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    PDAT phospholipid:diacylglycerol acyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831208, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PDAT
    Official Full Name
    phospholipid:diacylglycerol acyltransferase
    Primary source
    TAIR:AT5G13640
    Locus tag
    AT5G13640
    See related
    Araport:AT5G13640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE; ATPDAT; PDAT1; PHOSPHOLIPID DIACYLGLYCEROL ACYLTRANSFERASE; phospholipid:diacylglycerol acyltransferase; PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE 1; T6I14.2
    Summary
    arabidopsis phospholipid:diacylglycerol acyltransferase (PDAT)
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    Genomic context

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    See PDAT in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (4392937..4397541)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene magnesium-chelatase subunit chlH, chloroplast, putative / Mg-protoporphyrin IX chelatase, putative (CHLH) Neighboring gene elongation factor family protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PDAT1 genome editing reduces hydroxy fatty acid production in transgenic Arabidopsis. Park ME, et al. BMB Rep, 2024 Feb. PMID 38053289, Free PMC Article
    2. Characterization of the diversification of phospholipid:diacylglycerol acyltransferases in the green lineage. Falarz LJ, et al. Plant J, 2020 Sep. PMID 32538516
    3. Phospholipid:Diacylglycerol Acyltransferase-Mediated Triacylglyerol Synthesis Augments Basal Thermotolerance. Mueller SP, et al. Plant Physiol, 2017 Sep. PMID 28733391, Free PMC Article
    4. Phospholipid:diacylglycerol acyltransferase-mediated triacylglycerol biosynthesis is crucial for protection against fatty acid-induced cell death in growing tissues of Arabidopsis. Fan J, et al. Plant J, 2013 Dec. PMID 24118513
    5. Arabidopsis lipins, PDAT1 acyltransferase, and SDP1 triacylglycerol lipase synergistically direct fatty acids toward β-oxidation, thereby maintaining membrane lipid homeostasis. Fan J, et al. Plant Cell, 2014 Oct. PMID 25293755, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDAT1 genome editing reduces hydroxy fatty acid production in transgenic Arabidopsis.
      Title: PDAT1 genome editing reduces hydroxy fatty acid production in transgenic Arabidopsis.
    2. Oil-Producing Metabolons Containing DGAT1 Use Separate Substrate Pools from those Containing DGAT2 or PDAT.
      Title: Oil-Producing Metabolons Containing DGAT1 Use Separate Substrate Pools from those Containing DGAT2 or PDAT.
    3. PDAT1 expression is regulated by MYB96 in the Arabidopsis seeds.
      Title: The MYB96 Transcription Factor Regulates Triacylglycerol Accumulation by Activating DGAT1 and PDAT1 Expression in Arabidopsis Seeds.
    4. PDAT, transferring a fatty acyl moiety from phosphatidylcholine (PC) to diacylglycerol (DAG), was shown to be essential for heat-induced TAG accumulation. Finally, we show that pdat1mutant lines unable to accumulate TAGs under heat-stress conditions display normal short-term acquired thermotolerance but are compromised in basal thermotolerance.
      Title: Phospholipid:Diacylglycerol Acyltransferase-Mediated Triacylglyerol Synthesis Augments Basal Thermotolerance.
    5. Data show that PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE1 (PDAT1) and SUGAR-DEPENDENT1 (SDP1) TAG lipase, function synergistically in directing fatty acids (FAs) toward peroxisomal beta-oxidation via triacylglycerol (TAG) intermediates.
      Title: Arabidopsis lipins, PDAT1 acyltransferase, and SDP1 triacylglycerol lipase synergistically direct fatty acids toward β-oxidation, thereby maintaining membrane lipid homeostasis.
    6. PDAT1 plays a critical role in mediating triacylglycerol (TAG) synthesis and thereby protecting against free fatty acids (FFAs)-induced cell death in fast-growing tissues of plants.
      Title: Phospholipid:diacylglycerol acyltransferase-mediated triacylglycerol biosynthesis is crucial for protection against fatty acid-induced cell death in growing tissues of Arabidopsis.
    7. Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2.
      Title: Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2.
    8. PDAT1 and DGAT1 have overlapping functions for triacylglycerol synthesis in both seed and pollen, and that the absence of their function leads not only to a reduction in TAG, but also to critical defects in normal pollen and embryo development. [PDAT1]
      Title: DGAT1 and PDAT1 acyltransferases have overlapping functions in Arabidopsis triacylglycerol biosynthesis and are essential for normal pollen and seed development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001343284.1
    NM_121367.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid:diacylglycerol acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within triglyceride biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    phospholipid:diacylglycerol acyltransferase
    NP_196868.1
    • phospholipid:diacylglycerol acyltransferase (PDAT); FUNCTIONS IN: phosphatidylcholine-sterol O-acyltransferase activity, phospholipid:diacylglycerol acyltransferase activity; INVOLVED IN: lipid metabolic process; LOCATED IN: endoplasmic reticulum, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Lecithin:cholesterol acyltransferase (InterPro:IPR003386); BEST Arabidopsis thaliana protein match is: Lecithin:cholesterol acyltransferase family protein (TAIR:AT3G44830.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4392937..4397541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343283.1 → NP_001331240.1  phospholipid:diacylglycerol acyltransferase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BD95

    2. NM_121367.3 → NP_196868.1  phospholipid:diacylglycerol acyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196868.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6YC80, Q9FNA9
      UniProtKB/TrEMBL
      A0A178UIJ4, A0A5S9Y3U3
      Conserved Domains (1) summary
      PLN02517
      Location:34 → 671
      PLN02517; phosphatidylcholine-sterol O-acyltransferase

    3. NM_001343284.1 → NP_001331241.1  phospholipid:diacylglycerol acyltransferase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BD92
      Conserved Domains (1) summary
      PLN02517
      Location:6 → 527
      PLN02517; phosphatidylcholine-sterol O-acyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FNA9.1

    Gene LinkOut

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