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    CSA1 disease resistance protein (TIR-NBS-LRR class) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831656, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CSA1
    Official Full Name
    disease resistance protein (TIR-NBS-LRR class)
    Primary source
    TAIR:AT5G17880
    Locus tag
    AT5G17880
    See related
    Araport:AT5G17880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    constitutive shade-avoidance1; MPI7.20; MPI7_20
    Summary
    Encodes a TIR-NBS-LRR protein CSA1 that functions in photomorphogenic development. csa1 mutants display a constitutive shade-avoidance (CSA) phenotype (long stem) under high red:far-red rations (i.e. in the absence of a shade signal). csa1 mutation can be complemented by RPS4, a TIR-NBS-LRR protein that confers resistance against bacterium Pseudomonas syringae.
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    Genomic context

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    See CSA1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (5908834..5913317, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene calcium exchanger 7 Neighboring gene plastid-specific 50S ribosomal protein 6 Neighboring gene ncRNA Neighboring gene DA1-related protein 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual function of the CHS3-CSA1 immune receptor pair. He Y, et al. Trends Plant Sci, 2023 Apr. PMID 36804916
    2. A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development. Faigón-Soverna A, et al. Plant Cell, 2006 Nov. PMID 17114357, Free PMC Article
    3. The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis. Gu B, et al. Cell Host Microbe, 2023 Jun 14. PMID 37167970
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis.
      Title: The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis.
    2. Dual function of the CHS3-CSA1 immune receptor pair.
      Title: Dual function of the CHS3-CSA1 immune receptor pair.
    3. Arabidopsis constitutive shade-avoidance1 (csa1) mutant shows a shade-avoidance phenotype in the absence of shade and enhanced growth of a bacterial pathogen.
      Title: A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development.
    Submit: New GeneRIF Correction

    General gene information

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    NM_121794.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    disease resistance protein (TIR-NBS-LRR class)
    NP_197290.1
    • constitutive shade-avoidance1 (CSA1); FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: response to light stimulus, defense response to bacterium, response to red light, defense response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT3G51570.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5908834..5913317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343529.1 → NP_001331999.1  disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BFL2, A0A654G255

    2. NM_121794.2 → NP_197290.1  disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197290.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KIF3, Q9FKN9
      UniProtKB/TrEMBL
      A0A654G255
      Conserved Domains (7) summary
      COG4886
      Location:599 → 922
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:662 → 684
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:639 → 661
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00931
      Location:207 → 473
      NB-ARC; NB-ARC domain
      pfam01582
      Location:18 → 179
      TIR; TIR domain
      pfam07725
      Location:638 → 657
      LRR_3; Leucine Rich Repeat
      pfam13191
      Location:211 → 317
      AAA_16; AAA ATPase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4KIF3.1

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