MVD1 mevalonate diphosphate decarboxylase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: MVD1
Official Full Name: mevalonate diphosphate decarboxylase 1
Primary source: TAIR:AT2G38700
Locus tag: AT2G38700
See related: Araport:AT2G38700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATMVD1; MEVALONATE DIPHOSPHATE DECARBOXYLASE; mevalonate diphosphate decarboxylase 1; T6A23.10; T6A23_10
Summary: Encodes mevalonate diphosphate decarboxylase, the enzyme that catalyzes the synthesis of isopentenyl diphosphate, used in sterol and isoprenoid biosynthesis. The protein appears to form a homodimeric complex. Incidentally, it was shown that the Arabidopsis MVD protein could also interact with its yeast homolog to form a heterodimer.
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Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

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NM_129427.5

Function	Evidence Code	Pubs
enables diphosphomevalonate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables diphosphomevalonate decarboxylase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, mevalonate pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within lipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

NP_181404.1

mevalonate diphosphate decarboxylase 1 (MVD1); CONTAINS InterPro DOMAIN/s: Diphosphomevalonate decarboxylase (InterPro:IPR005935), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), GHMP kinase (InterPro:IPR006204), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721); BEST Arabidopsis thaliana protein match is: GHMP kinase family protein (TAIR:AT3G54250.1); Has 1516 Blast hits to 1513 proteins in 678 species: Archae - 56; Bacteria - 877; Metazoa - 121; Fungi - 149; Plants - 60; Viruses - 0; Other Eukaryotes - 253 (source: NCBI BLink).

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