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    Argp Arginine phosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 261628, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Argpprovided by FlyBase
    Official Full Name
    Arginine phosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051469
    Locus tag
    Dmel_CG31469
    See related
    AllianceGenome:FB:FBgn0051469
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31469; CG9599; DARP; Dmel\CG31469
    Summary
    Enables protein arginine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoplasm and extracellular exosome. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Argp in Genome Data Viewer
    Location:
    87F12-87F12; 3-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13709159..13709939, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9534881..9535661, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene neither inactivation nor afterpotential B Neighboring gene Adenosine deaminase-related growth factor D Neighboring gene Adenosine deaminase-related growth factor C Neighboring gene primo-1 Neighboring gene primo-2 Neighboring gene long non-coding RNA:CR34044

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria. Fuhrmann J, et al. Cell Rep, 2013 Jun 27. PMID 23770242
    2. Structural and Biochemical Characterization of the Two Drosophila Low Molecular Weight-Protein Tyrosine Phosphatases DARP and Primo-1. Lee HS, et al. Mol Cells, 2020 Dec 31. PMID 33372666, Free PMC Article
    3. The Recent De Novo Origin of Protein C-Termini. Andreatta ME, et al. Genome Biol Evol, 2015 May 21. PMID 26002864, Free PMC Article
    4. A Drosophila-centric view of protein tyrosine phosphatases. Hatzihristidis T, et al. FEBS Lett, 2015 Apr 13. PMID 25771859
    5. Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. Lai CQ, et al. Mech Ageing Dev, 2007 Mar. PMID 17196240

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein arginine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables protein tyrosine phosphatase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arginine phosphatase
    Names
    Argp-PA
    CG31469-PA
    drosophila ARginine phosphatase
    NP_731853.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13709159..13709939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169551.4 → NP_731853.2  arginine phosphatase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731853.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6G0, Q4V6L6, Q8ING6
      Conserved Domains (1) summary
      cd00115
      Location:1 → 151
      LMWPc; Low molecular weight phosphatase family;
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8ING6 Q8ING6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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