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Conserved domains on  [gi|145334715|ref|NP_001078703|]
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SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 417-679 2.96e-59

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


:

Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 199.13  E-value: 2.96e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 417 PVFHYIAQSLVYQDAaVKFSlgNIRDDQCCSsCCGDCLapSMACRC-ATAFNGFAYTVDGLLqedfleqciseardprkq 495
Cdd:cd10538    1 PSFTYIKDNIVGKNV-QPFS--NIIDSVGCK-CKDDCL--DSKCACaAESDGIFAYTKNGLL------------------ 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 496 mllyckecplekakkevilepcKGHLKRKAIKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPnGRGWGLRTLEKLPKGA 575
Cdd:cd10538   57 ----------------------RLNNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVRSLEFIPKGS 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 576 FVCELAGEILTIPELFQR--ISDRP--TSPVILDAYWGSEdisGDDKALSLEGTHYGNISRFINHRClDANLIEIPVHAE 651
Cdd:cd10538  114 FVCEYVGEVITTSEADRRgkIYDKSggSYLFDLDEFSDSD---GDGEELCVDATFCGNVSRFINHSC-DPNLFPFNVVID 189

                        250       260
                 ....*....|....*....|....*...
gi 145334715 652 TTDSHYYHLAFFTTREIDAMEELTWDYG 679
Cdd:cd10538  190 HDDLRYPRIALFATRDILPGEELTFDYG 217
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 6-60 1.76e-24

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


:

Pssm-ID: 431288  Cd Length: 58  Bit Score: 96.55  E-value: 1.76e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145334715    6 HIKKAFMAMRAMGIEDARVKPVLKNLLALYEKNWELIAEDNYRVLADAIFDSHED 60
Cdd:pfam10440   4 RIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
 
Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 417-679 2.96e-59

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 199.13  E-value: 2.96e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 417 PVFHYIAQSLVYQDAaVKFSlgNIRDDQCCSsCCGDCLapSMACRC-ATAFNGFAYTVDGLLqedfleqciseardprkq 495
Cdd:cd10538    1 PSFTYIKDNIVGKNV-QPFS--NIIDSVGCK-CKDDCL--DSKCACaAESDGIFAYTKNGLL------------------ 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 496 mllyckecplekakkevilepcKGHLKRKAIKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPnGRGWGLRTLEKLPKGA 575
Cdd:cd10538   57 ----------------------RLNNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVRSLEFIPKGS 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 576 FVCELAGEILTIPELFQR--ISDRP--TSPVILDAYWGSEdisGDDKALSLEGTHYGNISRFINHRClDANLIEIPVHAE 651
Cdd:cd10538  114 FVCEYVGEVITTSEADRRgkIYDKSggSYLFDLDEFSDSD---GDGEELCVDATFCGNVSRFINHSC-DPNLFPFNVVID 189

                        250       260
                 ....*....|....*....|....*...
gi 145334715 652 TTDSHYYHLAFFTTREIDAMEELTWDYG 679
Cdd:cd10538  190 HDDLRYPRIALFATRDILPGEELTFDYG 217
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 550-685 1.17e-25

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 102.41  E-value: 1.17e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715   550 NKLQVFFTPnGRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRIS----DRPTSPVILDAYWGsedisgddkaLSLEGT 625
Cdd:smart00317   1 NKLEVFKSP-GKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKaydtDGAKAFYLFDIDSD----------LCIDAR 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715   626 HYGNISRFINHRClDANLIEIPVhaetTDSHYYHLAFFTTREIDAMEELTWDYGVPFNQD 685
Cdd:smart00317  70 RKGNLARFINHSC-EPNCELLFV----EVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 6-60 1.76e-24

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


Pssm-ID: 431288  Cd Length: 58  Bit Score: 96.55  E-value: 1.76e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145334715    6 HIKKAFMAMRAMGIEDARVKPVLKNLLALYEKNWELIAEDNYRVLADAIFDSHED 60
Cdd:pfam10440   4 RIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 562-679 7.87e-19

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 82.57  E-value: 7.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715  562 GWGLRTLEKLPKGAFVCELAGEILTIPELFQRISDRPTSPVILDAYWGSEDISGDDKALSLEGT--HYGNISRFINHRCl 639
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDARalYYGNWARFINHSC- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 145334715  640 DANLIEIPVHAETTDshyyHLAFFTTREIDAMEELTWDYG 679
Cdd:pfam00856  80 DPNCEVRVVYVNGGP----RIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
562-702 5.75e-13

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 66.52  E-value: 5.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 562 GWGLRTLEKLPKGAFVCELAGEILTIPELfQRISDRPTsPVILDAYWGSEDISGDdkalsleGTHYGNISRFINHRClDA 641
Cdd:COG2940   17 GRGVFATRDIPKGTLIGEYPGEVITWAEA-ERREPHKE-PLHTYLFELDDDGVID-------GALGGNPARFINHSC-DP 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145334715 642 NLIeipvhAETTDSHYYhlaFFTTREIDAMEELTWDYGvpfnqDVFPTSPFHCQCGSdfCR 702
Cdd:COG2940   87 NCE-----ADEEDGRIF---IVALRDIAAGEELTYDYG-----LDYDEEEYPCRCPN--CR 132
 
Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 417-679 2.96e-59

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 199.13  E-value: 2.96e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 417 PVFHYIAQSLVYQDAaVKFSlgNIRDDQCCSsCCGDCLapSMACRC-ATAFNGFAYTVDGLLqedfleqciseardprkq 495
Cdd:cd10538    1 PSFTYIKDNIVGKNV-QPFS--NIIDSVGCK-CKDDCL--DSKCACaAESDGIFAYTKNGLL------------------ 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 496 mllyckecplekakkevilepcKGHLKRKAIKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPnGRGWGLRTLEKLPKGA 575
Cdd:cd10538   57 ----------------------RLNNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVRSLEFIPKGS 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 576 FVCELAGEILTIPELFQR--ISDRP--TSPVILDAYWGSEdisGDDKALSLEGTHYGNISRFINHRClDANLIEIPVHAE 651
Cdd:cd10538  114 FVCEYVGEVITTSEADRRgkIYDKSggSYLFDLDEFSDSD---GDGEELCVDATFCGNVSRFINHSC-DPNLFPFNVVID 189

                        250       260
                 ....*....|....*....|....*...
gi 145334715 652 TTDSHYYHLAFFTTREIDAMEELTWDYG 679
Cdd:cd10538  190 HDDLRYPRIALFATRDILPGEELTFDYG 217
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 417-702 7.30e-49

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 172.09  E-value: 7.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 417 PVFHYIAQSLVYQDAAV--KFSLGnirddqcCSsCCGDCLAPSMACRCATAFNGFAYTVDGLLQedfleqciseardprk 494
Cdd:cd10542    1 PNFQYINDYIPGDGVKIpeDFLVG-------CE-CTEDCHNNNPTCCPAESGVKFAYDKQGRLR---------------- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 495 qmllyckecplekakkeviLEPckghlkRKAIKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPNGRGWGLRTLEKLPKG 574
Cdd:cd10542   57 -------------------LPP------GTPIYECNSRCKCGPDCPNRVVQRGRKVPLCIFRTSNGRGWGVKTLEDIKKG 111

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 575 AFVCELAGEILTIPELFQR--ISDRPTSPVILDAywgseDISGDDKALSLEGTHYGNISRFINHRClDANLIEIPVHAET 652
Cdd:cd10542  112 TFVMEYVGEIITSEEAERRgkIYDANGRTYLFDL-----DYNDDDCEYTVDAAYYGNISHFINHSC-DPNLAVYAVWINH 185

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 145334715 653 TDSHYYHLAFFTTREIDAMEELTWDY-----GVPFNQDVFPTSPF--HCQCGSDFCR 702
Cdd:cd10542  186 LDPRLPRIAFFAKRDIKAGEELTFDYlmtgtGGSSESTIPKPKDVrvPCLCGSKNCR 242
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 395-704 2.01e-46

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 166.70  E-value: 2.01e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 395 DISLGKETVEIPWVNEVNDKVPPVFHYIAQSLVYQDaaVKFSLGniRDDQCCSSCCGDCLAPS-MACRCATAfNGFAYTV 473
Cdd:cd10517    8 DISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKG--VNINLD--PDFLVGCDCTDGCRDKSkCACQQLTI-EATAATP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 474 DGLLQEDF------LEQCIseardprkqmllyckecplekakkevilepckghlkRKAIKECWSKCGCMKNCGNRVVQQG 547
Cdd:cd10517   83 GGQINPSAgyqyrrLMEKL------------------------------------PTGVYECNSRCKCDKRCYNRVVQNG 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 548 IHNKLQVFFTPNgRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRISDrptspvILDAY--------------WGsEDI 613
Cdd:cd10517  127 LQVRLQVFKTEK-KGWGIRCLDDIPKGSFVCIYAGQILTEDEANEEGLQ------YGDEYfaeldyievveklkEG-YES 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 614 SGDDKALSLEGTHYGNISRFINHRClDANLIEIPVHAETTDSHYYHLAFFTTREIDAMEELTWDYGvpFNQDVFPTSPFH 693
Cdd:cd10517  199 DVEEHCYIIDAKSEGNLGRYLNHSC-SPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDYN--YEVGSVPGKVLY 275

                        330
                 ....*....|.
gi 145334715 694 CQCGSDFCRVR 704
Cdd:cd10517  276 CYCGSSNCRGR 286
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 417-702 5.77e-46

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 163.66  E-value: 5.77e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 417 PVFHYIAQSLVYQDAAVKFSLGNIrddQCCSsCCGDCLapSMACRCATAFNGFAYTVDGLLQEDFleqcisEARDPrkqm 496
Cdd:cd10543    1 PDFLYVTENCETSPLNIDRNITSL---QTCS-CRDDCS--SDNCVCGRLSVRCWYDKEGRLLPDF------NKLDP---- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 497 llyckecplekakkevilePCkghlkrkaIKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTpNGRGWGLRTLEKLPKGAF 576
Cdd:cd10543   65 -------------------PL--------IFECNRACSCWRNCRNRVVQNGIRYRLQLFRT-RGMGWGVRALQDIPKGTF 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 577 VCELAGEILTIPELFQRISdrptspvilDAYWGSEDISgDDKALSLEGTHYGNISRFINHRClDANLIEIPVHAETTDSH 656
Cdd:cd10543  117 VCEYIGELISDSEADSRED---------DSYLFDLDNK-DGETYCIDARRYGNISRFINHLC-EPNLIPVRVFVEHQDLR 185

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 145334715 657 YYHLAFFTTREIDAMEELTWDYGVPFNqdVFPTSPFHCQCGSDFCR 702
Cdd:cd10543  186 FPRIAFFASRDIKAGEELGFDYGEKFW--RIKGKYFTCRCGSPKCK 229
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 526-702 3.04e-40

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 148.22  E-value: 3.04e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 526 IKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPnGRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRISD--RPTSPVI 603
Cdd:cd10544   66 VFECNSMCKCSESCQNRVVQNGLQFKLQVFKTP-KKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSqtKGDMNYI 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 604 LDAywgSEDISGdDKALS--LEGTHYGNISRFINHRClDANLIEIPVHaetTDSHYYHLAFFTTREIDAMEELTWDYGVP 681
Cdd:cd10544  145 IVL---REHLSS-GKVLEtfVDPTYIGNIGRFLNHSC-EPNLFMVPVR---VDSMVPKLALFAARDIVAGEELSFDYSGE 216

                        170       180       190
                 ....*....|....*....|....*....|
gi 145334715 682 FNQDVFPTSPFH---------CQCGSDFCR 702
Cdd:cd10544  217 FSNSVESVTLARqdesksrkpCLCGAENCR 246
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 526-702 3.34e-35

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 133.52  E-value: 3.34e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 526 IKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTpNGRGWGLRTLEKLPKGAFVCELAGEIltipelfqrISDRPTSPVILD 605
Cdd:cd10535   67 IFECNHACSCWRNCRNRVVQNGLRARLQLYRT-RDMGWGVRSLQDIPPGTFVCEYVGEL---------ISDSEADVREED 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 606 AYWGSEDiSGDDKALSLEGTHYGNISRFINHRClDANLIEIPVHAETTDSHYYHLAFFTTREIDAMEELTWDYGVPFnQD 685
Cdd:cd10535  137 SYLFDLD-NKDGEVYCIDARFYGNVSRFINHHC-EPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERF-WD 213

                        170
                 ....*....|....*..
gi 145334715 686 VfPTSPFHCQCGSDFCR 702
Cdd:cd10535  214 I-KGKLFSCRCGSPKCR 229
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 526-702 1.56e-34

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 132.32  E-value: 1.56e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 526 IKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPNGRGWGLRTLEKLPKGAFVCELAGEILTIPELFQR--ISDRPTSPVI 603
Cdd:cd10525   62 IYECNSRCRCGPDCPNRVVQKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRgqIYDRQGATYL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 604 LDAYWgSEDISGDDKAlslegtHYGNISRFINHRClDANLIEIPVHAETTDSHYYHLAFFTTREIDAMEELTWDYGVP-- 681
Cdd:cd10525  142 FDLDY-VEDVYTVDAA------YYGNISHFVNHSC-DPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNMQvd 213

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 145334715 682 ------------FNQDVFPTSP-----FHCQCGSDFCR 702
Cdd:cd10525  214 pvdaestkmdsnFGLAGLPGSPkkrvrIECKCGVRSCR 251
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 518-702 2.61e-34

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 132.06  E-value: 2.61e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 518 KGHLK------RKAIKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPNGRGWGLRTLEKLPKGAFVCELAGEILTiPELF 591
Cdd:cd19473   67 KGCLRghmlnsRLPIYECHEGCACSDDCPNRVVERGRKVPLQIFRTSDGRGWGVRSTVDIKRGQFVDCYVGEIIT-PEEA 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 592 QRISDRPTSPVILDAYW-----GSEDISGDD----KALSLEGTHYGNISRFINHRClDANLIEIPVHAETTDSHYYHLAF 662
Cdd:cd19473  146 QRRRDAATIAQRKDVYLfaldkFSDPDSLDPrlrgDPYEIDGEFMSGPTRFINHSC-DPNLRIFARVGDHADKHIHDLAF 224

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 145334715 663 FTTREIDAMEELTWDY--GVPFNQDVFPTSPFH-----CQCGSDFCR 702
Cdd:cd19473  225 FAIKDIPRGTELTFDYvdGVTGLDDDAGDEEKEkemtkCLCGSPKCR 271
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 519-680 6.42e-33

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 126.75  E-value: 6.42e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 519 GHLKRK--AIKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPNgRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRIS- 595
Cdd:cd10545   53 GRLIRAkpAIYECGPLCKCPPSCYNRVTQKGLRYRLEVFKTAE-RGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSGn 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 596 -------DRPTSPVILDAYWGSEDISGDDKALSLEGT----------HYGNISRFINHRClDANLIEIPVHAETTDSHYY 658
Cdd:cd10545  132 ddylfdiDNRQTNRGWDGGQRLDVGMSDGERSSAEDEesseftidagSFGNVARFINHSC-SPNLFVQCVLYDHNDLRLP 210

                        170       180
                 ....*....|....*....|..
gi 145334715 659 HLAFFTTREIDAMEELTWDYGV 680
Cdd:cd10545  211 RVMLFAADNIPPLQELTYDYGY 232
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 526-702 1.89e-32

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 125.90  E-value: 1.89e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 526 IKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPNgRGWGLRTLEKLPKGAFVCELAGEIltipelfqrISDRPTSPVILD 605
Cdd:cd10533   67 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAK-MGWGVRALQTIPQGTFICEYVGEL---------ISDAEADVREDD 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 606 AYWGSEDiSGDDKALSLEGTHYGNISRFINHRClDANLIEIPVHAETTDSHYYHLAFFTTREIDAMEELTWDYGVPFnQD 685
Cdd:cd10533  137 SYLFDLD-NKDGEVYCIDARYYGNISRFINHLC-DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRF-WD 213

                        170
                 ....*....|....*..
gi 145334715 686 VfPTSPFHCQCGSDFCR 702
Cdd:cd10533  214 I-KSKYFTCQCGSEKCK 229
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 500-702 1.17e-31

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 123.46  E-value: 1.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 500 CKECPLEK---AKKEVILEPCK-GHLK---RKAIKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPNGRGWGLRTLEKLP 572
Cdd:cd10532   27 CSDCFFGKccpAEAGVLFAYNEhGQLKippGTPIYECNSRCKCGPDCPNRVVQKGTQYSLCIFRTSNGRGWGVKTLQKIK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 573 KGAFVCELAGEILTIPELFQR--ISDRPTSPVILDAYWGSEDISGDdkalsleGTHYGNISRFINHRClDANLIEIPVHA 650
Cdd:cd10532  107 KNSFVMEYVGEVITSEEAERRgqFYDSKGITYLFDLDYESDEFTVD-------AARYGNVSHFVNHSC-DPNLQVFNVFI 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145334715 651 ETTDSHYYHLAFFTTREIDAMEELTWDYGVPFNQDVFPTSPFH----------CQCGSDFCR 702
Cdd:cd10532  179 DNLDTRLPRIALFSTRTIKAGEELTFDYQMKGSGDLSSDSIDNspakkrvrtvCKCGAVTCR 240
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 526-702 6.46e-30

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 119.17  E-value: 6.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 526 IKECWSKCGCMKN-CGNRVVQQGIHNKLQVFFTpNGRGWGLRTLEKLPKGAFVCELAGEILtipelfQRISDrPTSPVIL 604
Cdd:cd10523   83 LYECNVSCKCNRMlCQNRVVQHGLQVRLQVFKT-EKKGWGVRCLDDIDKGTFVCIYAGRVL------SRARS-PTEPLPP 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 605 DAYWGSEDisGDDKALS----------------LEGTHYGNISRFINHRCLdANLIEIPVHAETTDSHYYHLAFFTTREI 668
Cdd:cd10523  155 KLELPSEN--EVEVVTSwlilskkrklrenvcfLDASKEGNVGRFLNHSCC-PNLFVQNVFVDTHDKNFPWVAFFTNRVV 231

                        170       180       190
                 ....*....|....*....|....*....|....
gi 145334715 669 DAMEELTWDYGvpFNQDVFPTSPFHCQCGSDFCR 702
Cdd:cd10523  232 KAGTELTWDYS--YDAGTSPEQEIPCLCGVNKCQ 263
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 526-704 1.92e-27

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 111.10  E-value: 1.92e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 526 IKECWSKCGCMKN-CGNRVVQQGIHNKLQVFFTPNgRGWGLRTLEKLPKGAFVCELAGEILTipELFQRISDRptspVIL 604
Cdd:cd10541   67 VYECNKLCKCDPNmCQNRLVQHGLQVRLQLFKTQN-KGWGIRCLDDIAKGTFVCIYAGKILT--DDFADKEGL----EMG 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 605 DAYWGSEDISgDDKALSLEGTHYGNISRFINHRClDANLIEIPVHAETTDSHYYHLAFFTTREIDAMEELTWDYGvpFNQ 684
Cdd:cd10541  140 DEYFANLDHI-EESCYIIDAKLEGNLGRYLNHSC-SPNLFVQNVFVDTHDLRFPWVAFFASKRIKAGTELTWDYN--YEV 215

                        170       180
                 ....*....|....*....|
gi 145334715 685 DVFPTSPFHCQCGSDFCRVR 704
Cdd:cd10541  216 GSVEGKELLCCCGSNECRGR 235
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 550-685 1.17e-25

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 102.41  E-value: 1.17e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715   550 NKLQVFFTPnGRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRIS----DRPTSPVILDAYWGsedisgddkaLSLEGT 625
Cdd:smart00317   1 NKLEVFKSP-GKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKaydtDGAKAFYLFDIDSD----------LCIDAR 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715   626 HYGNISRFINHRClDANLIEIPVhaetTDSHYYHLAFFTTREIDAMEELTWDYGVPFNQD 685
Cdd:smart00317  70 RKGNLARFINHSC-EPNCELLFV----EVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 526-702 2.26e-25

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 106.12  E-value: 2.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 526 IKECWSKCGCMKNCGNRVVQQGIHNKLQVFFTPNgRGWGLRTLEKLPKGAFVCELAGEILTIPELFQR----ISDRPTSP 601
Cdd:cd20073   69 IYECNENCDCGINCPNRVVQRGRKLPLEIFKTKH-KGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRgkkyDNVGVTYL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 602 VILDAYwgsEDisGDDKALSLEGTHYGNISRFINHRClDANLIEIPVHAETTDSHYYHLAFFTTREIDAMEELTWDY-GV 680
Cdd:cd20073  148 FDLDLF---ED--QVDEYYTVDAQYCGDVTRFINHSC-DPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELTFDYsGR 221

                        170       180       190
                 ....*....|....*....|....*....|....
gi 145334715 681 PFNQDVFPTSP------------FHCQCGSDFCR 702
Cdd:cd20073  222 NNFDQLGFIGNrsnskyinlknkRPCYCGSANCR 255
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 6-60 1.76e-24

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


Pssm-ID: 431288  Cd Length: 58  Bit Score: 96.55  E-value: 1.76e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145334715    6 HIKKAFMAMRAMGIEDARVKPVLKNLLALYEKNWELIAEDNYRVLADAIFDSHED 60
Cdd:pfam10440   4 RIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 560-702 1.90e-22

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 93.47  E-value: 1.90e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 560 GRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRISDRPTSPVIlDAYwgsedISGDDKALSLEGTHYGNISRFINHRCl 639
Cdd:cd10531    9 KKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGKS-NFY-----ILSLSDDVVIDATRKGNLSRFINHSC- 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145334715 640 DANLiEIPVhaeTTDSHYYHLAFFTTREIDAMEELTWDYgvpfNQDVFPTSPFHCQCGSDFCR 702
Cdd:cd10531   82 EPNC-ETQK---WIVNGEYRIGIFALRDIPAGEELTFDY----NFVNYNEAKQVCLCGAQNCR 136
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 551-702 3.83e-20

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 87.35  E-value: 3.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 551 KLQVFFTPNgRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRI----SDRP-------TSPVILDAYWgsedisgddka 619
Cdd:cd19174    1 GLERFRTED-KGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMieqyHNHShhyclnlDSGMVIDGYR----------- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 620 lslegthYGNISRFINHRClDANlieipVHAETTD-SHYYHLAFFTTREIDAMEELTWDYGV-PFNqdvfPTSPFHCQCG 697
Cdd:cd19174   69 -------MGNEARFVNHSC-DPN-----CEMQKWSvNGVYRIGLFALKDIPAGEELTYDYNFhSFN----VEKQQPCKCG 131


                 ....*
gi 145334715 698 SDFCR 702
Cdd:cd19174  132 SPNCR 136
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 562-679 7.87e-19

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 82.57  E-value: 7.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715  562 GWGLRTLEKLPKGAFVCELAGEILTIPELFQRISDRPTSPVILDAYWGSEDISGDDKALSLEGT--HYGNISRFINHRCl 639
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDARalYYGNWARFINHSC- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 145334715  640 DANLIEIPVHAETTDshyyHLAFFTTREIDAMEELTWDYG 679
Cdd:pfam00856  80 DPNCEVRVVYVNGGP----RIVIFALRDIKPGEELTIDYG 115
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 551-702 6.39e-18

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 80.70  E-value: 6.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 551 KLQVFFTPnGRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRI-----------------SDRptspvILDAywgsedi 613
Cdd:cd19172    3 KVEVFRTE-KKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMkeyaregnrhyyfmalkSDE-----IIDA------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 614 sgddkalslegTHYGNISRFINHRClDANlieipvhAET---TDSHYYHLAFFTTREIDAMEELTWDYgvpfNQDVFPTS 690
Cdd:cd19172   70 -----------TKKGNLSRFINHSC-EPN-------CETqkwTVNGELRVGFFAKRDIPAGEELTFDY----QFERYGKE 126

                        170
                 ....*....|..
gi 145334715 691 PFHCQCGSDFCR 702
Cdd:cd19172  127 AQKCYCGSPNCR 138
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 396-542 4.42e-17

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 77.07  E-value: 4.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715  396 ISLGKETVEIPWVNEVNDKVPPV-FHYIAQSLVYQDaavkfslGNIRDDQCCSscCGDCLapSMACRCATAFNG---FAY 471
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDEPPPPdFTYITSYIYPKE-------FLLIIPQGCD--CGDCS--SEKCSCAQLNGGefrFPY 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145334715  472 TVDGLLQEDfleqciseardprkqmllyckecplekakkevilepckghlKRKAIKECWSKCGCMKNCGNR 542
Cdd:pfam05033  70 DKDGLLVPE-----------------------------------------SKPPIYECNPLCGCPPSCPNR 99
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 551-701 1.26e-13

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 68.50  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 551 KLQVFFTpNGRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRISDRPTSPVilDAYWgsedISGDDKALSLEGTHYGNI 630
Cdd:cd19173    3 PTEPFKT-GDRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNI--TNFY----MLTLDKDRIIDAGPKGNL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145334715 631 SRFINHRClDANLieipvhaET---TDSHYYHLAFFTTREIDAMEELTWDYgvpfNQDVFPTSPFHCQCGSDFC 701
Cdd:cd19173   76 SRFMNHSC-QPNC-------ETqkwTVNGDTRVGLFAVRDIPAGEELTFNY----NLDCLGNEKKVCRCGAPNC 137
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
562-702 5.75e-13

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 66.52  E-value: 5.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 562 GWGLRTLEKLPKGAFVCELAGEILTIPELfQRISDRPTsPVILDAYWGSEDISGDdkalsleGTHYGNISRFINHRClDA 641
Cdd:COG2940   17 GRGVFATRDIPKGTLIGEYPGEVITWAEA-ERREPHKE-PLHTYLFELDDDGVID-------GALGGNPARFINHSC-DP 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145334715 642 NLIeipvhAETTDSHYYhlaFFTTREIDAMEELTWDYGvpfnqDVFPTSPFHCQCGSdfCR 702
Cdd:COG2940   87 NCE-----ADEEDGRIF---IVALRDIAAGEELTYDYG-----LDYDEEEYPCRCPN--CR 132
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 562-702 6.10e-13

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 66.85  E-value: 6.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 562 GWGLRTLEKLPKGAFVCELAGEILTipelfQRISDrptspvILDAYWGSEDISGD-----DKALSLEGTHYGNISRFINH 636
Cdd:cd10518   25 GWGLFAKRPIAAGEMVIEYVGEVIR-----PIVAD------KREKRYDEEGGGGTymfriDEDLVIDATKKGNIARFINH 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145334715 637 RClDANLIEIPVHAETTDshyyHLAFFTTREIDAMEELTWDYgvPFNQDVFPTSPfhCQCGSDFCR 702
Cdd:cd10518   94 SC-DPNCYAKIITVDGEK----HIVIFAKRDIAPGEELTYDY--KFPIEDEEKIP--CLCGAPNCR 150
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 562-702 2.98e-12

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 64.36  E-value: 2.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 562 GWGLRTLEKLPKGAFVCELAGEILTIPELFQRISDRpTSPVILDAYwgsedISGDDKALSLEGTHYGNISRFINHRClDA 641
Cdd:cd19175   11 GWGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDM-KHKGEKNFY-----MCEIDKDMVIDATFKGNLSRFINHSC-DP 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145334715 642 N--LIEIPVHAETtdshyyHLAFFTTREIDAMEELTWDYG-VPFNQDVfptspfHCQCGSDFCR 702
Cdd:cd19175   84 NceLQKWQVDGET------RIGVFAIRDIKKGEELTYDYQfVQFGADQ------DCHCGSKNCR 135
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 562-682 3.46e-12

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 63.75  E-value: 3.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 562 GWGLRTLEKLPKGAFVCELAGEILTIPELFQRisdrptsPVILDAYWGSEDISGDDKaLSLEGTHYGNISRFINH---RC 638
Cdd:cd19168   13 GLGLFAAEDIKEGEFVIEYTGELISHDEGVRR-------EHRRGDVSYLYLFEEQEG-IWVDAAIYGNLSRYINHatdKV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 145334715 639 LDANLIEIPVHaettDSHYYHLAFFTTREIDAMEELTWDYGVPF 682
Cdd:cd19168   85 KTGNCMPKIMY----VNHEWRIKFTAIKDIKIGEELFFNYGDNF 124
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 559-684 2.13e-11

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 61.59  E-value: 2.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 559 NGRGWGLRTLEKLPKGAFVCELAGEILTIPELFQR---------ISDRPTSPVILDAYWgsedisgddkalslegthYGN 629
Cdd:cd10522   11 SHNGLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDsvyhydplyPFDLNGDILVIDAGK------------------KGN 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 145334715 630 ISRFINHrCLDANLIEIPvhaeTTDSHYYHLAFFTTREIDAMEELTWDYGVPFNQ 684
Cdd:cd10522   73 LTRFINH-SDQPNLELIV----RTLKGEQHIGFVAIRDIKPGEELFISYGPKYWK 122
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 542-680 5.19e-11

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 61.05  E-value: 5.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 542 RVVQQGIHNKLQVFFTPnGRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRisdrptspviLDAYWGSEDI-------S 614
Cdd:cd10528    9 ELILSGKEEGLKVIEID-GKGRGVIATRPFEKGDFVVEYHGDLITITEAKKR----------EALYAKDPSTgcymyyfQ 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145334715 615 GDDKALSLEGTHY-GNISRFINHRCLDANLIEIPVHAETTDshyyHLAFFTTREIDAMEELTWDYGV 680
Cdd:cd10528   78 YKGKTYCVDATKEsGRLGRLINHSKKKPNLKTKLLVIDGVP----HLILVAKRDIKPGEELLYDYGD 140
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 551-702 8.65e-11

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 60.52  E-value: 8.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 551 KLQVFFTPNG-RGWGLRTLEKLPKGAFVCELAGEILTipelfQRISDRPTSPVILDAYwGSEDISGDDKALSLEGTHYGN 629
Cdd:cd20072   12 KKQLKFARSAiHNWGLYAMENISAKDMVIEYVGEVIR-----QQVADEREKRYLRQGI-GSSYLFRIDDDTVVDATKKGN 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334715 630 ISRFINHRClDANLIE--IPVHAETtdshyyHLAFFTTREIDAMEELTWDYGVPFNQDVFPtspfhCQCGSDFCR 702
Cdd:cd20072   86 IARFINHCC-DPNCTAkiIKVEGEK------RIVIYAKRDIAAGEELTYDYKFPREEDKIP-----CLCGAPNCR 148
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 395-534 4.72e-10

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 57.04  E-value: 4.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715   395 DISLGKETVEIPWVNEVNDKVPPV-FHYIAQSLVYQDAavkFSLGNIRDDQCCsSCCGDCLaPSMACRCATA-FNGFAYT 472
Cdd:smart00468   3 DISNGKENVPVPLVNEVDEDPPPPdFEYISEYIYGQGV---PIDRSPSPLVGC-SCSGDCS-SSNKCECARKnGGEFAYE 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145334715   473 VDGllqedfleqciseardprkqmllyckecplekakkevilepCKGHLKRKAIKECWSKCG 534
Cdd:smart00468  78 LNG-----------------------------------------GLRLKRKPLIYECNSRCS 98
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 560-701 4.97e-10

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 58.46  E-value: 4.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 560 GRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRISdRPTSPVILDAYwgsedISGDDKALSLEGTHYGNISRFINHRCL 639
Cdd:cd19211   11 GKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIK-HAHENDITHFY-----MLTIDKDRIIDAGPKGNYSRFMNHSCQ 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145334715 640 -DANLIEIPVHAETtdshyyHLAFFTTREIDAMEELTWDYgvpfNQDVFPTSPFHCQCGSDFC 701
Cdd:cd19211   85 pNCETQKWTVNGDT------RVGLFAVCDIPAGTELTFNY----NLDCLGNEKTVCRCGAPNC 137
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 562-679 7.66e-10

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 56.87  E-value: 7.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 562 GWGLRTLEKLPKGAFVCELAGEILTIPELFQR--ISDRPTSPVILDAywgsedisgdDKALSLEGTHYGNISRFINHRCl 639
Cdd:cd10519   12 GWGLFLKEPIKKDEFIGEYTGELISQDEADRRgkIYDKYNSSYLFNL----------NDQFVVDATRKGNKIRFANHSS- 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 145334715 640 DANlieipVHAET-TDSHYYHLAFFTTREIDAMEELTWDYG 679
Cdd:cd10519   81 NPN-----CYAKVmMVNGDHRIGIFAKRDIEAGEELFFDYG 116
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 551-701 1.10e-09

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 57.24  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 551 KLQVFFTPnGRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRISdrptspvildaYWGSEDISGD-----DKALSLEGT 625
Cdd:cd19210    3 EVEIFRTL-GRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIR-----------YAQEHDITNFymltlDKDRIIDAG 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145334715 626 HYGNISRFINHRCL-DANLIEIPVHAETtdshyyHLAFFTTREIDAMEELTWDYgvpfNQDVFPTSPFHCQCGSDFC 701
Cdd:cd19210   71 PKGNYARFMNHCCQpNCETQKWTVNGDT------RVGLFALCDIKAGTELTFNY----NLECLGNGKTVCKCGAPNC 137
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 562-702 2.04e-09

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 56.58  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 562 GWGLRTLEKLPKGAFVCELAGEIL--TIPELFQRisdRPTSPVIldaywGSEDISGDDKALSLEGTHYGNISRFINHRCl 639
Cdd:cd19169   24 DWGLFALEPIAADEMVIEYVGQVIrqSVADEREK---RYEAIGI-----GSSYLFRVDDDTIIDATKCGNLARFINHSC- 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145334715 640 DANLIEIPVhaeTTDSHyYHLAFFTTREIDAMEELTWDYGVPFNQDVFPtspfhCQCGSDFCR 702
Cdd:cd19169   95 NPNCYAKII---TVESQ-KKIVIYSKRPIAVNEEITYDYKFPIEDEKIP-----CLCGAPQCR 148
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 553-701 4.86e-09

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 55.32  E-value: 4.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 553 QVFFTpNGRGWGLRTLEKLPKGAFVCELAGEILTIPELFQRISdRPTSPVILDAYwgsedISGDDKALSLEGTHYGNISR 632
Cdd:cd19212    5 EIIKT-ERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIK-RAHENSVTNFY-----MLTVTKDRIIDAGPKGNYSR 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145334715 633 FINHRClDANlieipvhAET---TDSHYYHLAFFTTREIDAMEELTWDYgvpfNQDVFPTSPFHCQCGSDFC 701
Cdd:cd19212   78 FMNHSC-NPN-------CETqkwTVNGDVRVGLFALCDIPAGMELTFNY----NLDCLGNGRTECHCGADNC 137
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 562-702 2.04e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 53.93  E-value: 2.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 562 GWGLRTLEKLPKGAFVCELAGEILtipelfqrisdRPTSPVILDAYWGSEDIS----GDDKALSLEGTHYGNISRFINHR 637
Cdd:cd19170   25 GRGLFCKRNIDAGEMVIEYAGEVI-----------RSVLTDKREKYYESKGIGcymfRIDDDEVVDATMHGNAARFINHS 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334715 638 ClDANLIEIPVHAETTDshyyHLAFFTTREIDAMEELTWDYGVPFNQDVFPtspfhCQCGSDFCR 702
Cdd:cd19170   94 C-EPNCYSRVVNIDGKK----HIVIFALRRILRGEELTYDYKFPIEDVKIP-----CTCGSKKCR 148
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 557-679 6.62e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 49.94  E-value: 6.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 557 TPNGRGWGLRTLEKLPKGAFVCelageiltipelfqrisdrptspvildaywgsedisgddkalslegthygnISRFINH 636
Cdd:cd08161    6 TIPGAGFGLFATRDIPKGEVIG---------------------------------------------------LARFINH 34

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 145334715 637 RClDANLIEIPVHaettDSHYYHLAFFTTREIDAMEELTWDYG 679
Cdd:cd08161   35 SC-EPNCEFEEVY----VGGKPRVFIVALRDIKAGEELTVDYG 72
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 622-702 9.89e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 51.95  E-value: 9.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 622 LEGTHYGNISRFINHRClDANLIEIPVHAETTDshyyHLAFFTTREIDAMEELTWDYGVPFNQdvfPTSPFHCQCGSDFC 701
Cdd:cd19206   78 VDATMHGNAARFINHSC-EPNCYSRVINIDGQK----HIVIFAMRKIYRGEELTYDYKFPIED---ASNKLPCNCGAKKC 149


                 .
gi 145334715 702 R 702
Cdd:cd19206  150 R 150
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 622-702 9.45e-07

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 49.25  E-value: 9.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 622 LEGTHYGNISRFINHRClDANLIEIPVHAETTDshyyHLAFFTTREIDAMEELTWDYGVPFNQdvfPTSPFHCQCGSDFC 701
Cdd:cd19207   78 VDATMHGNAARFINHSC-EPNCYSRVIHVEGQK----HIVIFALRKIYRGEELTYDYKFPIED---ASNKLPCNCGAKRC 149


                 .
gi 145334715 702 R 702
Cdd:cd19207  150 R 150
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 563-702 1.09e-06

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 48.87  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 563 WGLRTLEKLPKGAFVCELAGEiltipELFQRISDRPTSPVILDAYwGSEDISGDDKALSLEGTHYGNISRFINHRCLD-- 640
Cdd:cd19204   26 WGLFAMEPIAADEMVIEYVGQ-----NIRQVVADMREKRYVQEGI-GSSYLFRVDHDTIIDATKCGNLARFINHCCTPnc 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145334715 641 -ANLIEIPVHAEttdshyyhLAFFTTREIDAMEELTWDYGVPFNQDVFPtspfhCQCGSDFCR 702
Cdd:cd19204  100 yAKVITIESQKK--------IVIYSKQPIGVNEEITYDYKFPIEDNKIP-----CLCGTENCR 149
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 564-678 1.40e-06

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 48.04  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 564 GLRTLEKLPKGAFVCELAGEILTIPElFQRIS---DRPTSPVILDAYWGSEDISGDdkalsleGTHYGNISRFINHRClD 640
Cdd:cd10529   18 GLVATEDISPGEPILEYKGEVSLRSE-FKEDNgffKRPSPFVFFYDGFEGLPLCVD-------ARKYGNEARFIRRSC-R 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 145334715 641 ANL-IEIPVHAETTdshyYHLAFFTTREIDAMEELT--WDY 678
Cdd:cd10529   89 PNAeLRHVVVSNGE----LRLFIFALKDIRKGTEITipFDY 125
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 563-702 4.35e-06

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 47.36  E-value: 4.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 563 WGLRTLEKLPKGAFVCELAGEilTIPELFQRISDRPTSpvilDAYWGSEDISGDDKALSLEGTHYGNISRFINHRClDAN 642
Cdd:cd19205   26 WGLFAMEPIAADEMVIEYVGQ--NIRQVIADMREKRYE----DEGIGSSYMFRVDHDTIIDATKCGNFARFINHSC-NPN 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 643 LIEIPVHAETTDShyyhLAFFTTREIDAMEELTWDYGVPFNQDVFPtspfhCQCGSDFCR 702
Cdd:cd19205   99 CYAKVITVESQKK----IVIYSKQHINVNEEITYDYKFPIEDVKIP-----CLCGSENCR 149
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 622-702 1.14e-05

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 45.88  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334715 622 LEGTHYGNISRFINHRClDANLIEIPVHAETTDshyyHLAFFTTREIDAMEELTWDYGVPFNQDvfpTSPFHCQCGSDFC 701
Cdd:cd19171   78 IDATMTGGPARYINHSC-NPNCVAEVVTFDKEK----KIIIISNRRIAKGEELTYDYKFDFEDD---QHKIPCLCGAPNC 149


                 .
gi 145334715 702 R 702
Cdd:cd19171  150 R 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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