Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.
Pssm-ID: 465732 Cd Length: 186 Bit Score: 269.81 E-value: 6.33e-90
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of ...
10-325
9.67e-88
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]
Pssm-ID: 130307 Cd Length: 305 Bit Score: 268.74 E-value: 9.67e-88
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
9-320
7.45e-87
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 442633 Cd Length: 322 Bit Score: 266.67 E-value: 7.45e-87
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.
Pssm-ID: 465732 Cd Length: 186 Bit Score: 269.81 E-value: 6.33e-90
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of ...
10-325
9.67e-88
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]
Pssm-ID: 130307 Cd Length: 305 Bit Score: 268.74 E-value: 9.67e-88
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
9-320
7.45e-87
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 442633 Cd Length: 322 Bit Score: 266.67 E-value: 7.45e-87
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
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specific hits meet or exceed a domain-specific e-value threshold
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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