSWGISIILLTVFLKLLLYPLNAWSIRSMRRMQKLSPYIQEIQQKYKKEPKRA 626
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  191 QLETSRLYKQAGVNPLAGCLPTLATIPVWIGLYQAL-SNVANEGL-FTEGffWIPSLGGPTSIaarqsgsgISWLFPFvd 268
Cdd:PRK01001 627 QMEIMALYKTNKVNPITGCLPLLIQLPFLIAMFDLLkSSFLLRGAsFIPG--WIDNLTAPDVL--------FSWETPI-- 694
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  269 ghpplgWYDTVAYLVLPVLL----IASQYVSMEIMKPPQTDDPAQKNTL-----LVFKFlplMIGYFalsvPSGLSIYWL 339
Cdd:PRK01001 695 ------WFIGNEFHLLPILLgvvmFAQQKISSLKRKGPVTDQQRQQEAMgtmmaLLFTF---MFYNF----PSGLNIYWL 761

                 ....*...
gi 30684018  340 VSLSLKLL 347
Cdd:PRK01001 762 SSMLLGVI 769
5TM_YidC_Oxa1_Alb3 cd19751
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ...
141-341 3.30e-28

Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410992 [Multi-domain]  Cd Length: 189  Bit Score: 108.41  E-value: 3.30e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 141 GFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRY------AGNQERIQLETSRLYKQAGVNPLAGCLPTLA 214
Cdd:cd19751   1 GLSIIIVTILIRLALLPLTLKQQKSMRKMQVIRPEMEAIREKYkekaskDKVQQEMQKEMLGLYKKHGVNPMAGCLPLFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 215 TIPVWIGLYQALSNVanEGLFTEGFFWIPSLGGPTSIaarqsgsgisWLFPFVDGhpplgwydtvaylvlpVLLIASQYV 294
Cdd:cd19751  81 QLPIFMAFYFAIMRT--EEIRYHTFLWFFDLGQPDYL----------YILPFVAG----------------ITTYFQFKM 132
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 30684018 295 SMEIMKPPQTDDPAQKNTLLVFkflPLMIGYFALSVPSGLSIYWLVS 341
Cdd:cd19751 133 TMSHQQQMQMMQMQMKVMLYVM---PVMIIIAGLSFPSALSLYWIIS 176
PRK01622 PRK01622
membrane protein insertase YidC;
133-341 4.89e-26

membrane protein insertase YidC;


Pssm-ID: 179310  Cd Length: 256  Bit Score: 104.45  E-value: 4.89e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  133 AVHVPYAYGFAIILLTIIVKAATYPLTKQQVESTLAMQN----LQPKIKAIQQRY-----AGNQERIQLETSRLYKQAGV 203
Cdd:PRK01622  53 AHHIGGSYGIAIIIVTLIIRSLMIPLAVSQYKSQRGMQEkmavMKPELDKIQAKLkvtkdLEKQKEYQKEMMELYKSGNI 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  204 NPLA-GCLPTLATIPVWIGLYQALSnvANEGLFTEGFFWipslggptsiaarqsgsgiswlfpFVDGHPPlgwydtvayL 282
Cdd:PRK01622 133 NPLAmGCLPLLIQMPILSAFYYAIR--RTEEIASHSFLW------------------------FNLGHAD---------H 177
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 30684018  283 VLPVLLIASQYVSMEIMKPPQTDDPAQKNTLLVFKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:PRK01622 178 ILPIIAGLTYFIQMKVSQSNGTSPEQVQMLKIQGIMMPAMILFMSFAAPSALVLYWITG 236
5TM_Oxa1-like cd20069
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ...
143-341 5.70e-26

Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410993 [Multi-domain]  Cd Length: 201  Bit Score: 102.60  E-value: 5.70e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 143 AIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQ-----RYAGNQE---RIQLETSRLYKQAGVNPLAGCLPTLA 214
Cdd:cd20069   7 TIAATTVALRLLLLPLVIKSQRNAARMANLQPELQKLQEklkeaRASGDQLeaaEARKELKELMKKHNVNPLKSLLLPLV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018 215 TIPVWIGLYQALSNVAN---EGLFTEGFFWIPSLggptsiaarqsgsgiswlfpfvdghpplgwydTVA--YLVLPVLLI 289
Cdd:cd20069  87 QAPVFISFFFALRKMANlpvPSFKTGGLLWFTDL--------------------------------TVPdpYYILPILTS 134
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 30684018 290 ASQYVSMEI-MKPPQTDDPAQKNTLLVFKFLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:cd20069 135 LTFLATIELgAETGTSGSPQSKTMKNVFRGLPVLMIPFTANFPSAVFLYWITS 187
PRK02944 PRK02944
YidC family membrane integrase SpoIIIJ;
140-340 4.21e-25

YidC family membrane integrase SpoIIIJ;


Pssm-ID: 179508  Cd Length: 255  Bit Score: 101.77  E-value: 4.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  140 YGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRY----AGNQERIQLETSRLYKQAGVNPLAGCLPTLAT 215
Cdd:PRK02944  59 YGLAIIVVTLLIRLLILPLMIKQTKSTKAMQALQPEMQKLKEKYsskdQATQQKLQQEMMQLFQKNGVNPLAGCLPIFIQ 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  216 IPVWIGLYQALSNVANEGlfTEGFFWipslggptsiaarqsgsgiswlfpFVDGHPPlgwydtvAYLVLPVLLIASQYVS 295
Cdd:PRK02944 139 MPILIAFYHAIMRTSEIS--KHSFLW------------------------FDLGQAD-------PYYILPIVAGITTFIQ 185
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 30684018  296 MEI-MKPPQTDDPAQKNTLLVfkfLPLMIGYFALSVPSGLSIYWLV 340
Cdd:PRK02944 186 QKLmMAGTAGQNPQMAMMLWL---MPIMILIFAINFPAALSLYWVV 228
PRK03449 PRK03449
putative inner membrane protein translocase component YidC; Provisional
139-339 7.14e-25

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 179580  Cd Length: 304  Bit Score: 102.45  E-value: 7.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  139 AYGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGNQERIQLETSRLYKQAGVNPLAGCLPTLATIPV 218
Cdd:PRK03449  31 AWALSVMFLVFTLRALLYKPFVRQIRTTRKMQELQPQIKALQKKYGNDRQKMALEMQKLQKEHGFNPILGCLPMLAQIPV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  219 WIGLYQAL-------SNVANEGLFTEGFFWIPSLG-GPTSIA----ARQSGSGIS-WLFPFVDGHPPLGWYDT--VAYLV 283
Cdd:PRK03449 111 FLGLFHVLrsfnrtgTGFGQLGMSVEENRNTPNYVfSAEDVQsfldARLFGAPLSaYITMPRSGLDAFVDFTRtnIILVG 190
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30684018  284 LPVLLIAS------QYVSMEIMKPPQTDDP--AQKNTLLVFkFLPLMIGYFALSVPSGLSIYWL 339
Cdd:PRK03449 191 VPLMIIAGvathfnSRASVARQSAEAAANPqtAMMNKLALW-VFPLGVLVGGPFLPLAILLYWV 253
PRK02654 PRK02654
putative inner membrane protein translocase component YidC; Provisional
114-226 5.01e-19

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235058  Cd Length: 375  Bit Score: 86.96  E-value: 5.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  114 GFISDamELVLKILkD---GLsavhVPyAYGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQP----KIKAIQQRYAGN 186
Cdd:PRK02654   6 GFISN--NVMLPIL-DffyGI----VP-SYGLAIVALTLVIRFALYPLSAGSIRNMRRMKIAQPvmqkRQAEIQERYKND 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 30684018  187 QERIQLETSRLYKQAGvNPLAGCLPTLATIPVWIGLYQAL 226
Cdd:PRK02654  78 PQKQQEEMGKLMKEFG-NPLAGCLPLLVQMPILFALFATL 116
PRK00247 PRK00247
putative inner membrane protein translocase component YidC; Validated
116-339 7.55e-19

putative inner membrane protein translocase component YidC; Validated


Pssm-ID: 178945 [Multi-domain]  Cd Length: 429  Bit Score: 86.83  E-value: 7.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  116 ISDAMELVLKILKDGLSAVHVpYAYGFAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAGN------QER 189
Cdd:PRK00247   9 VSGVMKLWHLLLHNVLGLDDS-LAWFASLFGLVITVRAIIAPFTWQQYKSGRTAAHIRPKRKALREEYKGKtdeasiREL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  190 IQLEtSRLYKQAGVNPLAGCLPTLATIPVWIGLYQALSNVAN--EGLFTEGFfwiPSLGGPTS------IAARQSGSGIs 261
Cdd:PRK00247  88 QQKQ-KDLNKEYGYNPLAGCVPALIQIPVFLGLYQVLLRMARpeGGLENPVH---QPIGFLTSeevesfLQGRVFNVPL- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  262 wlfPFVDGHPP-----LGW-YDTVAYLVLPVLLIASQY----VSMEIMKPPQTDDPAQKNTLLVFKFL----------PL 321
Cdd:PRK00247 163 ---PAYVSMPAeqlayLGTtQATVLAFVLPLFIAAAVFtainMAMSTYRSFQTNDHDSGFAVGMLKFLivmailapifPL 239
                        250
                 ....*....|....*...
gi 30684018  322 MIGYFAlSVPSGLSIYWL 339
Cdd:PRK00247 240 SLGLTG-PFPTAIALYWV 256
PRK02463 PRK02463
OxaA-like protein precursor; Provisional
133-341 4.29e-13

OxaA-like protein precursor; Provisional


Pssm-ID: 235040  Cd Length: 307  Bit Score: 68.99  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  133 AVHVPYAYGFAIILLTIIVKAATYPLTKQQV-ESTL---AMQNLQPKIKAIQQRY--AGNQER---IQLETSRLYKQAGV 203
Cdd:PRK02463  53 ANNLGLGFGLAIIIVTIIVRLIILPLGLYQSwKATYqseKMAYLKPVFEPINERLknATTQEEkmaAQTELMAAQRENGI 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  204 NPLA--GCLPTLATIPVWIGLYQALSNVanEGLFTEGFFWIPslggptsiaarqsgsgiswlfpfvdghppLGWYDTVAY 281
Cdd:PRK02463 133 SMLGgiGCLPLLIQMPFFSALYFAAQYT--KGVSTSTFLGID-----------------------------LGSPSLVLT 181
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  282 LVLPVLLIASQYVSMEIMKPPQTDdpAQKNTLLVfkfLPLMIGYFALSVPSGLSIYWLVS 341
Cdd:PRK02463 182 AIIGVLYFFQSWLSMMGVPEEQRE--QMKAMMYM---MPIMMVVFSFSSPAGVGLYWLVG 236
PRK02201 PRK02201
putative inner membrane protein translocase component YidC; Provisional
142-341 5.06e-11

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235012  Cd Length: 357  Bit Score: 63.11  E-value: 5.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  142 FAIILLTIIVKAATYPLTKQQVESTLAMQNLQPKIKAIQQRYAG------NQERIQLETSRLYKQAGVNPLAGCLPTLAT 215
Cdd:PRK02201 135 LAIIVVVLIIRLISFLITFKSTFNQEKQEELQGKKAKIDAKYKDykkdkqMKQRKQQEIQELYKKHNISPFSPFVQMFVT 214
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684018  216 IPVWIGLYQALSNvaneglftegffwIPSLGGPTSIAARQSGSGISWLFpfvdghpPLGWydtvAYLVLPVLLIASQYVS 295
Cdd:PRK02201 215 LPIFIAVYRVVQS-------------LPSIKVTTWLGIDLSATSWQEIF-------AGNW----IYLPILIIVVPVQALS 270
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30684018  296 MEImkpPQ----------TDDPAQKNTL-----------LVFKFlplmigyFALSVPSGLSIYWLVS 341
Cdd:PRK02201 271 QLL---PQilnkkknkerTLNVKEKEALkkqnktqniisIVFIF-------FGVIFAAGVQIYWIIG 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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