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    G6PD4 glucose-6-phosphate dehydrogenase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837465, updated on 18-Sep-2024

    Summary

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    Official Symbol
    G6PD4
    Official Full Name
    glucose-6-phosphate dehydrogenase 4
    Primary source
    TAIR:AT1G09420
    Locus tag
    AT1G09420
    See related
    Araport:AT1G09420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F14J9.8; F14J9_8; glucose-6-phosphate dehydrogenase 4
    Summary
    Encodes a protein similar to glucose-6-phosphate dehydrogenase but, based on amino acid differences in the active site and lack of activity, does not encode a functional G6PDH. The amino acid sequence for the consensus sequence of the G6PDH active site (DHYLGKE) differs in three places in this protein. gc exon splice site at 20574 is based on protein alignment, and is not confirmed experimentally.
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    Genomic context

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    See G6PD4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (3038462..3041873, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pentatricopeptide (PPR) repeat-containing protein Neighboring gene NIM1-interacting 3 Neighboring gene ncRNA Neighboring gene ATP-citrate lyase A-3 Neighboring gene Protein kinase superfamily protein Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative targeting of Arabidopsis plastidic glucose-6-phosphate dehydrogenase G6PD1 involves cysteine-dependent interaction with G6PD4 in the cytosol. Meyer T, et al. Plant J, 2011 Jun. PMID 21309870
    2. Genome-wide analysis of glucose-6-phosphate dehydrogenases in Arabidopsis. Wakao S, et al. Plant J, 2005 Jan. PMID 15634201
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thioredoxin m2 retains G6PD4 in the cytosol, and could mediate redox-relayed interaction with G6PD1.
      Title: Alternative targeting of Arabidopsis plastidic glucose-6-phosphate dehydrogenase G6PD1 involves cysteine-dependent interaction with G6PD4 in the cytosol.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198018.1
    NM_100813.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables glucose-6-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-6-phosphate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose-6-phosphate dehydrogenase 4
    NP_001184947.1
    • glucose-6-phosphate dehydrogenase 4 (G6PD4); FUNCTIONS IN: glucose-6-phosphate dehydrogenase activity; INVOLVED IN: oxidation reduction, glucose metabolic process, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Glucose-6-phosphate dehydrogenase, C-terminal (InterPro:IPR022675), NAD(P)-binding domain (InterPro:IPR016040), Glucose-6-phosphate dehydrogenase (InterPro:IPR001282), Glucose-6-phosphate dehydrogenase, NAD-binding (InterPro:IPR022674); BEST Arabidopsis thaliana protein match is: glucose-6-phosphate dehydrogenase 2 (TAIR:AT5G13110.1).
    NP_563844.1
    • glucose-6-phosphate dehydrogenase 4 (G6PD4); FUNCTIONS IN: glucose-6-phosphate dehydrogenase activity; INVOLVED IN: oxidation reduction, glucose metabolic process, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Glucose-6-phosphate dehydrogenase, C-terminal (InterPro:IPR022675), NAD(P)-binding domain (InterPro:IPR016040), Glucose-6-phosphate dehydrogenase (InterPro:IPR001282), Glucose-6-phosphate dehydrogenase, NAD-binding (InterPro:IPR022674); BEST Arabidopsis thaliana protein match is: glucose-6-phosphate dehydrogenase 2 (TAIR:AT5G13110.1); Has 8248 Blast hits to 8228 proteins in 2347 species: Archae - 0; Bacteria - 5681; Metazoa - 875; Fungi - 180; Plants - 375; Viruses - 4; Other Eukaryotes - 1133 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3038462..3041873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100813.2 → NP_563844.1  glucose-6-phosphate dehydrogenase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563844.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80525, Q93ZW0
      UniProtKB/TrEMBL
      A0A5S9TFV9, A0A654E8G0, Q0WPI4
      Conserved Domains (3) summary
      PLN02333
      Location:14 → 624
      PLN02333; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:158 → 330
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:339 → 622
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    2. NM_001198018.1 → NP_001184947.1  glucose-6-phosphate dehydrogenase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9TFV9, A0A654E8G0, F4I0Y8
      Conserved Domains (3) summary
      PLN02333
      Location:14 → 634
      PLN02333; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:158 → 330
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:339 → 632
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93ZW0.1

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