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    SUVR2 SET-domain containing protein lysine methyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834422, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUVR2
    Official Full Name
    SET-domain containing protein lysine methyltransferase family protein
    Primary source
    TAIR:AT5G43990
    Locus tag
    AT5G43990
    See related
    Araport:AT5G43990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MRH10.10; MRH10_10; SDG18; SET DOMAIN PROTEIN 18
    Summary
    Encodes SUVR2, one of the four closely related Arabidopsis SUVR proteins that belong to the SU(VAR)3-9 subgroup of SET-domain proteins. Proteins containing the evolutionarily conserved SET domain are involved in regulation of eukaryotic gene expression and chromatin structure through their histone lysine methyltransferase (HMTase) activity. SUVR1, SUVR2 and SUVR4 proteins contain a novel domain at their N-terminus, and a SUVR specific region preceding the SET domain. Localized to the nucleolus, maybe involved in regulation of rRNA expression.
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    Genomic context

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    See SUVR2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (17697686..17702036)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene translocase of outer membrane 22-V Neighboring gene plasmodesmata-located protein 1 Neighboring gene Glutathione S-transferase family protein Neighboring gene uncharacterized protein Neighboring gene fanconi anemia group F protein (FANCF)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SNF2 chromatin remodeler-family proteins FRG1 and -2 are required for RNA-directed DNA methylation. Groth M, et al. Proc Natl Acad Sci U S A, 2014 Dec 9. PMID 25425661, Free PMC Article
    2. The Arabidopsis SUVR4 protein is a nucleolar histone methyltransferase with preference for monomethylated H3K9. Thorstensen T, et al. Nucleic Acids Res, 2006. PMID 17020925, Free PMC Article
    3. The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure. Rahman MA, et al. Biochemistry, 2014 Apr 8. PMID 24625295, Free PMC Article
    4. SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis. Han YF, et al. Cell Res, 2014 Dec. PMID 25420628, Free PMC Article
    5. Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis. Miller MJ, et al. Proc Natl Acad Sci U S A, 2010 Sep 21. PMID 20813957, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study suggests that the involvement of SUVR2 in transcriptional gene silencing is related to nucleosome positioning mediated by its associated chromatin-remodeling proteins.
      Title: SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001085233.2
    NM_001085234.2
    NM_001203540.1
    NM_001344513.1
    NM_001344514.1
    NM_001344515.1
    NM_001344516.1
    NM_001344517.1
    NM_001344518.1
    NM_001344519.1
    NM_001344520.1
    NM_001344521.1
    NM_001344522.1
    NM_001344523.1
    NM_001344524.1
    NM_123766.3
    NM_203151.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gene silencing by siRNA-directed DNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SET-domain containing protein lysine methyltransferase family protein
    NP_001078702.1
    • SUVR2; FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus, chloroplast; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1); Has 3185 Blast hits to 3003 proteins in 299 species: Archae - 0; Bacteria - 104; Metazoa - 1652; Fungi - 402; Plants - 762; Viruses - 0; Other Eukaryotes - 265 (source: NCBI BLink).
    NP_001078703.1
    • SUVR2; FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus, chloroplast; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1); Has 3185 Blast hits to 3003 proteins in 299 species: Archae - 0; Bacteria - 104; Metazoa - 1652; Fungi - 402; Plants - 762; Viruses - 0; Other Eukaryotes - 265 (source: NCBI BLink).
    NP_001190469.1
    • SUVR2; FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1).
    NP_568631.1
    • SUVR2; FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus, chloroplast; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974880.1
    • SUVR2; FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus, chloroplast; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17697686..17702036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203540.1 → NP_001190469.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190469.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FDG4, F4K7E7
      Conserved Domains (3) summary
      smart00317
      Location:530 → 665
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:376 → 522
      Pre-SET; Pre-SET motif
      pfam10440
      Location:6 → 59
      WIYLD; Ubiquitin-binding WIYLD domain

    2. NM_001344521.1 → NP_001331765.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178URU9, A0A1P8BEV9

    3. NM_001344522.1 → NP_001331764.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UPJ7, A0A1P8BEV2

    4. NM_001344524.1 → NP_001331762.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UR43, F4K7E3

    5. NM_001344513.1 → NP_001331768.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEV8, A0A7G2FDG4

    6. NM_001344514.1 → NP_001331767.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WKU5, Q941L4, Q9FNC7
      UniProtKB/TrEMBL
      A0A178UR43

    7. NM_001344523.1 → NP_001331763.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178URU9, A0A1P8BEV9

    8. NM_001085234.2 → NP_001078703.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078703.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WKU5, Q941L4, Q9FNC7
      UniProtKB/TrEMBL
      A0A178UR43
      Conserved Domains (3) summary
      smart00317
      Location:550 → 685
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:396 → 542
      Pre-SET; Pre-SET motif
      pfam10440
      Location:6 → 59
      WIYLD; Ubiquitin-binding WIYLD domain

    9. NM_123766.3 → NP_568631.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568631.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WKU5, Q941L4, Q9FNC7
      UniProtKB/TrEMBL
      A0A178UR43
      Conserved Domains (3) summary
      smart00317
      Location:550 → 685
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:396 → 542
      Pre-SET; Pre-SET motif
      pfam10440
      Location:6 → 59
      WIYLD; Ubiquitin-binding WIYLD domain

    10. NM_001344517.1 → NP_001331772.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FDG4, F4K7E7

    11. NM_001344519.1 → NP_001331770.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FDG4, F4K7E7

    12. NM_001344515.1 → NP_001331773.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178URU9, A0A1P8BEV9

    13. NM_001344518.1 → NP_001331771.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEV8, A0A7G2FDG4

    14. NM_001344516.1 → NP_001331766.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178URU9, A0A1P8BEV9

    15. NM_001344520.1 → NP_001331769.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FDG4, F4K7E7

    16. NM_001085233.2 → NP_001078702.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078702.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WKU5, Q941L4, Q9FNC7
      UniProtKB/TrEMBL
      A0A178UR43
      Conserved Domains (3) summary
      smart00317
      Location:550 → 685
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:396 → 542
      Pre-SET; Pre-SET motif
      pfam10440
      Location:6 → 59
      WIYLD; Ubiquitin-binding WIYLD domain

    17. NM_203151.3 → NP_974880.1  SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974880.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UR43, F4K7E3
      Conserved Domains (3) summary
      smart00317
      Location:573 → 708
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:419 → 565
      Pre-SET; Pre-SET motif
      pfam10440
      Location:29 → 82
      WIYLD; Ubiquitin-binding WIYLD domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FNC7.2

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